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Editing gene: GYG2 (CAeditome ID:8908)

Gene summary for GYG2

Gene summary

Gene information	Gene symbol	GYG2
	Gene ID	8908
	Gene name	glycogenin 2
	Synonyms	GN-2\|GN2
	Cytomap	Xp22.33
	Type of gene	protein-coding
	Description	glycogenin-2glycogenin glucosyltransferase
	Modification date	20210518
	UniProtAcc	O15488
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
GYG2	GO:0008466	Glycogenin-2	9857012
GYG2	GO:0005978	Glycogenin-2	9857012

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RNA A-to-I events for GYG2

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000056998.17

RNA A-to-I editing events in Cancer.

CAediting_1497056(2836573, +), CAediting_1497057(2843048, +), CAediting_1497058(2843060, +), CAediting_1497059(2843065, +), CAediting_1497060(2843074, +), CAediting_1497061(2843691, +), CAediting_1497062(2843710, +), CAediting_1497063(2843755, +), CAediting_1497064(2843769, +), CAediting_1497065(2843772, +), CAediting_1497066(2846602, +), CAediting_1497067(2852030, +), CAediting_1497068(2862810, +), CAediting_1497069(2864866, +), CAediting_1497070(2864880, +), CAediting_1497071(2867831, +), CAediting_1497072(2867839, +), CAediting_1497073(2867876, +), CAediting_1497074(2867900, +), CAediting_1497075(2867975, +), CAediting_1497076(2867999, +), CAediting_1497077(2868016, +), CAediting_1497078(2868024, +), CAediting_1497079(2868080, +), CAediting_1497080(2868252, +), CAediting_1497081(2868253, +), CAediting_1497082(2868312, +), CAediting_1497083(2868330, +), CAediting_1497084(2868331, +), CAediting_1497085(2868332, +), CAediting_1497086(2868348, +), CAediting_1497087(2868352, +), CAediting_1497088(2868357, +), CAediting_1497089(2868402, +), CAediting_1497090(2868407, +), CAediting_1497091(2869725, +), CAediting_1497092(2869877, +), CAediting_1497093(2869916, +), CAediting_1497094(2871427, +), CAediting_1497095(2871570, +), CAediting_1497096(2873834, +), CAediting_1497097(2873870, +), CAediting_1497098(2873894, +), CAediting_1497099(2873949, +), CAediting_1497100(2874002, +), CAediting_1497101(2874045, +), CAediting_1497102(2877017, +), CAediting_1497103(2877046, +), CAediting_1497104(2877057, +), CAediting_1497105(2879539, +), CAediting_1497106(2880674, +), CAediting_1497107(2880675, +), CAediting_1497108(2880706, +), CAediting_1497109(2880722, +), CAediting_1497110(2880726, +), CAediting_1497111(2880786, +), CAediting_1497112(2881878, +),

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RNA editing positional annotations for GYG2 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_1497056	chrX_2836573_+	ncRNA_intronic
CAediting_1497057	chrX_2843048_+	exonic
CAediting_1497058	chrX_2843060_+	exonic
CAediting_1497059	chrX_2843065_+	exonic
CAediting_1497060	chrX_2843074_+	exonic
CAediting_1497061	chrX_2843691_+	ncRNA_intronic
CAediting_1497062	chrX_2843710_+	ncRNA_intronic
CAediting_1497063	chrX_2843755_+	ncRNA_intronic
CAediting_1497064	chrX_2843769_+	ncRNA_intronic
CAediting_1497065	chrX_2843772_+	ncRNA_intronic
CAediting_1497066	chrX_2846602_+	ncRNA_intronic
CAediting_1497067	chrX_2852030_+	ncRNA_intronic
CAediting_1497068	chrX_2862810_+	ncRNA_intronic
CAediting_1497069	chrX_2864866_+	ncRNA_intronic
CAediting_1497070	chrX_2864880_+	ncRNA_intronic
CAediting_1497071	chrX_2867831_+	ncRNA_intronic
CAediting_1497072	chrX_2867839_+	ncRNA_intronic
CAediting_1497073	chrX_2867876_+	ncRNA_intronic
CAediting_1497074	chrX_2867900_+	ncRNA_intronic
CAediting_1497075	chrX_2867975_+	ncRNA_intronic
CAediting_1497076	chrX_2867999_+	ncRNA_intronic
CAediting_1497077	chrX_2868016_+	ncRNA_intronic
CAediting_1497078	chrX_2868024_+	ncRNA_intronic
CAediting_1497079	chrX_2868080_+	ncRNA_intronic
CAediting_1497080	chrX_2868252_+	ncRNA_intronic
CAediting_1497081	chrX_2868253_+	ncRNA_intronic
CAediting_1497082	chrX_2868312_+	ncRNA_intronic
CAediting_1497083	chrX_2868330_+	ncRNA_intronic
CAediting_1497084	chrX_2868331_+	ncRNA_intronic
CAediting_1497085	chrX_2868332_+	ncRNA_intronic
CAediting_1497086	chrX_2868348_+	ncRNA_intronic
CAediting_1497087	chrX_2868352_+	ncRNA_intronic
CAediting_1497088	chrX_2868357_+	ncRNA_intronic
CAediting_1497089	chrX_2868402_+	ncRNA_intronic
CAediting_1497090	chrX_2868407_+	ncRNA_intronic
CAediting_1497091	chrX_2869725_+	ncRNA_intronic
CAediting_1497092	chrX_2869877_+	ncRNA_intronic
CAediting_1497093	chrX_2869916_+	ncRNA_intronic
CAediting_1497094	chrX_2871427_+	ncRNA_intronic
CAediting_1497095	chrX_2871570_+	ncRNA_intronic
CAediting_1497096	chrX_2873834_+	ncRNA_intronic
CAediting_1497097	chrX_2873870_+	ncRNA_intronic
CAediting_1497098	chrX_2873894_+	ncRNA_intronic
CAediting_1497099	chrX_2873949_+	ncRNA_intronic
CAediting_1497100	chrX_2874002_+	ncRNA_intronic
CAediting_1497101	chrX_2874045_+	ncRNA_intronic
CAediting_1497102	chrX_2877017_+	ncRNA_intronic
CAediting_1497103	chrX_2877046_+	ncRNA_intronic
CAediting_1497104	chrX_2877057_+	ncRNA_intronic
CAediting_1497105	chrX_2879539_+	ncRNA_intronic
CAediting_1497106	chrX_2880674_+	ncRNA_intronic
CAediting_1497107	chrX_2880675_+	ncRNA_intronic
CAediting_1497108	chrX_2880706_+	ncRNA_intronic
CAediting_1497109	chrX_2880722_+	ncRNA_intronic
CAediting_1497110	chrX_2880726_+	ncRNA_intronic
CAediting_1497111	chrX_2880786_+	ncRNA_intronic
CAediting_1497112	chrX_2881878_+	ncRNA_exonic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_1497056	chrX_2836573_+	SINE	Alu	AluJr
CAediting_1497057	chrX_2843048_+	SINE	Alu	AluJb
CAediting_1497058	chrX_2843060_+	SINE	Alu	AluJb
CAediting_1497059	chrX_2843065_+	SINE	Alu	AluJb
CAediting_1497060	chrX_2843074_+	SINE	Alu	AluJb
CAediting_1497061	chrX_2843691_+	SINE	Alu	AluJb
CAediting_1497062	chrX_2843710_+	SINE	Alu	AluJb
CAediting_1497063	chrX_2843755_+	SINE	Alu	AluJb
CAediting_1497064	chrX_2843769_+	SINE	Alu	AluJb
CAediting_1497065	chrX_2843772_+	SINE	Alu	AluJb
CAediting_1497066	chrX_2846602_+	SINE	Alu	AluJr
CAediting_1497067	chrX_2852030_+	SINE	Alu	AluJo
CAediting_1497068	chrX_2862810_+	SINE	Alu	AluJo
CAediting_1497069	chrX_2864866_+	SINE	Alu	AluSz
CAediting_1497070	chrX_2864880_+	SINE	Alu	AluSz
CAediting_1497071	chrX_2867831_+	SINE	Alu	AluSz
CAediting_1497072	chrX_2867839_+	SINE	Alu	AluSz
CAediting_1497073	chrX_2867876_+	SINE	Alu	AluSz
CAediting_1497074	chrX_2867900_+	SINE	Alu	AluSz
CAediting_1497075	chrX_2867975_+	SINE	Alu	AluSz
CAediting_1497076	chrX_2867999_+	SINE	Alu	AluSz
CAediting_1497077	chrX_2868016_+	SINE	Alu	AluSz
CAediting_1497078	chrX_2868024_+	SINE	Alu	AluSz
CAediting_1497079	chrX_2868080_+	SINE	Alu	AluSz
CAediting_1497080	chrX_2868252_+	SINE	Alu	AluSz
CAediting_1497081	chrX_2868253_+	SINE	Alu	AluSz
CAediting_1497082	chrX_2868312_+	SINE	Alu	AluSz
CAediting_1497083	chrX_2868330_+	SINE	Alu	AluSz
CAediting_1497084	chrX_2868331_+	SINE	Alu	AluSz
CAediting_1497085	chrX_2868332_+	SINE	Alu	AluSz
CAediting_1497086	chrX_2868348_+	SINE	Alu	AluSz
CAediting_1497087	chrX_2868352_+	SINE	Alu	AluSz
CAediting_1497088	chrX_2868357_+	SINE	Alu	AluSz
CAediting_1497089	chrX_2868402_+	SINE	Alu	AluSz
CAediting_1497090	chrX_2868407_+	SINE	Alu	AluSz
CAediting_1497091	chrX_2869725_+	SINE	Alu	AluJb
CAediting_1497092	chrX_2869877_+	SINE	Alu	AluJb
CAediting_1497093	chrX_2869916_+	SINE	Alu	AluJb
CAediting_1497094	chrX_2871427_+	SINE	Alu	AluSx
CAediting_1497095	chrX_2871570_+	SINE	Alu	AluSx
CAediting_1497096	chrX_2873834_+	SINE	Alu	AluSz
CAediting_1497097	chrX_2873870_+	SINE	Alu	AluSz
CAediting_1497098	chrX_2873894_+	SINE	Alu	AluSz
CAediting_1497099	chrX_2873949_+	SINE	Alu	AluSz
CAediting_1497100	chrX_2874002_+	SINE	Alu	AluSz
CAediting_1497101	chrX_2874045_+	SINE	Alu	AluSz
CAediting_1497102	chrX_2877017_+	SINE	Alu	AluJo
CAediting_1497103	chrX_2877046_+	SINE	Alu	AluJo
CAediting_1497104	chrX_2877057_+	SINE	Alu	AluJo
CAediting_1497105	chrX_2879539_+	SINE	Alu	AluSx1
CAediting_1497106	chrX_2880674_+	SINE	Alu	AluJo
CAediting_1497107	chrX_2880675_+	SINE	Alu	AluJo
CAediting_1497108	chrX_2880706_+	SINE	Alu	AluJo
CAediting_1497109	chrX_2880722_+	SINE	Alu	AluJo
CAediting_1497110	chrX_2880726_+	SINE	Alu	AluJo
CAediting_1497111	chrX_2880786_+	SINE	Alu	AluJo

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RNA A-to-I editing events in the alternative splicing sites for GYG2

RNA A-to-I editing(s) in the alternative splicing sites.

AStype	CAeditomID	Editing position	AS position	AS direction	Exonic location	Wildtype sequence	Wildtype splicing strength	RNA edited sequence	RNA edited splicing strength
ES	CAediting_1497065	chrX_2843772_+	2843770:2843778	5SS	1+0i	CAAGTATGT	7.44	CAGGTATGT	9.8

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000056998.17.GYG2.

Correlation between RNA A-to-I editing and PSI for ENSG00000056998.17.GYG2.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for GYG2

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for GYG2

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for GYG2

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1497112	chrX_2881878_+	ENSG00000056998.17	ENST00000381163	hsa-miR-4691-5p	2881876	2881882	7mer-m8	2881861	2881883	162.00	-28.12
CAediting_1497112	chrX_2881878_+	ENSG00000056998.17	ENST00000381163	hsa-miR-5695	2881874	2881880	7mer-m8	2881860	2881881	140.00	-16.31
CAediting_1497112	chrX_2881878_+	ENSG00000056998.17	ENST00000381163	hsa-miR-6792-3p	2881876	2881882	7mer-m8	2881862	2881883	159.00	-23.60

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_748296	chr10_51299626_+	ENSG00000056998.17	ENST00000381163	hsa-miR-605-3p	2882069	2882075	7mer-m8	2882059	2882076	147	-15.57
CAediting_688080	chr9_63819626_+	ENSG00000056998.17	ENST00000381163	hsa-miR-4477b	2882074	2882081	8mer-1a	2882060	2882081	159	-16.71
CAediting_1368054	chr19_46709310_-	ENSG00000056998.17	ENST00000381163	hsa-miR-320e	2882094	2882099	6mer	2882083	2882100	147	-21.82
CAediting_86358	chr1_109598906_+	ENSG00000056998.17	ENST00000381163	hsa-miR-197-5p	2881999	2882005	7mer-m8	2881982	2882006	148	-20.96
CAediting_573001	chr7_92204086_-	ENSG00000056998.17	ENST00000381163	hsa-miR-1285-5p	2881569	2881575	7mer-m8	2881555	2881576	142	-18.24
CAediting_468389	chr6_31355314_-	ENSG00000056998.17	ENST00000381163	hsa-miR-6891-5p	2882072	2882079	8mer-1a	2882061	2882079	155	-22.55

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_86358	chr1_109598906_+	ENSG00000056998.17	ENST00000381163	hsa-miR-197-5p	2881447	2881453	7mer-m8	2881432	2881454	149	-23.37
CAediting_86358	chr1_109598906_+	ENSG00000056998.17	ENST00000381163	hsa-miR-197-5p	2882027	2882033	7mer-m8	2882010	2882034	155	-23.31

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for GYG2

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for GYG2

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for GYG2

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for GYG2

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for GYG2

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for GYG2

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
GYG2	C0017919	Glycogen Storage Disease	1	GENOMICS_ENGLAND

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene