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Editing gene: RIPK2 (CAeditome ID:8767)

Gene summary for RIPK2

Gene summary

Gene information	Gene symbol	RIPK2
	Gene ID	8767
	Gene name	receptor interacting serine/threonine kinase 2
	Synonyms	CARD3\|CARDIAK\|CCK\|GIG30\|RICK\|RIP2
	Cytomap	8q21.3
	Type of gene	protein-coding
	Description	receptor-interacting serine/threonine-protein kinase 2CARD-carrying kinaseCARD-containing IL-1 beta ICE-kinaseCARD-containing interleukin-1 beta-converting enzyme (ICE)-associated kinaseRIP-2growth-inhibiting gene 30receptor-interacting protein (RIP
	Modification date	20210518
	UniProtAcc	O43353
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
RIPK2	GO:0034134	Receptor-interacting serine/threonine-protein kinase 2	11894098
RIPK2	GO:0043123	Receptor-interacting serine/threonine-protein kinase 2	10329646
RIPK2	GO:0042803	Receptor-interacting serine/threonine-protein kinase 2	19337385
RIPK2	GO:0050700	Receptor-interacting serine/threonine-protein kinase 2	10329646
RIPK2	GO:0010800	Receptor-interacting serine/threonine-protein kinase 2	21887730
RIPK2	GO:0010942	Receptor-interacting serine/threonine-protein kinase 2	16920334
RIPK2	GO:0032731	Receptor-interacting serine/threonine-protein kinase 2	11432859
RIPK2	GO:0033138	Receptor-interacting serine/threonine-protein kinase 2	21887730
RIPK2	GO:0045087	Receptor-interacting serine/threonine-protein kinase 2	23806334
RIPK2	GO:0050731	Receptor-interacting serine/threonine-protein kinase 2	21887730
RIPK2	GO:0051092	Receptor-interacting serine/threonine-protein kinase 2	11821383
RIPK2	GO:0070431	Receptor-interacting serine/threonine-protein kinase 2	23806334
RIPK2	GO:0071225	Receptor-interacting serine/threonine-protein kinase 2	21887730
RIPK2	GO:0097202	Receptor-interacting serine/threonine-protein kinase 2	11821383
RIPK2	GO:0005737	Receptor-interacting serine/threonine-protein kinase 2	21887730
RIPK2	GO:0005829	Receptor-interacting serine/threonine-protein kinase 2	0000052
RIPK2	GO:0005856	Receptor-interacting serine/threonine-protein kinase 2	21887730
RIPK2	GO:0031982	Receptor-interacting serine/threonine-protein kinase 2	21887730
RIPK2	GO:0032991	Receptor-interacting serine/threonine-protein kinase 2	11536016
RIPK2	GO:0032991	Receptor-interacting serine/threonine-protein kinase 2	15383541
RIPK2	GO:0032991	Receptor-interacting serine/threonine-protein kinase 2	21887730

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RNA A-to-I events for RIPK2

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000104312.7

RNA A-to-I editing events in Cancer.

CAediting_648549(89773776, +), CAediting_648550(89773814, +), CAediting_648551(89773821, +), CAediting_648552(89774239, +), CAediting_648553(89774240, +), CAediting_648554(89774241, +), CAediting_648555(89778785, +), CAediting_648556(89778873, +), CAediting_648557(89778874, +), CAediting_648558(89778900, +), CAediting_648559(89779666, +), CAediting_648560(89779679, +), CAediting_648561(89779717, +), CAediting_648562(89781390, +), CAediting_648563(89781436, +), CAediting_648564(89781466, +), CAediting_648565(89782056, +), CAediting_648566(89782060, +), CAediting_648567(89782075, +), CAediting_648568(89782527, +), CAediting_648569(89782572, +), CAediting_648570(89782573, +), CAediting_648571(89782576, +), CAediting_648572(89788671, +), CAediting_648573(89790323, +),

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RNA editing positional annotations for RIPK2 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_648549	chr8_89773776_+	intronic
CAediting_648550	chr8_89773814_+	intronic
CAediting_648551	chr8_89773821_+	intronic
CAediting_648552	chr8_89774239_+	intronic
CAediting_648553	chr8_89774240_+	intronic
CAediting_648554	chr8_89774241_+	intronic
CAediting_648555	chr8_89778785_+	intronic
CAediting_648556	chr8_89778873_+	intronic
CAediting_648557	chr8_89778874_+	intronic
CAediting_648558	chr8_89778900_+	intronic
CAediting_648559	chr8_89779666_+	intronic
CAediting_648560	chr8_89779679_+	intronic
CAediting_648561	chr8_89779717_+	intronic
CAediting_648562	chr8_89781390_+	intronic
CAediting_648563	chr8_89781436_+	intronic
CAediting_648564	chr8_89781466_+	intronic
CAediting_648565	chr8_89782056_+	intronic
CAediting_648566	chr8_89782060_+	intronic
CAediting_648567	chr8_89782075_+	intronic
CAediting_648568	chr8_89782527_+	intronic
CAediting_648569	chr8_89782572_+	intronic
CAediting_648570	chr8_89782573_+	intronic
CAediting_648571	chr8_89782576_+	intronic
CAediting_648572	chr8_89788671_+	intronic
CAediting_648573	chr8_89790323_+	exonic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_648549	chr8_89773776_+	LINE	L1	L1M4
CAediting_648550	chr8_89773814_+	LINE	L1	L1M4
CAediting_648551	chr8_89773821_+	LINE	L1	L1M4
CAediting_648552	chr8_89774239_+	LINE	L1	L1M4
CAediting_648553	chr8_89774240_+	LINE	L1	L1M4
CAediting_648554	chr8_89774241_+	LINE	L1	L1M4
CAediting_648555	chr8_89778785_+	LINE	L1	L1MB8
CAediting_648556	chr8_89778873_+	LINE	L1	L1MB8
CAediting_648557	chr8_89778874_+	LINE	L1	L1MB8
CAediting_648558	chr8_89778900_+	LINE	L1	L1MB8
CAediting_648559	chr8_89779666_+	LINE	L1	L1MB8
CAediting_648560	chr8_89779679_+	LINE	L1	L1MB8
CAediting_648561	chr8_89779717_+	LINE	L1	L1MB8
CAediting_648562	chr8_89781390_+	SINE	Alu	AluJr
CAediting_648563	chr8_89781436_+	SINE	Alu	AluJr
CAediting_648564	chr8_89781466_+	SINE	Alu	AluJr
CAediting_648565	chr8_89782056_+	SINE	Alu	AluJb
CAediting_648566	chr8_89782060_+	SINE	Alu	AluJb
CAediting_648567	chr8_89782075_+	SINE	Alu	AluJb
CAediting_648568	chr8_89782527_+	SINE	Alu	FLAM_A
CAediting_648569	chr8_89782572_+	SINE	Alu	FLAM_A
CAediting_648570	chr8_89782573_+	SINE	Alu	FLAM_A
CAediting_648571	chr8_89782576_+	SINE	Alu	FLAM_A
CAediting_648572	chr8_89788671_+	SINE	Alu	AluSq2

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RNA A-to-I editing events in the alternative splicing sites for RIPK2

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000104312.7.RIPK2.

Correlation between RNA A-to-I editing and PSI for ENSG00000104312.7.RIPK2.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for RIPK2

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for RIPK2

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for RIPK2

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_688080	chr9_63819626_+	ENSG00000104312.7	ENST00000522965	hsa-miR-4477b	89786660	89786666	7mer-m8	89786646	89786667	140	-11.23
CAediting_1368054	chr19_46709310_-	ENSG00000104312.7	ENST00000522965	hsa-miR-320e	89786655	89786661	7mer-m8	89786646	89786662	141	-14.05
CAediting_1160181	chr17_7017644_-	ENSG00000104312.7	ENST00000522965	hsa-miR-195-3p	89790129	89790134	6mer	89790114	89790135	140	-17.95

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for RIPK2

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000220751.4	protein_coding
ENST00000522965.1	nonsense_mediated_decay

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID	ENST	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
CAediting_648573	ENST00000220751.4	chr8_89790323_+	-699.40	-699.40	-699.40
CAediting_648573	ENST00000522965.1	chr8_89790323_+	-534.30	-534.30	-534.30

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Relation with ADAR for RIPK2

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for RIPK2

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for RIPK2

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for RIPK2

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
RIPK2	O43353	DB12010	Fostamatinib	Receptor-interacting serine/threonine-protein kinase 2	SmallMoleculeDrug	approved\|investigational

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RelatedDiseases for RIPK2

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
RIPK2	C0009324	Ulcerative Colitis	1	CTD_human

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene