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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: B4GALT2 (CAeditome ID:8704)

Gene summary for B4GALT2

check button Gene summary
Gene informationGene symbol

B4GALT2

Gene ID

8704

Gene namebeta-1,4-galactosyltransferase 2
SynonymsB4Gal-T2|B4Gal-T3|beta4Gal-T2
Cytomap

1p34.1

Type of geneprotein-coding
Descriptionbeta-1,4-galactosyltransferase 2N-acetyllactosamine synthaseUDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 2UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase 2UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 2UDP-galactose:beta-N-a
Modification date20210518
UniProtAcc

O60909

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
B4GALT2

GO:0005654

Beta-1,4-galactosyltransferase 2

0000052

B4GALT2

GO:0005794

Beta-1,4-galactosyltransferase 2

0000052

B4GALT2

GO:0043231

Beta-1,4-galactosyltransferase 2

0000052


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RNA A-to-I events for B4GALT2

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000117411.15

check button RNA A-to-I editing events in Cancer.
CAediting_54350(43986142, +), CAediting_54351(43986145, +), CAediting_54352(43986157, +), CAediting_54353(43986159, +), CAediting_54354(43986160, +), CAediting_54355(43986167, +), CAediting_54356(43986168, +), CAediting_54357(43986169, +), CAediting_54358(43986179, +), CAediting_54359(43986180, +), CAediting_54360(43986181, +), CAediting_54361(43986185, +), CAediting_54362(43986186, +), CAediting_54363(43986187, +), CAediting_54364(43986189, +), CAediting_54365(43986190, +), CAediting_54366(43986201, +), CAediting_54367(43986212, +), CAediting_54368(43986221, +), CAediting_54369(43986222, +), CAediting_54370(43986223, +), CAediting_54371(43986239, +), CAediting_54372(43986241, +), CAediting_54373(43986245, +), CAediting_54374(43986247, +), CAediting_54375(43986250, +), CAediting_54376(43986256, +), CAediting_54377(43987302, +), CAediting_54378(43987312, +), CAediting_54379(43987315, +), CAediting_54380(43987329, +), CAediting_54381(43987335, +), CAediting_54382(43987337, +), CAediting_54383(43987338, +), CAediting_54384(43987344, +), CAediting_54385(43987347, +), CAediting_54386(43987349, +), CAediting_54387(43987350, +), CAediting_54388(43987356, +), CAediting_54389(43987358, +), CAediting_54390(43987361, +), CAediting_54391(43987367, +), CAediting_54392(43987370, +), CAediting_54393(43987371, +), CAediting_54394(43987382, +), CAediting_54395(43987384, +), CAediting_54396(43987389, +), CAediting_54397(43987391, +), CAediting_54398(43987393, +), CAediting_54399(43987400, +), CAediting_54400(43987413, +), CAediting_54401(43987417, +), CAediting_54402(43987425, +), CAediting_54403(43987428, +), CAediting_54404(43987430, +), CAediting_54405(43988282, +), CAediting_54406(43988288, +), CAediting_54407(43988403, +), CAediting_54408(43988419, +), CAediting_54409(43988433, +), CAediting_54410(43988459, +), CAediting_54411(43988471, +), CAediting_54412(43988472, +), CAediting_54413(43988513, +), CAediting_54414(43988539, +), CAediting_54415(43988540, +), CAediting_54416(43988652, +), CAediting_54417(43988732, +), CAediting_54418(43988740, +), CAediting_54419(43988748, +), CAediting_54420(43988753, +), CAediting_54421(43988822, +), CAediting_54422(43988827, +), CAediting_54423(43989113, +), CAediting_54424(43989140, +), CAediting_54425(43989171, +), CAediting_54426(43989189, +), CAediting_54427(43989195, +), CAediting_54428(43989200, +), CAediting_54429(43989209, +), CAediting_54430(43989226, +), CAediting_54431(43989239, +), CAediting_54432(43989248, +),

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RNA editing positional annotations for B4GALT2 using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_54350chr1_43986142_+ncRNA_exonic
CAediting_54351chr1_43986145_+ncRNA_exonic
CAediting_54352chr1_43986157_+ncRNA_exonic
CAediting_54353chr1_43986159_+ncRNA_exonic
CAediting_54354chr1_43986160_+ncRNA_exonic
CAediting_54355chr1_43986167_+ncRNA_exonic
CAediting_54356chr1_43986168_+ncRNA_exonic
CAediting_54357chr1_43986169_+ncRNA_exonic
CAediting_54358chr1_43986179_+ncRNA_exonic
CAediting_54359chr1_43986180_+ncRNA_exonic
CAediting_54360chr1_43986181_+ncRNA_exonic
CAediting_54361chr1_43986185_+ncRNA_exonic
CAediting_54362chr1_43986186_+ncRNA_exonic
CAediting_54363chr1_43986187_+ncRNA_exonic
CAediting_54364chr1_43986189_+ncRNA_exonic
CAediting_54365chr1_43986190_+ncRNA_exonic
CAediting_54366chr1_43986201_+ncRNA_exonic
CAediting_54367chr1_43986212_+intronic
CAediting_54368chr1_43986221_+intronic
CAediting_54369chr1_43986222_+intronic
CAediting_54370chr1_43986223_+intronic
CAediting_54371chr1_43986239_+intronic
CAediting_54372chr1_43986241_+intronic
CAediting_54373chr1_43986245_+intronic
CAediting_54374chr1_43986247_+intronic
CAediting_54375chr1_43986250_+intronic
CAediting_54376chr1_43986256_+intronic
CAediting_54377chr1_43987302_+intronic
CAediting_54378chr1_43987312_+intronic
CAediting_54379chr1_43987315_+intronic
CAediting_54380chr1_43987329_+intronic
CAediting_54381chr1_43987335_+intronic
CAediting_54382chr1_43987337_+intronic
CAediting_54383chr1_43987338_+intronic
CAediting_54384chr1_43987344_+intronic
CAediting_54385chr1_43987347_+intronic
CAediting_54386chr1_43987349_+intronic
CAediting_54387chr1_43987350_+intronic
CAediting_54388chr1_43987356_+intronic
CAediting_54389chr1_43987358_+intronic
CAediting_54390chr1_43987361_+intronic
CAediting_54391chr1_43987367_+intronic
CAediting_54392chr1_43987370_+intronic
CAediting_54393chr1_43987371_+intronic
CAediting_54394chr1_43987382_+intronic
CAediting_54395chr1_43987384_+intronic
CAediting_54396chr1_43987389_+intronic
CAediting_54397chr1_43987391_+intronic
CAediting_54398chr1_43987393_+intronic
CAediting_54399chr1_43987400_+intronic
CAediting_54400chr1_43987413_+intronic
CAediting_54401chr1_43987417_+intronic
CAediting_54402chr1_43987425_+intronic
CAediting_54403chr1_43987428_+intronic
CAediting_54404chr1_43987430_+intronic
CAediting_54405chr1_43988282_+intronic
CAediting_54406chr1_43988288_+intronic
CAediting_54407chr1_43988403_+intronic
CAediting_54408chr1_43988419_+intronic
CAediting_54409chr1_43988433_+intronic
CAediting_54410chr1_43988459_+intronic
CAediting_54411chr1_43988471_+intronic
CAediting_54412chr1_43988472_+intronic
CAediting_54413chr1_43988513_+intronic
CAediting_54414chr1_43988539_+intronic
CAediting_54415chr1_43988540_+intronic
CAediting_54416chr1_43988652_+intronic
CAediting_54417chr1_43988732_+intronic
CAediting_54418chr1_43988740_+intronic
CAediting_54419chr1_43988748_+intronic
CAediting_54420chr1_43988753_+intronic
CAediting_54421chr1_43988822_+intronic
CAediting_54422chr1_43988827_+intronic
CAediting_54423chr1_43989113_+intronic
CAediting_54424chr1_43989140_+intronic
CAediting_54425chr1_43989171_+intronic
CAediting_54426chr1_43989189_+intronic
CAediting_54427chr1_43989195_+intronic
CAediting_54428chr1_43989200_+intronic
CAediting_54429chr1_43989209_+intronic
CAediting_54430chr1_43989226_+intronic
CAediting_54431chr1_43989239_+intronic
CAediting_54432chr1_43989248_+intronic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_54362chr1_43986186_+LINEL2L2b
CAediting_54363chr1_43986187_+LINEL2L2b
CAediting_54364chr1_43986189_+LINEL2L2b
CAediting_54365chr1_43986190_+LINEL2L2b
CAediting_54366chr1_43986201_+LINEL2L2b
CAediting_54367chr1_43986212_+LINEL2L2b
CAediting_54368chr1_43986221_+LINEL2L2b
CAediting_54369chr1_43986222_+LINEL2L2b
CAediting_54370chr1_43986223_+LINEL2L2b
CAediting_54371chr1_43986239_+LINEL2L2b
CAediting_54372chr1_43986241_+LINEL2L2b
CAediting_54373chr1_43986245_+LINEL2L2b
CAediting_54374chr1_43986247_+LINEL2L2b
CAediting_54375chr1_43986250_+LINEL2L2b
CAediting_54376chr1_43986256_+LINEL2L2b
CAediting_54405chr1_43988282_+SINEAluAluSz
CAediting_54406chr1_43988288_+SINEAluAluSz
CAediting_54407chr1_43988403_+SINEAluAluSx1
CAediting_54408chr1_43988419_+SINEAluAluSx1
CAediting_54409chr1_43988433_+SINEAluAluSx1
CAediting_54410chr1_43988459_+SINEAluAluSx1
CAediting_54411chr1_43988471_+SINEAluAluSx1
CAediting_54412chr1_43988472_+SINEAluAluSx1
CAediting_54413chr1_43988513_+SINEAluAluSx1
CAediting_54414chr1_43988539_+SINEAluAluSx1
CAediting_54415chr1_43988540_+SINEAluAluSx1
CAediting_54416chr1_43988652_+SINEAluAluSx1
CAediting_54417chr1_43988732_+SINEAluAluSz
CAediting_54418chr1_43988740_+SINEAluAluSz
CAediting_54419chr1_43988748_+SINEAluAluSz
CAediting_54420chr1_43988753_+SINEAluAluSz
CAediting_54421chr1_43988822_+SINEAluAluSz
CAediting_54422chr1_43988827_+SINEAluAluSz
CAediting_54423chr1_43989113_+SINEAluAluSq2
CAediting_54424chr1_43989140_+SINEAluAluSq2
CAediting_54425chr1_43989171_+SINEAluAluSq2
CAediting_54426chr1_43989189_+SINEAluAluSq2
CAediting_54427chr1_43989195_+SINEAluAluSq2
CAediting_54428chr1_43989200_+SINEAluAluSq2
CAediting_54429chr1_43989209_+SINEAluAluSq2
CAediting_54430chr1_43989226_+SINEAluAluSq2
CAediting_54431chr1_43989239_+SINEAluAluSq2
CAediting_54432chr1_43989248_+SINEAluAluSq2

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RNA A-to-I editing events in the alternative splicing sites for B4GALT2

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000117411.15.B4GALT2.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000117411.15.B4GALT2.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for B4GALT2

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.
boxplot

check button Correlation between RNA A-to-I editing and gene expression.
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.
BRCA.CAediting_54394.ENSG00000117411.B4GALT2.png
Soverview
HNSC.CAediting_54387.ENSG00000117411.B4GALT2.png
Soverview
OV.CAediting_54390.ENSG00000117411.B4GALT2.png
Soverview
SKCM.CAediting_54365.ENSG00000117411.B4GALT2.png
Soverview

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Protein coding region RNA A-to-I editings for B4GALT2

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for B4GALT2

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_1054808chr15_66496985_-ENSG00000117411.15ENST00000356836hsa-miR-451243990576439905827mer-m84399056343990583146-20.71
CAediting_1160181chr17_7017644_-ENSG00000117411.15ENST00000356836hsa-miR-195-3p43990918439909247mer-m84399090443990925153-12.06
CAediting_524911chr7_5495852_-ENSG00000117411.15ENST00000356836hsa-miR-589-3p43990518439905247mer-m84399050243990525162-29.21
CAediting_1054808chr15_66496985_-ENSG00000117411.15ENST00000309519hsa-miR-451243990576439905827mer-m84399056343990583146-20.71
CAediting_1160181chr17_7017644_-ENSG00000117411.15ENST00000309519hsa-miR-195-3p43990918439909247mer-m84399090443990925153-12.06
CAediting_524911chr7_5495852_-ENSG00000117411.15ENST00000309519hsa-miR-589-3p43990518439905247mer-m84399050243990525162-29.21
CAediting_1524209chrX_134546392_-ENSG00000117411.15ENST00000356836hsa-miR-503-5p43990995439910017mer-m84399098043991002154-26.42
CAediting_1524209chrX_134546392_-ENSG00000117411.15ENST00000309519hsa-miR-503-5p43990995439910017mer-m84399098043991002154-26.42

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for B4GALT2

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.
ENST00000481924.1processed_transcriptSoverviewSoverview

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI
CAediting_54350ENST00000481924.1chr1_43986142_+-349.30-348.30-376.50
CAediting_54351ENST00000481924.1chr1_43986145_+-347.60-348.30-376.50
CAediting_54352ENST00000481924.1chr1_43986157_+-347.60-348.30-376.50
CAediting_54353ENST00000481924.1chr1_43986159_+-349.30-348.30-376.50
CAediting_54354ENST00000481924.1chr1_43986160_+-350.80-348.30-376.50
CAediting_54355ENST00000481924.1chr1_43986167_+-348.60-348.30-376.50
CAediting_54356ENST00000481924.1chr1_43986168_+-348.70-348.30-376.50
CAediting_54357ENST00000481924.1chr1_43986169_+-351.50-348.30-376.50
CAediting_54358ENST00000481924.1chr1_43986179_+-353.00-348.30-376.50
CAediting_54359ENST00000481924.1chr1_43986180_+-351.20-348.30-376.50
CAediting_54360ENST00000481924.1chr1_43986181_+-350.60-348.30-376.50
CAediting_54361ENST00000481924.1chr1_43986185_+-348.30-348.30-376.50
CAediting_54362ENST00000481924.1chr1_43986186_+-348.40-348.30-376.50
CAediting_54363ENST00000481924.1chr1_43986187_+-348.80-348.30-376.50
CAediting_54364ENST00000481924.1chr1_43986189_+-352.00-348.30-376.50
CAediting_54365ENST00000481924.1chr1_43986190_+-350.60-348.30-376.50
CAediting_54366ENST00000481924.1chr1_43986201_+-351.40-348.30-376.50

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Relation with ADAR for B4GALT2

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
BRCACAediting_54350chr1_43986142_+0.004400576604618220.260405470743163....
HNSCCAediting_54350chr1_43986142_+0.0006850200496910170.344066171589427..0.001936015657391360.315731833032234
SKCMCAediting_54350chr1_43986142_+0.0004825330119787310.423874356553975....
HNSCCAediting_54368chr1_43986221_+0.009541333384294330.326747634744246....
SKCMCAediting_54368chr1_43986221_+0.001858489156647240.381677021814384....
BRCACAediting_54375chr1_43986250_+0.0004700757345949040.250005074775951....
HNSCCAediting_54375chr1_43986250_+0.003851871177634740.317690460979561..0.04327749134202390.225165185128503
SKCMCAediting_54375chr1_43986250_+3.98600282174802e-060.466888218966706....
BRCACAediting_54384chr1_43987344_+0.000530362154244730.415023917071716....
OVCAediting_54386chr1_43987349_+0.0292512158852390.305507043119917....
BRCACAediting_54387chr1_43987350_+0.007069631462129310.344277563074607....
SKCMCAediting_54387chr1_43987350_+0.01852810842541640.313770037560862..0.04003747415465040.275274710594464

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Relation with cancer stages for B4GALT2

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.
HNSCclinical_stageCAediting_54369chr1_43986222_+0.00073710621336079-0.453381126021999
HNSCpathologic_stageCAediting_54350chr1_43986142_+0.02745878201617390.236450667351291

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Relation with survival for B4GALT2

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR

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RelatedDrugs for B4GALT2

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for B4GALT2

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource