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Editing gene: CARD6 (CAeditome ID:84674)

Gene summary for CARD6

Gene summary

Gene information	Gene symbol	CARD6
	Gene ID	84674
	Gene name	caspase recruitment domain family member 6
	Synonyms	CINCIN1
	Cytomap	5p13.1
	Type of gene	protein-coding
	Description	caspase recruitment domain-containing protein 6CARD-containing inhibitor of Nod1 and Cardiak-induced NF-kB activationcaspase recruitment domain protein 6
	Modification date	20210518
	UniProtAcc	Q9BX69
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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RNA A-to-I events for CARD6

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000132357.12

RNA A-to-I editing events in Cancer.

CAediting_403942(40844327, +), CAediting_403943(40844367, +), CAediting_403944(40844942, +), CAediting_403945(40844985, +), CAediting_403946(40844997, +), CAediting_403947(40845009, +), CAediting_403948(40845058, +), CAediting_403949(40845063, +), CAediting_403950(40846112, +), CAediting_403951(40846113, +), CAediting_403952(40846130, +), CAediting_403953(40849869, +), CAediting_403954(40849882, +), CAediting_403955(40849900, +), CAediting_403956(40850251, +), CAediting_403957(40850320, +), CAediting_403958(40850334, +), CAediting_403959(40850335, +), CAediting_403960(40850339, +), CAediting_403961(40850500, +), CAediting_403962(40850505, +), CAediting_403963(40850601, +), CAediting_403964(40850607, +), CAediting_403965(40850628, +), CAediting_403966(40850650, +), CAediting_403967(40851614, +), CAediting_403968(40851625, +), CAediting_403969(40851869, +), CAediting_403970(40851945, +), CAediting_403971(40852026, +), CAediting_403972(40852082, +), CAediting_403973(40854563, +), CAediting_403974(40854613, +), CAediting_403975(40854615, +), CAediting_403976(40854647, +), CAediting_403977(40854652, +), CAediting_403978(40854655, +), CAediting_403979(40854665, +), CAediting_403980(40854671, +), CAediting_403981(40854690, +), CAediting_403982(40854691, +), CAediting_403983(40854695, +), CAediting_403984(40854717, +), CAediting_403985(40854720, +), CAediting_403986(40854730, +), CAediting_403987(40854736, +), CAediting_403988(40854740, +), CAediting_403989(40854743, +), CAediting_403990(40854748, +), CAediting_403991(40854770, +), CAediting_403992(40854775, +), CAediting_403993(40854779, +), CAediting_403994(40854799, +), CAediting_403995(40854812, +), CAediting_403996(40854837, +), CAediting_403997(40854841, +), CAediting_403998(40854864, +), CAediting_403999(40854872, +), CAediting_404000(40854873, +), CAediting_404001(40855573, +), CAediting_404002(40855626, +), CAediting_404003(40855647, +), CAediting_404004(40855650, +), CAediting_404005(40855672, +), CAediting_404006(40855673, +), CAediting_404007(40855676, +), CAediting_404008(40855686, +), CAediting_404009(40855728, +), CAediting_404010(40855783, +), CAediting_404011(40858820, +), CAediting_404012(40858863, +), CAediting_404013(40859074, +), CAediting_404014(40859753, +), CAediting_404015(40859756, +), CAediting_404016(40859757, +), CAediting_404017(40860021, +), CAediting_404018(40860022, +), CAediting_404019(40860034, +), CAediting_404020(40860049, +),

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RNA editing positional annotations for CARD6 using Annovar

Protein coding RNA editing(s).

CAeditome ID	Position	Variant type	ENST	NTchange	AAchange	SIFT_score	Polyphen2_HVAR_score	PROVEAN_pred
CAediting_404017	chr5_40860021_+	nonsynonymous SNV	ENST00000381677.4	c.A865G	p.K289E	D	.	N
CAediting_404018	chr5_40860022_+	nonsynonymous SNV	ENST00000381677.4	c.A866G	p.K289R	D	.	N
CAediting_404019	chr5_40860034_+	nonsynonymous SNV	ENST00000381677.4	c.A878G	p.H293R	D	.	N
CAediting_404020	chr5_40860049_+	nonsynonymous SNV	ENST00000381677.4	c.A893G	p.K298R	D	.	N

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_403942	chr5_40844327_+	intronic
CAediting_403943	chr5_40844367_+	intronic
CAediting_403944	chr5_40844942_+	intronic
CAediting_403945	chr5_40844985_+	intronic
CAediting_403946	chr5_40844997_+	intronic
CAediting_403947	chr5_40845009_+	intronic
CAediting_403948	chr5_40845058_+	intronic
CAediting_403949	chr5_40845063_+	intronic
CAediting_403950	chr5_40846112_+	intronic
CAediting_403951	chr5_40846113_+	intronic
CAediting_403952	chr5_40846130_+	intronic
CAediting_403953	chr5_40849869_+	intronic
CAediting_403954	chr5_40849882_+	intronic
CAediting_403955	chr5_40849900_+	intronic
CAediting_403956	chr5_40850251_+	intronic
CAediting_403957	chr5_40850320_+	intronic
CAediting_403958	chr5_40850334_+	intronic
CAediting_403959	chr5_40850335_+	intronic
CAediting_403960	chr5_40850339_+	intronic
CAediting_403961	chr5_40850500_+	intronic
CAediting_403962	chr5_40850505_+	intronic
CAediting_403963	chr5_40850601_+	intronic
CAediting_403964	chr5_40850607_+	intronic
CAediting_403965	chr5_40850628_+	intronic
CAediting_403966	chr5_40850650_+	intronic
CAediting_403967	chr5_40851614_+	intronic
CAediting_403968	chr5_40851625_+	intronic
CAediting_403969	chr5_40851869_+	intronic
CAediting_403970	chr5_40851945_+	intronic
CAediting_403971	chr5_40852026_+	intronic
CAediting_403972	chr5_40852082_+	intronic
CAediting_403973	chr5_40854563_+	UTR3
CAediting_403974	chr5_40854613_+	UTR3
CAediting_403975	chr5_40854615_+	UTR3
CAediting_403976	chr5_40854647_+	UTR3
CAediting_403977	chr5_40854652_+	UTR3
CAediting_403978	chr5_40854655_+	UTR3
CAediting_403979	chr5_40854665_+	UTR3
CAediting_403980	chr5_40854671_+	UTR3
CAediting_403981	chr5_40854690_+	UTR3
CAediting_403982	chr5_40854691_+	UTR3
CAediting_403983	chr5_40854695_+	UTR3
CAediting_403984	chr5_40854717_+	UTR3
CAediting_403985	chr5_40854720_+	UTR3
CAediting_403986	chr5_40854730_+	UTR3
CAediting_403987	chr5_40854736_+	UTR3
CAediting_403988	chr5_40854740_+	UTR3
CAediting_403989	chr5_40854743_+	UTR3
CAediting_403990	chr5_40854748_+	UTR3
CAediting_403991	chr5_40854770_+	UTR3
CAediting_403992	chr5_40854775_+	UTR3
CAediting_403993	chr5_40854779_+	UTR3
CAediting_403994	chr5_40854799_+	UTR3
CAediting_403995	chr5_40854812_+	UTR3
CAediting_403996	chr5_40854837_+	UTR3
CAediting_403997	chr5_40854841_+	UTR3
CAediting_403998	chr5_40854864_+	UTR3
CAediting_403999	chr5_40854872_+	UTR3
CAediting_404000	chr5_40854873_+	UTR3
CAediting_404001	chr5_40855573_+	intronic
CAediting_404002	chr5_40855626_+	intronic
CAediting_404003	chr5_40855647_+	intronic
CAediting_404004	chr5_40855650_+	intronic
CAediting_404005	chr5_40855672_+	intronic
CAediting_404006	chr5_40855673_+	intronic
CAediting_404007	chr5_40855676_+	intronic
CAediting_404008	chr5_40855686_+	intronic
CAediting_404009	chr5_40855728_+	intronic
CAediting_404010	chr5_40855783_+	intronic
CAediting_404011	chr5_40858820_+	intronic
CAediting_404012	chr5_40858863_+	intronic
CAediting_404013	chr5_40859074_+	intronic
CAediting_404014	chr5_40859753_+	intronic
CAediting_404015	chr5_40859756_+	intronic
CAediting_404016	chr5_40859757_+	intronic
CAediting_404017	chr5_40860021_+	exonic
CAediting_404018	chr5_40860022_+	exonic
CAediting_404019	chr5_40860034_+	exonic
CAediting_404020	chr5_40860049_+	exonic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_403942	chr5_40844327_+	SINE	Alu	AluJb
CAediting_403943	chr5_40844367_+	SINE	Alu	AluJb
CAediting_403944	chr5_40844942_+	SINE	Alu	AluSz
CAediting_403945	chr5_40844985_+	SINE	Alu	AluSz
CAediting_403946	chr5_40844997_+	SINE	Alu	AluSz
CAediting_403947	chr5_40845009_+	SINE	Alu	AluSz
CAediting_403948	chr5_40845058_+	SINE	Alu	AluSz
CAediting_403949	chr5_40845063_+	SINE	Alu	AluSz
CAediting_403950	chr5_40846112_+	SINE	Alu	AluSx1
CAediting_403951	chr5_40846113_+	SINE	Alu	AluSx1
CAediting_403952	chr5_40846130_+	SINE	Alu	AluSx1
CAediting_403953	chr5_40849869_+	SINE	Alu	AluJb
CAediting_403954	chr5_40849882_+	SINE	Alu	AluJb
CAediting_403955	chr5_40849900_+	SINE	Alu	AluJb
CAediting_403956	chr5_40850251_+	SINE	Alu	AluSc8
CAediting_403957	chr5_40850320_+	SINE	Alu	AluSc8
CAediting_403958	chr5_40850334_+	SINE	Alu	AluSc8
CAediting_403959	chr5_40850335_+	SINE	Alu	AluSc8
CAediting_403960	chr5_40850339_+	SINE	Alu	AluSc8
CAediting_403961	chr5_40850500_+	SINE	Alu	AluSx1
CAediting_403962	chr5_40850505_+	SINE	Alu	AluSx1
CAediting_403963	chr5_40850601_+	SINE	Alu	AluSx1
CAediting_403964	chr5_40850607_+	SINE	Alu	AluSx1
CAediting_403965	chr5_40850628_+	SINE	Alu	AluSx1
CAediting_403966	chr5_40850650_+	SINE	Alu	AluSx1
CAediting_403967	chr5_40851614_+	SINE	Alu	AluSz6
CAediting_403968	chr5_40851625_+	SINE	Alu	AluSz6
CAediting_403969	chr5_40851869_+	SINE	Alu	AluJr
CAediting_403970	chr5_40851945_+	SINE	Alu	AluJr
CAediting_403971	chr5_40852026_+	SINE	Alu	AluJr
CAediting_403972	chr5_40852082_+	SINE	Alu	AluJr
CAediting_403974	chr5_40854613_+	SINE	Alu	AluSp
CAediting_403975	chr5_40854615_+	SINE	Alu	AluSp
CAediting_403976	chr5_40854647_+	SINE	Alu	AluSp
CAediting_403977	chr5_40854652_+	SINE	Alu	AluSp
CAediting_403978	chr5_40854655_+	SINE	Alu	AluSp
CAediting_403979	chr5_40854665_+	SINE	Alu	AluSp
CAediting_403980	chr5_40854671_+	SINE	Alu	AluSp
CAediting_403981	chr5_40854690_+	SINE	Alu	AluSp
CAediting_403982	chr5_40854691_+	SINE	Alu	AluSp
CAediting_403983	chr5_40854695_+	SINE	Alu	AluSp
CAediting_403984	chr5_40854717_+	SINE	Alu	AluSp
CAediting_403985	chr5_40854720_+	SINE	Alu	AluSp
CAediting_403986	chr5_40854730_+	SINE	Alu	AluSp
CAediting_403987	chr5_40854736_+	SINE	Alu	AluSp
CAediting_403988	chr5_40854740_+	SINE	Alu	AluSp
CAediting_403989	chr5_40854743_+	SINE	Alu	AluSp
CAediting_403990	chr5_40854748_+	SINE	Alu	AluSp
CAediting_403991	chr5_40854770_+	SINE	Alu	AluSp
CAediting_403992	chr5_40854775_+	SINE	Alu	AluSp
CAediting_403993	chr5_40854779_+	SINE	Alu	AluSp
CAediting_403994	chr5_40854799_+	SINE	Alu	AluSp
CAediting_403995	chr5_40854812_+	SINE	Alu	AluSp
CAediting_403996	chr5_40854837_+	SINE	Alu	AluSp
CAediting_403997	chr5_40854841_+	SINE	Alu	AluSp
CAediting_403998	chr5_40854864_+	SINE	Alu	AluSp
CAediting_403999	chr5_40854872_+	SINE	Alu	AluSp
CAediting_404000	chr5_40854873_+	SINE	Alu	AluSp
CAediting_404001	chr5_40855573_+	SINE	Alu	AluSx1
CAediting_404002	chr5_40855626_+	SINE	Alu	AluSx1
CAediting_404003	chr5_40855647_+	SINE	Alu	AluSx1
CAediting_404004	chr5_40855650_+	SINE	Alu	AluSx1
CAediting_404005	chr5_40855672_+	SINE	Alu	AluSx1
CAediting_404006	chr5_40855673_+	SINE	Alu	AluSx1
CAediting_404007	chr5_40855676_+	SINE	Alu	AluSx1
CAediting_404008	chr5_40855686_+	SINE	Alu	AluSx1
CAediting_404009	chr5_40855728_+	SINE	Alu	AluSx1
CAediting_404010	chr5_40855783_+	SINE	Alu	AluSx1
CAediting_404011	chr5_40858820_+	SINE	Alu	AluJo
CAediting_404012	chr5_40858863_+	SINE	Alu	AluJo
CAediting_404013	chr5_40859074_+	SINE	Alu	AluSx1
CAediting_404014	chr5_40859753_+	SINE	Alu	AluSx
CAediting_404015	chr5_40859756_+	SINE	Alu	AluSx
CAediting_404016	chr5_40859757_+	SINE	Alu	AluSx
CAediting_404017	chr5_40860021_+	SINE	Alu	FLAM_C
CAediting_404018	chr5_40860022_+	SINE	Alu	FLAM_C
CAediting_404019	chr5_40860034_+	SINE	Alu	FLAM_C
CAediting_404020	chr5_40860049_+	SINE	Alu	FLAM_C

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RNA A-to-I editing events in the alternative splicing sites for CARD6

RNA A-to-I editing(s) in the alternative splicing sites.

AStype	CAeditomID	Editing position	AS position	AS direction	Exonic location	Wildtype sequence	Wildtype splicing strength	RNA edited sequence	RNA edited splicing strength
ES	CAediting_403947	chr5_40845009_+	40845008:40845016	5SS	2+0i	CAGGTGCGT	9.73	CGGGTGCGT	7.91

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000132357.12.CARD6.

Correlation between RNA A-to-I editing and PSI for ENSG00000132357.12.CARD6.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for CARD6

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for CARD6

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for CARD6

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_403973	chr5_40854563_+	ENSG00000132357.12	ENST00000254691	hsa-miR-3124-3p	40854561	40854568	8mer-1a	40854547	40854568	140.00	-13.29
CAediting_403974	chr5_40854613_+	ENSG00000132357.12	ENST00000254691	hsa-miR-340-3p	40854607	40854614	8mer-1a	40854593	40854614	149.00	-20.13
CAediting_403974	chr5_40854613_+	ENSG00000132357.12	ENST00000254691	hsa-miR-6827-3p	40854607	40854614	8mer-1a	40854594	40854614	140.00	-14.67
CAediting_403975	chr5_40854615_+	ENSG00000132357.12	ENST00000254691	hsa-miR-10a-5p	40854610	40854616	7mer-m8	40854594	40854617	141.00	-14.93
CAediting_403975	chr5_40854615_+	ENSG00000132357.12	ENST00000254691	hsa-miR-10b-5p	40854610	40854616	7mer-m8	40854594	40854617	149.00	-16.54
CAediting_403975	chr5_40854615_+	ENSG00000132357.12	ENST00000254691	hsa-miR-339-5p	40854609	40854615	7mer-m8	40854595	40854616	147.00	-17.88
CAediting_403975	chr5_40854615_+	ENSG00000132357.12	ENST00000254691	hsa-miR-4421	40854608	40854614	7mer-m8	40854593	40854615	151.00	-15.70
CAediting_403975	chr5_40854615_+	ENSG00000132357.12	ENST00000254691	hsa-miR-5699-3p	40854608	40854614	7mer-m8	40854594	40854615	141.00	-16.39
CAediting_403975	chr5_40854615_+	ENSG00000132357.12	ENST00000254691	hsa-miR-6732-3p	40854611	40854617	7mer-m8	40854597	40854618	151.00	-17.63
CAediting_403979	chr5_40854665_+	ENSG00000132357.12	ENST00000254691	hsa-miR-4285	40854661	40854667	7mer-m8	40854652	40854668	151.00	-24.79
CAediting_403979	chr5_40854665_+	ENSG00000132357.12	ENST00000254691	hsa-miR-8072	40854663	40854669	7mer-1a	40854647	40854669	140.00	-25.81
CAediting_403980	chr5_40854671_+	ENSG00000132357.12	ENST00000254691	hsa-miR-485-5p	40854668	40854674	7mer-m8	40854655	40854675	153.00	-20.87
CAediting_403980	chr5_40854671_+	ENSG00000132357.12	ENST00000254691	hsa-miR-604	40854666	40854672	7mer-m8	40854655	40854673	145.00	-21.23
CAediting_403980	chr5_40854671_+	ENSG00000132357.12	ENST00000254691	hsa-miR-6884-5p	40854668	40854674	7mer-m8	40854652	40854675	147.00	-28.25
CAediting_403981	chr5_40854690_+	ENSG00000132357.12	ENST00000254691	hsa-miR-6794-3p	40854688	40854694	7mer-m8	40854676	40854695	153.00	-13.91
CAediting_403983	chr5_40854695_+	ENSG00000132357.12	ENST00000254691	hsa-miR-1255b-2-3p	40854689	40854695	7mer-m8	40854675	40854696	145.00	-12.60
CAediting_403983	chr5_40854695_+	ENSG00000132357.12	ENST00000254691	hsa-miR-589-5p	40854693	40854699	7mer-m8	40854679	40854700	152.00	-18.71
CAediting_403984	chr5_40854717_+	ENSG00000132357.12	ENST00000254691	hsa-miR-4740-3p	40854711	40854717	7mer-m8	40854697	40854718	153.00	-22.26
CAediting_403985	chr5_40854720_+	ENSG00000132357.12	ENST00000254691	hsa-miR-4691-3p	40854717	40854723	7mer-m8	40854706	40854724	147.00	-29.46
CAediting_403989	chr5_40854743_+	ENSG00000132357.12	ENST00000254691	hsa-miR-4746-3p	40854737	40854743	7mer-m8	40854722	40854744	153.00	-23.89
CAediting_403990	chr5_40854748_+	ENSG00000132357.12	ENST00000254691	hsa-miR-1268a	40854744	40854751	8mer-1a	40854734	40854751	170.00	-31.28
CAediting_403990	chr5_40854748_+	ENSG00000132357.12	ENST00000254691	hsa-miR-1268b	40854744	40854751	8mer-1a	40854732	40854751	170.00	-31.78
CAediting_403990	chr5_40854748_+	ENSG00000132357.12	ENST00000254691	hsa-miR-4486	40854746	40854752	7mer-m8	40854738	40854753	153.00	-26.36
CAediting_403992	chr5_40854775_+	ENSG00000132357.12	ENST00000254691	hsa-miR-1913	40854773	40854779	7mer-m8	40854759	40854780	140.00	-17.59
CAediting_403996	chr5_40854837_+	ENSG00000132357.12	ENST00000254691	hsa-miR-4767	40854831	40854837	7mer-m8	40854813	40854838	146.00	-23.95
CAediting_403997	chr5_40854841_+	ENSG00000132357.12	ENST00000254691	hsa-miR-4726-3p	40854836	40854842	7mer-m8	40854822	40854843	140.00	-18.56
CAediting_403999	chr5_40854872_+	ENSG00000132357.12	ENST00000254691	hsa-miR-342-3p	40854867	40854873	7mer-m8	40854851	40854874	167.00	-19.03
CAediting_403999	chr5_40854872_+	ENSG00000132357.12	ENST00000254691	hsa-miR-377-3p	40854866	40854872	7mer-m8	40854848	40854873	146.00	-15.24
CAediting_403999	chr5_40854872_+	ENSG00000132357.12	ENST00000254691	hsa-miR-4284	40854869	40854876	8mer-1a	40854860	40854876	151.00	-18.24
CAediting_403976	chr5_40854647_+	ENSG00000132357.12	ENST00000254691	hsa-miR-324-3p	40854643	40854649	7mer-m8	40854628	40854650	148.00	-24.15
CAediting_403976	chr5_40854647_+	ENSG00000132357.12	ENST00000254691	hsa-miR-4252	40854644	40854651	8mer-1a	40854631	40854651	149.00	-22.82
CAediting_403976	chr5_40854647_+	ENSG00000132357.12	ENST00000254691	hsa-miR-4793-3p	40854640	40854646	7mer-m8	40854625	40854647	149.00	-19.36
CAediting_403976	chr5_40854647_+	ENSG00000132357.12	ENST00000254691	hsa-miR-6807-3p	40854642	40854647	6mer	40854626	40854648	164.00	-33.60
CAediting_403995	chr5_40854812_+	ENSG00000132357.12	ENST00000254691	hsa-miR-3670	40854808	40854814	7mer-m8	40854792	40854815	154.00	-19.00
CAediting_403995	chr5_40854812_+	ENSG00000132357.12	ENST00000254691	hsa-miR-3670	40854808	40854814	7mer-m8	40854792	40854815	154.00	-19.00
CAediting_403995	chr5_40854812_+	ENSG00000132357.12	ENST00000254691	hsa-miR-3670	40854808	40854814	7mer-m8	40854792	40854815	154.00	-19.00
CAediting_403995	chr5_40854812_+	ENSG00000132357.12	ENST00000254691	hsa-miR-3670	40854808	40854814	7mer-m8	40854792	40854815	154.00	-19.00
CAediting_403995	chr5_40854812_+	ENSG00000132357.12	ENST00000254691	hsa-miR-4300	40854810	40854816	7mer-m8	40854798	40854817	149.00	-21.56
CAediting_403995	chr5_40854812_+	ENSG00000132357.12	ENST00000254691	hsa-miR-5591-5p	40854810	40854816	7mer-m8	40854795	40854817	148.00	-20.58
CAediting_403995	chr5_40854812_+	ENSG00000132357.12	ENST00000254691	hsa-miR-6726-5p	40854810	40854816	7mer-m8	40854796	40854817	152.00	-29.11
CAediting_403995	chr5_40854812_+	ENSG00000132357.12	ENST00000254691	hsa-miR-920	40854810	40854816	7mer-m8	40854799	40854817	148.00	-20.57

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_403996	chr5_40854837_+	ENSG00000132357.12	ENST00000254691	hsa-miR-1228-5p	40854830	40854836	7mer-m8	40854818	40854837	145	-24.49
CAediting_403997	chr5_40854841_+	ENSG00000132357.12	ENST00000254691	hsa-miR-3135a	40854837	40854843	7mer-m8	40854824	40854844	143	-17.32
CAediting_403976	chr5_40854647_+	ENSG00000132357.12	ENST00000254691	hsa-miR-32-5p	40854641	40854647	7mer-m8	40854627	40854648	144	-12.53
CAediting_403983	chr5_40854695_+	ENSG00000132357.12	ENST00000254691	hsa-miR-34b-3p	40854690	40854696	7mer-m8	40854675	40854697	142	-9.51
CAediting_403976	chr5_40854647_+	ENSG00000132357.12	ENST00000254691	hsa-miR-363-3p	40854641	40854647	7mer-m8	40854627	40854648	147	-16.12
CAediting_403974	chr5_40854613_+	ENSG00000132357.12	ENST00000254691	hsa-miR-3664-5p	40854610	40854616	7mer-m8	40854595	40854617	155	-17.19
CAediting_403975	chr5_40854615_+	ENSG00000132357.12	ENST00000254691	hsa-miR-3664-5p	40854610	40854616	7mer-m8	40854595	40854617	155	-17.19
CAediting_403980	chr5_40854671_+	ENSG00000132357.12	ENST00000254691	hsa-miR-377-5p	40854668	40854674	7mer-m8	40854652	40854675	150	-21.59
CAediting_403999	chr5_40854872_+	ENSG00000132357.12	ENST00000254691	hsa-miR-3941	40854865	40854872	8mer-1a	40854851	40854872	140	-11.88
CAediting_403994	chr5_40854799_+	ENSG00000132357.12	ENST00000254691	hsa-miR-4293	40854796	40854802	7mer-m8	40854787	40854803	146	-21.19
CAediting_403990	chr5_40854748_+	ENSG00000132357.12	ENST00000254691	hsa-miR-4455	40854744	40854751	8mer-1a	40854736	40854751	148	-16.7
CAediting_403999	chr5_40854872_+	ENSG00000132357.12	ENST00000254691	hsa-miR-466	40854866	40854872	7mer-1a	40854848	40854872	142	-16.33
CAediting_403987	chr5_40854736_+	ENSG00000132357.12	ENST00000254691	hsa-miR-4666b	40854734	40854739	6mer	40854722	40854740	144	-20.68
CAediting_403988	chr5_40854740_+	ENSG00000132357.12	ENST00000254691	hsa-miR-4666b	40854734	40854739	6mer	40854722	40854740	144	-20.68
CAediting_403996	chr5_40854837_+	ENSG00000132357.12	ENST00000254691	hsa-miR-541-3p	40854832	40854838	7mer-m8	40854818	40854839	155	-22.36
CAediting_403985	chr5_40854720_+	ENSG00000132357.12	ENST00000254691	hsa-miR-5690	40854717	40854723	7mer-m8	40854704	40854724	145	-16.75
CAediting_403980	chr5_40854671_+	ENSG00000132357.12	ENST00000254691	hsa-miR-6086	40854668	40854674	7mer-m8	40854656	40854675	154	-22.96
CAediting_403996	chr5_40854837_+	ENSG00000132357.12	ENST00000254691	hsa-miR-654-5p	40854832	40854838	7mer-m8	40854819	40854839	149	-19.51
CAediting_403993	chr5_40854779_+	ENSG00000132357.12	ENST00000254691	hsa-miR-6747-3p	40854774	40854780	7mer-m8	40854760	40854781	143	-17.96
CAediting_403993	chr5_40854779_+	ENSG00000132357.12	ENST00000254691	hsa-miR-6752-3p	40854775	40854781	7mer-m8	40854764	40854782	149	-18.23
CAediting_403974	chr5_40854613_+	ENSG00000132357.12	ENST00000254691	hsa-miR-6888-3p	40854608	40854614	7mer-m8	40854595	40854615	151	-14.9
CAediting_403975	chr5_40854615_+	ENSG00000132357.12	ENST00000254691	hsa-miR-6888-3p	40854608	40854614	7mer-m8	40854595	40854615	151	-14.9
CAediting_403976	chr5_40854647_+	ENSG00000132357.12	ENST00000254691	hsa-miR-92a-3p	40854641	40854647	7mer-m8	40854631	40854648	155	-26.92
CAediting_403976	chr5_40854647_+	ENSG00000132357.12	ENST00000254691	hsa-miR-92a-3p	40854641	40854647	7mer-m8	40854631	40854648	155	-26.92

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_688081	chr9_63819627_+	ENSG00000132357.12	ENST00000254691	hsa-miR-4477b	40854926	40854932	7mer-m8	40854912	40854933	147	-12.24
CAediting_1229414	chr17_67471546_+	ENSG00000132357.12	ENST00000254691	hsa-miR-548aa	40854802	40854808	7mer-m8	40854785	40854809	144	-12.97
CAediting_77128	chr1_85133844_+	ENSG00000132357.12	ENST00000254691	hsa-miR-4423-3p	40854879	40854885	7mer-m8	40854866	40854886	140	-13.48
CAediting_228905	chr2_188297554_+	ENSG00000132357.12	ENST00000254691	hsa-miR-561-3p	40855281	40855287	7mer-m8	40855269	40855288	141	-13.23

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for CARD6

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000254691.8	protein_coding
ENST00000381677.4	protein_coding

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID	ENST	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
CAediting_403973	ENST00000254691.8	chr5_40854563_+	-1244.50	-1244.80	-1284.30
CAediting_403974	ENST00000254691.8	chr5_40854613_+	-1244.10	-1244.80	-1284.30
CAediting_403975	ENST00000254691.8	chr5_40854615_+	-1244.10	-1244.80	-1284.30
CAediting_403976	ENST00000254691.8	chr5_40854647_+	-1245.90	-1244.80	-1284.30
CAediting_403977	ENST00000254691.8	chr5_40854652_+	-1244.70	-1244.80	-1284.30
CAediting_403978	ENST00000254691.8	chr5_40854655_+	-1248.10	-1244.80	-1284.30
CAediting_403979	ENST00000254691.8	chr5_40854665_+	-1244.80	-1244.80	-1284.30
CAediting_403980	ENST00000254691.8	chr5_40854671_+	-1246.40	-1244.80	-1284.30
CAediting_403981	ENST00000254691.8	chr5_40854690_+	-1246.20	-1244.80	-1284.30
CAediting_403982	ENST00000254691.8	chr5_40854691_+	-1247.10	-1244.80	-1284.30
CAediting_403983	ENST00000254691.8	chr5_40854695_+	-1246.40	-1244.80	-1284.30
CAediting_403984	ENST00000254691.8	chr5_40854717_+	-1245.90	-1244.80	-1284.30
CAediting_403985	ENST00000254691.8	chr5_40854720_+	-1247.60	-1244.80	-1284.30
CAediting_403986	ENST00000254691.8	chr5_40854730_+	-1247.30	-1244.80	-1284.30
CAediting_403987	ENST00000254691.8	chr5_40854736_+	-1244.80	-1244.80	-1284.30
CAediting_403988	ENST00000254691.8	chr5_40854740_+	-1248.40	-1244.80	-1284.30
CAediting_403989	ENST00000254691.8	chr5_40854743_+	-1246.50	-1244.80	-1284.30
CAediting_403990	ENST00000254691.8	chr5_40854748_+	-1245.60	-1244.80	-1284.30
CAediting_403991	ENST00000254691.8	chr5_40854770_+	-1247.30	-1244.80	-1284.30
CAediting_403992	ENST00000254691.8	chr5_40854775_+	-1243.90	-1244.80	-1284.30
CAediting_403993	ENST00000254691.8	chr5_40854779_+	-1244.40	-1244.80	-1284.30
CAediting_403994	ENST00000254691.8	chr5_40854799_+	-1250.00	-1244.80	-1284.30
CAediting_403995	ENST00000254691.8	chr5_40854812_+	-1244.80	-1244.80	-1284.30
CAediting_403996	ENST00000254691.8	chr5_40854837_+	-1244.40	-1244.80	-1284.30
CAediting_403997	ENST00000254691.8	chr5_40854841_+	-1248.10	-1244.80	-1284.30
CAediting_403998	ENST00000254691.8	chr5_40854864_+	-1247.10	-1244.80	-1284.30
CAediting_403999	ENST00000254691.8	chr5_40854872_+	-1244.80	-1244.80	-1284.30
CAediting_404000	ENST00000254691.8	chr5_40854873_+	-1244.80	-1244.80	-1284.30
CAediting_404017	ENST00000381677.4	chr5_40860021_+	-287.80	-287.70	-290.20
CAediting_404018	ENST00000381677.4	chr5_40860022_+	-288.20	-287.70	-290.20
CAediting_404019	ENST00000381677.4	chr5_40860034_+	-287.30	-287.70	-290.20
CAediting_404020	ENST00000381677.4	chr5_40860049_+	-287.70	-287.70	-290.20

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Relation with ADAR for CARD6

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for CARD6

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

Top

Relation with survival for CARD6

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

Top

RelatedDrugs for CARD6

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for CARD6

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene