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Editing gene: MKNK1 (CAeditome ID:8569)

Gene summary for MKNK1

Gene summary

Gene information	Gene symbol	MKNK1
	Gene ID	8569
	Gene name	MAPK interacting serine/threonine kinase 1
	Synonyms	MNK1
	Cytomap	1p33
	Type of gene	protein-coding
	Description	MAP kinase-interacting serine/threonine-protein kinase 1MAP kinase interacting serine/threonine kinase 1MAP kinase signal-integrating kinase 1MAPK signal-integrating kinase 1
	Modification date	20210518
	UniProtAcc	Q9BUB5
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
MKNK1	GO:0004674	MAP kinase-interacting serine/threonine-protein kinase 1	17130135
MKNK1	GO:0004674	MAP kinase-interacting serine/threonine-protein kinase 1	9155018
MKNK1	GO:0005524	MAP kinase-interacting serine/threonine-protein kinase 1	9155018
MKNK1	GO:0006468	MAP kinase-interacting serine/threonine-protein kinase 1	9155018
MKNK1	GO:0018105	MAP kinase-interacting serine/threonine-protein kinase 1	17130135
MKNK1	GO:0035556	MAP kinase-interacting serine/threonine-protein kinase 1	9155018
MKNK1	GO:0005654	MAP kinase-interacting serine/threonine-protein kinase 1	0000052

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RNA A-to-I events for MKNK1

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000079277.18

RNA A-to-I editing events in Cancer.

CAediting_60264(46572337, -), CAediting_60265(46572423, -), CAediting_60266(46572424, -), CAediting_60267(46572427, -), CAediting_60268(46572438, -), CAediting_60269(46572490, -), CAediting_60270(46573830, -), CAediting_60271(46573975, -), CAediting_60272(46578655, -), CAediting_60273(46578662, -), CAediting_60274(46578671, -), CAediting_60275(46578672, -), CAediting_60276(46578679, -), CAediting_60277(46578724, -), CAediting_60278(46585174, -), CAediting_60279(46585187, -), CAediting_60280(46586336, -), CAediting_60281(46586820, -), CAediting_60282(46586827, -), CAediting_60283(46586834, -), CAediting_60284(46586842, -), CAediting_60285(46586845, -), CAediting_60286(46586847, -), CAediting_60287(46586874, -), CAediting_60288(46586880, -), CAediting_60289(46586893, -), CAediting_60290(46586904, -), CAediting_60291(46586913, -), CAediting_60292(46586919, -), CAediting_60293(46586936, -), CAediting_60294(46586946, -), CAediting_60295(46586972, -), CAediting_60296(46587060, -), CAediting_60297(46587061, -), CAediting_60298(46587082, -), CAediting_60299(46587083, -), CAediting_60300(46587091, -), CAediting_60301(46587099, -), CAediting_60302(46587545, -), CAediting_60303(46587552, -), CAediting_60304(46587561, -), CAediting_60305(46587754, -), CAediting_60306(46587765, -), CAediting_60307(46587804, -), CAediting_60308(46588551, -), CAediting_60309(46588564, -), CAediting_60310(46588626, -), CAediting_60311(46588695, -), CAediting_60312(46591678, -), CAediting_60313(46591682, -), CAediting_60314(46591983, -), CAediting_60315(46592005, -), CAediting_60316(46592010, -), CAediting_60317(46592066, -), CAediting_60318(46592068, -), CAediting_60319(46592074, -), CAediting_60320(46592076, -), CAediting_60321(46592083, -), CAediting_60322(46592118, -), CAediting_60323(46592123, -), CAediting_60324(46592127, -), CAediting_60325(46592128, -), CAediting_60326(46592177, -), CAediting_60327(46592204, -), CAediting_60328(46592226, -), CAediting_60329(46592234, -), CAediting_60330(46592236, -), CAediting_60331(46592238, -), CAediting_60332(46593234, -), CAediting_60333(46593239, -), CAediting_60334(46593251, -), CAediting_60335(46593256, -), CAediting_60336(46593264, -), CAediting_60337(46593266, -), CAediting_60338(46593295, -), CAediting_60339(46593296, -), CAediting_60340(46593307, -), CAediting_60341(46593309, -), CAediting_60342(46593310, -), CAediting_60343(46593314, -), CAediting_60344(46593327, -), CAediting_60345(46593331, -), CAediting_60346(46593337, -), CAediting_60347(46593347, -), CAediting_60348(46593358, -), CAediting_60349(46593359, -), CAediting_60350(46593366, -), CAediting_60351(46593367, -), CAediting_60352(46593368, -), CAediting_60353(46593374, -), CAediting_60354(46593378, -), CAediting_60355(46593381, -), CAediting_60356(46593392, -), CAediting_60357(46593396, -), CAediting_60358(46593593, -), CAediting_60359(46593596, -), CAediting_60360(46593602, -), CAediting_60361(46593614, -), CAediting_60362(46593641, -), CAediting_60363(46593642, -), CAediting_60364(46593654, -), CAediting_60365(46593655, -), CAediting_60366(46593667, -), CAediting_60367(46593671, -), CAediting_60368(46593692, -), CAediting_60369(46593695, -), CAediting_60370(46593707, -), CAediting_60371(46593712, -), CAediting_60372(46593734, -), CAediting_60373(46593744, -), CAediting_60374(46593756, -), CAediting_60375(46593773, -), CAediting_60376(46593774, -), CAediting_60377(46593793, -), CAediting_60378(46593794, -), CAediting_60379(46593809, -), CAediting_60380(46593830, -), CAediting_60381(46593848, -), CAediting_60382(46593850, -), CAediting_60383(46594904, -), CAediting_60384(46595819, -), CAediting_60385(46596020, -), CAediting_60386(46596021, -), CAediting_60387(46596023, -), CAediting_60388(46598650, -), CAediting_60389(46605708, -), CAediting_60390(46605717, -), CAediting_60391(46605720, -), CAediting_60392(46605730, -), CAediting_60393(46605743, -), CAediting_60394(46605770, -), CAediting_60395(46605893, -), CAediting_60396(46607260, -), CAediting_60397(46610473, -), CAediting_60398(46615897, -),

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RNA editing positional annotations for MKNK1 using Annovar

Protein coding RNA editing(s).

CAeditome ID	Position	Variant type	ENST	NTchange	AAchange	SIFT_score	Polyphen2_HVAR_score	PROVEAN_pred
CAediting_60383	chr1_46594904_-	nonsynonymous SNV	ENST00000532110.1	c.A40G	p.S14G	D	.	N

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_60264	chr1_46572337_-	intronic
CAediting_60265	chr1_46572423_-	intronic
CAediting_60266	chr1_46572424_-	intronic
CAediting_60267	chr1_46572427_-	intronic
CAediting_60268	chr1_46572438_-	intronic
CAediting_60269	chr1_46572490_-	intronic
CAediting_60270	chr1_46573830_-	ncRNA_exonic
CAediting_60271	chr1_46573975_-	ncRNA_exonic
CAediting_60272	chr1_46578655_-	ncRNA_intronic
CAediting_60273	chr1_46578662_-	ncRNA_intronic
CAediting_60274	chr1_46578671_-	ncRNA_intronic
CAediting_60275	chr1_46578672_-	ncRNA_intronic
CAediting_60276	chr1_46578679_-	ncRNA_intronic
CAediting_60277	chr1_46578724_-	ncRNA_intronic
CAediting_60278	chr1_46585174_-	ncRNA_intronic
CAediting_60279	chr1_46585187_-	ncRNA_intronic
CAediting_60280	chr1_46586336_-	ncRNA_intronic
CAediting_60281	chr1_46586820_-	ncRNA_intronic
CAediting_60282	chr1_46586827_-	ncRNA_intronic
CAediting_60283	chr1_46586834_-	ncRNA_intronic
CAediting_60284	chr1_46586842_-	ncRNA_intronic
CAediting_60285	chr1_46586845_-	ncRNA_intronic
CAediting_60286	chr1_46586847_-	ncRNA_intronic
CAediting_60287	chr1_46586874_-	ncRNA_intronic
CAediting_60288	chr1_46586880_-	ncRNA_intronic
CAediting_60289	chr1_46586893_-	ncRNA_intronic
CAediting_60290	chr1_46586904_-	ncRNA_intronic
CAediting_60291	chr1_46586913_-	ncRNA_intronic
CAediting_60292	chr1_46586919_-	ncRNA_intronic
CAediting_60293	chr1_46586936_-	ncRNA_intronic
CAediting_60294	chr1_46586946_-	ncRNA_intronic
CAediting_60295	chr1_46586972_-	ncRNA_intronic
CAediting_60296	chr1_46587060_-	ncRNA_intronic
CAediting_60297	chr1_46587061_-	ncRNA_intronic
CAediting_60298	chr1_46587082_-	ncRNA_intronic
CAediting_60299	chr1_46587083_-	ncRNA_intronic
CAediting_60300	chr1_46587091_-	ncRNA_intronic
CAediting_60301	chr1_46587099_-	ncRNA_intronic
CAediting_60302	chr1_46587545_-	ncRNA_intronic
CAediting_60303	chr1_46587552_-	ncRNA_intronic
CAediting_60304	chr1_46587561_-	ncRNA_intronic
CAediting_60305	chr1_46587754_-	ncRNA_intronic
CAediting_60306	chr1_46587765_-	ncRNA_intronic
CAediting_60307	chr1_46587804_-	ncRNA_intronic
CAediting_60308	chr1_46588551_-	ncRNA_intronic
CAediting_60309	chr1_46588564_-	ncRNA_intronic
CAediting_60310	chr1_46588626_-	ncRNA_intronic
CAediting_60311	chr1_46588695_-	ncRNA_intronic
CAediting_60312	chr1_46591678_-	ncRNA_intronic
CAediting_60313	chr1_46591682_-	ncRNA_intronic
CAediting_60314	chr1_46591983_-	ncRNA_intronic
CAediting_60315	chr1_46592005_-	ncRNA_intronic
CAediting_60316	chr1_46592010_-	ncRNA_intronic
CAediting_60317	chr1_46592066_-	ncRNA_intronic
CAediting_60318	chr1_46592068_-	ncRNA_intronic
CAediting_60319	chr1_46592074_-	ncRNA_intronic
CAediting_60320	chr1_46592076_-	ncRNA_intronic
CAediting_60321	chr1_46592083_-	ncRNA_intronic
CAediting_60322	chr1_46592118_-	ncRNA_intronic
CAediting_60323	chr1_46592123_-	ncRNA_intronic
CAediting_60324	chr1_46592127_-	ncRNA_intronic
CAediting_60325	chr1_46592128_-	ncRNA_intronic
CAediting_60326	chr1_46592177_-	ncRNA_intronic
CAediting_60327	chr1_46592204_-	ncRNA_intronic
CAediting_60328	chr1_46592226_-	ncRNA_intronic
CAediting_60329	chr1_46592234_-	ncRNA_intronic
CAediting_60330	chr1_46592236_-	ncRNA_intronic
CAediting_60331	chr1_46592238_-	ncRNA_intronic
CAediting_60332	chr1_46593234_-	ncRNA_intronic
CAediting_60333	chr1_46593239_-	ncRNA_intronic
CAediting_60334	chr1_46593251_-	ncRNA_intronic
CAediting_60335	chr1_46593256_-	ncRNA_intronic
CAediting_60336	chr1_46593264_-	ncRNA_intronic
CAediting_60337	chr1_46593266_-	ncRNA_intronic
CAediting_60338	chr1_46593295_-	ncRNA_intronic
CAediting_60339	chr1_46593296_-	ncRNA_intronic
CAediting_60340	chr1_46593307_-	ncRNA_intronic
CAediting_60341	chr1_46593309_-	ncRNA_intronic
CAediting_60342	chr1_46593310_-	ncRNA_intronic
CAediting_60343	chr1_46593314_-	ncRNA_intronic
CAediting_60344	chr1_46593327_-	ncRNA_intronic
CAediting_60345	chr1_46593331_-	ncRNA_intronic
CAediting_60346	chr1_46593337_-	ncRNA_intronic
CAediting_60347	chr1_46593347_-	ncRNA_intronic
CAediting_60348	chr1_46593358_-	ncRNA_intronic
CAediting_60349	chr1_46593359_-	ncRNA_intronic
CAediting_60350	chr1_46593366_-	ncRNA_intronic
CAediting_60351	chr1_46593367_-	ncRNA_intronic
CAediting_60352	chr1_46593368_-	ncRNA_intronic
CAediting_60353	chr1_46593374_-	ncRNA_intronic
CAediting_60354	chr1_46593378_-	ncRNA_intronic
CAediting_60355	chr1_46593381_-	ncRNA_intronic
CAediting_60356	chr1_46593392_-	ncRNA_intronic
CAediting_60357	chr1_46593396_-	ncRNA_intronic
CAediting_60358	chr1_46593593_-	ncRNA_exonic
CAediting_60359	chr1_46593596_-	ncRNA_exonic
CAediting_60360	chr1_46593602_-	ncRNA_exonic
CAediting_60361	chr1_46593614_-	ncRNA_exonic
CAediting_60362	chr1_46593641_-	ncRNA_exonic
CAediting_60363	chr1_46593642_-	ncRNA_exonic
CAediting_60364	chr1_46593654_-	ncRNA_exonic
CAediting_60365	chr1_46593655_-	ncRNA_exonic
CAediting_60366	chr1_46593667_-	ncRNA_exonic
CAediting_60367	chr1_46593671_-	ncRNA_exonic
CAediting_60368	chr1_46593692_-	ncRNA_exonic
CAediting_60369	chr1_46593695_-	ncRNA_exonic
CAediting_60370	chr1_46593707_-	ncRNA_exonic
CAediting_60371	chr1_46593712_-	ncRNA_exonic
CAediting_60372	chr1_46593734_-	ncRNA_exonic
CAediting_60373	chr1_46593744_-	ncRNA_exonic
CAediting_60374	chr1_46593756_-	ncRNA_exonic
CAediting_60375	chr1_46593773_-	ncRNA_exonic
CAediting_60376	chr1_46593774_-	ncRNA_exonic
CAediting_60377	chr1_46593793_-	ncRNA_exonic
CAediting_60378	chr1_46593794_-	ncRNA_exonic
CAediting_60379	chr1_46593809_-	ncRNA_exonic
CAediting_60380	chr1_46593830_-	ncRNA_exonic
CAediting_60381	chr1_46593848_-	ncRNA_exonic
CAediting_60382	chr1_46593850_-	ncRNA_exonic
CAediting_60383	chr1_46594904_-	exonic
CAediting_60384	chr1_46595819_-	ncRNA_intronic
CAediting_60385	chr1_46596020_-	ncRNA_intronic
CAediting_60386	chr1_46596021_-	ncRNA_intronic
CAediting_60387	chr1_46596023_-	ncRNA_intronic
CAediting_60388	chr1_46598650_-	ncRNA_intronic
CAediting_60389	chr1_46605708_-	intronic
CAediting_60390	chr1_46605717_-	intronic
CAediting_60391	chr1_46605720_-	intronic
CAediting_60392	chr1_46605730_-	intronic
CAediting_60393	chr1_46605743_-	intronic
CAediting_60394	chr1_46605770_-	intronic
CAediting_60395	chr1_46605893_-	intronic
CAediting_60396	chr1_46607260_-	intronic
CAediting_60397	chr1_46610473_-	ncRNA_intronic
CAediting_60398	chr1_46615897_-	ncRNA_intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_60264	chr1_46572337_-	SINE	Alu	AluSz
CAediting_60265	chr1_46572423_-	SINE	Alu	AluSz
CAediting_60266	chr1_46572424_-	SINE	Alu	AluSz
CAediting_60267	chr1_46572427_-	SINE	Alu	AluSz
CAediting_60268	chr1_46572438_-	SINE	Alu	AluSz
CAediting_60269	chr1_46572490_-	SINE	Alu	AluSz
CAediting_60270	chr1_46573830_-	SINE	Alu	AluSz
CAediting_60271	chr1_46573975_-	SINE	Alu	AluSz
CAediting_60272	chr1_46578655_-	SINE	Alu	AluSx
CAediting_60273	chr1_46578662_-	SINE	Alu	AluSx
CAediting_60274	chr1_46578671_-	SINE	Alu	AluSx
CAediting_60275	chr1_46578672_-	SINE	Alu	AluSx
CAediting_60276	chr1_46578679_-	SINE	Alu	AluSx
CAediting_60277	chr1_46578724_-	SINE	Alu	AluSx
CAediting_60278	chr1_46585174_-	SINE	Alu	AluSx1
CAediting_60279	chr1_46585187_-	SINE	Alu	AluSx1
CAediting_60281	chr1_46586820_-	SINE	Alu	AluSx3
CAediting_60282	chr1_46586827_-	SINE	Alu	AluSx3
CAediting_60283	chr1_46586834_-	SINE	Alu	AluSx3
CAediting_60284	chr1_46586842_-	SINE	Alu	AluSx3
CAediting_60285	chr1_46586845_-	SINE	Alu	AluSx3
CAediting_60286	chr1_46586847_-	SINE	Alu	AluSx3
CAediting_60287	chr1_46586874_-	SINE	Alu	AluSx3
CAediting_60288	chr1_46586880_-	SINE	Alu	AluSx3
CAediting_60289	chr1_46586893_-	SINE	Alu	AluSx3
CAediting_60290	chr1_46586904_-	SINE	Alu	AluSx3
CAediting_60291	chr1_46586913_-	SINE	Alu	AluSx3
CAediting_60292	chr1_46586919_-	SINE	Alu	AluSx3
CAediting_60293	chr1_46586936_-	SINE	Alu	AluSx3
CAediting_60294	chr1_46586946_-	SINE	Alu	AluSx3
CAediting_60295	chr1_46586972_-	SINE	Alu	AluSx3
CAediting_60296	chr1_46587060_-	SINE	Alu	AluSx3
CAediting_60297	chr1_46587061_-	SINE	Alu	AluSx3
CAediting_60298	chr1_46587082_-	SINE	Alu	AluSx3
CAediting_60299	chr1_46587083_-	SINE	Alu	AluSx3
CAediting_60300	chr1_46587091_-	SINE	Alu	AluSx3
CAediting_60301	chr1_46587099_-	SINE	Alu	AluSx3
CAediting_60302	chr1_46587545_-	SINE	Alu	AluSp
CAediting_60303	chr1_46587552_-	SINE	Alu	AluSp
CAediting_60304	chr1_46587561_-	SINE	Alu	AluSp
CAediting_60305	chr1_46587754_-	SINE	Alu	AluSp
CAediting_60306	chr1_46587765_-	SINE	Alu	AluSp
CAediting_60307	chr1_46587804_-	SINE	Alu	AluSp
CAediting_60308	chr1_46588551_-	SINE	Alu	AluYe5
CAediting_60309	chr1_46588564_-	SINE	Alu	AluYe5
CAediting_60310	chr1_46588626_-	SINE	Alu	AluYe5
CAediting_60311	chr1_46588695_-	SINE	Alu	AluYe5
CAediting_60314	chr1_46591983_-	SINE	Alu	AluSx1
CAediting_60315	chr1_46592005_-	SINE	Alu	AluSx1
CAediting_60316	chr1_46592010_-	SINE	Alu	AluSx1
CAediting_60317	chr1_46592066_-	SINE	Alu	AluSx1
CAediting_60318	chr1_46592068_-	SINE	Alu	AluSx1
CAediting_60319	chr1_46592074_-	SINE	Alu	AluSx1
CAediting_60320	chr1_46592076_-	SINE	Alu	AluSx1
CAediting_60321	chr1_46592083_-	SINE	Alu	AluSx1
CAediting_60322	chr1_46592118_-	SINE	Alu	AluSx1
CAediting_60323	chr1_46592123_-	SINE	Alu	AluSx1
CAediting_60324	chr1_46592127_-	SINE	Alu	AluSx1
CAediting_60325	chr1_46592128_-	SINE	Alu	AluSx1
CAediting_60326	chr1_46592177_-	SINE	Alu	AluSx1
CAediting_60327	chr1_46592204_-	SINE	Alu	AluSx1
CAediting_60328	chr1_46592226_-	SINE	Alu	AluSx1
CAediting_60329	chr1_46592234_-	SINE	Alu	AluSx1
CAediting_60330	chr1_46592236_-	SINE	Alu	AluSx1
CAediting_60331	chr1_46592238_-	SINE	Alu	AluSx1
CAediting_60332	chr1_46593234_-	SINE	Alu	AluJb
CAediting_60333	chr1_46593239_-	SINE	Alu	AluJb
CAediting_60334	chr1_46593251_-	SINE	Alu	AluJb
CAediting_60335	chr1_46593256_-	SINE	Alu	AluJb
CAediting_60336	chr1_46593264_-	SINE	Alu	AluJb
CAediting_60337	chr1_46593266_-	SINE	Alu	AluJb
CAediting_60338	chr1_46593295_-	SINE	Alu	AluJb
CAediting_60339	chr1_46593296_-	SINE	Alu	AluJb
CAediting_60340	chr1_46593307_-	SINE	Alu	AluJb
CAediting_60341	chr1_46593309_-	SINE	Alu	AluJb
CAediting_60342	chr1_46593310_-	SINE	Alu	AluJb
CAediting_60343	chr1_46593314_-	SINE	Alu	AluJb
CAediting_60344	chr1_46593327_-	SINE	Alu	AluJb
CAediting_60345	chr1_46593331_-	SINE	Alu	AluJb
CAediting_60346	chr1_46593337_-	SINE	Alu	AluJb
CAediting_60347	chr1_46593347_-	SINE	Alu	AluJb
CAediting_60348	chr1_46593358_-	SINE	Alu	AluJb
CAediting_60349	chr1_46593359_-	SINE	Alu	AluJb
CAediting_60350	chr1_46593366_-	SINE	Alu	AluJb
CAediting_60351	chr1_46593367_-	SINE	Alu	AluJb
CAediting_60352	chr1_46593368_-	SINE	Alu	AluJb
CAediting_60353	chr1_46593374_-	SINE	Alu	AluJb
CAediting_60354	chr1_46593378_-	SINE	Alu	AluJb
CAediting_60355	chr1_46593381_-	SINE	Alu	AluJb
CAediting_60356	chr1_46593392_-	SINE	Alu	AluJb
CAediting_60357	chr1_46593396_-	SINE	Alu	AluJb
CAediting_60358	chr1_46593593_-	SINE	Alu	AluSz
CAediting_60359	chr1_46593596_-	SINE	Alu	AluSz
CAediting_60360	chr1_46593602_-	SINE	Alu	AluSz
CAediting_60361	chr1_46593614_-	SINE	Alu	AluSz
CAediting_60362	chr1_46593641_-	SINE	Alu	AluSz
CAediting_60363	chr1_46593642_-	SINE	Alu	AluSz
CAediting_60364	chr1_46593654_-	SINE	Alu	AluSz
CAediting_60365	chr1_46593655_-	SINE	Alu	AluSz
CAediting_60366	chr1_46593667_-	SINE	Alu	AluSz
CAediting_60367	chr1_46593671_-	SINE	Alu	AluSz
CAediting_60368	chr1_46593692_-	SINE	Alu	AluSz
CAediting_60369	chr1_46593695_-	SINE	Alu	AluSz
CAediting_60370	chr1_46593707_-	SINE	Alu	AluSz
CAediting_60371	chr1_46593712_-	SINE	Alu	AluSz
CAediting_60372	chr1_46593734_-	SINE	Alu	AluSz
CAediting_60373	chr1_46593744_-	SINE	Alu	AluSz
CAediting_60374	chr1_46593756_-	SINE	Alu	AluSz
CAediting_60375	chr1_46593773_-	SINE	Alu	AluSz
CAediting_60376	chr1_46593774_-	SINE	Alu	AluSz
CAediting_60377	chr1_46593793_-	SINE	Alu	AluSz
CAediting_60378	chr1_46593794_-	SINE	Alu	AluSz
CAediting_60379	chr1_46593809_-	SINE	Alu	AluSz
CAediting_60380	chr1_46593830_-	SINE	Alu	AluSz
CAediting_60381	chr1_46593848_-	SINE	Alu	AluSz
CAediting_60382	chr1_46593850_-	SINE	Alu	AluSz
CAediting_60383	chr1_46594904_-	SINE	Alu	AluJb
CAediting_60384	chr1_46595819_-	SINE	Alu	AluJb
CAediting_60385	chr1_46596020_-	SINE	Alu	AluJb
CAediting_60386	chr1_46596021_-	SINE	Alu	AluJb
CAediting_60387	chr1_46596023_-	SINE	Alu	AluJb
CAediting_60388	chr1_46598650_-	SINE	MIR	MIR
CAediting_60389	chr1_46605708_-	SINE	Alu	AluJb
CAediting_60390	chr1_46605717_-	SINE	Alu	AluJb
CAediting_60391	chr1_46605720_-	SINE	Alu	AluJb
CAediting_60392	chr1_46605730_-	SINE	Alu	AluJb
CAediting_60393	chr1_46605743_-	SINE	Alu	AluJb
CAediting_60394	chr1_46605770_-	SINE	Alu	AluJb
CAediting_60395	chr1_46605893_-	SINE	Alu	AluJb
CAediting_60396	chr1_46607260_-	SINE	Alu	AluY
CAediting_60397	chr1_46610473_-	SINE	Alu	AluSp

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RNA A-to-I editing events in the alternative splicing sites for MKNK1

RNA A-to-I editing(s) in the alternative splicing sites.

AStype	CAeditomID	Editing position	AS position	AS direction	Exonic location	Wildtype sequence	Wildtype splicing strength	RNA edited sequence	RNA edited splicing strength
ES	CAediting_60375	chr1_46593773_-	46593772:46593780	5SS	0+5i	AGGTTCAAG	-12.66	AGGTTCAGG	-5.91
MEX_2	CAediting_60375	chr1_46593773_-	46593772:46593780	5SS	0+5i	AGGTTCAAG	-12.66	AGGTTCAGG	-5.91
ES	CAediting_60376	chr1_46593774_-	46593772:46593780	5SS	0+4i	AGGTTCAAG	-12.66	AGGTTCGAG	-17.82
MEX_2	CAediting_60376	chr1_46593774_-	46593772:46593780	5SS	0+4i	AGGTTCAAG	-12.66	AGGTTCGAG	-17.82
ES	CAediting_60382	chr1_46593850_-	46593850:46593872	3SS	3+0i	TTTTTTTTTTTTTTTTTCAGATA	12.91	TTTTTTTTTTTTTTTTTCAGATG	13.03
MEX_2	CAediting_60382	chr1_46593850_-	46593850:46593872	3SS	3+0i	TTTTTTTTTTTTTTTTTCAGATA	12.91	TTTTTTTTTTTTTTTTTCAGATG	13.03

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000079277.18.MKNK1.

Correlation between RNA A-to-I editing and PSI for ENSG00000079277.18.MKNK1.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for MKNK1

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for MKNK1

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for MKNK1

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_524911	chr7_5495852_-	ENSG00000079277.18	ENST00000341183	hsa-miR-589-3p	46557630	46557636	7mer-m8	46557629	46557653	150	-24.66
CAediting_524911	chr7_5495852_-	ENSG00000079277.18	ENST00000341183	hsa-miR-589-3p	46558473	46558479	7mer-m8	46558472	46558495	160	-18
CAediting_524911	chr7_5495852_-	ENSG00000079277.18	ENST00000371946	hsa-miR-589-3p	46557630	46557636	7mer-m8	46557629	46557653	150	-24.66
CAediting_524911	chr7_5495852_-	ENSG00000079277.18	ENST00000371946	hsa-miR-589-3p	46558473	46558479	7mer-m8	46558472	46558495	160	-18
CAediting_524911	chr7_5495852_-	ENSG00000079277.18	ENST00000524749	hsa-miR-589-3p	46558473	46558479	7mer-m8	46558472	46558495	160	-18
CAediting_1229414	chr17_67471546_+	ENSG00000079277.18	ENST00000528077	hsa-miR-548aa	46562800	46562805	6mer	46562799	46562823	140	-16.39
CAediting_1399425	chr20_1392958_-	ENSG00000079277.18	ENST00000528077	hsa-miR-6869-5p	46562715	46562721	7mer-m8	46562714	46562733	153	-27.26
CAediting_573000	chr7_92204081_-	ENSG00000079277.18	ENST00000528077	hsa-miR-1285-5p	46561532	46561538	7mer-m8	46561531	46561551	140	-17.97
CAediting_524911	chr7_5495852_-	ENSG00000079277.18	ENST00000528077	hsa-miR-589-3p	46558473	46558479	7mer-m8	46558472	46558495	160	-18
CAediting_1229414	chr17_67471546_+	ENSG00000079277.18	ENST00000531355	hsa-miR-548aa	46562800	46562805	6mer	46562799	46562823	140	-16.39
CAediting_1399425	chr20_1392958_-	ENSG00000079277.18	ENST00000531355	hsa-miR-6869-5p	46562715	46562721	7mer-m8	46562714	46562733	153	-27.26
CAediting_573000	chr7_92204081_-	ENSG00000079277.18	ENST00000531355	hsa-miR-1285-5p	46561532	46561538	7mer-m8	46561531	46561551	140	-17.97
CAediting_1524209	chrX_134546392_-	ENSG00000079277.18	ENST00000341183	hsa-miR-503-5p	46557562	46557567	6mer	46557561	46557583	153	-24.52
CAediting_1524209	chrX_134546392_-	ENSG00000079277.18	ENST00000371946	hsa-miR-503-5p	46557562	46557567	6mer	46557561	46557583	153	-24.52

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1524209	chrX_134546392_-	ENSG00000079277.18	ENST00000341183	hsa-miR-503-5p	46557685	46557690	6mer	46557684	46557707	147	-22.55
CAediting_1524209	chrX_134546392_-	ENSG00000079277.18	ENST00000371946	hsa-miR-503-5p	46557685	46557690	6mer	46557684	46557707	147	-22.55

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for MKNK1

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000484301.4	retained_intron
ENST00000532110.1	protein_coding
ENST00000468852.2	retained_intron

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID	ENST	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
CAediting_60270	ENST00000484301.4	chr1_46573830_-	-1038.20	-1032.80	-1039.50
CAediting_60271	ENST00000484301.4	chr1_46573975_-	-1034.10	-1032.80	-1039.50
CAediting_60383	ENST00000532110.1	chr1_46594904_-	-156.50	-153.90	-156.50
CAediting_60358	ENST00000468852.2	chr1_46593593_-	-188.80	-187.90	-221.60
CAediting_60359	ENST00000468852.2	chr1_46593596_-	-189.50	-187.90	-221.60
CAediting_60360	ENST00000468852.2	chr1_46593602_-	-191.90	-187.90	-221.60
CAediting_60361	ENST00000468852.2	chr1_46593614_-	-192.00	-187.90	-221.60
CAediting_60362	ENST00000468852.2	chr1_46593641_-	-191.30	-187.90	-221.60
CAediting_60363	ENST00000468852.2	chr1_46593642_-	-189.60	-187.90	-221.60
CAediting_60364	ENST00000468852.2	chr1_46593654_-	-189.40	-187.90	-221.60
CAediting_60365	ENST00000468852.2	chr1_46593655_-	-190.90	-187.90	-221.60
CAediting_60366	ENST00000468852.2	chr1_46593667_-	-187.80	-187.90	-221.60
CAediting_60367	ENST00000468852.2	chr1_46593671_-	-191.60	-187.90	-221.60
CAediting_60368	ENST00000468852.2	chr1_46593692_-	-188.00	-187.90	-221.60
CAediting_60369	ENST00000468852.2	chr1_46593695_-	-189.60	-187.90	-221.60
CAediting_60370	ENST00000468852.2	chr1_46593707_-	-190.00	-187.90	-221.60
CAediting_60371	ENST00000468852.2	chr1_46593712_-	-187.20	-187.90	-221.60
CAediting_60372	ENST00000468852.2	chr1_46593734_-	-190.00	-187.90	-221.60
CAediting_60373	ENST00000468852.2	chr1_46593744_-	-187.90	-187.90	-221.60
CAediting_60374	ENST00000468852.2	chr1_46593756_-	-190.70	-187.90	-221.60
CAediting_60375	ENST00000468852.2	chr1_46593773_-	-189.50	-187.90	-221.60
CAediting_60376	ENST00000468852.2	chr1_46593774_-	-189.50	-187.90	-221.60
CAediting_60377	ENST00000468852.2	chr1_46593793_-	-189.80	-187.90	-221.60
CAediting_60378	ENST00000468852.2	chr1_46593794_-	-188.20	-187.90	-221.60
CAediting_60379	ENST00000468852.2	chr1_46593809_-	-188.80	-187.90	-221.60
CAediting_60380	ENST00000468852.2	chr1_46593830_-	-188.00	-187.90	-221.60
CAediting_60381	ENST00000468852.2	chr1_46593848_-	-187.10	-187.90	-221.60
CAediting_60382	ENST00000468852.2	chr1_46593850_-	-187.50	-187.90	-221.60

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Relation with ADAR for MKNK1

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for MKNK1

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for MKNK1

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for MKNK1

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
MKNK1	Q9BUB5	DB12010	Fostamatinib	MAP kinase-interacting serine/threonine-protein kinase 1	SmallMoleculeDrug	approved\|investigational

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RelatedDiseases for MKNK1

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
MKNK1	C0013146	Drug abuse	1	CTD_human
MKNK1	C0013170	Drug habituation	1	CTD_human
MKNK1	C0013222	Drug Use Disorders	1	CTD_human
MKNK1	C0029231	Organic Mental Disorders, Substance-Induced	1	CTD_human
MKNK1	C0038580	Substance Dependence	1	CTD_human
MKNK1	C0038586	Substance Use Disorders	1	CTD_human
MKNK1	C0236969	Substance-Related Disorders	1	CTD_human
MKNK1	C0740858	Substance abuse problem	1	CTD_human
MKNK1	C1510472	Drug Dependence	1	CTD_human
MKNK1	C4316881	Prescription Drug Abuse	1	CTD_human

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene