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Editing gene: CALML4 (CAeditome ID:91860)

Gene summary for CALML4

Gene summary

Gene information	Gene symbol	CALML4
	Gene ID	91860
	Gene name	calmodulin like 4
	Synonyms	NY-BR-20
	Cytomap	15q23
	Type of gene	protein-coding
	Description	calmodulin-like protein 4serologically defined breast cancer antigen NY-BR-20
	Modification date	20210518
	UniProtAcc	Q96GE6
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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RNA A-to-I events for CALML4

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000129007.13

RNA A-to-I editing events in Cancer.

CAediting_1056076(68198883, -), CAediting_1056077(68198905, -), CAediting_1056078(68198996, -), CAediting_1056079(68199167, -), CAediting_1056080(68199822, -), CAediting_1056081(68199872, -), CAediting_1056082(68202340, -), CAediting_1056083(68202347, -), CAediting_1056084(68202349, -), CAediting_1056085(68202361, -), CAediting_1056086(68202362, -), CAediting_1056087(68202363, -), CAediting_1056088(68202371, -), CAediting_1056089(68202382, -), CAediting_1056090(68202414, -), CAediting_1056091(68202421, -), CAediting_1056092(68202433, -), CAediting_1056093(68202440, -), CAediting_1056094(68202471, -), CAediting_1056095(68202474, -), CAediting_1056096(68202484, -), CAediting_1056097(68202494, -), CAediting_1056098(68202497, -), CAediting_1056099(68202511, -), CAediting_1056100(68202523, -), CAediting_1056101(68202524, -), CAediting_1056102(68202530, -), CAediting_1056103(68202534, -), CAediting_1056104(68202537, -), CAediting_1056105(68202543, -), CAediting_1056106(68202544, -), CAediting_1056107(68202567, -), CAediting_1056108(68202568, -), CAediting_1056109(68202710, -), CAediting_1056110(68202740, -), CAediting_1056111(68202749, -), CAediting_1056112(68202755, -), CAediting_1056113(68202765, -), CAediting_1056114(68202781, -), CAediting_1056115(68202784, -), CAediting_1056116(68202792, -), CAediting_1056117(68202869, -), CAediting_1056118(68202886, -), CAediting_1056119(68202907, -), CAediting_1056120(68202911, -), CAediting_1056121(68202917, -), CAediting_1056122(68202926, -), CAediting_1056123(68202930, -), CAediting_1056124(68202939, -), CAediting_1056125(68202943, -), CAediting_1056126(68202947, -), CAediting_1056127(68202952, -), CAediting_1056128(68202953, -), CAediting_1056129(68202963, -), CAediting_1056130(68202979, -), CAediting_1056131(68203047, -), CAediting_1056132(68203052, -), CAediting_1056133(68203057, -), CAediting_1056134(68203061, -), CAediting_1056135(68203073, -), CAediting_1056136(68203079, -), CAediting_1056137(68203105, -), CAediting_1056138(68203111, -), CAediting_1056139(68203143, -), CAediting_1056140(68203151, -), CAediting_1056141(68203166, -), CAediting_1056142(68203167, -), CAediting_1056143(68203177, -), CAediting_1056144(68203187, -), CAediting_1056145(68203214, -), CAediting_1056146(68203222, -), CAediting_1056147(68203223, -), CAediting_1056148(68203231, -), CAediting_1056149(68203239, -), CAediting_1056150(68203244, -),

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RNA editing positional annotations for CALML4 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_1056076	chr15_68198883_-	intronic
CAediting_1056077	chr15_68198905_-	intronic
CAediting_1056078	chr15_68198996_-	intronic
CAediting_1056079	chr15_68199167_-	intronic
CAediting_1056080	chr15_68199822_-	UTR5
CAediting_1056081	chr15_68199872_-	UTR5
CAediting_1056082	chr15_68202340_-	intronic
CAediting_1056083	chr15_68202347_-	intronic
CAediting_1056084	chr15_68202349_-	intronic
CAediting_1056085	chr15_68202361_-	intronic
CAediting_1056086	chr15_68202362_-	intronic
CAediting_1056087	chr15_68202363_-	intronic
CAediting_1056088	chr15_68202371_-	intronic
CAediting_1056089	chr15_68202382_-	intronic
CAediting_1056090	chr15_68202414_-	intronic
CAediting_1056091	chr15_68202421_-	intronic
CAediting_1056092	chr15_68202433_-	intronic
CAediting_1056093	chr15_68202440_-	intronic
CAediting_1056094	chr15_68202471_-	intronic
CAediting_1056095	chr15_68202474_-	intronic
CAediting_1056096	chr15_68202484_-	intronic
CAediting_1056097	chr15_68202494_-	intronic
CAediting_1056098	chr15_68202497_-	intronic
CAediting_1056099	chr15_68202511_-	intronic
CAediting_1056100	chr15_68202523_-	intronic
CAediting_1056101	chr15_68202524_-	intronic
CAediting_1056102	chr15_68202530_-	intronic
CAediting_1056103	chr15_68202534_-	intronic
CAediting_1056104	chr15_68202537_-	intronic
CAediting_1056105	chr15_68202543_-	intronic
CAediting_1056106	chr15_68202544_-	intronic
CAediting_1056107	chr15_68202567_-	intronic
CAediting_1056108	chr15_68202568_-	intronic
CAediting_1056109	chr15_68202710_-	intronic
CAediting_1056110	chr15_68202740_-	intronic
CAediting_1056111	chr15_68202749_-	intronic
CAediting_1056112	chr15_68202755_-	intronic
CAediting_1056113	chr15_68202765_-	intronic
CAediting_1056114	chr15_68202781_-	intronic
CAediting_1056115	chr15_68202784_-	intronic
CAediting_1056116	chr15_68202792_-	intronic
CAediting_1056117	chr15_68202869_-	intronic
CAediting_1056118	chr15_68202886_-	intronic
CAediting_1056119	chr15_68202907_-	intronic
CAediting_1056120	chr15_68202911_-	intronic
CAediting_1056121	chr15_68202917_-	intronic
CAediting_1056122	chr15_68202926_-	intronic
CAediting_1056123	chr15_68202930_-	intronic
CAediting_1056124	chr15_68202939_-	intronic
CAediting_1056125	chr15_68202943_-	intronic
CAediting_1056126	chr15_68202947_-	intronic
CAediting_1056127	chr15_68202952_-	intronic
CAediting_1056128	chr15_68202953_-	intronic
CAediting_1056129	chr15_68202963_-	intronic
CAediting_1056130	chr15_68202979_-	intronic
CAediting_1056131	chr15_68203047_-	intronic
CAediting_1056132	chr15_68203052_-	intronic
CAediting_1056133	chr15_68203057_-	intronic
CAediting_1056134	chr15_68203061_-	intronic
CAediting_1056135	chr15_68203073_-	intronic
CAediting_1056136	chr15_68203079_-	intronic
CAediting_1056137	chr15_68203105_-	intronic
CAediting_1056138	chr15_68203111_-	intronic
CAediting_1056139	chr15_68203143_-	intronic
CAediting_1056140	chr15_68203151_-	intronic
CAediting_1056141	chr15_68203166_-	intronic
CAediting_1056142	chr15_68203167_-	intronic
CAediting_1056143	chr15_68203177_-	intronic
CAediting_1056144	chr15_68203187_-	intronic
CAediting_1056145	chr15_68203214_-	intronic
CAediting_1056146	chr15_68203222_-	intronic
CAediting_1056147	chr15_68203223_-	intronic
CAediting_1056148	chr15_68203231_-	intronic
CAediting_1056149	chr15_68203239_-	intronic
CAediting_1056150	chr15_68203244_-	intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_1056076	chr15_68198883_-	SINE	Alu	AluSx1
CAediting_1056077	chr15_68198905_-	SINE	Alu	AluSx1
CAediting_1056078	chr15_68198996_-	SINE	Alu	AluSx1
CAediting_1056079	chr15_68199167_-	SINE	Alu	AluSx1
CAediting_1056080	chr15_68199822_-	DNA	hAT-Blackjack	MER53
CAediting_1056081	chr15_68199872_-	DNA	hAT-Blackjack	MER53
CAediting_1056082	chr15_68202340_-	SINE	Alu	AluJb
CAediting_1056083	chr15_68202347_-	SINE	Alu	AluJb
CAediting_1056084	chr15_68202349_-	SINE	Alu	AluJb
CAediting_1056085	chr15_68202361_-	SINE	Alu	AluJb
CAediting_1056086	chr15_68202362_-	SINE	Alu	AluJb
CAediting_1056087	chr15_68202363_-	SINE	Alu	AluJb
CAediting_1056088	chr15_68202371_-	SINE	Alu	AluJb
CAediting_1056089	chr15_68202382_-	SINE	Alu	AluJb
CAediting_1056090	chr15_68202414_-	SINE	Alu	AluJb
CAediting_1056091	chr15_68202421_-	SINE	Alu	AluJb
CAediting_1056092	chr15_68202433_-	SINE	Alu	AluJb
CAediting_1056093	chr15_68202440_-	SINE	Alu	AluJb
CAediting_1056094	chr15_68202471_-	SINE	Alu	AluJb
CAediting_1056095	chr15_68202474_-	SINE	Alu	AluJb
CAediting_1056096	chr15_68202484_-	SINE	Alu	AluJb
CAediting_1056097	chr15_68202494_-	SINE	Alu	AluJb
CAediting_1056098	chr15_68202497_-	SINE	Alu	AluJb
CAediting_1056099	chr15_68202511_-	SINE	Alu	AluJb
CAediting_1056100	chr15_68202523_-	SINE	Alu	AluJb
CAediting_1056101	chr15_68202524_-	SINE	Alu	AluJb
CAediting_1056102	chr15_68202530_-	SINE	Alu	AluJb
CAediting_1056103	chr15_68202534_-	SINE	Alu	AluJb
CAediting_1056104	chr15_68202537_-	SINE	Alu	AluJb
CAediting_1056105	chr15_68202543_-	SINE	Alu	AluJb
CAediting_1056106	chr15_68202544_-	SINE	Alu	AluJb
CAediting_1056107	chr15_68202567_-	SINE	Alu	AluJb
CAediting_1056108	chr15_68202568_-	SINE	Alu	AluJb
CAediting_1056109	chr15_68202710_-	SINE	Alu	AluSq2
CAediting_1056110	chr15_68202740_-	SINE	Alu	AluSq2
CAediting_1056111	chr15_68202749_-	SINE	Alu	AluSq2
CAediting_1056112	chr15_68202755_-	SINE	Alu	AluSq2
CAediting_1056113	chr15_68202765_-	SINE	Alu	AluSq2
CAediting_1056114	chr15_68202781_-	SINE	Alu	AluSq2
CAediting_1056115	chr15_68202784_-	SINE	Alu	AluSq2
CAediting_1056116	chr15_68202792_-	SINE	Alu	AluSq2
CAediting_1056117	chr15_68202869_-	SINE	Alu	AluSq
CAediting_1056118	chr15_68202886_-	SINE	Alu	AluSq
CAediting_1056119	chr15_68202907_-	SINE	Alu	AluSq
CAediting_1056120	chr15_68202911_-	SINE	Alu	AluSq
CAediting_1056121	chr15_68202917_-	SINE	Alu	AluSq
CAediting_1056122	chr15_68202926_-	SINE	Alu	AluSq
CAediting_1056123	chr15_68202930_-	SINE	Alu	AluSq
CAediting_1056124	chr15_68202939_-	SINE	Alu	AluSq
CAediting_1056125	chr15_68202943_-	SINE	Alu	AluSq
CAediting_1056126	chr15_68202947_-	SINE	Alu	AluSq
CAediting_1056127	chr15_68202952_-	SINE	Alu	AluSq
CAediting_1056128	chr15_68202953_-	SINE	Alu	AluSq
CAediting_1056129	chr15_68202963_-	SINE	Alu	AluSq
CAediting_1056130	chr15_68202979_-	SINE	Alu	AluSq
CAediting_1056131	chr15_68203047_-	SINE	Alu	AluSq
CAediting_1056132	chr15_68203052_-	SINE	Alu	AluSq
CAediting_1056133	chr15_68203057_-	SINE	Alu	AluSq
CAediting_1056134	chr15_68203061_-	SINE	Alu	AluSq
CAediting_1056135	chr15_68203073_-	SINE	Alu	AluSq
CAediting_1056136	chr15_68203079_-	SINE	Alu	AluSq
CAediting_1056137	chr15_68203105_-	SINE	Alu	AluSq
CAediting_1056138	chr15_68203111_-	SINE	Alu	AluSq
CAediting_1056139	chr15_68203143_-	SINE	Alu	AluSq2
CAediting_1056140	chr15_68203151_-	SINE	Alu	AluSq2
CAediting_1056141	chr15_68203166_-	SINE	Alu	AluSq2
CAediting_1056142	chr15_68203167_-	SINE	Alu	AluSq2
CAediting_1056143	chr15_68203177_-	SINE	Alu	AluSq2
CAediting_1056144	chr15_68203187_-	SINE	Alu	AluSq2
CAediting_1056145	chr15_68203214_-	SINE	Alu	AluSq2
CAediting_1056146	chr15_68203222_-	SINE	Alu	AluSq2
CAediting_1056147	chr15_68203223_-	SINE	Alu	AluSq2
CAediting_1056148	chr15_68203231_-	SINE	Alu	AluSq2
CAediting_1056149	chr15_68203239_-	SINE	Alu	AluSq2
CAediting_1056150	chr15_68203244_-	SINE	Alu	AluSq2

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RNA A-to-I editing events in the alternative splicing sites for CALML4

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000129007.13.CALML4.

Correlation between RNA A-to-I editing and PSI for ENSG00000129007.13.CALML4.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for CALML4

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for CALML4

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for CALML4

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_688080	chr9_63819626_+	ENSG00000129007.13	ENST00000448060	hsa-miR-4477b	68193680	68193687	8mer-1a	68193680	68193701	151	-14.95
CAediting_1229415	chr17_67471547_+	ENSG00000129007.13	ENST00000448060	hsa-miR-548aa	68192995	68193001	7mer-m8	68192994	68193019	146	-14.03
CAediting_1229415	chr17_67471547_+	ENSG00000129007.13	ENST00000448060	hsa-miR-548aa	68192786	68192792	7mer-m8	68192785	68192809	150	-18.16
CAediting_1306323	chr19_13836462_-	ENSG00000129007.13	ENST00000448060	hsa-miR-27a-3p	68193793	68193799	7mer-m8	68193792	68193812	158	-18.04

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1306323	chr19_13836462_-	ENSG00000129007.13	ENST00000448060	hsa-miR-27a-3p	68193708	68193714	7mer-m8	68193707	68193726	154	-18.45
CAediting_1054808	chr15_66496985_-	ENSG00000129007.13	ENST00000448060	hsa-miR-4512	68192596	68192602	7mer-m8	68192595	68192613	142	-18.04
CAediting_1524209	chrX_134546392_-	ENSG00000129007.13	ENST00000448060	hsa-miR-503-5p	68193719	68193724	6mer	68193718	68193740	148	-25.18

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for CALML4

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for CALML4

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
STAD	CAediting_1056107	chr15_68202567_-	0.000165832879366954	0.27130900286454	.	.	.	.
ESCA	CAediting_1056107	chr15_68202567_-	0.0494962131737657	0.201061196936216	0.00758058129436351	0.27095755594705	.	.

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Relation with cancer stages for CALML4

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for CALML4

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for CALML4

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for CALML4

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene