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Editing gene: VAMP8 (CAeditome ID:8673)

Gene summary for VAMP8

Gene summary

Gene information	Gene symbol	VAMP8
	Gene ID	8673
	Gene name	vesicle associated membrane protein 8
	Synonyms	EDB\|VAMP-8
	Cytomap	2p11.2
	Type of gene	protein-coding
	Description	vesicle-associated membrane protein 8vesicle-associated membrane protein 8 (endobrevin)
	Modification date	20210518
	UniProtAcc	Q9BV40
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
VAMP8	GO:0019869	Vesicle-associated membrane protein 8	18570918
VAMP8	GO:0016240	Vesicle-associated membrane protein 8	25686604
VAMP8	GO:1903076	Vesicle-associated membrane protein 8	18570918
VAMP8	GO:1903531	Vesicle-associated membrane protein 8	12130530
VAMP8	GO:0005737	Vesicle-associated membrane protein 8	18253931
VAMP8	GO:0005765	Vesicle-associated membrane protein 8	23217709
VAMP8	GO:0005829	Vesicle-associated membrane protein 8	22589474
VAMP8	GO:0005886	Vesicle-associated membrane protein 8	18253931
VAMP8	GO:0016020	Vesicle-associated membrane protein 8	16677249
VAMP8	GO:0030667	Vesicle-associated membrane protein 8	16677249
VAMP8	GO:0031902	Vesicle-associated membrane protein 8	23217709
VAMP8	GO:0031982	Vesicle-associated membrane protein 8	18570918
VAMP8	GO:0035577	Vesicle-associated membrane protein 8	16677249
VAMP8	GO:0048471	Vesicle-associated membrane protein 8	18570918
VAMP8	GO:0055037	Vesicle-associated membrane protein 8	18570918
VAMP8	GO:0098594	Vesicle-associated membrane protein 8	22144578
VAMP8	GO:0031201	Vesicle-associated membrane protein 8	12130530
VAMP8	GO:0031201	Vesicle-associated membrane protein 8	18253931
VAMP8	GO:0031201	Vesicle-associated membrane protein 8	23217709
VAMP8	GO:0031201	Vesicle-associated membrane protein 8	24550300

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RNA A-to-I events for VAMP8

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000118640.9

RNA A-to-I editing events in Cancer.

CAediting_196888(85562159, +), CAediting_196889(85562353, +), CAediting_196890(85565823, +), CAediting_196891(85566762, +), CAediting_196892(85579957, +), CAediting_196893(85579975, +), CAediting_196894(85579979, +), CAediting_196895(85580004, +), CAediting_196896(85580026, +), CAediting_196897(85580032, +), CAediting_196898(85580051, +), CAediting_196899(85580052, +), CAediting_196900(85580053, +), CAediting_196901(85580056, +), CAediting_196902(85580069, +), CAediting_196903(85580081, +), CAediting_196904(85580091, +), CAediting_196905(85580108, +), CAediting_196906(85580116, +), CAediting_196907(85580135, +), CAediting_196908(85580143, +), CAediting_196909(85580161, +), CAediting_196910(85580186, +), CAediting_196911(85580213, +), CAediting_196912(85580214, +), CAediting_196913(85580226, +), CAediting_196914(85580731, +), CAediting_196915(85580792, +), CAediting_196916(85580793, +), CAediting_196917(85580796, +), CAediting_196918(85580806, +), CAediting_196919(85580824, +), CAediting_196920(85580832, +), CAediting_196921(85580843, +), CAediting_196922(85580849, +), CAediting_196923(85580852, +), CAediting_196924(85580866, +), CAediting_196925(85580868, +), CAediting_196926(85580878, +), CAediting_196927(85580891, +), CAediting_196928(85580931, +), CAediting_196929(85580943, +), CAediting_196930(85581035, +), CAediting_196931(85581051, +), CAediting_196932(85581061, +), CAediting_196933(85581067, +), CAediting_196934(85581073, +), CAediting_196935(85581101, +), CAediting_196936(85581116, +), CAediting_196937(85581190, +), CAediting_196938(85581197, +), CAediting_196939(85581202, +), CAediting_196940(85581216, +), CAediting_196941(85581225, +), CAediting_196942(85581230, +), CAediting_196943(85581247, +), CAediting_196944(85581293, +), CAediting_196945(85581294, +), CAediting_196946(85581302, +), CAediting_196947(85581304, +), CAediting_196948(85581315, +), CAediting_196949(85581318, +), CAediting_196950(85581319, +), CAediting_196951(85581320, +), CAediting_196952(85581324, +), CAediting_196953(85581329, +), CAediting_196954(85581333, +), CAediting_196955(85581359, +), CAediting_196956(85581360, +), CAediting_196957(85581365, +), CAediting_196958(85581369, +), CAediting_196959(85581373, +), CAediting_196960(85581382, +), CAediting_196961(85581386, +), CAediting_196962(85581392, +), CAediting_196963(85581395, +), CAediting_196964(85581400, +), CAediting_196965(85581401, +), CAediting_196966(85581405, +), CAediting_196967(85581408, +), CAediting_196968(85581418, +), CAediting_196969(85581429, +), CAediting_196970(85581430, +), CAediting_196971(85581448, +), CAediting_196972(85581454, +),

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RNA editing positional annotations for VAMP8 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_196888	chr2_85562159_+	intronic
CAediting_196889	chr2_85562353_+	intronic
CAediting_196890	chr2_85565823_+	intronic
CAediting_196891	chr2_85566762_+	intronic
CAediting_196892	chr2_85579957_+	intronic
CAediting_196893	chr2_85579975_+	intronic
CAediting_196894	chr2_85579979_+	intronic
CAediting_196895	chr2_85580004_+	intronic
CAediting_196896	chr2_85580026_+	intronic
CAediting_196897	chr2_85580032_+	intronic
CAediting_196898	chr2_85580051_+	intronic
CAediting_196899	chr2_85580052_+	intronic
CAediting_196900	chr2_85580053_+	intronic
CAediting_196901	chr2_85580056_+	intronic
CAediting_196902	chr2_85580069_+	intronic
CAediting_196903	chr2_85580081_+	intronic
CAediting_196904	chr2_85580091_+	intronic
CAediting_196905	chr2_85580108_+	intronic
CAediting_196906	chr2_85580116_+	intronic
CAediting_196907	chr2_85580135_+	intronic
CAediting_196908	chr2_85580143_+	intronic
CAediting_196909	chr2_85580161_+	intronic
CAediting_196910	chr2_85580186_+	intronic
CAediting_196911	chr2_85580213_+	intronic
CAediting_196912	chr2_85580214_+	intronic
CAediting_196913	chr2_85580226_+	intronic
CAediting_196914	chr2_85580731_+	intronic
CAediting_196915	chr2_85580792_+	intronic
CAediting_196916	chr2_85580793_+	intronic
CAediting_196917	chr2_85580796_+	intronic
CAediting_196918	chr2_85580806_+	intronic
CAediting_196919	chr2_85580824_+	intronic
CAediting_196920	chr2_85580832_+	intronic
CAediting_196921	chr2_85580843_+	intronic
CAediting_196922	chr2_85580849_+	intronic
CAediting_196923	chr2_85580852_+	intronic
CAediting_196924	chr2_85580866_+	intronic
CAediting_196925	chr2_85580868_+	intronic
CAediting_196926	chr2_85580878_+	intronic
CAediting_196927	chr2_85580891_+	intronic
CAediting_196928	chr2_85580931_+	intronic
CAediting_196929	chr2_85580943_+	intronic
CAediting_196930	chr2_85581035_+	intronic
CAediting_196931	chr2_85581051_+	intronic
CAediting_196932	chr2_85581061_+	intronic
CAediting_196933	chr2_85581067_+	intronic
CAediting_196934	chr2_85581073_+	intronic
CAediting_196935	chr2_85581101_+	intronic
CAediting_196936	chr2_85581116_+	intronic
CAediting_196937	chr2_85581190_+	intronic
CAediting_196938	chr2_85581197_+	intronic
CAediting_196939	chr2_85581202_+	intronic
CAediting_196940	chr2_85581216_+	intronic
CAediting_196941	chr2_85581225_+	intronic
CAediting_196942	chr2_85581230_+	intronic
CAediting_196943	chr2_85581247_+	intronic
CAediting_196944	chr2_85581293_+	intronic
CAediting_196945	chr2_85581294_+	intronic
CAediting_196946	chr2_85581302_+	intronic
CAediting_196947	chr2_85581304_+	intronic
CAediting_196948	chr2_85581315_+	intronic
CAediting_196949	chr2_85581318_+	intronic
CAediting_196950	chr2_85581319_+	intronic
CAediting_196951	chr2_85581320_+	intronic
CAediting_196952	chr2_85581324_+	intronic
CAediting_196953	chr2_85581329_+	intronic
CAediting_196954	chr2_85581333_+	intronic
CAediting_196955	chr2_85581359_+	intronic
CAediting_196956	chr2_85581360_+	intronic
CAediting_196957	chr2_85581365_+	intronic
CAediting_196958	chr2_85581369_+	intronic
CAediting_196959	chr2_85581373_+	intronic
CAediting_196960	chr2_85581382_+	intronic
CAediting_196961	chr2_85581386_+	intronic
CAediting_196962	chr2_85581392_+	intronic
CAediting_196963	chr2_85581395_+	intronic
CAediting_196964	chr2_85581400_+	intronic
CAediting_196965	chr2_85581401_+	intronic
CAediting_196966	chr2_85581405_+	intronic
CAediting_196967	chr2_85581408_+	intronic
CAediting_196968	chr2_85581418_+	intronic
CAediting_196969	chr2_85581429_+	intronic
CAediting_196970	chr2_85581430_+	intronic
CAediting_196971	chr2_85581448_+	intronic
CAediting_196972	chr2_85581454_+	intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_196888	chr2_85562159_+	SINE	Alu	AluJr
CAediting_196889	chr2_85562353_+	SINE	Alu	AluSz
CAediting_196890	chr2_85565823_+	SINE	Alu	AluJb
CAediting_196891	chr2_85566762_+	SINE	Alu	AluSx
CAediting_196893	chr2_85579975_+	SINE	Alu	AluSz6
CAediting_196894	chr2_85579979_+	SINE	Alu	AluSz6
CAediting_196895	chr2_85580004_+	SINE	Alu	AluSz6
CAediting_196896	chr2_85580026_+	SINE	Alu	AluSz6
CAediting_196897	chr2_85580032_+	SINE	Alu	AluSz6
CAediting_196898	chr2_85580051_+	SINE	Alu	AluSz6
CAediting_196899	chr2_85580052_+	SINE	Alu	AluSz6
CAediting_196900	chr2_85580053_+	SINE	Alu	AluSz6
CAediting_196901	chr2_85580056_+	SINE	Alu	AluSz6
CAediting_196902	chr2_85580069_+	SINE	Alu	AluSz6
CAediting_196903	chr2_85580081_+	SINE	Alu	AluSz6
CAediting_196904	chr2_85580091_+	SINE	Alu	AluSz6
CAediting_196905	chr2_85580108_+	SINE	Alu	AluSz6
CAediting_196906	chr2_85580116_+	SINE	Alu	AluSz6
CAediting_196907	chr2_85580135_+	SINE	Alu	AluSz6
CAediting_196908	chr2_85580143_+	SINE	Alu	AluSz6
CAediting_196909	chr2_85580161_+	SINE	Alu	AluSz6
CAediting_196910	chr2_85580186_+	SINE	Alu	AluSz6
CAediting_196911	chr2_85580213_+	SINE	Alu	AluSz6
CAediting_196912	chr2_85580214_+	SINE	Alu	AluSz6
CAediting_196913	chr2_85580226_+	SINE	Alu	AluSz6
CAediting_196914	chr2_85580731_+	SINE	Alu	AluSx1
CAediting_196915	chr2_85580792_+	SINE	Alu	AluSx1
CAediting_196916	chr2_85580793_+	SINE	Alu	AluSx1
CAediting_196917	chr2_85580796_+	SINE	Alu	AluSx1
CAediting_196918	chr2_85580806_+	SINE	Alu	AluSx1
CAediting_196919	chr2_85580824_+	SINE	Alu	AluSx1
CAediting_196920	chr2_85580832_+	SINE	Alu	AluSx1
CAediting_196921	chr2_85580843_+	SINE	Alu	AluSx1
CAediting_196922	chr2_85580849_+	SINE	Alu	AluSx1
CAediting_196923	chr2_85580852_+	SINE	Alu	AluSx1
CAediting_196924	chr2_85580866_+	SINE	Alu	AluSx1
CAediting_196925	chr2_85580868_+	SINE	Alu	AluSx1
CAediting_196926	chr2_85580878_+	SINE	Alu	AluSx1
CAediting_196927	chr2_85580891_+	SINE	Alu	AluSx1
CAediting_196928	chr2_85580931_+	SINE	Alu	AluSx1
CAediting_196929	chr2_85580943_+	SINE	Alu	AluSx1
CAediting_196930	chr2_85581035_+	SINE	Alu	AluJb
CAediting_196931	chr2_85581051_+	SINE	Alu	AluJb
CAediting_196932	chr2_85581061_+	SINE	Alu	AluJb
CAediting_196933	chr2_85581067_+	SINE	Alu	AluJb
CAediting_196934	chr2_85581073_+	SINE	Alu	AluJb
CAediting_196935	chr2_85581101_+	SINE	Alu	AluJb
CAediting_196936	chr2_85581116_+	SINE	Alu	AluJb
CAediting_196937	chr2_85581190_+	SINE	Alu	AluJb
CAediting_196938	chr2_85581197_+	SINE	Alu	AluJb
CAediting_196939	chr2_85581202_+	SINE	Alu	AluSx1
CAediting_196940	chr2_85581216_+	SINE	Alu	AluSx1
CAediting_196941	chr2_85581225_+	SINE	Alu	AluSx1
CAediting_196942	chr2_85581230_+	SINE	Alu	AluSx1
CAediting_196943	chr2_85581247_+	SINE	Alu	AluSx1
CAediting_196944	chr2_85581293_+	SINE	Alu	AluSx1
CAediting_196945	chr2_85581294_+	SINE	Alu	AluSx1
CAediting_196946	chr2_85581302_+	SINE	Alu	AluSx1
CAediting_196947	chr2_85581304_+	SINE	Alu	AluSx1
CAediting_196948	chr2_85581315_+	SINE	Alu	AluSx1
CAediting_196949	chr2_85581318_+	SINE	Alu	AluSx1
CAediting_196950	chr2_85581319_+	SINE	Alu	AluSx1
CAediting_196951	chr2_85581320_+	SINE	Alu	AluSx1
CAediting_196952	chr2_85581324_+	SINE	Alu	AluSx1
CAediting_196953	chr2_85581329_+	SINE	Alu	AluSx1
CAediting_196954	chr2_85581333_+	SINE	Alu	AluSx1
CAediting_196955	chr2_85581359_+	SINE	Alu	AluSx1
CAediting_196956	chr2_85581360_+	SINE	Alu	AluSx1
CAediting_196957	chr2_85581365_+	SINE	Alu	AluSx1
CAediting_196958	chr2_85581369_+	SINE	Alu	AluSx1
CAediting_196959	chr2_85581373_+	SINE	Alu	AluSx1
CAediting_196960	chr2_85581382_+	SINE	Alu	AluSx1
CAediting_196961	chr2_85581386_+	SINE	Alu	AluSx1
CAediting_196962	chr2_85581392_+	SINE	Alu	AluSx1
CAediting_196963	chr2_85581395_+	SINE	Alu	AluSx1
CAediting_196964	chr2_85581400_+	SINE	Alu	AluSx1
CAediting_196965	chr2_85581401_+	SINE	Alu	AluSx1
CAediting_196966	chr2_85581405_+	SINE	Alu	AluSx1
CAediting_196967	chr2_85581408_+	SINE	Alu	AluSx1
CAediting_196968	chr2_85581418_+	SINE	Alu	AluSx1
CAediting_196969	chr2_85581429_+	SINE	Alu	AluSx1
CAediting_196970	chr2_85581430_+	SINE	Alu	AluSx1
CAediting_196971	chr2_85581448_+	SINE	Alu	AluSx1
CAediting_196972	chr2_85581454_+	SINE	Alu	AluSx1

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RNA A-to-I editing events in the alternative splicing sites for VAMP8

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000118640.9.VAMP8.

Correlation between RNA A-to-I editing and PSI for ENSG00000118640.9.VAMP8.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for VAMP8

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for VAMP8

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for VAMP8

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for VAMP8

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for VAMP8

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for VAMP8

Correlation between Cancer stages and RNA editing frequency

Cancer	Stage_type	CAeditomID	position	P-val	Coeff.
LUAD	pathologic_stage	CAediting_196966	chr2_85581405_+	0.0258464989441108	0.213447156011488

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Relation with survival for VAMP8

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for VAMP8

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for VAMP8

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
VAMP8	C0007097	Carcinoma	1	CTD_human
VAMP8	C0024667	Animal Mammary Neoplasms	1	CTD_human
VAMP8	C0024668	Mammary Neoplasms, Experimental	1	CTD_human
VAMP8	C0205696	Anaplastic carcinoma	1	CTD_human
VAMP8	C0205697	Carcinoma, Spindle-Cell	1	CTD_human
VAMP8	C0205698	Undifferentiated carcinoma	1	CTD_human
VAMP8	C0205699	Carcinomatosis	1	CTD_human
VAMP8	C1257925	Mammary Carcinoma, Animal	1	CTD_human

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene