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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

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Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

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Relation with ADAR

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Relation with cancer stages

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Relation with survival state

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Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: TUBA1C (CAeditome ID:84790)

Gene summary for TUBA1C

check button Gene summary
Gene informationGene symbol

TUBA1C

Gene ID

84790

Gene nametubulin alpha 1c
SynonymsTUBA6|bcm948
Cytomap

12q13.12

Type of geneprotein-coding
Descriptiontubulin alpha-1C chainalpha-tubulin 6tubulin alpha-6 chaintubulin, alpha 6
Modification date20210518
UniProtAcc

Q9BQE3

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
TUBA1C

GO:0005634

Tubulin alpha-1C chain

22720776

TUBA1C

GO:0015630

Tubulin alpha-1C chain

0000052


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RNA A-to-I events for TUBA1C

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000167553.13
boxplot

check button RNA A-to-I editing events in Cancer.
CAediting_884653(49195242, +), CAediting_884654(49196734, +), CAediting_884655(49199656, +), CAediting_884656(49199662, +), CAediting_884657(49199682, +), CAediting_884658(49199686, +), CAediting_884659(49200108, +), CAediting_884660(49207834, +), CAediting_884661(49210876, +), CAediting_884662(49210931, +), CAediting_884663(49210933, +), CAediting_884664(49215814, +), CAediting_884665(49215852, +), CAediting_884666(49273425, +), CAediting_884667(49273436, +), CAediting_884668(49273459, +), CAediting_884669(49273489, +), CAediting_884670(49273562, +), CAediting_884671(49273571, +), CAediting_884672(49273637, +), CAediting_884673(49273858, +), CAediting_884674(49273859, +), CAediting_884675(49273872, +), CAediting_884676(49273875, +), CAediting_884677(49273880, +), CAediting_884678(49273884, +), CAediting_884679(49273903, +), CAediting_884680(49273904, +), CAediting_884681(49273906, +), CAediting_884682(49273914, +), CAediting_884683(49273925, +), CAediting_884684(49273973, +), CAediting_884685(49273989, +), CAediting_884686(49273990, +), CAediting_884687(49274014, +), CAediting_884688(49274019, +), CAediting_884689(49274032, +), CAediting_884690(49274164, +), CAediting_884691(49274170, +), CAediting_884692(49274175, +), CAediting_884693(49274183, +), CAediting_884694(49274210, +), CAediting_884695(49274369, +),

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RNA editing positional annotations for TUBA1C using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_884653chr12_49195242_+ncRNA_intronic
CAediting_884654chr12_49196734_+ncRNA_intronic
CAediting_884655chr12_49199656_+ncRNA_intronic
CAediting_884656chr12_49199662_+ncRNA_intronic
CAediting_884657chr12_49199682_+ncRNA_intronic
CAediting_884658chr12_49199686_+ncRNA_intronic
CAediting_884659chr12_49200108_+ncRNA_intronic
CAediting_884660chr12_49207834_+ncRNA_intronic
CAediting_884661chr12_49210876_+ncRNA_intronic
CAediting_884662chr12_49210931_+ncRNA_intronic
CAediting_884663chr12_49210933_+ncRNA_intronic
CAediting_884664chr12_49215814_+ncRNA_intronic
CAediting_884665chr12_49215852_+ncRNA_intronic
CAediting_884666chr12_49273425_+UTR3
CAediting_884667chr12_49273436_+UTR3
CAediting_884668chr12_49273459_+UTR3
CAediting_884669chr12_49273489_+UTR3
CAediting_884670chr12_49273562_+UTR3
CAediting_884671chr12_49273571_+UTR3
CAediting_884672chr12_49273637_+UTR3
CAediting_884673chr12_49273858_+UTR3
CAediting_884674chr12_49273859_+UTR3
CAediting_884675chr12_49273872_+UTR3
CAediting_884676chr12_49273875_+UTR3
CAediting_884677chr12_49273880_+UTR3
CAediting_884678chr12_49273884_+UTR3
CAediting_884679chr12_49273903_+UTR3
CAediting_884680chr12_49273904_+UTR3
CAediting_884681chr12_49273906_+UTR3
CAediting_884682chr12_49273914_+UTR3
CAediting_884683chr12_49273925_+UTR3
CAediting_884684chr12_49273973_+UTR3
CAediting_884685chr12_49273989_+UTR3
CAediting_884686chr12_49273990_+UTR3
CAediting_884687chr12_49274014_+UTR3
CAediting_884688chr12_49274019_+UTR3
CAediting_884689chr12_49274032_+UTR3
CAediting_884690chr12_49274164_+UTR3
CAediting_884691chr12_49274170_+UTR3
CAediting_884692chr12_49274175_+UTR3
CAediting_884693chr12_49274183_+UTR3
CAediting_884694chr12_49274210_+UTR3
CAediting_884695chr12_49274369_+UTR3

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_884653chr12_49195242_+SINEAluAluJo
CAediting_884654chr12_49196734_+SINEAluAluJo
CAediting_884655chr12_49199656_+SINEAluAluSz
CAediting_884656chr12_49199662_+SINEAluAluSz
CAediting_884657chr12_49199682_+SINEAluAluSz
CAediting_884658chr12_49199686_+SINEAluAluSz
CAediting_884659chr12_49200108_+SINEAluAluSx
CAediting_884660chr12_49207834_+SINEAluAluSz
CAediting_884661chr12_49210876_+SINEAluAluSz
CAediting_884662chr12_49210931_+SINEAluAluSz
CAediting_884663chr12_49210933_+SINEAluAluSz
CAediting_884664chr12_49215814_+SINEAluAluSq2
CAediting_884665chr12_49215852_+SINEAluAluSq2
CAediting_884666chr12_49273425_+SINEAluAluJr
CAediting_884667chr12_49273436_+SINEAluAluJr
CAediting_884668chr12_49273459_+SINEAluAluJr
CAediting_884669chr12_49273489_+SINEAluAluJr
CAediting_884670chr12_49273562_+SINEAluAluJr
CAediting_884671chr12_49273571_+SINEAluAluJr
CAediting_884672chr12_49273637_+SINEAluAluJr
CAediting_884673chr12_49273858_+SINEAluAluJb
CAediting_884674chr12_49273859_+SINEAluAluJb
CAediting_884675chr12_49273872_+SINEAluAluJb
CAediting_884676chr12_49273875_+SINEAluAluJb
CAediting_884677chr12_49273880_+SINEAluAluJb
CAediting_884678chr12_49273884_+SINEAluAluJb
CAediting_884679chr12_49273903_+SINEAluAluJb
CAediting_884680chr12_49273904_+SINEAluAluJb
CAediting_884681chr12_49273906_+SINEAluAluJb
CAediting_884682chr12_49273914_+SINEAluAluJb
CAediting_884683chr12_49273925_+SINEAluAluJb
CAediting_884684chr12_49273973_+SINEAluAluJb
CAediting_884685chr12_49273989_+SINEAluAluJb
CAediting_884686chr12_49273990_+SINEAluAluJb
CAediting_884687chr12_49274014_+SINEAluAluJb
CAediting_884688chr12_49274019_+SINEAluAluJb
CAediting_884689chr12_49274032_+SINEAluAluJb
CAediting_884690chr12_49274164_+SINEAluAluJo
CAediting_884691chr12_49274170_+SINEAluAluJo
CAediting_884692chr12_49274175_+SINEAluAluJo
CAediting_884693chr12_49274183_+SINEAluAluJo
CAediting_884694chr12_49274210_+SINEAluAluJo
CAediting_884695chr12_49274369_+SINEAluAluJo

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RNA A-to-I editing events in the alternative splicing sites for TUBA1C

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000167553.13.TUBA1C.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000167553.13.TUBA1C.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for TUBA1C

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.
boxplot

check button Correlation between RNA A-to-I editing and gene expression.
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.
GBM.CAediting_884693.ENSG00000167553.TUBA1C.png
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KIRP.CAediting_884693.ENSG00000167553.TUBA1C.png
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LUAD.CAediting_884693.ENSG00000167553.TUBA1C.png
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LUSC.CAediting_884693.ENSG00000167553.TUBA1C.png
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Protein coding region RNA A-to-I editings for TUBA1C

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for TUBA1C

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_1368054chr19_46709310_-ENSG00000167553.13ENST00000552448hsa-miR-320e49269852492698587mer-m84926984149269859149-18.89
CAediting_86358chr1_109598906_+ENSG00000167553.13ENST00000552448hsa-miR-197-5p49269860492698667mer-m84926984249269867162-28.22
CAediting_86358chr1_109598906_+ENSG00000167553.13ENST00000552448hsa-miR-197-5p49272445492724517mer-1a4927243849272460140-27.69
CAediting_86358chr1_109598906_+ENSG00000167553.13ENST00000552448hsa-miR-197-5p49272454492724596mer4927243849272460140-27.69
CAediting_1368054chr19_46709310_-ENSG00000167553.13ENST00000552125hsa-miR-320e49269852492698587mer-m84926984149269859149-18.89
CAediting_86358chr1_109598906_+ENSG00000167553.13ENST00000552125hsa-miR-197-5p49269860492698667mer-m84926984249269867162-28.22
CAediting_1524209chrX_134546392_-ENSG00000167553.13ENST00000552448hsa-miR-503-5p49272864492728707mer-1a4927284849272870140-18.5

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_1524209chrX_134546392_-ENSG00000167553.13ENST00000552448hsa-miR-503-5p49272328492723347mer-m84927231349272335152-19.69
CAediting_1229413chr17_67471544_+ENSG00000167553.13ENST00000552448hsa-miR-548aa49272283492722897mer-m84927226649272290143-10.77

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for TUBA1C

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for TUBA1C

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
OVCAediting_884670chr12_49273562_+0.01658187240112010.285511504639096....
BLCACAediting_884693chr12_49274183_+0.002213882887456650.339398259775512....
BRCACAediting_884693chr12_49274183_+3.76108478456858e-130.542284592374766....
CESCCAediting_884693chr12_49274183_+8.76699522507645e-060.418742952220767....
LUADCAediting_884693chr12_49274183_+0.0365390510174230.261939925971948....
COADCAediting_884693chr12_49274183_+0.02038068078224750.2787404902432620.009592847244945590.309768347536365..
LUSCCAediting_884693chr12_49274183_+1.81026979994106e-080.416288859068576....
HNSCCAediting_884693chr12_49274183_+0.008794793046158240.1667190596401570.03180921987736980.136927027104686..
STADCAediting_884693chr12_49274183_+3.68037591788292e-070.377152974992964....
KIRPCAediting_884693chr12_49274183_+0.01515743513519830.314826691177242....
ESCACAediting_884693chr12_49274183_+0.00137573151500640.315713551647831....
OVCAediting_884693chr12_49274183_+1.82391169700644e-100.372246700344089....
SKCMCAediting_884693chr12_49274183_+9.97802098007348e-070.587541514409272....
TGCTCAediting_884693chr12_49274183_+4.2275877038592e-080.610124279789255....

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Relation with cancer stages for TUBA1C

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.
COADpathologic_stageCAediting_884693chr12_49274183_+0.00443350088792534-0.343459900338742
HNSCclinical_stageCAediting_884680chr12_49273904_+0.0355499752588685-0.298018915233441
TGCTclinical_stageCAediting_884693chr12_49274183_+0.0301849557581776-0.34751034991519
TGCTpathologic_stageCAediting_884693chr12_49274183_+0.00639475251700905-0.434641444879457

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Relation with survival for TUBA1C

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR
HNSCCAediting_884693chr12_49274183_+0.01113834835343350.005447985.50853

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RelatedDrugs for TUBA1C

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TUBA1C

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource
TUBA1CC0024623Malignant neoplasm of stomach1CTD_human
TUBA1CC0038356Stomach Neoplasms1CTD_human
TUBA1CC0948089Acute Coronary Syndrome1CTD_human
TUBA1CC1708349Hereditary Diffuse Gastric Cancer1CTD_human