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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: CACNA1G (CAeditome ID:8913)

Gene summary for CACNA1G

check button Gene summary
Gene informationGene symbol

CACNA1G

Gene ID

8913

Gene namecalcium voltage-gated channel subunit alpha1 G
SynonymsCa(V)T.1|Cav3.1|NBR13|SCA42|SCA42ND
Cytomap

17q21.33

Type of geneprotein-coding
Descriptionvoltage-dependent T-type calcium channel subunit alpha-1Gcalcium channel, voltage-dependent, T type, alpha 1G subunitcav3.1cvoltage-dependent T-type calcium channel alpha 1G subunitvoltage-dependent calcium channel alpha 1G subunitvoltage-gated calci
Modification date20210518
UniProtAcc

O43497

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
CACNA1G

GO:0008332

Voltage-dependent T-type calcium channel subunit alpha-1G

21084288

CACNA1G

GO:0008332

Voltage-dependent T-type calcium channel subunit alpha-1G

26456284

CACNA1G

GO:0008332

Voltage-dependent T-type calcium channel subunit alpha-1G

26715324

CACNA1G

GO:0042391

Voltage-dependent T-type calcium channel subunit alpha-1G

21084288

CACNA1G

GO:0070509

Voltage-dependent T-type calcium channel subunit alpha-1G

21084288

CACNA1G

GO:0070588

Voltage-dependent T-type calcium channel subunit alpha-1G

26456284

CACNA1G

GO:0070588

Voltage-dependent T-type calcium channel subunit alpha-1G

26715324

CACNA1G

GO:0005737

Voltage-dependent T-type calcium channel subunit alpha-1G

26715324

CACNA1G

GO:0005886

Voltage-dependent T-type calcium channel subunit alpha-1G

26715324


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RNA A-to-I events for CACNA1G

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000006283.16

check button RNA A-to-I editing events in Cancer.
CAediting_1212477(50626234, +),

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RNA editing positional annotations for CACNA1G using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_1212477chr17_50626234_+exonic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name

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RNA A-to-I editing events in the alternative splicing sites for CACNA1G

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000006283.16.CACNA1G.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000006283.16.CACNA1G.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for CACNA1G

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

check button Correlation between RNA A-to-I editing and gene expression.

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for CACNA1G

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.
all structure


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The effects of the RNA editing to the miRNA binding sites for CACNA1G

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_1212477chr17_50626234_+ENSG00000006283.16ENST00000511765hsa-miR-191350626227506262337mer-m85062621250626234146.00-19.29
CAediting_1212477chr17_50626234_+ENSG00000006283.16ENST00000511765hsa-miR-210-5p50626231506262377mer-m85062621750626238155.00-25.14
CAediting_1212477chr17_50626234_+ENSG00000006283.16ENST00000511765hsa-miR-6752-3p50626229506262357mer-m85062621650626236150.00-23.13
CAediting_1212477chr17_50626234_+ENSG00000006283.16ENST00000511765hsa-miR-6801-3p50626230506262367mer-m85062621950626237148.00-22.79
CAediting_1212477chr17_50626234_+ENSG00000006283.16ENST00000511765hsa-miR-6810-3p50626230506262367mer-m85062621250626237156.00-24.41
CAediting_1212477chr17_50626234_+ENSG00000006283.16ENST00000506406hsa-miR-191350626227506262337mer-m85062621250626234146.00-19.29
CAediting_1212477chr17_50626234_+ENSG00000006283.16ENST00000506406hsa-miR-210-5p50626231506262377mer-m85062621750626238155.00-25.14
CAediting_1212477chr17_50626234_+ENSG00000006283.16ENST00000506406hsa-miR-6752-3p50626229506262357mer-m85062621650626236150.00-23.13
CAediting_1212477chr17_50626234_+ENSG00000006283.16ENST00000506406hsa-miR-6801-3p50626230506262367mer-m85062621950626237148.00-22.79
CAediting_1212477chr17_50626234_+ENSG00000006283.16ENST00000506406hsa-miR-6810-3p50626230506262367mer-m85062621250626237156.00-24.41
CAediting_1212477chr17_50626234_+ENSG00000006283.16ENST00000504076hsa-miR-191350626227506262337mer-m85062621250626234146.00-19.29
CAediting_1212477chr17_50626234_+ENSG00000006283.16ENST00000504076hsa-miR-210-5p50626231506262377mer-m85062621750626238155.00-25.14
CAediting_1212477chr17_50626234_+ENSG00000006283.16ENST00000504076hsa-miR-6752-3p50626229506262357mer-m85062621650626236150.00-23.13
CAediting_1212477chr17_50626234_+ENSG00000006283.16ENST00000504076hsa-miR-6801-3p50626230506262367mer-m85062621950626237148.00-22.79
CAediting_1212477chr17_50626234_+ENSG00000006283.16ENST00000504076hsa-miR-6810-3p50626230506262367mer-m85062621250626237156.00-24.41
CAediting_1212477chr17_50626234_+ENSG00000006283.16ENST00000503436hsa-miR-191350626227506262337mer-m85062621250626234146.00-19.29
CAediting_1212477chr17_50626234_+ENSG00000006283.16ENST00000503436hsa-miR-210-5p50626231506262377mer-m85062621750626238155.00-25.14
CAediting_1212477chr17_50626234_+ENSG00000006283.16ENST00000503436hsa-miR-6752-3p50626229506262357mer-m85062621650626236150.00-23.13
CAediting_1212477chr17_50626234_+ENSG00000006283.16ENST00000503436hsa-miR-6801-3p50626230506262367mer-m85062621950626237148.00-22.79
CAediting_1212477chr17_50626234_+ENSG00000006283.16ENST00000503436hsa-miR-6810-3p50626230506262367mer-m85062621250626237156.00-24.41
CAediting_1212477chr17_50626234_+ENSG00000006283.16ENST00000511768hsa-miR-191350626227506262337mer-m85062621250626234146.00-19.29
CAediting_1212477chr17_50626234_+ENSG00000006283.16ENST00000511768hsa-miR-210-5p50626231506262377mer-m85062621750626238155.00-25.14
CAediting_1212477chr17_50626234_+ENSG00000006283.16ENST00000511768hsa-miR-6752-3p50626229506262357mer-m85062621650626236150.00-23.13
CAediting_1212477chr17_50626234_+ENSG00000006283.16ENST00000511768hsa-miR-6801-3p50626230506262367mer-m85062621950626237148.00-22.79
CAediting_1212477chr17_50626234_+ENSG00000006283.16ENST00000511768hsa-miR-6810-3p50626230506262367mer-m85062621250626237156.00-24.41
CAediting_1212477chr17_50626234_+ENSG00000006283.16ENST00000503607hsa-miR-191350626227506262337mer-m85062621250626234146.00-19.29
CAediting_1212477chr17_50626234_+ENSG00000006283.16ENST00000503607hsa-miR-210-5p50626231506262377mer-m85062621750626238155.00-25.14
CAediting_1212477chr17_50626234_+ENSG00000006283.16ENST00000503607hsa-miR-6752-3p50626229506262357mer-m85062621650626236150.00-23.13
CAediting_1212477chr17_50626234_+ENSG00000006283.16ENST00000503607hsa-miR-6801-3p50626230506262367mer-m85062621950626237148.00-22.79
CAediting_1212477chr17_50626234_+ENSG00000006283.16ENST00000503607hsa-miR-6810-3p50626230506262367mer-m85062621250626237156.00-24.41

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_1212477chr17_50626234_+ENSG00000006283.16ENST00000511765hsa-miR-1915-5p50626229506262357mer-m85062621550626236145-19.29
CAediting_1212477chr17_50626234_+ENSG00000006283.16ENST00000511765hsa-miR-6851-3p50626232506262387mer-m85062622050626239144-20.79
CAediting_1212477chr17_50626234_+ENSG00000006283.16ENST00000506406hsa-miR-1915-5p50626229506262357mer-m85062621550626236145-19.29
CAediting_1212477chr17_50626234_+ENSG00000006283.16ENST00000506406hsa-miR-6851-3p50626232506262387mer-m85062622050626239144-20.79
CAediting_1212477chr17_50626234_+ENSG00000006283.16ENST00000504076hsa-miR-1915-5p50626229506262357mer-m85062621550626236145-19.29
CAediting_1212477chr17_50626234_+ENSG00000006283.16ENST00000504076hsa-miR-6851-3p50626232506262387mer-m85062622050626239144-20.79
CAediting_1212477chr17_50626234_+ENSG00000006283.16ENST00000503436hsa-miR-1915-5p50626229506262357mer-m85062621550626236145-19.29
CAediting_1212477chr17_50626234_+ENSG00000006283.16ENST00000503436hsa-miR-6851-3p50626232506262387mer-m85062622050626239144-20.79
CAediting_1212477chr17_50626234_+ENSG00000006283.16ENST00000511768hsa-miR-1915-5p50626229506262357mer-m85062621550626236145-19.29
CAediting_1212477chr17_50626234_+ENSG00000006283.16ENST00000511768hsa-miR-6851-3p50626232506262387mer-m85062622050626239144-20.79
CAediting_1212477chr17_50626234_+ENSG00000006283.16ENST00000503607hsa-miR-1915-5p50626229506262357mer-m85062621550626236145-19.29
CAediting_1212477chr17_50626234_+ENSG00000006283.16ENST00000503607hsa-miR-6851-3p50626232506262387mer-m85062622050626239144-20.79

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_980496chr14_31014685_-ENSG00000006283.16ENST00000506520hsa-miR-624-3p50607482506074887mer-m85060746750607489158-14.71
CAediting_1351755chr19_40282625_-ENSG00000006283.16ENST00000354983hsa-miR-64150627129506271357mer-1a5062711150627135140-15.98
CAediting_1351755chr19_40282625_-ENSG00000006283.16ENST00000352832hsa-miR-64150627129506271357mer-1a5062711150627135140-15.98
CAediting_573000chr7_92204081_-ENSG00000006283.16ENST00000511765hsa-miR-1285-5p50618969506189757mer-m85061895550618976147-22.48
CAediting_1054808chr15_66496985_-ENSG00000006283.16ENST00000511765hsa-miR-451250624030506240356mer5062401550624036143-22.31
CAediting_442554chr5_154685830_+ENSG00000006283.16ENST00000511765hsa-miR-130350626176506261827mer-m85062616150626183151-19.05
CAediting_604450chr7_133034877_-ENSG00000006283.16ENST00000511765hsa-miR-365450626624506266307mer-m85062661250626631144-16.23
CAediting_573000chr7_92204081_-ENSG00000006283.16ENST00000506406hsa-miR-1285-5p50618969506189757mer-m85061895550618976147-22.48
CAediting_1054808chr15_66496985_-ENSG00000006283.16ENST00000506406hsa-miR-451250624030506240356mer5062401550624036143-22.31
CAediting_442554chr5_154685830_+ENSG00000006283.16ENST00000506406hsa-miR-130350626176506261827mer-m85062616150626183151-19.05
CAediting_604450chr7_133034877_-ENSG00000006283.16ENST00000506406hsa-miR-365450626624506266307mer-m85062661250626631144-16.23
CAediting_573000chr7_92204081_-ENSG00000006283.16ENST00000504076hsa-miR-1285-5p50618969506189757mer-m85061895550618976147-22.48
CAediting_1054808chr15_66496985_-ENSG00000006283.16ENST00000504076hsa-miR-451250624030506240356mer5062401550624036143-22.31
CAediting_442554chr5_154685830_+ENSG00000006283.16ENST00000504076hsa-miR-130350626176506261827mer-m85062616150626183151-19.05
CAediting_604450chr7_133034877_-ENSG00000006283.16ENST00000504076hsa-miR-365450626624506266307mer-m85062661250626631144-16.23
CAediting_573000chr7_92204081_-ENSG00000006283.16ENST00000503436hsa-miR-1285-5p50618969506189757mer-m85061895550618976147-22.48
CAediting_1054808chr15_66496985_-ENSG00000006283.16ENST00000503436hsa-miR-451250624030506240356mer5062401550624036143-22.31
CAediting_442554chr5_154685830_+ENSG00000006283.16ENST00000503436hsa-miR-130350626176506261827mer-m85062616150626183151-19.05
CAediting_604450chr7_133034877_-ENSG00000006283.16ENST00000503436hsa-miR-365450626624506266307mer-m85062661250626631144-16.23
CAediting_573000chr7_92204081_-ENSG00000006283.16ENST00000511768hsa-miR-1285-5p50618969506189757mer-m85061895550618976147-22.48
CAediting_1054808chr15_66496985_-ENSG00000006283.16ENST00000511768hsa-miR-451250624030506240356mer5062401550624036143-22.31
CAediting_442554chr5_154685830_+ENSG00000006283.16ENST00000511768hsa-miR-130350626176506261827mer-m85062616150626183151-19.05
CAediting_604450chr7_133034877_-ENSG00000006283.16ENST00000511768hsa-miR-365450626624506266307mer-m85062661250626631144-16.23
CAediting_573000chr7_92204081_-ENSG00000006283.16ENST00000503607hsa-miR-1285-5p50618969506189757mer-m85061895550618976147-22.48
CAediting_1054808chr15_66496985_-ENSG00000006283.16ENST00000503607hsa-miR-451250624030506240356mer5062401550624036143-22.31
CAediting_442554chr5_154685830_+ENSG00000006283.16ENST00000503607hsa-miR-130350626176506261827mer-m85062616150626183151-19.05
CAediting_604450chr7_133034877_-ENSG00000006283.16ENST00000503607hsa-miR-365450626624506266307mer-m85062661250626631144-16.23
CAediting_1351755chr19_40282625_-ENSG00000006283.16ENST00000358244hsa-miR-64150627129506271357mer-1a5062711150627135140-15.98
CAediting_1399425chr20_1392958_-ENSG00000006283.16ENST00000570567hsa-miR-6869-5p50573664505736718mer-1a5057365050573671140-14.84
CAediting_524911chr7_5495852_-ENSG00000006283.16ENST00000570567hsa-miR-589-3p50573358505733647mer-m85057334350573365151-21
CAediting_1368054chr19_46709310_-ENSG00000006283.16ENST00000506520hsa-miR-320e50607331506073377mer-m85060732150607338145-18.25

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_1229413chr17_67471544_+ENSG00000006283.16ENST00000570567hsa-miR-548aa50573536505735427mer-m85057351850573543151-10.97
CAediting_1229414chr17_67471546_+ENSG00000006283.16ENST00000570567hsa-miR-548aa50573536505735427mer-m85057351850573543151-10.97
CAediting_1229415chr17_67471547_+ENSG00000006283.16ENST00000570567hsa-miR-548aa50573536505735427mer-m85057351850573543151-10.97

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for CACNA1G

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for CACNA1G

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)

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Relation with cancer stages for CACNA1G

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.

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Relation with survival for CACNA1G

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR

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RelatedDrugs for CACNA1G

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
CACNA1GO43497DB00347TrimethadioneVoltage-dependent T-type calcium channel subunit alpha-1G SmallMoleculeDrugapproved
CACNA1GO43497DB00421SpironolactoneVoltage-dependent T-type calcium channel subunit alpha-1G SmallMoleculeDrugapproved
CACNA1GO43497DB00593EthosuximideVoltage-dependent T-type calcium channel subunit alpha-1G SmallMoleculeDrugapproved
CACNA1GO43497DB00661VerapamilVoltage-dependent T-type calcium channel subunit alpha-1G SmallMoleculeDrugapproved
CACNA1GO43497DB01115NifedipineVoltage-dependent T-type calcium channel subunit alpha-1G SmallMoleculeDrugapproved
CACNA1GO43497DB04841FlunarizineVoltage-dependent T-type calcium channel subunit alpha-1G SmallMoleculeDrugapproved
CACNA1GO43497DB05246MethsuximideVoltage-dependent T-type calcium channel subunit alpha-1G SmallMoleculeDrugapproved
CACNA1GO43497DB09089TrimebutineVoltage-dependent T-type calcium channel subunit alpha-1G SmallMoleculeDrugapproved
CACNA1GO43497DB13746BioallethrinVoltage-dependent T-type calcium channel subunit alpha-1G SmallMoleculeDrugapproved|experimental
CACNA1GO43497DB00568CinnarizineVoltage-dependent T-type calcium channel subunit alpha-1G SmallMoleculeDrugapproved|investigational
CACNA1GO43497DB00909ZonisamideVoltage-dependent T-type calcium channel subunit alpha-1G SmallMoleculeDrugapproved|investigational
CACNA1GO43497DB09061CannabidiolVoltage-dependent T-type calcium channel subunit alpha-1G SmallMoleculeDrugapproved|investigational
CACNA1GO43497DB09238ManidipineVoltage-dependent T-type calcium channel subunit alpha-1G SmallMoleculeDrugapproved|investigational
CACNA1GO43497DB00228EnfluraneVoltage-dependent T-type calcium channel subunit alpha-1G SmallMoleculeDrugapproved|investigational|vet_approved
CACNA1GO43497DB00153ErgocalciferolVoltage-dependent T-type calcium channel subunit alpha-1G SmallMoleculeDrugapproved|nutraceutical
CACNA1GO43497DB11148ButambenVoltage-dependent T-type calcium channel subunit alpha-1G SmallMoleculeDrugapproved|withdrawn

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RelatedDiseases for CACNA1G

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource
CACNA1GC4225205SPINOCEREBELLAR ATAXIA 424GENOMICS_ENGLAND;ORPHANET;UNIPROT
CACNA1GC0020796Profound Mental Retardation1CTD_human
CACNA1GC0025363Mental Retardation, Psychosocial1CTD_human
CACNA1GC0917816Mental deficiency1CTD_human
CACNA1GC3714756Intellectual Disability1CTD_human
CACNA1GC4748120SPINOCEREBELLAR ATAXIA 42, EARLY-ONSET, SEVERE, WITH NEURODEVELOPMENTAL DEFICITS1GENOMICS_ENGLAND;UNIPROT