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Editing gene: LZTS2 (CAeditome ID:84445)

Gene summary for LZTS2

Gene summary

Gene information	Gene symbol	LZTS2
	Gene ID	84445
	Gene name	leucine zipper tumor suppressor 2
	Synonyms	LAPSER1
	Cytomap	10q24.31
	Type of gene	protein-coding
	Description	leucine zipper putative tumor suppressor 2leucine zipper, putative tumor suppressor 2protein LAPSER1
	Modification date	20210519
	UniProtAcc	Q9BRK4
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
LZTS2	GO:0005829	Leucine zipper putative tumor suppressor 2	0000052
LZTS2	GO:0005886	Leucine zipper putative tumor suppressor 2	0000052
LZTS2	GO:0031982	Leucine zipper putative tumor suppressor 2	25468996

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RNA A-to-I events for LZTS2

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000107816.16

RNA A-to-I editing events in Cancer.

CAediting_776974(101004192, +), CAediting_776975(101004325, +), CAediting_776976(101004329, +), CAediting_776977(101004345, +), CAediting_776978(101004351, +), CAediting_776979(101004352, +), CAediting_776980(101004360, +), CAediting_776981(101004374, +), CAediting_776982(101004400, +), CAediting_776983(101004406, +), CAediting_776984(101004408, +), CAediting_776985(101004411, +), CAediting_776986(101004412, +), CAediting_776987(101004420, +), CAediting_776988(101004436, +), CAediting_776989(101004447, +), CAediting_776990(101004448, +), CAediting_776991(101004456, +), CAediting_776992(101004461, +), CAediting_776993(101004472, +), CAediting_776994(101004476, +), CAediting_776995(101004482, +), CAediting_776996(101004488, +), CAediting_776997(101004492, +), CAediting_776998(101004499, +), CAediting_776999(101004505, +), CAediting_777000(101004518, +), CAediting_777001(101004528, +), CAediting_777002(101004531, +), CAediting_777003(101004537, +), CAediting_777004(101004542, +), CAediting_777005(101004545, +), CAediting_777006(101004555, +), CAediting_777007(101004560, +), CAediting_777008(101004573, +), CAediting_777009(101004587, +), CAediting_777010(101004871, +), CAediting_777011(101004877, +), CAediting_777012(101004884, +), CAediting_777013(101004886, +), CAediting_777014(101004941, +), CAediting_777015(101004959, +), CAediting_777016(101004960, +), CAediting_777017(101005015, +), CAediting_777018(101005023, +), CAediting_777019(101005025, +), CAediting_777020(101005027, +), CAediting_777021(101005028, +), CAediting_777022(101005035, +), CAediting_777023(101005043, +), CAediting_777024(101005052, +), CAediting_777025(101005056, +), CAediting_777026(101005059, +), CAediting_777027(101005068, +), CAediting_777028(101005073, +), CAediting_777029(101005083, +), CAediting_777030(101005089, +), CAediting_777031(101005090, +), CAediting_777032(101005103, +), CAediting_777033(101005104, +), CAediting_777034(101005107, +), CAediting_777035(101005121, +), CAediting_777036(101005129, +), CAediting_777037(101005130, +), CAediting_777038(101005133, +), CAediting_777039(101005138, +), CAediting_777040(101005140, +), CAediting_777041(101005143, +), CAediting_777042(101005145, +), CAediting_777043(101005156, +), CAediting_777044(101005164, +), CAediting_777045(101005169, +), CAediting_777046(101005191, +), CAediting_777047(101005211, +), CAediting_777048(101005224, +), CAediting_777049(101005231, +), CAediting_777050(101005236, +), CAediting_777051(101005245, +),

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RNA editing positional annotations for LZTS2 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_776974	chr10_101004192_+	intronic
CAediting_776975	chr10_101004325_+	intronic
CAediting_776976	chr10_101004329_+	intronic
CAediting_776977	chr10_101004345_+	intronic
CAediting_776978	chr10_101004351_+	intronic
CAediting_776979	chr10_101004352_+	intronic
CAediting_776980	chr10_101004360_+	intronic
CAediting_776981	chr10_101004374_+	intronic
CAediting_776982	chr10_101004400_+	intronic
CAediting_776983	chr10_101004406_+	intronic
CAediting_776984	chr10_101004408_+	intronic
CAediting_776985	chr10_101004411_+	intronic
CAediting_776986	chr10_101004412_+	intronic
CAediting_776987	chr10_101004420_+	intronic
CAediting_776988	chr10_101004436_+	intronic
CAediting_776989	chr10_101004447_+	intronic
CAediting_776990	chr10_101004448_+	intronic
CAediting_776991	chr10_101004456_+	intronic
CAediting_776992	chr10_101004461_+	intronic
CAediting_776993	chr10_101004472_+	intronic
CAediting_776994	chr10_101004476_+	intronic
CAediting_776995	chr10_101004482_+	intronic
CAediting_776996	chr10_101004488_+	intronic
CAediting_776997	chr10_101004492_+	intronic
CAediting_776998	chr10_101004499_+	intronic
CAediting_776999	chr10_101004505_+	intronic
CAediting_777000	chr10_101004518_+	intronic
CAediting_777001	chr10_101004528_+	intronic
CAediting_777002	chr10_101004531_+	intronic
CAediting_777003	chr10_101004537_+	intronic
CAediting_777004	chr10_101004542_+	intronic
CAediting_777005	chr10_101004545_+	intronic
CAediting_777006	chr10_101004555_+	intronic
CAediting_777007	chr10_101004560_+	intronic
CAediting_777008	chr10_101004573_+	intronic
CAediting_777009	chr10_101004587_+	intronic
CAediting_777010	chr10_101004871_+	intronic
CAediting_777011	chr10_101004877_+	intronic
CAediting_777012	chr10_101004884_+	intronic
CAediting_777013	chr10_101004886_+	intronic
CAediting_777014	chr10_101004941_+	intronic
CAediting_777015	chr10_101004959_+	intronic
CAediting_777016	chr10_101004960_+	intronic
CAediting_777017	chr10_101005015_+	intronic
CAediting_777018	chr10_101005023_+	intronic
CAediting_777019	chr10_101005025_+	intronic
CAediting_777020	chr10_101005027_+	intronic
CAediting_777021	chr10_101005028_+	intronic
CAediting_777022	chr10_101005035_+	intronic
CAediting_777023	chr10_101005043_+	intronic
CAediting_777024	chr10_101005052_+	intronic
CAediting_777025	chr10_101005056_+	intronic
CAediting_777026	chr10_101005059_+	intronic
CAediting_777027	chr10_101005068_+	intronic
CAediting_777028	chr10_101005073_+	intronic
CAediting_777029	chr10_101005083_+	intronic
CAediting_777030	chr10_101005089_+	intronic
CAediting_777031	chr10_101005090_+	intronic
CAediting_777032	chr10_101005103_+	intronic
CAediting_777033	chr10_101005104_+	intronic
CAediting_777034	chr10_101005107_+	intronic
CAediting_777035	chr10_101005121_+	intronic
CAediting_777036	chr10_101005129_+	intronic
CAediting_777037	chr10_101005130_+	intronic
CAediting_777038	chr10_101005133_+	intronic
CAediting_777039	chr10_101005138_+	intronic
CAediting_777040	chr10_101005140_+	intronic
CAediting_777041	chr10_101005143_+	intronic
CAediting_777042	chr10_101005145_+	intronic
CAediting_777043	chr10_101005156_+	intronic
CAediting_777044	chr10_101005164_+	intronic
CAediting_777045	chr10_101005169_+	intronic
CAediting_777046	chr10_101005191_+	intronic
CAediting_777047	chr10_101005211_+	intronic
CAediting_777048	chr10_101005224_+	intronic
CAediting_777049	chr10_101005231_+	intronic
CAediting_777050	chr10_101005236_+	intronic
CAediting_777051	chr10_101005245_+	intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_776975	chr10_101004325_+	SINE	MIR	MIR1_Amn
CAediting_776976	chr10_101004329_+	SINE	Alu	AluSz
CAediting_776977	chr10_101004345_+	SINE	Alu	AluSz
CAediting_776978	chr10_101004351_+	SINE	Alu	AluSz
CAediting_776979	chr10_101004352_+	SINE	Alu	AluSz
CAediting_776980	chr10_101004360_+	SINE	Alu	AluSz
CAediting_776981	chr10_101004374_+	SINE	Alu	AluSz
CAediting_776982	chr10_101004400_+	SINE	Alu	AluSz
CAediting_776983	chr10_101004406_+	SINE	Alu	AluSz
CAediting_776984	chr10_101004408_+	SINE	Alu	AluSz
CAediting_776985	chr10_101004411_+	SINE	Alu	AluSz
CAediting_776986	chr10_101004412_+	SINE	Alu	AluSz
CAediting_776987	chr10_101004420_+	SINE	Alu	AluSz
CAediting_776988	chr10_101004436_+	SINE	Alu	AluSz
CAediting_776989	chr10_101004447_+	SINE	Alu	AluSz
CAediting_776990	chr10_101004448_+	SINE	Alu	AluSz
CAediting_776991	chr10_101004456_+	SINE	Alu	AluSz
CAediting_776992	chr10_101004461_+	SINE	Alu	AluSz
CAediting_776993	chr10_101004472_+	SINE	Alu	AluSz
CAediting_776994	chr10_101004476_+	SINE	Alu	AluSz
CAediting_776995	chr10_101004482_+	SINE	Alu	AluSz
CAediting_776996	chr10_101004488_+	SINE	Alu	AluSz
CAediting_776997	chr10_101004492_+	SINE	Alu	AluSz
CAediting_776998	chr10_101004499_+	SINE	Alu	AluSz
CAediting_776999	chr10_101004505_+	SINE	Alu	AluSz
CAediting_777000	chr10_101004518_+	SINE	Alu	AluSz
CAediting_777001	chr10_101004528_+	SINE	Alu	AluSz
CAediting_777002	chr10_101004531_+	SINE	Alu	AluSz
CAediting_777003	chr10_101004537_+	SINE	Alu	AluSz
CAediting_777004	chr10_101004542_+	SINE	Alu	AluSz
CAediting_777005	chr10_101004545_+	SINE	Alu	AluSz
CAediting_777006	chr10_101004555_+	SINE	Alu	AluSz
CAediting_777007	chr10_101004560_+	SINE	Alu	AluSz
CAediting_777008	chr10_101004573_+	SINE	Alu	AluSz
CAediting_777009	chr10_101004587_+	SINE	Alu	AluSz
CAediting_777010	chr10_101004871_+	SINE	Alu	AluSz
CAediting_777011	chr10_101004877_+	SINE	Alu	AluSz
CAediting_777012	chr10_101004884_+	SINE	Alu	AluSz
CAediting_777013	chr10_101004886_+	SINE	Alu	AluSz
CAediting_777014	chr10_101004941_+	SINE	Alu	AluSz
CAediting_777015	chr10_101004959_+	SINE	Alu	AluSz
CAediting_777016	chr10_101004960_+	SINE	Alu	AluSz
CAediting_777017	chr10_101005015_+	SINE	Alu	AluJb
CAediting_777018	chr10_101005023_+	SINE	Alu	AluJb
CAediting_777019	chr10_101005025_+	SINE	Alu	AluJb
CAediting_777020	chr10_101005027_+	SINE	Alu	AluJb
CAediting_777021	chr10_101005028_+	SINE	Alu	AluJb
CAediting_777022	chr10_101005035_+	SINE	Alu	AluJb
CAediting_777023	chr10_101005043_+	SINE	Alu	AluJb
CAediting_777024	chr10_101005052_+	SINE	Alu	AluJb
CAediting_777025	chr10_101005056_+	SINE	Alu	AluJb
CAediting_777026	chr10_101005059_+	SINE	Alu	AluJb
CAediting_777027	chr10_101005068_+	SINE	Alu	AluJb
CAediting_777028	chr10_101005073_+	SINE	Alu	AluJb
CAediting_777029	chr10_101005083_+	SINE	Alu	AluJb
CAediting_777030	chr10_101005089_+	SINE	Alu	AluJb
CAediting_777031	chr10_101005090_+	SINE	Alu	AluJb
CAediting_777032	chr10_101005103_+	SINE	Alu	AluJb
CAediting_777033	chr10_101005104_+	SINE	Alu	AluJb
CAediting_777034	chr10_101005107_+	SINE	Alu	AluJb
CAediting_777035	chr10_101005121_+	SINE	Alu	AluJb
CAediting_777036	chr10_101005129_+	SINE	Alu	AluJb
CAediting_777037	chr10_101005130_+	SINE	Alu	AluJb
CAediting_777038	chr10_101005133_+	SINE	Alu	AluJb
CAediting_777039	chr10_101005138_+	SINE	Alu	AluJb
CAediting_777040	chr10_101005140_+	SINE	Alu	AluJb
CAediting_777041	chr10_101005143_+	SINE	Alu	AluJb
CAediting_777042	chr10_101005145_+	SINE	Alu	AluJb
CAediting_777043	chr10_101005156_+	SINE	Alu	AluJb
CAediting_777044	chr10_101005164_+	SINE	Alu	AluJb
CAediting_777045	chr10_101005169_+	SINE	Alu	AluJb
CAediting_777046	chr10_101005191_+	SINE	Alu	AluJb
CAediting_777047	chr10_101005211_+	SINE	Alu	AluJb
CAediting_777048	chr10_101005224_+	SINE	Alu	AluJb
CAediting_777049	chr10_101005231_+	SINE	Alu	AluJb
CAediting_777050	chr10_101005236_+	SINE	Alu	AluJb
CAediting_777051	chr10_101005245_+	SINE	Alu	AluJb

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RNA A-to-I editing events in the alternative splicing sites for LZTS2

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000107816.16.LZTS2.

Correlation between RNA A-to-I editing and PSI for ENSG00000107816.16.LZTS2.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for LZTS2

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

LAML.CAediting_777021.ENSG00000107816.LZTS2.png
Soverview

THCA.CAediting_777021.ENSG00000107816.LZTS2.png
Soverview

THYM.CAediting_777039.ENSG00000107816.LZTS2.png
Soverview

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Protein coding region RNA A-to-I editings for LZTS2

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for LZTS2

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_980496	chr14_31014685_-	ENSG00000107816.16	ENST00000370223	hsa-miR-624-3p	101007444	101007450	7mer-m8	101007433	101007451	150	-15.58
CAediting_980496	chr14_31014685_-	ENSG00000107816.16	ENST00000370220	hsa-miR-624-3p	101007444	101007450	7mer-m8	101007433	101007451	150	-15.58
CAediting_1399425	chr20_1392958_-	ENSG00000107816.16	ENST00000370223	hsa-miR-6869-5p	101007385	101007390	6mer	101007368	101007391	143	-26.74
CAediting_1399425	chr20_1392958_-	ENSG00000107816.16	ENST00000370223	hsa-miR-6869-5p	101007404	101007410	7mer-m8	101007390	101007411	159	-25.84
CAediting_1399425	chr20_1392958_-	ENSG00000107816.16	ENST00000370220	hsa-miR-6869-5p	101007385	101007390	6mer	101007368	101007391	143	-26.74
CAediting_1399425	chr20_1392958_-	ENSG00000107816.16	ENST00000370220	hsa-miR-6869-5p	101007404	101007410	7mer-m8	101007390	101007411	159	-25.84
CAediting_468389	chr6_31355314_-	ENSG00000107816.16	ENST00000370223	hsa-miR-6891-5p	101007506	101007512	7mer-m8	101007495	101007513	151	-21.75
CAediting_1524209	chrX_134546392_-	ENSG00000107816.16	ENST00000370223	hsa-miR-503-5p	101007424	101007431	8mer-1a	101007409	101007431	145	-20.96
CAediting_468389	chr6_31355314_-	ENSG00000107816.16	ENST00000370220	hsa-miR-6891-5p	101007506	101007512	7mer-m8	101007495	101007513	151	-21.75
CAediting_1524209	chrX_134546392_-	ENSG00000107816.16	ENST00000370220	hsa-miR-503-5p	101007424	101007431	8mer-1a	101007409	101007431	145	-20.96

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1351755	chr19_40282625_-	ENSG00000107816.16	ENST00000370223	hsa-miR-641	101007688	101007694	7mer-m8	101007672	101007695	140	-12.84
CAediting_1351755	chr19_40282625_-	ENSG00000107816.16	ENST00000370220	hsa-miR-641	101007688	101007694	7mer-m8	101007672	101007695	140	-12.84

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for LZTS2

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for LZTS2

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
LUSC	CAediting_776995	chr10_101004482_+	0.0170059741250189	0.177704906358659	.	.	.	.
ESCA	CAediting_776995	chr10_101004482_+	.	.	0.0138160358660879	0.251845350335443	.	.
LUAD	CAediting_776996	chr10_101004488_+	0.0415884416469412	0.170044574616695	.	.	.	.
SARC	CAediting_776996	chr10_101004488_+	.	.	0.0477827154126228	0.25881100328543	.	.
BLCA	CAediting_777021	chr10_101005028_+	7.7939952061941e-05	0.299988625004659	.	.	.	.
BRCA	CAediting_777021	chr10_101005028_+	0.000493045578198144	0.173017715850702	.	.	.	.
LUAD	CAediting_777021	chr10_101005028_+	0.000315730000865287	0.273011053025357	.	.	.	.
LUSC	CAediting_777021	chr10_101005028_+	0.00136197574426404	0.235027630982352	.	.	.	.
BLCA	CAediting_777024	chr10_101005052_+	0.00077148790401111	0.295799153057931	.	.	.	.
LGG	CAediting_777024	chr10_101005052_+	0.0412842821921266	0.194925811564898	0.0459762894415277	0.190702530415519	.	.
BRCA	CAediting_777024	chr10_101005052_+	0.0114257310845609	0.142808065011185	.	.	.	.
LUAD	CAediting_777024	chr10_101005052_+	0.0196951762712756	0.202798545707125	.	.	.	.
LUSC	CAediting_777024	chr10_101005052_+	.	.	0.00263448424871626	0.272187409480979	0.00186749145810141	0.281144156846055
SKCM	CAediting_777024	chr10_101005052_+	.	.	0.00630610136724615	0.275516660230004	.	.
BRCA	CAediting_777034	chr10_101005107_+	.	.	.	.	0.000321857381549949	0.488246596883912
BLCA	CAediting_777037	chr10_101005130_+	0.0362774110168038	0.240622694542786	.	.	.	.
LGG	CAediting_777037	chr10_101005130_+	.	.	0.0217410251793461	0.306164502207205	.	.
CESC	CAediting_777037	chr10_101005130_+	0.0344859131103488	0.299682930120362	.	.	.	.
LUAD	CAediting_777037	chr10_101005130_+	0.0437863072734625	0.231945910618255	.	.	.	.
SKCM	CAediting_777037	chr10_101005130_+	0.00522269043924275	0.337493438194863	.	.	.	.
BLCA	CAediting_777038	chr10_101005133_+	0.000508751479991426	0.265344661289204	0.00426673176206995	0.21942401681617	.	.
LUAD	CAediting_777038	chr10_101005133_+	.	.	.	.	0.0209608212967047	0.184146424472659
LUSC	CAediting_777038	chr10_101005133_+	0.0172897336167367	0.190987855527962	.	.	.	.
THCA	CAediting_777038	chr10_101005133_+	0.0353799888846741	0.123609757229146	.	.	.	.
KIRP	CAediting_777038	chr10_101005133_+	.	.	.	.	0.017404860953414	0.248792513431126
PAAD	CAediting_777038	chr10_101005133_+	.	.	0.0297518153001756	0.276245740437999	.	.
BLCA	CAediting_777039	chr10_101005138_+	2.24090575724591e-08	0.356915840472892	0.0029585113728997	0.194308813383887	.	.
LGG	CAediting_777039	chr10_101005138_+	1.4065733246458e-06	0.277918448406607	.	.	.	.
BRCA	CAediting_777039	chr10_101005138_+	6.90918631100308e-07	0.198889596007356	.	.	.	.
CESC	CAediting_777039	chr10_101005138_+	3.37669643161121e-07	0.372194200290887	.	.	.	.
LUAD	CAediting_777039	chr10_101005138_+	8.6180510226427e-07	0.318416294225371	.	.	.	.
LUSC	CAediting_777039	chr10_101005138_+	2.39113594109279e-05	0.264810447702868	0.00762600667977171	0.169063298970758	0.00292950077196377	0.188175368501108
PRAD	CAediting_777039	chr10_101005138_+	0.0165624231717024	0.176950488471288	.	.	.	.
HNSC	CAediting_777039	chr10_101005138_+	.	.	.	.	0.0140302956735252	0.246200163622203
THCA	CAediting_777039	chr10_101005138_+	0.00120465529543718	0.170700528598429	.	.	.	.
UCEC	CAediting_777039	chr10_101005138_+	0.0171653967885221	0.17272983916074	.	.	.	.
KIRP	CAediting_777039	chr10_101005138_+	0.00192790577830824	0.282645307035856	.	.	.	.
PAAD	CAediting_777039	chr10_101005138_+	.	.	0.0268045853361642	0.238808007262698	.	.
SARC	CAediting_777039	chr10_101005138_+	0.0158752429276781	0.219765210105235	.	.	.	.
THYM	CAediting_777039	chr10_101005138_+	0.0253780329501768	0.301325074817448	.	.	.	.
BLCA	CAediting_777041	chr10_101005143_+	0.000111089557519345	0.315465657463062	0.000145015956561209	0.310384569299707	.	.
LGG	CAediting_777041	chr10_101005143_+	.	.	0.0420157777555834	0.14357395309044	.	.
BRCA	CAediting_777041	chr10_101005143_+	0.0425595030438789	0.0949118651055009	.	.	.	.
CESC	CAediting_777041	chr10_101005143_+	0.00923634233790997	0.238708433185568	.	.	.	.
LUAD	CAediting_777041	chr10_101005143_+	0.000690617470973684	0.263902317695106	.	.	.	.
LUSC	CAediting_777041	chr10_101005143_+	0.00750460583241682	0.215369838231713	.	.	.	.
HNSC	CAediting_777041	chr10_101005143_+	.	.	.	.	0.00373140186762633	0.371865349899308
STAD	CAediting_777041	chr10_101005143_+	.	.	7.96659116705498e-05	0.429058712105915	.	.
THCA	CAediting_777041	chr10_101005143_+	0.014426101018717	0.150711306531143	.	.	.	.
SKCM	CAediting_777041	chr10_101005143_+	0.0255285503929763	0.181738099161061	.	.	.	.

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Relation with cancer stages for LZTS2

Correlation between Cancer stages and RNA editing frequency

Cancer	Stage_type	CAeditomID	position	P-val	Coeff.
BLCA	pathologic_stage	CAediting_777021	chr10_101005028_+	0.00294653939601504	0.229417327153864
BLCA	pathologic_stage	CAediting_777038	chr10_101005133_+	0.031613887973309	0.16690410763534
BLCA	pathologic_stage	CAediting_777039	chr10_101005138_+	0.0149050585795199	0.160371218285567
BLCA	pathologic_stage	CAediting_777041	chr10_101005143_+	0.00410558861167748	0.236981319657882
CESC	clinical_stage	CAediting_777021	chr10_101005028_+	0.0359298337043741	-0.178754904728725
COAD	pathologic_stage	CAediting_777039	chr10_101005138_+	0.00190266741456891	-0.428555492240934
ESCA	clinical_stage	CAediting_776996	chr10_101004488_+	0.0437624596121801	0.526515171120134
KIRC	pathologic_stage	CAediting_776995	chr10_101004482_+	0.000121916724250439	0.261448208669019
KIRC	pathologic_stage	CAediting_777021	chr10_101005028_+	0.000103524696110753	0.278622837842144
KIRC	pathologic_stage	CAediting_777039	chr10_101005138_+	0.00252016044174449	0.184845100073921
KIRP	clinical_stage	CAediting_776995	chr10_101004482_+	0.00136092982705219	0.463019496723972
KIRP	clinical_stage	CAediting_777038	chr10_101005133_+	0.00218510632118583	0.385007954632409
KIRP	clinical_stage	CAediting_777039	chr10_101005138_+	0.000167586556489233	0.418629482272865
KIRP	clinical_stage	CAediting_777041	chr10_101005143_+	0.0118304918124815	0.404245627779583
KIRP	pathologic_stage	CAediting_777038	chr10_101005133_+	0.00982327033701488	0.29070313260829
KIRP	pathologic_stage	CAediting_777039	chr10_101005138_+	1.50093851578843e-05	0.410542591765541
LUAD	pathologic_stage	CAediting_777029	chr10_101005083_+	0.0254968281612753	0.246643062267887
LUSC	pathologic_stage	CAediting_776995	chr10_101004482_+	0.00105249037328588	0.242227204976376
LUSC	pathologic_stage	CAediting_777039	chr10_101005138_+	0.0434187960960897	0.128625973409048
SKCM	pathologic_stage	CAediting_777024	chr10_101005052_+	0.0224668291139141	0.248826036891128
THCA	pathologic_stage	CAediting_776995	chr10_101004482_+	0.00127238066331623	0.205131601706479
THCA	pathologic_stage	CAediting_776996	chr10_101004488_+	0.0106844590924888	0.159003341413754
THCA	pathologic_stage	CAediting_777022	chr10_101005035_+	0.0287645833211219	0.237295393368426
THCA	pathologic_stage	CAediting_777039	chr10_101005138_+	0.0449893316294763	0.10662467262828
UCEC	clinical_stage	CAediting_777037	chr10_101005130_+	0.00198835008696909	-0.340651602103789

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Relation with survival for LZTS2

Correlation between RNA editing and survival

Cancer	CAeditomID	position	KMpvalue	Coxpvalue	CoxHR
BLCA	CAediting_777024	chr10_101005052_+	0.0214767287572026	0.0281082	0.0595231
COAD	CAediting_777039	chr10_101005138_+	0.0297663186804492	0.0222839	0.00153076
LUSC	CAediting_777037	chr10_101005130_+	0.0299900966201658	0.0206846	0.000402229
GBM	CAediting_777021	chr10_101005028_+	0.018247025220498	0.0135129	10.8821
KIRC	CAediting_777021	chr10_101005028_+	0.00802487012324216	0.024374	3.90484
KIRC	CAediting_777023	chr10_101005043_+	0.00655553822867505	0.0385556	35.1801
KIRC	CAediting_777042	chr10_101005145_+	0.0393834070499048	0.0120767	0.00057323

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RelatedDrugs for LZTS2

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for LZTS2

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene