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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: REPS2 (CAeditome ID:9185)

Gene summary for REPS2

check button Gene summary
Gene informationGene symbol

REPS2

Gene ID

9185

Gene nameRALBP1 associated Eps domain containing 2
SynonymsPOB1
Cytomap

Xp22.2

Type of geneprotein-coding
DescriptionralBP1-associated Eps domain-containing protein 2RALBP1-interacting protein 2partner of Ral-binding protein 1partner of RalBP1
Modification date20210518
UniProtAcc

Q8NFH8

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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RNA A-to-I events for REPS2

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000169891.16
boxplot

check button RNA A-to-I editing events in Cancer.
CAediting_1500964(16951321, +), CAediting_1500965(16951323, +), CAediting_1500966(16951324, +), CAediting_1500967(16960332, +), CAediting_1500968(16963005, +), CAediting_1500969(16988027, +), CAediting_1500970(17019568, +), CAediting_1500971(17019582, +), CAediting_1500972(17019642, +), CAediting_1500973(17019645, +), CAediting_1500974(17088844, +), CAediting_1500975(17088845, +), CAediting_1500976(17108009, +), CAediting_1500977(17110633, +), CAediting_1500978(17110939, +), CAediting_1500979(17110955, +), CAediting_1500980(17111001, +), CAediting_1500981(17112036, +), CAediting_1500982(17112089, +), CAediting_1500983(17112099, +), CAediting_1500984(17112117, +), CAediting_1500985(17112143, +), CAediting_1500986(17112160, +), CAediting_1500987(17112162, +), CAediting_1500988(17112189, +), CAediting_1500989(17112198, +), CAediting_1500990(17112212, +), CAediting_1500991(17112221, +), CAediting_1500992(17112222, +), CAediting_1500993(17112851, +), CAediting_1500994(17112855, +), CAediting_1500995(17112869, +), CAediting_1500996(17112885, +), CAediting_1500997(17112903, +), CAediting_1500998(17112944, +), CAediting_1500999(17112953, +), CAediting_1501000(17112971, +), CAediting_1501001(17113020, +), CAediting_1501002(17113041, +), CAediting_1501003(17113042, +), CAediting_1501004(17141606, +), CAediting_1501005(17142747, +), CAediting_1501006(17142754, +), CAediting_1501007(17148172, +), CAediting_1501008(17148182, +), CAediting_1501009(17148268, +), CAediting_1501010(17148271, +), CAediting_1501011(17149409, +), CAediting_1501012(17149435, +), CAediting_1501013(17149445, +), CAediting_1501014(17149467, +), CAediting_1501015(17149471, +), CAediting_1501016(17149520, +), CAediting_1501017(17149549, +), CAediting_1501018(17149580, +),

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RNA editing positional annotations for REPS2 using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_1500964chrX_16951321_+ncRNA_intronic
CAediting_1500965chrX_16951323_+ncRNA_intronic
CAediting_1500966chrX_16951324_+ncRNA_intronic
CAediting_1500967chrX_16960332_+ncRNA_intronic
CAediting_1500968chrX_16963005_+ncRNA_intronic
CAediting_1500969chrX_16988027_+ncRNA_intronic
CAediting_1500970chrX_17019568_+ncRNA_intronic
CAediting_1500971chrX_17019582_+ncRNA_intronic
CAediting_1500972chrX_17019642_+ncRNA_intronic
CAediting_1500973chrX_17019645_+ncRNA_intronic
CAediting_1500974chrX_17088844_+ncRNA_intronic
CAediting_1500975chrX_17088845_+ncRNA_intronic
CAediting_1500976chrX_17108009_+ncRNA_intronic
CAediting_1500977chrX_17110633_+ncRNA_intronic
CAediting_1500978chrX_17110939_+ncRNA_intronic
CAediting_1500979chrX_17110955_+ncRNA_intronic
CAediting_1500980chrX_17111001_+ncRNA_intronic
CAediting_1500981chrX_17112036_+ncRNA_intronic
CAediting_1500982chrX_17112089_+ncRNA_intronic
CAediting_1500983chrX_17112099_+ncRNA_intronic
CAediting_1500984chrX_17112117_+ncRNA_intronic
CAediting_1500985chrX_17112143_+ncRNA_intronic
CAediting_1500986chrX_17112160_+ncRNA_intronic
CAediting_1500987chrX_17112162_+ncRNA_intronic
CAediting_1500988chrX_17112189_+ncRNA_intronic
CAediting_1500989chrX_17112198_+ncRNA_intronic
CAediting_1500990chrX_17112212_+ncRNA_intronic
CAediting_1500991chrX_17112221_+ncRNA_intronic
CAediting_1500992chrX_17112222_+ncRNA_intronic
CAediting_1500993chrX_17112851_+ncRNA_intronic
CAediting_1500994chrX_17112855_+ncRNA_intronic
CAediting_1500995chrX_17112869_+ncRNA_intronic
CAediting_1500996chrX_17112885_+ncRNA_intronic
CAediting_1500997chrX_17112903_+ncRNA_intronic
CAediting_1500998chrX_17112944_+ncRNA_intronic
CAediting_1500999chrX_17112953_+ncRNA_intronic
CAediting_1501000chrX_17112971_+ncRNA_intronic
CAediting_1501001chrX_17113020_+ncRNA_intronic
CAediting_1501002chrX_17113041_+ncRNA_intronic
CAediting_1501003chrX_17113042_+ncRNA_intronic
CAediting_1501004chrX_17141606_+ncRNA_intronic
CAediting_1501005chrX_17142747_+ncRNA_intronic
CAediting_1501006chrX_17142754_+ncRNA_intronic
CAediting_1501007chrX_17148172_+UTR3
CAediting_1501008chrX_17148182_+UTR3
CAediting_1501009chrX_17148268_+UTR3
CAediting_1501010chrX_17148271_+UTR3
CAediting_1501011chrX_17149409_+UTR3
CAediting_1501012chrX_17149435_+UTR3
CAediting_1501013chrX_17149445_+UTR3
CAediting_1501014chrX_17149467_+UTR3
CAediting_1501015chrX_17149471_+UTR3
CAediting_1501016chrX_17149520_+UTR3
CAediting_1501017chrX_17149549_+UTR3
CAediting_1501018chrX_17149580_+UTR3

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_1500967chrX_16960332_+SINEAluAluJr
CAediting_1500968chrX_16963005_+SINEAluAluJb
CAediting_1500969chrX_16988027_+SINEAluAluJo
CAediting_1500970chrX_17019568_+SINEAluAluJo
CAediting_1500971chrX_17019582_+SINEAluAluJo
CAediting_1500972chrX_17019642_+SINEAluAluJo
CAediting_1500973chrX_17019645_+SINEAluAluJo
CAediting_1500974chrX_17088844_+SINEAluAluY
CAediting_1500975chrX_17088845_+SINEAluAluY
CAediting_1500976chrX_17108009_+SINEAluAluJb
CAediting_1500977chrX_17110633_+SINEAluAluSq2
CAediting_1500978chrX_17110939_+SINEAluAluSx
CAediting_1500979chrX_17110955_+SINEAluAluSx
CAediting_1500980chrX_17111001_+SINEAluAluSx
CAediting_1500981chrX_17112036_+SINEAluAluJo
CAediting_1500982chrX_17112089_+SINEAluAluJo
CAediting_1500983chrX_17112099_+SINEAluAluJo
CAediting_1500984chrX_17112117_+SINEAluAluJo
CAediting_1500985chrX_17112143_+SINEAluAluJo
CAediting_1500986chrX_17112160_+SINEAluAluJo
CAediting_1500987chrX_17112162_+SINEAluAluJo
CAediting_1500988chrX_17112189_+SINEAluAluJo
CAediting_1500989chrX_17112198_+SINEAluAluJo
CAediting_1500990chrX_17112212_+SINEAluAluJo
CAediting_1500991chrX_17112221_+SINEAluAluJo
CAediting_1500992chrX_17112222_+SINEAluAluJo
CAediting_1500993chrX_17112851_+SINEAluAluY
CAediting_1500994chrX_17112855_+SINEAluAluY
CAediting_1500995chrX_17112869_+SINEAluAluY
CAediting_1500996chrX_17112885_+SINEAluAluY
CAediting_1500997chrX_17112903_+SINEAluAluY
CAediting_1500998chrX_17112944_+SINEAluAluY
CAediting_1500999chrX_17112953_+SINEAluAluY
CAediting_1501000chrX_17112971_+SINEAluAluY
CAediting_1501001chrX_17113020_+SINEAluAluY
CAediting_1501002chrX_17113041_+SINEAluAluY
CAediting_1501003chrX_17113042_+SINEAluAluY
CAediting_1501004chrX_17141606_+LINEL1L1ME2z
CAediting_1501005chrX_17142747_+LINEL1L1ME1
CAediting_1501006chrX_17142754_+LINEL1L1ME1
CAediting_1501011chrX_17149409_+SINEAluAluSz6
CAediting_1501012chrX_17149435_+SINEAluAluSz6
CAediting_1501013chrX_17149445_+SINEAluAluSz6
CAediting_1501014chrX_17149467_+SINEAluAluSz6
CAediting_1501015chrX_17149471_+SINEAluAluSz6
CAediting_1501016chrX_17149520_+SINEAluAluSz6
CAediting_1501017chrX_17149549_+SINEAluAluSz6
CAediting_1501018chrX_17149580_+SINEAluAluSz6

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RNA A-to-I editing events in the alternative splicing sites for REPS2

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000169891.16.REPS2.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000169891.16.REPS2.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for REPS2

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.
boxplot

check button Correlation between RNA A-to-I editing and gene expression.
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.
LGG.CAediting_1501008.ENSG00000169891.REPS2.png
Soverview

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Protein coding region RNA A-to-I editings for REPS2

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for REPS2

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_1501008chrX_17148182_+ENSG00000169891.16ENST00000303843hsa-miR-3190-5p17148175171481817mer-m81714816317148182143.00-16.94
CAediting_1501012chrX_17149435_+ENSG00000169891.16ENST00000303843hsa-miR-4691-3p17149432171494387mer-m81714941317149439153.00-28.71
CAediting_1501015chrX_17149471_+ENSG00000169891.16ENST00000303843hsa-miR-34a-3p17149467171494737mer-m81714945217149474145.00-8.14
CAediting_1501016chrX_17149520_+ENSG00000169891.16ENST00000303843hsa-miR-4786-5p17149518171495247mer-m81714950517149525149.00-24.52
CAediting_1501016chrX_17149520_+ENSG00000169891.16ENST00000303843hsa-miR-6849-3p17149514171495207mer-m81714950117149521152.00-19.52
CAediting_1501017chrX_17149549_+ENSG00000169891.16ENST00000303843hsa-miR-476717149547171495537mer-m81714953017149554143.00-18.04
CAediting_1501018chrX_17149580_+ENSG00000169891.16ENST00000303843hsa-miR-106a-3p17149576171495816mer1714956117149582146.00-23.59

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_1501011chrX_17149409_+ENSG00000169891.16ENST00000303843hsa-miR-219b-3p17149406171494127mer-m81714939317149413153-18.56
CAediting_1501011chrX_17149409_+ENSG00000169891.16ENST00000303843hsa-miR-302f17149405171494117mer-m81714939617149412145-8.67
CAediting_1501017chrX_17149549_+ENSG00000169891.16ENST00000303843hsa-miR-316517149544171495507mer-m81714953217149551149-16.89
CAediting_1501008chrX_17148182_+ENSG00000169891.16ENST00000303843hsa-miR-445317148178171481858mer-1a1714816317148185148-21.07
CAediting_1501014chrX_17149467_+ENSG00000169891.16ENST00000303843hsa-miR-466317149462171494687mer-m81714944517149469148-22.78
CAediting_1501012chrX_17149435_+ENSG00000169891.16ENST00000303843hsa-miR-569017149432171494387mer-m81714941917149439145-16.75
CAediting_1501017chrX_17149549_+ENSG00000169891.16ENST00000303843hsa-miR-674517149545171495517mer-m81714952817149552150-25.73
CAediting_1501017chrX_17149549_+ENSG00000169891.16ENST00000303843hsa-miR-6756-5p17149546171495516mer1714952817149552152-30.31
CAediting_1501014chrX_17149467_+ENSG00000169891.16ENST00000303843hsa-miR-807717149463171494686mer1714944817149469145-19.68

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_748296chr10_51299626_+ENSG00000169891.16ENST00000303843hsa-miR-605-3p17152171171521777mer-m81715215717152178143-17.44
CAediting_748296chr10_51299626_+ENSG00000169891.16ENST00000303843hsa-miR-605-3p17148013171480197mer-m81714799817148020151-21.66
CAediting_1306324chr19_13836464_-ENSG00000169891.16ENST00000303843hsa-miR-27a-3p17151147171511537mer-m81715113317151154156-16.91
CAediting_1229414chr17_67471546_+ENSG00000169891.16ENST00000303843hsa-miR-548aa17150357171503637mer-m81715034217150364147-13.9
CAediting_1229414chr17_67471546_+ENSG00000169891.16ENST00000303843hsa-miR-548aa17152442171524487mer-m81715242817152449149-9.06
CAediting_1229415chr17_67471547_+ENSG00000169891.16ENST00000303843hsa-miR-548aa17149643171496497mer-m81714962617149650155-11.61
CAediting_86358chr1_109598906_+ENSG00000169891.16ENST00000303843hsa-miR-197-5p17149545171495517mer-m81714952417149552143-28.95
CAediting_77128chr1_85133844_+ENSG00000169891.16ENST00000303843hsa-miR-4423-3p17150641171506477mer-m81715062817150648140-16.75
CAediting_228905chr2_188297554_+ENSG00000169891.16ENST00000303843hsa-miR-561-3p17149208171492147mer-m81714919417149215153-14.71
CAediting_228905chr2_188297554_+ENSG00000169891.16ENST00000303843hsa-miR-561-3p17151814171518207mer-m81715179417151821162-25.17
CAediting_396018chr5_1062918_-ENSG00000169891.16ENST00000303843hsa-miR-463517149535171495417mer-m81714952117149542165-23.21
CAediting_442554chr5_154685830_+ENSG00000169891.16ENST00000303843hsa-miR-130317153201171532077mer-m81715318717153208140-11.22
CAediting_524911chr7_5495852_-ENSG00000169891.16ENST00000303843hsa-miR-589-3p17149335171493417mer-m81714931917149342154-19.19
CAediting_524911chr7_5495852_-ENSG00000169891.16ENST00000303843hsa-miR-589-3p17152387171523937mer-m81715237117152394145-13.76

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_1160181chr17_7017644_-ENSG00000169891.16ENST00000303843hsa-miR-195-3p17149794171498018mer-1a1714977417149801141-10.94
CAediting_1160181chr17_7017644_-ENSG00000169891.16ENST00000303843hsa-miR-195-3p17151427171514337mer-m81715141417151434154-15.94
CAediting_86358chr1_109598906_+ENSG00000169891.16ENST00000303843hsa-miR-197-5p17150834171508407mer-m81715081917150841151-17.77
CAediting_1229413chr17_67471544_+ENSG00000169891.16ENST00000303843hsa-miR-548aa17149862171498676mer1714986017149887145-12.23
CAediting_1229414chr17_67471546_+ENSG00000169891.16ENST00000303843hsa-miR-548aa17149862171498676mer1714986017149887145-12.23
CAediting_1229415chr17_67471547_+ENSG00000169891.16ENST00000303843hsa-miR-548aa17149862171498676mer1714986017149887145-12.23
CAediting_1229413chr17_67471544_+ENSG00000169891.16ENST00000303843hsa-miR-548aa17149880171498867mer-m81714986017149887145-12.23
CAediting_1229414chr17_67471546_+ENSG00000169891.16ENST00000303843hsa-miR-548aa17149880171498867mer-m81714986017149887145-12.23
CAediting_1229415chr17_67471547_+ENSG00000169891.16ENST00000303843hsa-miR-548aa17149880171498867mer-m81714986017149887145-12.23
CAediting_117844chr1_162342605_+ENSG00000169891.16ENST00000303843hsa-miR-556-3p17151390171513978mer-1a1715137717151397153-11.52
CAediting_228905chr2_188297554_+ENSG00000169891.16ENST00000303843hsa-miR-561-3p17153206171532116mer1715319117153212143-15.7
CAediting_524911chr7_5495852_-ENSG00000169891.16ENST00000303843hsa-miR-589-3p17149267171492748mer-1a1714924717149274152-17.12
CAediting_524911chr7_5495852_-ENSG00000169891.16ENST00000303843hsa-miR-589-3p17149612171496198mer-1a1714959717149619155-19.27
CAediting_748296chr10_51299626_+ENSG00000169891.16ENST00000303843hsa-miR-605-3p17152989171529957mer-m81715297617152996154-12.19
CAediting_1351755chr19_40282625_-ENSG00000169891.16ENST00000303843hsa-miR-64117151474171514807mer-m81715145817151481155-16.96
CAediting_1351755chr19_40282625_-ENSG00000169891.16ENST00000303843hsa-miR-64117151957171519637mer-m81715194017151964148-14.65

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for REPS2

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for REPS2

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
BRCACAediting_1501007chrX_17148172_+1.68580233606865e-060.380578149921338....
LGGCAediting_1501008chrX_17148182_+..4.37033055342891e-050.445474501736542..
LGGCAediting_1501009chrX_17148268_+0.0001127406355913320.460659925716832....
BRCACAediting_1501009chrX_17148268_+5.57149153631891e-240.519323408446335....
PRADCAediting_1501009chrX_17148268_+4.85055923695997e-090.52647187776526....
STADCAediting_1501009chrX_17148268_+0.003468833679484110.264806699082552....
KIRCCAediting_1501009chrX_17148268_+0.0008805142575393320.243173675939111....

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Relation with cancer stages for REPS2

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.

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Relation with survival for REPS2

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR

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RelatedDrugs for REPS2

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for REPS2

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource
REPS2C0006142Malignant neoplasm of breast1CTD_human
REPS2C0678222Breast Carcinoma1CTD_human
REPS2C1257931Mammary Neoplasms, Human1CTD_human
REPS2C1458155Mammary Neoplasms1CTD_human
REPS2C4704874Mammary Carcinoma, Human1CTD_human