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Editing gene: DGKI (CAeditome ID:9162)

Gene summary for DGKI

Gene summary

Gene information	Gene symbol	DGKI
	Gene ID	9162
	Gene name	diacylglycerol kinase iota
	Synonyms	DGK-IOTA
	Cytomap	7q33
	Type of gene	protein-coding
	Description	diacylglycerol kinase iotaDAG kinase iotadiglyceride kinase iota
	Modification date	20210518
	UniProtAcc	O75912
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
DGKI	GO:0004143	Diacylglycerol kinase iota	9830018
DGKI	GO:0046834	Diacylglycerol kinase iota	9830018
DGKI	GO:0005634	Diacylglycerol kinase iota	9830018
DGKI	GO:0005737	Diacylglycerol kinase iota	9830018
DGKI	GO:0043197	Diacylglycerol kinase iota	21119615
DGKI	GO:0045202	Diacylglycerol kinase iota	21119615
DGKI	GO:0032991	Diacylglycerol kinase iota	21119615

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RNA A-to-I events for DGKI

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000157680.14

RNA A-to-I editing events in Cancer.

CAediting_605706(137383171, -), CAediting_605707(137383172, -), CAediting_605708(137383188, -), CAediting_605709(137383189, -), CAediting_605710(137383190, -), CAediting_605711(137383191, -), CAediting_605712(137383192, -), CAediting_605713(137383193, -), CAediting_605714(137383200, -), CAediting_605715(137383208, -), CAediting_605716(137383213, -), CAediting_605717(137383232, -), CAediting_605718(137383239, -), CAediting_605719(137383261, -), CAediting_605720(137383280, -), CAediting_605721(137383300, -), CAediting_605722(137383313, -), CAediting_605723(137383314, -), CAediting_605724(137383320, -), CAediting_605725(137435872, -), CAediting_605726(137624634, -), CAediting_605727(137625215, -), CAediting_605728(137625885, -), CAediting_605729(137625898, -), CAediting_605730(137625899, -), CAediting_605731(137625913, -), CAediting_605732(137626459, -), CAediting_605733(137626473, -), CAediting_605734(137626492, -), CAediting_605735(137734238, -), CAediting_605736(137734317, -), CAediting_605737(137734362, -), CAediting_605738(137734414, -), CAediting_605739(137735068, -), CAediting_605740(137735075, -), CAediting_605741(137735077, -), CAediting_605742(137735081, -), CAediting_605743(137844516, -),

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RNA editing positional annotations for DGKI using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_605706	chr7_137383171_-	UTR3
CAediting_605707	chr7_137383172_-	UTR3
CAediting_605708	chr7_137383188_-	UTR3
CAediting_605709	chr7_137383189_-	UTR3
CAediting_605710	chr7_137383190_-	UTR3
CAediting_605711	chr7_137383191_-	UTR3
CAediting_605712	chr7_137383192_-	UTR3
CAediting_605713	chr7_137383193_-	UTR3
CAediting_605714	chr7_137383200_-	UTR3
CAediting_605715	chr7_137383208_-	UTR3
CAediting_605716	chr7_137383213_-	UTR3
CAediting_605717	chr7_137383232_-	UTR3
CAediting_605718	chr7_137383239_-	UTR3
CAediting_605719	chr7_137383261_-	UTR3
CAediting_605720	chr7_137383280_-	UTR3
CAediting_605721	chr7_137383300_-	UTR3
CAediting_605722	chr7_137383313_-	UTR3
CAediting_605723	chr7_137383314_-	UTR3
CAediting_605724	chr7_137383320_-	UTR3
CAediting_605725	chr7_137435872_-	ncRNA_intronic
CAediting_605726	chr7_137624634_-	ncRNA_intronic
CAediting_605727	chr7_137625215_-	ncRNA_intronic
CAediting_605728	chr7_137625885_-	ncRNA_intronic
CAediting_605729	chr7_137625898_-	ncRNA_intronic
CAediting_605730	chr7_137625899_-	ncRNA_intronic
CAediting_605731	chr7_137625913_-	ncRNA_intronic
CAediting_605732	chr7_137626459_-	ncRNA_intronic
CAediting_605733	chr7_137626473_-	ncRNA_intronic
CAediting_605734	chr7_137626492_-	ncRNA_intronic
CAediting_605735	chr7_137734238_-	ncRNA_intronic
CAediting_605736	chr7_137734317_-	ncRNA_intronic
CAediting_605737	chr7_137734362_-	ncRNA_intronic
CAediting_605738	chr7_137734414_-	ncRNA_intronic
CAediting_605739	chr7_137735068_-	ncRNA_intronic
CAediting_605740	chr7_137735075_-	ncRNA_intronic
CAediting_605741	chr7_137735077_-	ncRNA_intronic
CAediting_605742	chr7_137735081_-	ncRNA_intronic
CAediting_605743	chr7_137844516_-	ncRNA_intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_605725	chr7_137435872_-	SINE	Alu	AluSx
CAediting_605726	chr7_137624634_-	SINE	Alu	AluY
CAediting_605727	chr7_137625215_-	SINE	Alu	AluSx1
CAediting_605737	chr7_137734362_-	LTR	ERVL-MaLR	MLT1F2
CAediting_605738	chr7_137734414_-	LTR	ERVL-MaLR	MLT1F2
CAediting_605739	chr7_137735068_-	LINE	L2	L2c
CAediting_605740	chr7_137735075_-	LINE	L2	L2c
CAediting_605741	chr7_137735077_-	LINE	L2	L2c
CAediting_605742	chr7_137735081_-	LINE	L2	L2c
CAediting_605743	chr7_137844516_-	DNA	hAT-Charlie	MER5A1

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RNA A-to-I editing events in the alternative splicing sites for DGKI

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000157680.14.DGKI.

Correlation between RNA A-to-I editing and PSI for ENSG00000157680.14.DGKI.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for DGKI

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for DGKI

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for DGKI

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_605708	chr7_137383188_-	ENSG00000157680.14	ENST00000453654	hsa-miR-501-5p	137383184	137383191	8mer-1a	137383184	137383205	142.00	-12.11
CAediting_605709	chr7_137383189_-	ENSG00000157680.14	ENST00000453654	hsa-miR-130a-5p	137383186	137383193	8mer-1a	137383186	137383208	142.00	-6.85
CAediting_605709	chr7_137383189_-	ENSG00000157680.14	ENST00000453654	hsa-miR-4753-3p	137383186	137383192	7mer-m8	137383185	137383206	147.00	-8.66
CAediting_605712	chr7_137383192_-	ENSG00000157680.14	ENST00000453654	hsa-miR-627-3p	137383186	137383193	8mer-1a	137383186	137383205	156.00	-16.12
CAediting_605716	chr7_137383213_-	ENSG00000157680.14	ENST00000453654	hsa-miR-548s	137383208	137383215	8mer-1a	137383208	137383231	153.00	-13.67
CAediting_605717	chr7_137383232_-	ENSG00000157680.14	ENST00000453654	hsa-miR-1202	137383228	137383235	8mer-1a	137383228	137383246	143.00	-14.24
CAediting_605717	chr7_137383232_-	ENSG00000157680.14	ENST00000453654	hsa-miR-3194-5p	137383229	137383236	8mer-1a	137383229	137383249	145.00	-20.72
CAediting_605717	chr7_137383232_-	ENSG00000157680.14	ENST00000453654	hsa-miR-3972	137383228	137383235	8mer-1a	137383228	137383249	163.00	-25.18
CAediting_605721	chr7_137383300_-	ENSG00000157680.14	ENST00000453654	hsa-miR-150-5p	137383295	137383302	8mer-1a	137383295	137383316	140.00	-12.97
CAediting_605721	chr7_137383300_-	ENSG00000157680.14	ENST00000453654	hsa-miR-186-3p	137383297	137383303	7mer-1a	137383297	137383319	146.00	-14.20
CAediting_605721	chr7_137383300_-	ENSG00000157680.14	ENST00000453654	hsa-miR-3613-3p	137383300	137383306	7mer-m8	137383299	137383322	144.00	-4.07
CAediting_605721	chr7_137383300_-	ENSG00000157680.14	ENST00000453654	hsa-miR-4713-5p	137383295	137383301	7mer-m8	137383294	137383315	140.00	-12.61
CAediting_605724	chr7_137383320_-	ENSG00000157680.14	ENST00000453654	hsa-miR-330-3p	137383320	137383326	7mer-m8	137383319	137383340	147.00	-10.93
CAediting_605707	chr7_137383172_-	ENSG00000157680.14	ENST00000453654	hsa-miR-1301-5p	137383168	137383175	8mer-1a	137383168	137383186	140.00	-11.78
CAediting_605707	chr7_137383172_-	ENSG00000157680.14	ENST00000453654	hsa-miR-325	137383171	137383178	8mer-1a	137383171	137383193	141.00	-11.77
CAediting_605707	chr7_137383172_-	ENSG00000157680.14	ENST00000453654	hsa-miR-6502-5p	137383168	137383175	8mer-1a	137383168	137383189	149.00	-11.86
CAediting_605713	chr7_137383193_-	ENSG00000157680.14	ENST00000453654	hsa-miR-4768-3p	137383192	137383199	8mer-1a	137383192	137383211	145.00	-14.10
CAediting_605714	chr7_137383200_-	ENSG00000157680.14	ENST00000453654	hsa-miR-12126	137383199	137383205	7mer-m8	137383198	137383221	146.00	-16.91
CAediting_605715	chr7_137383208_-	ENSG00000157680.14	ENST00000453654	hsa-miR-4471	137383202	137383209	8mer-1a	137383202	137383223	151.00	-17.04
CAediting_605715	chr7_137383208_-	ENSG00000157680.14	ENST00000453654	hsa-miR-4794	137383208	137383214	7mer-m8	137383207	137383231	143.00	-15.35
CAediting_605715	chr7_137383208_-	ENSG00000157680.14	ENST00000453654	hsa-miR-582-3p	137383206	137383211	6mer	137383205	137383225	152.00	-15.15
CAediting_605715	chr7_137383208_-	ENSG00000157680.14	ENST00000453654	hsa-miR-664a-5p	137383208	137383214	7mer-m8	137383207	137383236	149.00	-21.80
CAediting_605715	chr7_137383208_-	ENSG00000157680.14	ENST00000453654	hsa-miR-8059	137383202	137383209	8mer-1a	137383202	137383221	152.00	-14.77
CAediting_605715	chr7_137383208_-	ENSG00000157680.14	ENST00000453654	hsa-miR-892b	137383207	137383213	7mer-m8	137383206	137383227	141.00	-15.70
CAediting_605719	chr7_137383261_-	ENSG00000157680.14	ENST00000453654	hsa-miR-548s	137383256	137383263	8mer-1a	137383256	137383280	154.00	-14.50
CAediting_605720	chr7_137383280_-	ENSG00000157680.14	ENST00000453654	hsa-miR-1202	137383277	137383283	7mer-m8	137383276	137383294	143.00	-14.85
CAediting_605720	chr7_137383280_-	ENSG00000157680.14	ENST00000453654	hsa-miR-3194-5p	137383277	137383284	8mer-1a	137383277	137383297	145.00	-20.72
CAediting_605720	chr7_137383280_-	ENSG00000157680.14	ENST00000453654	hsa-miR-3972	137383277	137383283	7mer-m8	137383276	137383297	159.00	-24.59
CAediting_605723	chr7_137383314_-	ENSG00000157680.14	ENST00000453654	hsa-miR-4684-5p	137383313	137383319	7mer-m8	137383312	137383333	151.00	-15.23
CAediting_605723	chr7_137383314_-	ENSG00000157680.14	ENST00000453654	hsa-miR-593-3p	137383311	137383317	7mer-1a	137383311	137383329	145.00	-22.39
CAediting_605723	chr7_137383314_-	ENSG00000157680.14	ENST00000453654	hsa-miR-6818-3p	137383311	137383317	7mer-m8	137383310	137383331	140.00	-9.65

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_605720	chr7_137383280_-	ENSG00000157680.14	ENST00000453654	hsa-miR-3146	137383276	137383282	7mer-m8	137383275	137383296	140	-9.51
CAediting_605706	chr7_137383171_-	ENSG00000157680.14	ENST00000453654	hsa-miR-6885-3p	137383165	137383172	8mer-1a	137383165	137383185	140	-5.12

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_748296	chr10_51299626_+	ENSG00000157680.14	ENST00000453654	hsa-miR-605-3p	137391169	137391175	7mer-m8	137391168	137391188	155	-17.49
CAediting_393	chr1_1167164_+	ENSG00000157680.14	ENST00000453654	hsa-miR-200b-3p	137384186	137384192	7mer-m8	137384185	137384205	141	-8.97
CAediting_688081	chr9_63819627_+	ENSG00000157680.14	ENST00000453654	hsa-miR-4477b	137389694	137389701	8mer-1a	137389694	137389716	142	-14.38
CAediting_688081	chr9_63819627_+	ENSG00000157680.14	ENST00000453654	hsa-miR-4477b	137389533	137389539	7mer-m8	137389532	137389556	152	-17.29
CAediting_688081	chr9_63819627_+	ENSG00000157680.14	ENST00000453654	hsa-miR-4477b	137381228	137381234	7mer-m8	137381227	137381253	154	-18.18
CAediting_748296	chr10_51299626_+	ENSG00000157680.14	ENST00000288490	hsa-miR-605-3p	137391169	137391175	7mer-m8	137391168	137391188	155	-17.49
CAediting_748296	chr10_51299626_+	ENSG00000157680.14	ENST00000424189	hsa-miR-605-3p	137391169	137391175	7mer-m8	137391168	137391188	155	-17.49
CAediting_748296	chr10_51299626_+	ENSG00000157680.14	ENST00000446122	hsa-miR-605-3p	137391169	137391175	7mer-m8	137391168	137391188	155	-17.49
CAediting_1229415	chr17_67471547_+	ENSG00000157680.14	ENST00000453654	hsa-miR-548aa	137389087	137389093	7mer-m8	137389086	137389110	156	-10.23
CAediting_1229415	chr17_67471547_+	ENSG00000157680.14	ENST00000453654	hsa-miR-548aa	137387852	137387859	8mer-1a	137387852	137387876	150	-7.87
CAediting_1229415	chr17_67471547_+	ENSG00000157680.14	ENST00000453654	hsa-miR-548aa	137385380	137385386	7mer-m8	137385379	137385408	156	-12.27
CAediting_1160181	chr17_7017644_-	ENSG00000157680.14	ENST00000453654	hsa-miR-195-3p	137383680	137383686	7mer-m8	137383679	137383700	140	-7.21
CAediting_1399425	chr20_1392958_-	ENSG00000157680.14	ENST00000453654	hsa-miR-6869-5p	137390817	137390823	7mer-m8	137390816	137390837	149	-18.17
CAediting_1399425	chr20_1392958_-	ENSG00000157680.14	ENST00000453654	hsa-miR-6869-5p	137384920	137384926	7mer-m8	137384919	137384940	144	-19.09
CAediting_1399425	chr20_1392958_-	ENSG00000157680.14	ENST00000453654	hsa-miR-6869-5p	137383098	137383104	7mer-m8	137383097	137383118	150	-20.83
CAediting_228905	chr2_188297554_+	ENSG00000157680.14	ENST00000453654	hsa-miR-561-3p	137385924	137385930	7mer-m8	137385923	137385944	140	-6.54
CAediting_228905	chr2_188297554_+	ENSG00000157680.14	ENST00000453654	hsa-miR-561-3p	137384966	137384972	7mer-m8	137384965	137384986	150	-11.31
CAediting_228905	chr2_188297554_+	ENSG00000157680.14	ENST00000453654	hsa-miR-561-3p	137383535	137383541	7mer-m8	137383534	137383555	140	-16.49
CAediting_228905	chr2_188297554_+	ENSG00000157680.14	ENST00000453654	hsa-miR-561-3p	137381834	137381839	6mer	137381833	137381855	144	-13.53
CAediting_1399425	chr20_1392958_-	ENSG00000157680.14	ENST00000288490	hsa-miR-6869-5p	137390817	137390823	7mer-m8	137390816	137390837	149	-18.17
CAediting_1399425	chr20_1392958_-	ENSG00000157680.14	ENST00000424189	hsa-miR-6869-5p	137390817	137390823	7mer-m8	137390816	137390837	149	-18.17
CAediting_1399425	chr20_1392958_-	ENSG00000157680.14	ENST00000446122	hsa-miR-6869-5p	137390817	137390823	7mer-m8	137390816	137390837	149	-18.17
CAediting_468389	chr6_31355314_-	ENSG00000157680.14	ENST00000453654	hsa-miR-6891-5p	137386210	137386216	7mer-m8	137386209	137386227	145	-23.69

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_573001	chr7_92204086_-	ENSG00000157680.14	ENST00000453654	hsa-miR-1285-5p	137383528	137383534	7mer-m8	137383527	137383547	146	-12.24
CAediting_573001	chr7_92204086_-	ENSG00000157680.14	ENST00000453654	hsa-miR-1285-5p	137382099	137382105	7mer-m8	137382098	137382118	141	-13.15
CAediting_442554	chr5_154685830_+	ENSG00000157680.14	ENST00000453654	hsa-miR-1303	137388966	137388973	8mer-1a	137388966	137388987	140	-11.32
CAediting_442554	chr5_154685830_+	ENSG00000157680.14	ENST00000453654	hsa-miR-1303	137386660	137386666	7mer-m8	137386659	137386680	140	-13.32
CAediting_1160181	chr17_7017644_-	ENSG00000157680.14	ENST00000453654	hsa-miR-195-3p	137388263	137388269	7mer-m8	137388262	137388283	145	-9.81
CAediting_1160181	chr17_7017644_-	ENSG00000157680.14	ENST00000453654	hsa-miR-195-3p	137382611	137382617	7mer-1a	137382611	137382633	141	-11.85
CAediting_393	chr1_1167164_+	ENSG00000157680.14	ENST00000453654	hsa-miR-200b-3p	137385150	137385156	7mer-m8	137385149	137385170	148	-6.77
CAediting_1306324	chr19_13836464_-	ENSG00000157680.14	ENST00000453654	hsa-miR-27a-3p	137385409	137385414	6mer	137385408	137385428	149	-13.67
CAediting_1306323	chr19_13836462_-	ENSG00000157680.14	ENST00000453654	hsa-miR-27a-3p	137385409	137385414	6mer	137385408	137385428	149	-13.67
CAediting_1368054	chr19_46709310_-	ENSG00000157680.14	ENST00000453654	hsa-miR-320e	137388582	137388588	7mer-1a	137388582	137388599	144	-16.07
CAediting_688081	chr9_63819627_+	ENSG00000157680.14	ENST00000453654	hsa-miR-4477b	137389108	137389114	7mer-m8	137389107	137389131	147	-10.37
CAediting_688080	chr9_63819626_+	ENSG00000157680.14	ENST00000453654	hsa-miR-4477b	137389108	137389114	7mer-m8	137389107	137389131	147	-10.37
CAediting_1229415	chr17_67471547_+	ENSG00000157680.14	ENST00000453654	hsa-miR-548aa	137390037	137390042	6mer	137390029	137390051	150	-8.04
CAediting_1229413	chr17_67471544_+	ENSG00000157680.14	ENST00000453654	hsa-miR-548aa	137390037	137390042	6mer	137390029	137390051	150	-8.04
CAediting_1229415	chr17_67471547_+	ENSG00000157680.14	ENST00000453654	hsa-miR-548aa	137390030	137390036	7mer-m8	137390029	137390051	150	-8.04
CAediting_1229413	chr17_67471544_+	ENSG00000157680.14	ENST00000453654	hsa-miR-548aa	137390030	137390036	7mer-m8	137390029	137390051	150	-8.04
CAediting_1229414	chr17_67471546_+	ENSG00000157680.14	ENST00000453654	hsa-miR-548aa	137390853	137390859	7mer-m8	137390852	137390876	140	-8.68
CAediting_1229415	chr17_67471547_+	ENSG00000157680.14	ENST00000453654	hsa-miR-548aa	137390853	137390859	7mer-m8	137390852	137390876	140	-8.68
CAediting_1229413	chr17_67471544_+	ENSG00000157680.14	ENST00000453654	hsa-miR-548aa	137390853	137390859	7mer-m8	137390852	137390876	140	-8.68
CAediting_228905	chr2_188297554_+	ENSG00000157680.14	ENST00000453654	hsa-miR-561-3p	137385508	137385514	7mer-m8	137385507	137385527	153	-6.23
CAediting_228905	chr2_188297554_+	ENSG00000157680.14	ENST00000453654	hsa-miR-561-3p	137385316	137385322	7mer-m8	137385315	137385335	154	-11.77
CAediting_228905	chr2_188297554_+	ENSG00000157680.14	ENST00000453654	hsa-miR-561-3p	137390229	137390235	7mer-m8	137390228	137390249	148	-11.96
CAediting_524911	chr7_5495852_-	ENSG00000157680.14	ENST00000453654	hsa-miR-589-3p	137382369	137382375	7mer-m8	137382368	137382391	147	-15.9
CAediting_748296	chr10_51299626_+	ENSG00000157680.14	ENST00000453654	hsa-miR-605-3p	137384847	137384853	7mer-m8	137384846	137384865	144	-13.87
CAediting_748296	chr10_51299626_+	ENSG00000157680.14	ENST00000453654	hsa-miR-605-3p	137384464	137384471	8mer-1a	137384464	137384487	154	-12.44
CAediting_980496	chr14_31014685_-	ENSG00000157680.14	ENST00000453654	hsa-miR-624-3p	137382273	137382279	7mer-m8	137382272	137382292	149	-10.66
CAediting_1399425	chr20_1392958_-	ENSG00000157680.14	ENST00000453654	hsa-miR-6869-5p	137387952	137387959	8mer-1a	137387952	137387976	150	-27.42

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for DGKI

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000453654.5	protein_coding

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID	ENST	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
CAediting_605706	ENST00000453654.5	chr7_137383171_-	-3622.50	-3622.80	-3614.40
CAediting_605707	ENST00000453654.5	chr7_137383172_-	-3622.90	-3622.80	-3614.40
CAediting_605708	ENST00000453654.5	chr7_137383188_-	-3622.50	-3622.80	-3614.40
CAediting_605709	ENST00000453654.5	chr7_137383189_-	-3622.90	-3622.80	-3614.40
CAediting_605710	ENST00000453654.5	chr7_137383190_-	-3622.90	-3622.80	-3614.40
CAediting_605711	ENST00000453654.5	chr7_137383191_-	-3622.90	-3622.80	-3614.40
CAediting_605712	ENST00000453654.5	chr7_137383192_-	-3622.90	-3622.80	-3614.40
CAediting_605713	ENST00000453654.5	chr7_137383193_-	-3622.90	-3622.80	-3614.40
CAediting_605714	ENST00000453654.5	chr7_137383200_-	-3622.80	-3622.80	-3614.40
CAediting_605715	ENST00000453654.5	chr7_137383208_-	-3622.80	-3622.80	-3614.40
CAediting_605716	ENST00000453654.5	chr7_137383213_-	-3622.50	-3622.80	-3614.40
CAediting_605717	ENST00000453654.5	chr7_137383232_-	-3622.40	-3622.80	-3614.40
CAediting_605718	ENST00000453654.5	chr7_137383239_-	-3622.80	-3622.80	-3614.40
CAediting_605719	ENST00000453654.5	chr7_137383261_-	-3622.50	-3622.80	-3614.40
CAediting_605720	ENST00000453654.5	chr7_137383280_-	-3622.40	-3622.80	-3614.40
CAediting_605721	ENST00000453654.5	chr7_137383300_-	-3622.50	-3622.80	-3614.40
CAediting_605722	ENST00000453654.5	chr7_137383313_-	-3622.80	-3622.80	-3614.40
CAediting_605723	ENST00000453654.5	chr7_137383314_-	-3622.90	-3622.80	-3614.40
CAediting_605724	ENST00000453654.5	chr7_137383320_-	-3622.50	-3622.80	-3614.40

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Relation with ADAR for DGKI

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
LGG	CAediting_605709	chr7_137383189_-	0.0481664750623109	0.143550604381711	.	.	.	.
LGG	CAediting_605710	chr7_137383190_-	3.06754832156587e-07	0.324516007529228	.	.	.	.
THCA	CAediting_605710	chr7_137383190_-	0.00333637923914073	0.316685225498858	.	.	.	.
SKCM	CAediting_605710	chr7_137383190_-	0.00984286284369642	0.345219448060475	.	.	.	.
LGG	CAediting_605711	chr7_137383191_-	6.70046564817877e-05	0.270913477928686	.	.	.	.
LGG	CAediting_605712	chr7_137383192_-	2.92428413621368e-07	0.292756911053883	.	.	.	.
THCA	CAediting_605712	chr7_137383192_-	6.28666849473989e-06	0.419280480946252	.	.	.	.
SKCM	CAediting_605712	chr7_137383192_-	2.94828838651472e-06	0.550507453048025	.	.	.	.
LGG	CAediting_605716	chr7_137383213_-	0.0450696575049577	0.180313101496704	.	.	.	.
LGG	CAediting_605717	chr7_137383232_-	0.00640484747491284	0.216722213865906	.	.	.	.
LGG	CAediting_605720	chr7_137383280_-	.	.	.	.	0.0184946925002039	0.319573343258556
LGG	CAediting_605721	chr7_137383300_-	0.000361010613203912	0.21358719160234	3.19429201976563e-06	0.276642040767732	.	.
THCA	CAediting_605721	chr7_137383300_-	0.0358171141502668	0.217979395380806	.	.	.	.
SKCM	CAediting_605721	chr7_137383300_-	0.00157831331991855	0.405741625984386	.	.	.	.
LGG	CAediting_605724	chr7_137383320_-	5.62509842127439e-09	0.300232380200468	.	.	.	.
THCA	CAediting_605724	chr7_137383320_-	0.00261672843333028	0.262854931448231	.	.	.	.
SKCM	CAediting_605724	chr7_137383320_-	8.86283424335813e-05	0.421597908191751	.	.	.	.

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Relation with cancer stages for DGKI

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for DGKI

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for DGKI

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
DGKI	O75912	DB14001	alpha-Tocopherol succinate	Diacylglycerol kinase iota	SmallMoleculeDrug	approved\|nutraceutical\|vet_approved

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RelatedDiseases for DGKI

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene