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Editing gene: KLHL6 (CAeditome ID:89857)

Gene summary for KLHL6

Gene summary

Gene information	Gene symbol	KLHL6
	Gene ID	89857
	Gene name	kelch like family member 6
	Synonyms	-
	Cytomap	3q27.1
	Type of gene	protein-coding
	Description	kelch-like protein 6
	Modification date	20210518
	UniProtAcc	Q8WZ60
	Context	- 30646831(KLHL6 is a tumor suppressor gene in diffuse large B-cell lymphoma)

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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RNA A-to-I events for KLHL6

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000172578.10

RNA A-to-I editing events in Cancer.

CAediting_327820(183490548, -), CAediting_327821(183490550, -), CAediting_327822(183490562, -), CAediting_327823(183490563, -), CAediting_327824(183490593, -), CAediting_327825(183490600, -), CAediting_327826(183490601, -), CAediting_327827(183490613, -), CAediting_327828(183490639, -), CAediting_327829(183490642, -), CAediting_327830(183490648, -), CAediting_327831(183490656, -), CAediting_327832(183490657, -), CAediting_327833(183490681, -), CAediting_327834(183490683, -), CAediting_327835(183490693, -), CAediting_327836(183490696, -), CAediting_327837(183490705, -), CAediting_327838(183490718, -), CAediting_327839(183490722, -), CAediting_327840(183490723, -), CAediting_327841(183490742, -), CAediting_327842(183490743, -), CAediting_327843(183490767, -), CAediting_327844(183490779, -), CAediting_327845(183491199, -), CAediting_327846(183491206, -), CAediting_327847(183491207, -), CAediting_327848(183491212, -), CAediting_327849(183491218, -), CAediting_327850(183491225, -), CAediting_327851(183491234, -), CAediting_327852(183491238, -), CAediting_327853(183491242, -), CAediting_327854(183491247, -), CAediting_327855(183491248, -), CAediting_327856(183491258, -), CAediting_327857(183491264, -), CAediting_327858(183491278, -), CAediting_327859(183491279, -), CAediting_327860(183491280, -), CAediting_327861(183491281, -), CAediting_327862(183491283, -), CAediting_327863(183491285, -), CAediting_327864(183491286, -), CAediting_327865(183491287, -), CAediting_327866(183491288, -), CAediting_327867(183491289, -), CAediting_327868(183491292, -), CAediting_327869(183491308, -), CAediting_327870(183491316, -), CAediting_327871(183491331, -), CAediting_327872(183491337, -), CAediting_327873(183491340, -), CAediting_327874(183491380, -), CAediting_327875(183491385, -), CAediting_327876(183491386, -), CAediting_327877(183491394, -), CAediting_327878(183499300, -), CAediting_327879(183503799, -), CAediting_327880(183506733, -), CAediting_327881(183506752, -), CAediting_327882(183507570, -), CAediting_327883(183507661, -), CAediting_327884(183517005, -), CAediting_327885(183517141, -), CAediting_327886(183517156, -), CAediting_327887(183521754, -), CAediting_327888(183521770, -), CAediting_327889(183521848, -), CAediting_327890(183521867, -), CAediting_327891(183521873, -), CAediting_327892(183522279, -), CAediting_327893(183522832, -), CAediting_327894(183522876, -), CAediting_327895(183522894, -), CAediting_327896(183522898, -), CAediting_327897(183522978, -), CAediting_327898(183526933, -), CAediting_327899(183529575, -), CAediting_327900(183529578, -), CAediting_327901(183529581, -), CAediting_327902(183529593, -), CAediting_327903(183529594, -), CAediting_327904(183529650, -), CAediting_327905(183529662, -), CAediting_327906(183529664, -), CAediting_327907(183529733, -), CAediting_327908(183530928, -), CAediting_327909(183530929, -), CAediting_327910(183530943, -), CAediting_327911(183531518, -), CAediting_327912(183531522, -), CAediting_327913(183531585, -), CAediting_327914(183540636, -), CAediting_327915(183540677, -), CAediting_327916(183547857, -), CAediting_327917(183547858, -), CAediting_327918(183555126, -),

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RNA editing positional annotations for KLHL6 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_327820	chr3_183490548_-	UTR3
CAediting_327821	chr3_183490550_-	UTR3
CAediting_327822	chr3_183490562_-	UTR3
CAediting_327823	chr3_183490563_-	UTR3
CAediting_327824	chr3_183490593_-	UTR3
CAediting_327825	chr3_183490600_-	UTR3
CAediting_327826	chr3_183490601_-	UTR3
CAediting_327827	chr3_183490613_-	splicing
CAediting_327828	chr3_183490639_-	UTR3
CAediting_327829	chr3_183490642_-	UTR3
CAediting_327830	chr3_183490648_-	UTR3
CAediting_327831	chr3_183490656_-	UTR3
CAediting_327832	chr3_183490657_-	UTR3
CAediting_327833	chr3_183490681_-	UTR3
CAediting_327834	chr3_183490683_-	UTR3
CAediting_327835	chr3_183490693_-	UTR3
CAediting_327836	chr3_183490696_-	UTR3
CAediting_327837	chr3_183490705_-	UTR3
CAediting_327838	chr3_183490718_-	UTR3
CAediting_327839	chr3_183490722_-	UTR3
CAediting_327840	chr3_183490723_-	UTR3
CAediting_327841	chr3_183490742_-	UTR3
CAediting_327842	chr3_183490743_-	UTR3
CAediting_327843	chr3_183490767_-	UTR3
CAediting_327844	chr3_183490779_-	UTR3
CAediting_327845	chr3_183491199_-	ncRNA_exonic
CAediting_327846	chr3_183491206_-	ncRNA_exonic
CAediting_327847	chr3_183491207_-	ncRNA_exonic
CAediting_327848	chr3_183491212_-	ncRNA_exonic
CAediting_327849	chr3_183491218_-	ncRNA_exonic
CAediting_327850	chr3_183491225_-	ncRNA_exonic
CAediting_327851	chr3_183491234_-	ncRNA_exonic
CAediting_327852	chr3_183491238_-	ncRNA_exonic
CAediting_327853	chr3_183491242_-	ncRNA_exonic
CAediting_327854	chr3_183491247_-	ncRNA_exonic
CAediting_327855	chr3_183491248_-	ncRNA_exonic
CAediting_327856	chr3_183491258_-	ncRNA_exonic
CAediting_327857	chr3_183491264_-	ncRNA_exonic
CAediting_327858	chr3_183491278_-	ncRNA_exonic
CAediting_327859	chr3_183491279_-	ncRNA_exonic
CAediting_327860	chr3_183491280_-	ncRNA_exonic
CAediting_327861	chr3_183491281_-	ncRNA_exonic
CAediting_327862	chr3_183491283_-	ncRNA_exonic
CAediting_327863	chr3_183491285_-	ncRNA_exonic
CAediting_327864	chr3_183491286_-	ncRNA_exonic
CAediting_327865	chr3_183491287_-	ncRNA_exonic
CAediting_327866	chr3_183491288_-	ncRNA_exonic
CAediting_327867	chr3_183491289_-	ncRNA_exonic
CAediting_327868	chr3_183491292_-	ncRNA_exonic
CAediting_327869	chr3_183491308_-	ncRNA_exonic
CAediting_327870	chr3_183491316_-	ncRNA_exonic
CAediting_327871	chr3_183491331_-	ncRNA_exonic
CAediting_327872	chr3_183491337_-	ncRNA_exonic
CAediting_327873	chr3_183491340_-	ncRNA_exonic
CAediting_327874	chr3_183491380_-	ncRNA_exonic
CAediting_327875	chr3_183491385_-	ncRNA_exonic
CAediting_327876	chr3_183491386_-	ncRNA_exonic
CAediting_327877	chr3_183491394_-	ncRNA_exonic
CAediting_327878	chr3_183499300_-	ncRNA_intronic
CAediting_327879	chr3_183503799_-	ncRNA_intronic
CAediting_327880	chr3_183506733_-	ncRNA_intronic
CAediting_327881	chr3_183506752_-	ncRNA_intronic
CAediting_327882	chr3_183507570_-	ncRNA_intronic
CAediting_327883	chr3_183507661_-	ncRNA_intronic
CAediting_327884	chr3_183517005_-	ncRNA_intronic
CAediting_327885	chr3_183517141_-	ncRNA_intronic
CAediting_327886	chr3_183517156_-	ncRNA_intronic
CAediting_327887	chr3_183521754_-	ncRNA_exonic
CAediting_327888	chr3_183521770_-	ncRNA_exonic
CAediting_327889	chr3_183521848_-	ncRNA_intronic
CAediting_327890	chr3_183521867_-	ncRNA_intronic
CAediting_327891	chr3_183521873_-	ncRNA_intronic
CAediting_327892	chr3_183522279_-	ncRNA_intronic
CAediting_327893	chr3_183522832_-	ncRNA_exonic
CAediting_327894	chr3_183522876_-	ncRNA_exonic
CAediting_327895	chr3_183522894_-	ncRNA_exonic
CAediting_327896	chr3_183522898_-	ncRNA_exonic
CAediting_327897	chr3_183522978_-	ncRNA_exonic
CAediting_327898	chr3_183526933_-	ncRNA_intronic
CAediting_327899	chr3_183529575_-	ncRNA_intronic
CAediting_327900	chr3_183529578_-	ncRNA_intronic
CAediting_327901	chr3_183529581_-	ncRNA_intronic
CAediting_327902	chr3_183529593_-	ncRNA_intronic
CAediting_327903	chr3_183529594_-	ncRNA_intronic
CAediting_327904	chr3_183529650_-	ncRNA_intronic
CAediting_327905	chr3_183529662_-	ncRNA_intronic
CAediting_327906	chr3_183529664_-	ncRNA_intronic
CAediting_327907	chr3_183529733_-	ncRNA_intronic
CAediting_327908	chr3_183530928_-	ncRNA_intronic
CAediting_327909	chr3_183530929_-	ncRNA_intronic
CAediting_327910	chr3_183530943_-	ncRNA_intronic
CAediting_327911	chr3_183531518_-	ncRNA_intronic
CAediting_327912	chr3_183531522_-	ncRNA_intronic
CAediting_327913	chr3_183531585_-	ncRNA_intronic
CAediting_327914	chr3_183540636_-	ncRNA_intronic
CAediting_327915	chr3_183540677_-	ncRNA_intronic
CAediting_327916	chr3_183547857_-	ncRNA_intronic
CAediting_327917	chr3_183547858_-	ncRNA_intronic
CAediting_327918	chr3_183555126_-	ncRNA_intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_327820	chr3_183490548_-	SINE	Alu	AluSg4
CAediting_327821	chr3_183490550_-	SINE	Alu	AluSg4
CAediting_327822	chr3_183490562_-	SINE	Alu	AluSg4
CAediting_327823	chr3_183490563_-	SINE	Alu	AluSg4
CAediting_327824	chr3_183490593_-	SINE	Alu	AluSg4
CAediting_327825	chr3_183490600_-	SINE	Alu	AluSg4
CAediting_327826	chr3_183490601_-	SINE	Alu	AluSg4
CAediting_327827	chr3_183490613_-	SINE	Alu	AluSg4
CAediting_327828	chr3_183490639_-	SINE	Alu	AluSg4
CAediting_327829	chr3_183490642_-	SINE	Alu	AluSg4
CAediting_327830	chr3_183490648_-	SINE	Alu	AluSg4
CAediting_327831	chr3_183490656_-	SINE	Alu	AluSg4
CAediting_327832	chr3_183490657_-	SINE	Alu	AluSg4
CAediting_327833	chr3_183490681_-	SINE	Alu	AluSg4
CAediting_327834	chr3_183490683_-	SINE	Alu	AluSg4
CAediting_327835	chr3_183490693_-	SINE	Alu	AluSg4
CAediting_327836	chr3_183490696_-	SINE	Alu	AluSg4
CAediting_327837	chr3_183490705_-	SINE	Alu	AluSg4
CAediting_327838	chr3_183490718_-	SINE	Alu	AluSg4
CAediting_327839	chr3_183490722_-	SINE	Alu	AluSg4
CAediting_327840	chr3_183490723_-	SINE	Alu	AluSg4
CAediting_327841	chr3_183490742_-	SINE	Alu	AluSg4
CAediting_327842	chr3_183490743_-	SINE	Alu	AluSg4
CAediting_327843	chr3_183490767_-	SINE	Alu	AluSg4
CAediting_327844	chr3_183490779_-	SINE	Alu	AluSg4
CAediting_327845	chr3_183491199_-	SINE	Alu	AluSq
CAediting_327846	chr3_183491206_-	SINE	Alu	AluSq
CAediting_327847	chr3_183491207_-	SINE	Alu	AluSq
CAediting_327848	chr3_183491212_-	SINE	Alu	AluSq
CAediting_327849	chr3_183491218_-	SINE	Alu	AluSq
CAediting_327850	chr3_183491225_-	SINE	Alu	AluSq
CAediting_327851	chr3_183491234_-	SINE	Alu	AluSq
CAediting_327852	chr3_183491238_-	SINE	Alu	AluSq
CAediting_327853	chr3_183491242_-	SINE	Alu	AluSq
CAediting_327854	chr3_183491247_-	SINE	Alu	AluSq
CAediting_327855	chr3_183491248_-	SINE	Alu	AluSq
CAediting_327856	chr3_183491258_-	SINE	Alu	AluSq
CAediting_327857	chr3_183491264_-	SINE	Alu	AluSq
CAediting_327858	chr3_183491278_-	SINE	Alu	AluSq
CAediting_327859	chr3_183491279_-	SINE	Alu	AluSq
CAediting_327860	chr3_183491280_-	SINE	Alu	AluSq
CAediting_327861	chr3_183491281_-	SINE	Alu	AluSq
CAediting_327862	chr3_183491283_-	SINE	Alu	AluSq
CAediting_327863	chr3_183491285_-	SINE	Alu	AluSq
CAediting_327864	chr3_183491286_-	SINE	Alu	AluSq
CAediting_327865	chr3_183491287_-	SINE	Alu	AluSq
CAediting_327866	chr3_183491288_-	SINE	Alu	AluSq
CAediting_327867	chr3_183491289_-	SINE	Alu	AluSq
CAediting_327868	chr3_183491292_-	SINE	Alu	AluSq
CAediting_327869	chr3_183491308_-	SINE	Alu	AluSq
CAediting_327870	chr3_183491316_-	SINE	Alu	AluSq
CAediting_327871	chr3_183491331_-	SINE	Alu	AluSq
CAediting_327872	chr3_183491337_-	SINE	Alu	AluSq
CAediting_327873	chr3_183491340_-	SINE	Alu	AluSq
CAediting_327874	chr3_183491380_-	SINE	Alu	AluSq
CAediting_327875	chr3_183491385_-	SINE	Alu	AluSq
CAediting_327876	chr3_183491386_-	SINE	Alu	AluSq
CAediting_327877	chr3_183491394_-	SINE	Alu	AluSq
CAediting_327878	chr3_183499300_-	SINE	Alu	AluSx1
CAediting_327879	chr3_183503799_-	SINE	Alu	AluSp
CAediting_327880	chr3_183506733_-	SINE	Alu	AluJb
CAediting_327881	chr3_183506752_-	SINE	Alu	AluJb
CAediting_327882	chr3_183507570_-	SINE	Alu	AluSc8
CAediting_327883	chr3_183507661_-	SINE	Alu	AluSc8
CAediting_327884	chr3_183517005_-	SINE	Alu	AluSz6
CAediting_327885	chr3_183517141_-	SINE	Alu	AluSz6
CAediting_327886	chr3_183517156_-	SINE	Alu	AluSz6
CAediting_327887	chr3_183521754_-	SINE	Alu	AluSx1
CAediting_327888	chr3_183521770_-	SINE	Alu	AluSx1
CAediting_327889	chr3_183521848_-	SINE	Alu	AluSx1
CAediting_327890	chr3_183521867_-	SINE	Alu	AluSx1
CAediting_327891	chr3_183521873_-	SINE	Alu	AluSx1
CAediting_327892	chr3_183522279_-	SINE	Alu	AluSx
CAediting_327893	chr3_183522832_-	Simple_repeat	Simple_repeat	(GTTT)n
CAediting_327894	chr3_183522876_-	SINE	Alu	AluSc
CAediting_327895	chr3_183522894_-	SINE	Alu	AluSc
CAediting_327896	chr3_183522898_-	SINE	Alu	AluSc
CAediting_327897	chr3_183522978_-	SINE	Alu	AluSc
CAediting_327898	chr3_183526933_-	SINE	Alu	AluSz
CAediting_327899	chr3_183529575_-	SINE	Alu	AluSz
CAediting_327900	chr3_183529578_-	SINE	Alu	AluSz
CAediting_327901	chr3_183529581_-	SINE	Alu	AluSz
CAediting_327902	chr3_183529593_-	SINE	Alu	AluSz
CAediting_327903	chr3_183529594_-	SINE	Alu	AluSz
CAediting_327904	chr3_183529650_-	SINE	Alu	AluSz
CAediting_327905	chr3_183529662_-	SINE	Alu	AluSz
CAediting_327906	chr3_183529664_-	SINE	Alu	AluSz
CAediting_327907	chr3_183529733_-	SINE	Alu	AluSz
CAediting_327908	chr3_183530928_-	SINE	Alu	AluSx1
CAediting_327909	chr3_183530929_-	SINE	Alu	AluSx1
CAediting_327910	chr3_183530943_-	SINE	Alu	AluSx1
CAediting_327911	chr3_183531518_-	SINE	Alu	AluY
CAediting_327912	chr3_183531522_-	SINE	Alu	AluY
CAediting_327913	chr3_183531585_-	SINE	Alu	AluY
CAediting_327914	chr3_183540636_-	SINE	Alu	FLAM_A
CAediting_327915	chr3_183540677_-	SINE	Alu	FLAM_A
CAediting_327918	chr3_183555126_-	SINE	Alu	AluSp

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RNA A-to-I editing events in the alternative splicing sites for KLHL6

RNA A-to-I editing(s) in the alternative splicing sites.

AStype	CAeditomID	Editing position	AS position	AS direction	Exonic location	Wildtype sequence	Wildtype splicing strength	RNA edited sequence	RNA edited splicing strength
IR	CAediting_327827	chr3_183490613_-	183490609:183490631	3SS	0+2i	GGTTTCACCATCTTGGCCAGGCT	1.96	GGTTTCACCATCTTGGCCGGGCT	-5.99

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000172578.10.KLHL6.

Correlation between RNA A-to-I editing and PSI for ENSG00000172578.10.KLHL6.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for KLHL6

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for KLHL6

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for KLHL6

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_327875	chr3_183491385_-	ENSG00000172578.10	ENST00000468734	hsa-miR-8052	183491380	183491386	7mer-1a	183491380	183491398	140.00	-24.15
CAediting_327876	chr3_183491386_-	ENSG00000172578.10	ENST00000468734	hsa-miR-513a-5p	183491385	183491391	7mer-m8	183491384	183491404	147.00	-22.37
CAediting_327876	chr3_183491386_-	ENSG00000172578.10	ENST00000468734	hsa-miR-513a-5p	183491385	183491391	7mer-m8	183491384	183491404	147.00	-22.37
CAediting_327876	chr3_183491386_-	ENSG00000172578.10	ENST00000468734	hsa-miR-638	183491380	183491386	7mer-1a	183491380	183491404	163.00	-37.94
CAediting_327820	chr3_183490548_-	ENSG00000172578.10	ENST00000468734	hsa-miR-100-5p	183490545	183490551	7mer-m8	183490544	183490566	162.00	-22.90
CAediting_327820	chr3_183490548_-	ENSG00000172578.10	ENST00000468734	hsa-miR-99a-5p	183490545	183490551	7mer-m8	183490544	183490564	155.00	-21.47
CAediting_327820	chr3_183490548_-	ENSG00000172578.10	ENST00000468734	hsa-miR-99b-5p	183490545	183490551	7mer-m8	183490544	183490566	154.00	-27.63
CAediting_327821	chr3_183490550_-	ENSG00000172578.10	ENST00000468734	hsa-miR-106a-3p	183490548	183490553	6mer	183490547	183490568	146.00	-23.59
CAediting_327824	chr3_183490593_-	ENSG00000172578.10	ENST00000468734	hsa-miR-3922-5p	183490588	183490594	7mer-m8	183490587	183490609	160.00	-20.24
CAediting_327824	chr3_183490593_-	ENSG00000172578.10	ENST00000468734	hsa-miR-4753-5p	183490589	183490595	7mer-m8	183490588	183490609	140.00	-19.55
CAediting_327824	chr3_183490593_-	ENSG00000172578.10	ENST00000468734	hsa-miR-4755-3p	183490592	183490597	6mer	183490591	183490611	152.00	-20.20
CAediting_327874	chr3_183491380_-	ENSG00000172578.10	ENST00000468734	hsa-miR-6781-5p	183491376	183491382	7mer-m8	183491375	183491394	157.00	-29.18
CAediting_327877	chr3_183491394_-	ENSG00000172578.10	ENST00000468734	hsa-miR-4634	183491390	183491396	7mer-m8	183491389	183491408	155.00	-26.12
CAediting_327823	chr3_183490563_-	ENSG00000172578.10	ENST00000468734	hsa-miR-4497	183490562	183490568	7mer-m8	183490561	183490576	153.00	-31.89

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_327875	chr3_183491385_-	ENSG00000172578.10	ENST00000468734	hsa-miR-10399-5p	183491384	183491390	7mer-m8	183491383	183491403	140	-10.39
CAediting_327876	chr3_183491386_-	ENSG00000172578.10	ENST00000468734	hsa-miR-10399-5p	183491384	183491390	7mer-m8	183491383	183491403	140	-10.39
CAediting_327874	chr3_183491380_-	ENSG00000172578.10	ENST00000468734	hsa-miR-4492	183491376	183491382	7mer-m8	183491375	183491391	145	-19.7
CAediting_327874	chr3_183491380_-	ENSG00000172578.10	ENST00000468734	hsa-miR-4498	183491376	183491382	7mer-m8	183491375	183491396	155	-22.65
CAediting_327874	chr3_183491380_-	ENSG00000172578.10	ENST00000468734	hsa-miR-4505	183491377	183491383	7mer-m8	183491376	183491393	144	-21.6
CAediting_327874	chr3_183491380_-	ENSG00000172578.10	ENST00000468734	hsa-miR-5089-5p	183491380	183491386	7mer-m8	183491379	183491401	148	-14.93
CAediting_327875	chr3_183491385_-	ENSG00000172578.10	ENST00000468734	hsa-miR-5089-5p	183491380	183491386	7mer-m8	183491379	183491401	148	-14.93
CAediting_327874	chr3_183491380_-	ENSG00000172578.10	ENST00000468734	hsa-miR-5787	183491377	183491383	7mer-m8	183491376	183491396	146	-27.6
CAediting_327875	chr3_183491385_-	ENSG00000172578.10	ENST00000468734	hsa-miR-6504-3p	183491384	183491390	7mer-m8	183491383	183491404	141	-11.32
CAediting_327876	chr3_183491386_-	ENSG00000172578.10	ENST00000468734	hsa-miR-6504-3p	183491384	183491390	7mer-m8	183491383	183491404	141	-11.32
CAediting_327874	chr3_183491380_-	ENSG00000172578.10	ENST00000468734	hsa-miR-6506-5p	183491379	183491385	7mer-m8	183491378	183491400	144	-13.57
CAediting_327876	chr3_183491386_-	ENSG00000172578.10	ENST00000468734	hsa-miR-7151-3p	183491385	183491392	8mer-1a	183491385	183491405	146	-16.2
CAediting_327874	chr3_183491380_-	ENSG00000172578.10	ENST00000468734	hsa-miR-762	183491376	183491382	7mer-m8	183491375	183491396	151	-28.26
CAediting_327824	chr3_183490593_-	ENSG00000172578.10	ENST00000468734	hsa-miR-3974	183490589	183490595	7mer-m8	183490588	183490611	149	-14.89

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_393	chr1_1167164_+	ENSG00000172578.10	ENST00000468734	hsa-miR-200b-3p	183488312	183488318	7mer-m8	183488311	183488334	149	-15.26
CAediting_1351755	chr19_40282625_-	ENSG00000172578.10	ENST00000468734	hsa-miR-641	183490385	183490391	7mer-m8	183490384	183490407	140	-13.66
CAediting_117844	chr1_162342605_+	ENSG00000172578.10	ENST00000468734	hsa-miR-556-3p	183489688	183489694	7mer-m8	183489687	183489708	144	-9.95
CAediting_414656	chr5_72878640_+	ENSG00000172578.10	ENST00000468734	hsa-miR-4804-3p	183489541	183489547	7mer-m8	183489540	183489560	140	-9.04
CAediting_524911	chr7_5495852_-	ENSG00000172578.10	ENST00000468734	hsa-miR-589-3p	183489744	183489750	7mer-m8	183489743	183489766	140	-16.21

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1160181	chr17_7017644_-	ENSG00000172578.10	ENST00000468734	hsa-miR-195-3p	183487617	183487623	7mer-m8	183487616	183487637	140	-5.32
CAediting_396018	chr5_1062918_-	ENSG00000172578.10	ENST00000468734	hsa-miR-4635	183489446	183489452	7mer-m8	183489445	183489463	143	-9.67
CAediting_1229414	chr17_67471546_+	ENSG00000172578.10	ENST00000468734	hsa-miR-548aa	183490194	183490200	7mer-m8	183490193	183490221	150	-8.36
CAediting_524911	chr7_5495852_-	ENSG00000172578.10	ENST00000468734	hsa-miR-589-3p	183488573	183488579	7mer-m8	183488572	183488596	155	-23.92

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for KLHL6

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000341319.6	protein_coding
ENST00000468734.1	nonsense_mediated_decay
ENST00000489245.4	retained_intron
ENST00000487643.1	processed_transcript

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID	ENST	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
CAediting_327820	ENST00000341319.6	chr3_183490548_-	-2237.94	-2238.64	-2229.44
CAediting_327821	ENST00000341319.6	chr3_183490550_-	-2238.64	-2238.64	-2229.44
CAediting_327822	ENST00000341319.6	chr3_183490562_-	-2241.44	-2238.64	-2229.44
CAediting_327823	ENST00000341319.6	chr3_183490563_-	-2238.64	-2238.64	-2229.44
CAediting_327824	ENST00000341319.6	chr3_183490593_-	-2238.04	-2238.64	-2229.44
CAediting_327825	ENST00000341319.6	chr3_183490600_-	-2238.64	-2238.64	-2229.44
CAediting_327826	ENST00000341319.6	chr3_183490601_-	-2238.14	-2238.64	-2229.44
CAediting_327827	ENST00000341319.6	chr3_183490613_-	-2237.94	-2238.64	-2229.44
CAediting_327828	ENST00000341319.6	chr3_183490639_-	-2238.34	-2238.64	-2229.44
CAediting_327829	ENST00000341319.6	chr3_183490642_-	-2238.34	-2238.64	-2229.44
CAediting_327830	ENST00000341319.6	chr3_183490648_-	-2238.34	-2238.64	-2229.44
CAediting_327831	ENST00000341319.6	chr3_183490656_-	-2238.64	-2238.64	-2229.44
CAediting_327832	ENST00000341319.6	chr3_183490657_-	-2238.74	-2238.64	-2229.44
CAediting_327833	ENST00000341319.6	chr3_183490681_-	-2237.94	-2238.64	-2229.44
CAediting_327834	ENST00000341319.6	chr3_183490683_-	-2238.64	-2238.64	-2229.44
CAediting_327835	ENST00000341319.6	chr3_183490693_-	-2238.34	-2238.64	-2229.44
CAediting_327836	ENST00000341319.6	chr3_183490696_-	-2237.74	-2238.64	-2229.44
CAediting_327837	ENST00000341319.6	chr3_183490705_-	-2237.94	-2238.64	-2229.44
CAediting_327838	ENST00000341319.6	chr3_183490718_-	-2238.04	-2238.64	-2229.44
CAediting_327839	ENST00000341319.6	chr3_183490722_-	-2238.34	-2238.64	-2229.44
CAediting_327840	ENST00000341319.6	chr3_183490723_-	-2238.34	-2238.64	-2229.44
CAediting_327841	ENST00000341319.6	chr3_183490742_-	-2238.64	-2238.64	-2229.44
CAediting_327842	ENST00000341319.6	chr3_183490743_-	-2238.34	-2238.64	-2229.44
CAediting_327843	ENST00000341319.6	chr3_183490767_-	-2237.94	-2238.64	-2229.44
CAediting_327844	ENST00000341319.6	chr3_183490779_-	-2244.84	-2238.64	-2229.44
CAediting_327845	ENST00000341319.6	chr3_183491199_-	-2239.04	-2238.64	-2229.44
CAediting_327846	ENST00000341319.6	chr3_183491206_-	-2238.64	-2238.64	-2229.44
CAediting_327847	ENST00000341319.6	chr3_183491207_-	-2238.14	-2238.64	-2229.44
CAediting_327848	ENST00000341319.6	chr3_183491212_-	-2238.24	-2238.64	-2229.44
CAediting_327849	ENST00000341319.6	chr3_183491218_-	-2237.64	-2238.64	-2229.44
CAediting_327850	ENST00000341319.6	chr3_183491225_-	-2237.74	-2238.64	-2229.44
CAediting_327851	ENST00000341319.6	chr3_183491234_-	-2237.94	-2238.64	-2229.44
CAediting_327852	ENST00000341319.6	chr3_183491238_-	-2238.64	-2238.64	-2229.44
CAediting_327853	ENST00000341319.6	chr3_183491242_-	-2237.94	-2238.64	-2229.44
CAediting_327854	ENST00000341319.6	chr3_183491247_-	-2238.64	-2238.64	-2229.44
CAediting_327855	ENST00000341319.6	chr3_183491248_-	-2238.74	-2238.64	-2229.44
CAediting_327856	ENST00000341319.6	chr3_183491258_-	-2237.94	-2238.64	-2229.44
CAediting_327857	ENST00000341319.6	chr3_183491264_-	-2244.84	-2238.64	-2229.44
CAediting_327858	ENST00000341319.6	chr3_183491278_-	-2238.74	-2238.64	-2229.44
CAediting_327859	ENST00000341319.6	chr3_183491279_-	-2238.74	-2238.64	-2229.44
CAediting_327860	ENST00000341319.6	chr3_183491280_-	-2238.74	-2238.64	-2229.44
CAediting_327861	ENST00000341319.6	chr3_183491281_-	-2238.34	-2238.64	-2229.44
CAediting_327862	ENST00000341319.6	chr3_183491283_-	-2238.64	-2238.64	-2229.44
CAediting_327863	ENST00000341319.6	chr3_183491285_-	-2241.24	-2238.64	-2229.44
CAediting_327864	ENST00000341319.6	chr3_183491286_-	-2238.34	-2238.64	-2229.44
CAediting_327865	ENST00000341319.6	chr3_183491287_-	-2238.74	-2238.64	-2229.44
CAediting_327866	ENST00000341319.6	chr3_183491288_-	-2238.74	-2238.64	-2229.44
CAediting_327867	ENST00000341319.6	chr3_183491289_-	-2238.74	-2238.64	-2229.44
CAediting_327868	ENST00000341319.6	chr3_183491292_-	-2238.64	-2238.64	-2229.44
CAediting_327869	ENST00000341319.6	chr3_183491308_-	-2237.64	-2238.64	-2229.44
CAediting_327870	ENST00000341319.6	chr3_183491316_-	-2238.34	-2238.64	-2229.44
CAediting_327871	ENST00000341319.6	chr3_183491331_-	-2238.34	-2238.64	-2229.44
CAediting_327872	ENST00000341319.6	chr3_183491337_-	-2240.74	-2238.64	-2229.44
CAediting_327873	ENST00000341319.6	chr3_183491340_-	-2237.94	-2238.64	-2229.44
CAediting_327874	ENST00000341319.6	chr3_183491380_-	-2237.94	-2238.64	-2229.44
CAediting_327875	ENST00000341319.6	chr3_183491385_-	-2238.64	-2238.64	-2229.44
CAediting_327876	ENST00000341319.6	chr3_183491386_-	-2238.74	-2238.64	-2229.44
CAediting_327877	ENST00000341319.6	chr3_183491394_-	-2238.24	-2238.64	-2229.44
CAediting_327820	ENST00000468734.1	chr3_183490548_-	-1736.20	-1736.90	-1743.00
CAediting_327821	ENST00000468734.1	chr3_183490550_-	-1736.90	-1736.90	-1743.00
CAediting_327822	ENST00000468734.1	chr3_183490562_-	-1739.70	-1736.90	-1743.00
CAediting_327823	ENST00000468734.1	chr3_183490563_-	-1736.90	-1736.90	-1743.00
CAediting_327824	ENST00000468734.1	chr3_183490593_-	-1736.90	-1736.90	-1743.00
CAediting_327825	ENST00000468734.1	chr3_183490600_-	-1737.30	-1736.90	-1743.00
CAediting_327826	ENST00000468734.1	chr3_183490601_-	-1738.10	-1736.90	-1743.00
CAediting_327874	ENST00000468734.1	chr3_183491380_-	-1736.20	-1736.90	-1743.00
CAediting_327875	ENST00000468734.1	chr3_183491385_-	-1736.90	-1736.90	-1743.00
CAediting_327876	ENST00000468734.1	chr3_183491386_-	-1737.00	-1736.90	-1743.00
CAediting_327877	ENST00000468734.1	chr3_183491394_-	-1736.50	-1736.90	-1743.00
CAediting_327845	ENST00000489245.4	chr3_183491199_-	-1416.74	-1417.10	-1446.64
CAediting_327846	ENST00000489245.4	chr3_183491206_-	-1417.10	-1417.10	-1446.64
CAediting_327847	ENST00000489245.4	chr3_183491207_-	-1419.00	-1417.10	-1446.64
CAediting_327848	ENST00000489245.4	chr3_183491212_-	-1420.10	-1417.10	-1446.64
CAediting_327849	ENST00000489245.4	chr3_183491218_-	-1418.00	-1417.10	-1446.64
CAediting_327850	ENST00000489245.4	chr3_183491225_-	-1418.50	-1417.10	-1446.64
CAediting_327851	ENST00000489245.4	chr3_183491234_-	-1417.10	-1417.10	-1446.64
CAediting_327852	ENST00000489245.4	chr3_183491238_-	-1418.60	-1417.10	-1446.64
CAediting_327853	ENST00000489245.4	chr3_183491242_-	-1417.50	-1417.10	-1446.64
CAediting_327854	ENST00000489245.4	chr3_183491247_-	-1418.50	-1417.10	-1446.64
CAediting_327855	ENST00000489245.4	chr3_183491248_-	-1418.20	-1417.10	-1446.64
CAediting_327856	ENST00000489245.4	chr3_183491258_-	-1416.60	-1417.10	-1446.64
CAediting_327857	ENST00000489245.4	chr3_183491264_-	-1417.10	-1417.10	-1446.64
CAediting_327858	ENST00000489245.4	chr3_183491278_-	-1417.10	-1417.10	-1446.64
CAediting_327859	ENST00000489245.4	chr3_183491279_-	-1417.10	-1417.10	-1446.64
CAediting_327860	ENST00000489245.4	chr3_183491280_-	-1417.80	-1417.10	-1446.64
CAediting_327861	ENST00000489245.4	chr3_183491281_-	-1417.10	-1417.10	-1446.64
CAediting_327862	ENST00000489245.4	chr3_183491283_-	-1417.10	-1417.10	-1446.64
CAediting_327863	ENST00000489245.4	chr3_183491285_-	-1417.60	-1417.10	-1446.64
CAediting_327864	ENST00000489245.4	chr3_183491286_-	-1417.10	-1417.10	-1446.64
CAediting_327865	ENST00000489245.4	chr3_183491287_-	-1417.10	-1417.10	-1446.64
CAediting_327866	ENST00000489245.4	chr3_183491288_-	-1417.10	-1417.10	-1446.64
CAediting_327867	ENST00000489245.4	chr3_183491289_-	-1416.80	-1417.10	-1446.64
CAediting_327868	ENST00000489245.4	chr3_183491292_-	-1420.40	-1417.10	-1446.64
CAediting_327869	ENST00000489245.4	chr3_183491308_-	-1417.10	-1417.10	-1446.64
CAediting_327870	ENST00000489245.4	chr3_183491316_-	-1417.50	-1417.10	-1446.64
CAediting_327871	ENST00000489245.4	chr3_183491331_-	-1417.10	-1417.10	-1446.64
CAediting_327872	ENST00000489245.4	chr3_183491337_-	-1419.90	-1417.10	-1446.64
CAediting_327873	ENST00000489245.4	chr3_183491340_-	-1416.40	-1417.10	-1446.64
CAediting_327874	ENST00000489245.4	chr3_183491380_-	-1416.20	-1417.10	-1446.64
CAediting_327875	ENST00000489245.4	chr3_183491385_-	-1417.10	-1417.10	-1446.64
CAediting_327876	ENST00000489245.4	chr3_183491386_-	-1417.10	-1417.10	-1446.64
CAediting_327877	ENST00000489245.4	chr3_183491394_-	-1417.10	-1417.10	-1446.64
CAediting_327887	ENST00000487643.1	chr3_183521754_-	-907.30	-903.80	-920.90
CAediting_327888	ENST00000487643.1	chr3_183521770_-	-903.00	-903.80	-920.90
CAediting_327893	ENST00000487643.1	chr3_183522832_-	-907.10	-903.80	-920.90
CAediting_327894	ENST00000487643.1	chr3_183522876_-	-908.20	-903.80	-920.90
CAediting_327895	ENST00000487643.1	chr3_183522894_-	-908.50	-903.80	-920.90
CAediting_327896	ENST00000487643.1	chr3_183522898_-	-907.10	-903.80	-920.90
CAediting_327897	ENST00000487643.1	chr3_183522978_-	-904.20	-903.80	-920.90

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Relation with ADAR for KLHL6

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
BRCA	CAediting_327852	chr3_183491238_-	0.0166886654643287	0.318645112272727	.	.	.	.
LUAD	CAediting_327852	chr3_183491238_-	0.00549124905680371	0.330850772619749	.	.	.	.
HNSC	CAediting_327852	chr3_183491238_-	0.0149439156517067	0.33903582947957	.	.	.	.
STAD	CAediting_327852	chr3_183491238_-	.	.	.	.	0.000673249437120267	0.426751559314029
STAD	CAediting_327875	chr3_183491385_-	.	.	0.010400421564788	0.342825080925864	.	.

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Relation with cancer stages for KLHL6

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for KLHL6

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for KLHL6

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for KLHL6

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene