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![]() | Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples |
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![]() | The effects of the RNA editing to the stability of the RNA structures |
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Editing gene: PAPSS1 (CAeditome ID:9061) |
Gene summary for PAPSS1 |
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Gene information | Gene symbol | PAPSS1 | Gene ID | 9061 |
Gene name | 3'-phosphoadenosine 5'-phosphosulfate synthase 1 | |
Synonyms | ATPSK1|PAPSS|SK1 | |
Cytomap | 4q25 | |
Type of gene | protein-coding | |
Description | bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 13-prime-phosphoadenosine 5-prime-phosphosulfate synthase 1PAPS synthase 1PAPSS 1SK 1adenylyl-sulfate kinasesulfate adenylyltransferasesulfurylase kinase 1 | |
Modification date | 20210518 | |
UniProtAcc | O43252 | |
Context |
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Gene | GO ID | GO term | PubMed ID |
PAPSS1 | GO:0004020 | Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 | 14747722 |
PAPSS1 | GO:0004020 | Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 | 23207770 |
PAPSS1 | GO:0004781 | Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 | 14747722 |
PAPSS1 | GO:0000103 | Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 | 14747722 |
PAPSS1 | GO:0050428 | Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 | 14747722 |
PAPSS1 | GO:0050428 | Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 | 23207770 |
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RNA A-to-I events for PAPSS1 |
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CAediting_379065(107621726, -), CAediting_379066(107621788, -), CAediting_379067(107621790, -), CAediting_379068(107621792, -), CAediting_379069(107621884, -), CAediting_379070(107621892, -), CAediting_379071(107634234, -), CAediting_379072(107670784, -), CAediting_379073(107670787, -), CAediting_379074(107713010, -), CAediting_379075(107720175, -), CAediting_379076(107720195, -), |
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RNA editing positional annotations for PAPSS1 using Annovar |
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CAeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
CAediting_379075 | chr4_107720175_- | nonsynonymous SNV | ENST00000265174.4 | c.A5G | p.E2G | D | B | N |
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CAeditome ID | Position | Variant type |
CAediting_379065 | chr4_107621726_- | ncRNA_intronic |
CAediting_379066 | chr4_107621788_- | ncRNA_intronic |
CAediting_379067 | chr4_107621790_- | ncRNA_intronic |
CAediting_379068 | chr4_107621792_- | ncRNA_intronic |
CAediting_379069 | chr4_107621884_- | ncRNA_intronic |
CAediting_379070 | chr4_107621892_- | ncRNA_intronic |
CAediting_379071 | chr4_107634234_- | intronic |
CAediting_379072 | chr4_107670784_- | ncRNA_intronic |
CAediting_379073 | chr4_107670787_- | ncRNA_intronic |
CAediting_379074 | chr4_107713010_- | ncRNA_intronic |
CAediting_379075 | chr4_107720175_- | exonic |
CAediting_379076 | chr4_107720195_- | ncRNA_exonic |
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CAeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
CAediting_379065 | chr4_107621726_- | SINE | Alu | AluY |
CAediting_379066 | chr4_107621788_- | SINE | Alu | AluY |
CAediting_379067 | chr4_107621790_- | SINE | Alu | AluY |
CAediting_379068 | chr4_107621792_- | SINE | Alu | AluY |
CAediting_379069 | chr4_107621884_- | SINE | Alu | AluY |
CAediting_379070 | chr4_107621892_- | SINE | Alu | AluY |
CAediting_379071 | chr4_107634234_- | SINE | Alu | AluJb |
CAediting_379072 | chr4_107670784_- | SINE | Alu | AluJr |
CAediting_379073 | chr4_107670787_- | SINE | Alu | AluJr |
CAediting_379074 | chr4_107713010_- | SINE | Alu | AluSx3 |
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RNA A-to-I editing events in the alternative splicing sites for PAPSS1 |
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AStype | CAeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for PAPSS1 |
![]() * The grey color means N/A. |
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Protein coding region RNA A-to-I editings for PAPSS1 |
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The effects of the RNA editing to the miRNA binding sites for PAPSS1 |
**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page. |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
CAediting_1229414 | chr17_67471546_+ | ENSG00000138801.7 | ENST00000265174 | hsa-miR-548aa | 107613756 | 107613762 | 7mer-m8 | 107613755 | 107613781 | 143 | -11.59 |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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The effects of the RNA editing to the stability of the RNA structures for PAPSS1 |
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CAeditom_ID | ENST | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
CAediting_379075 | ENST00000265174.4 | chr4_107720175_- | -848.90 | -845.90 | -849.00 |
CAediting_379076 | ENST00000265174.4 | chr4_107720195_- | -845.20 | -845.90 | -849.00 |
CAediting_379075 | ENST00000511304.4 | chr4_107720175_- | -267.80 | -265.10 | -269.40 |
CAediting_379076 | ENST00000511304.4 | chr4_107720195_- | -267.40 | -265.10 | -269.40 |
CAediting_379075 | ENST00000504987.1 | chr4_107720175_- | -186.70 | -186.70 | -186.00 |
CAediting_379076 | ENST00000504987.1 | chr4_107720195_- | -186.00 | -186.70 | -186.00 |
CAediting_379075 | ENST00000514489.4 | chr4_107720175_- | -174.90 | -173.80 | -175.90 |
CAediting_379076 | ENST00000514489.4 | chr4_107720195_- | -176.30 | -173.80 | -175.90 |
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Relation with ADAR for PAPSS1 |
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Cancer | CAeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
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Relation with cancer stages for PAPSS1 |
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Cancer | Stage_type | CAeditomID | position | P-val | Coeff. |
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Relation with survival for PAPSS1 |
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Cancer | CAeditomID | position | KMpvalue | Coxpvalue | CoxHR |
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RelatedDrugs for PAPSS1 |
![]() (DrugBank Version 5.1.8 2021-01-03) |
Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
PAPSS1 | O43252 | DB09462 | Glycerin | Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 | SmallMoleculeDrug | approved|investigational |
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RelatedDiseases for PAPSS1 |
![]() (DisGeNet 7.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |