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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: MRI1 (CAeditome ID:84245)

Gene summary for MRI1

check button Gene summary
Gene informationGene symbol

MRI1

Gene ID

84245

Gene namemethylthioribose-1-phosphate isomerase 1
SynonymsM1Pi|MRDI|MTNA|Ypr118w
Cytomap

19p13.13

Type of geneprotein-coding
Descriptionmethylthioribose-1-phosphate isomeraseMTR-1-P isomeraseS-methyl-5-thioribose-1-phosphate isomerase 1mediator of RhoA-dependent invasionmethylthioribose-1-phosphate isomerase homologtranslation initiation factor eIF-2B subunit alpha/beta/delta-like pr
Modification date20210518
UniProtAcc

Q9BV20

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
MRI1

GO:0001650

Methylthioribose-1-phosphate isomerase

0000052

MRI1

GO:0005654

Methylthioribose-1-phosphate isomerase

0000052

MRI1

GO:0005829

Methylthioribose-1-phosphate isomerase

0000052


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RNA A-to-I events for MRI1

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000037757.12
boxplot

check button RNA A-to-I editing events in Cancer.
CAediting_1305749(13767074, +), CAediting_1305750(13767124, +), CAediting_1305751(13767146, +), CAediting_1305752(13767147, +), CAediting_1305753(13767149, +), CAediting_1305754(13767164, +), CAediting_1305755(13767186, +), CAediting_1305756(13767195, +), CAediting_1305757(13767202, +), CAediting_1305758(13767213, +), CAediting_1305759(13767227, +), CAediting_1305760(13767281, +), CAediting_1305761(13767307, +), CAediting_1305762(13767321, +), CAediting_1305763(13767330, +), CAediting_1305764(13767429, +), CAediting_1305765(13767435, +), CAediting_1305766(13767446, +), CAediting_1305767(13767455, +), CAediting_1305768(13767458, +), CAediting_1305769(13767461, +), CAediting_1305770(13767493, +), CAediting_1305771(13767499, +), CAediting_1305772(13767501, +), CAediting_1305773(13767513, +), CAediting_1305774(13767514, +), CAediting_1305775(13767518, +), CAediting_1305776(13767521, +), CAediting_1305777(13767522, +), CAediting_1305778(13767549, +), CAediting_1305779(13767550, +), CAediting_1305780(13767555, +), CAediting_1305781(13767558, +), CAediting_1305782(13767571, +), CAediting_1305783(13767572, +), CAediting_1305784(13767595, +), CAediting_1305785(13767603, +), CAediting_1305786(13767605, +), CAediting_1305787(13767606, +), CAediting_1305788(13767609, +), CAediting_1305789(13767626, +), CAediting_1305790(13767627, +), CAediting_1305791(13767629, +), CAediting_1305792(13767640, +), CAediting_1305793(13767645, +), CAediting_1305794(13767646, +), CAediting_1305795(13767647, +), CAediting_1305796(13767653, +), CAediting_1305797(13767654, +), CAediting_1305798(13767655, +), CAediting_1305799(13767658, +), CAediting_1305800(13767694, +), CAediting_1305801(13767712, +), CAediting_1305802(13767749, +), CAediting_1305803(13767753, +), CAediting_1305804(13767786, +), CAediting_1305805(13767794, +), CAediting_1305806(13767892, +), CAediting_1305807(13768067, +), CAediting_1305808(13768079, +), CAediting_1305809(13768111, +), CAediting_1305810(13768119, +), CAediting_1305811(13768128, +), CAediting_1305812(13768129, +), CAediting_1305813(13768130, +), CAediting_1305814(13768142, +), CAediting_1305815(13769347, +), CAediting_1305816(13769644, +), CAediting_1305817(13769660, +), CAediting_1305818(13769667, +), CAediting_1305819(13769738, +), CAediting_1305820(13769764, +), CAediting_1305821(13769773, +), CAediting_1305822(13769813, +), CAediting_1305823(13769841, +), CAediting_1305824(13769990, +), CAediting_1305825(13770021, +), CAediting_1305826(13770036, +), CAediting_1305827(13770053, +), CAediting_1305828(13770062, +), CAediting_1305829(13770070, +), CAediting_1305830(13770508, +), CAediting_1305831(13770980, +), CAediting_1305832(13771247, +), CAediting_1305833(13771322, +), CAediting_1305834(13771357, +), CAediting_1305835(13771388, +), CAediting_1305836(13771424, +), CAediting_1305837(13771434, +), CAediting_1305838(13771470, +), CAediting_1305839(13771736, +), CAediting_1305840(13771741, +), CAediting_1305841(13771745, +), CAediting_1305842(13771847, +),

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RNA editing positional annotations for MRI1 using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_1305749chr19_13767074_+ncRNA_intronic
CAediting_1305750chr19_13767124_+ncRNA_intronic
CAediting_1305751chr19_13767146_+ncRNA_intronic
CAediting_1305752chr19_13767147_+ncRNA_intronic
CAediting_1305753chr19_13767149_+ncRNA_intronic
CAediting_1305754chr19_13767164_+ncRNA_intronic
CAediting_1305755chr19_13767186_+ncRNA_intronic
CAediting_1305756chr19_13767195_+ncRNA_intronic
CAediting_1305757chr19_13767202_+ncRNA_intronic
CAediting_1305758chr19_13767213_+ncRNA_intronic
CAediting_1305759chr19_13767227_+ncRNA_intronic
CAediting_1305760chr19_13767281_+ncRNA_intronic
CAediting_1305761chr19_13767307_+ncRNA_intronic
CAediting_1305762chr19_13767321_+ncRNA_intronic
CAediting_1305763chr19_13767330_+ncRNA_intronic
CAediting_1305764chr19_13767429_+ncRNA_intronic
CAediting_1305765chr19_13767435_+ncRNA_intronic
CAediting_1305766chr19_13767446_+ncRNA_intronic
CAediting_1305767chr19_13767455_+ncRNA_intronic
CAediting_1305768chr19_13767458_+ncRNA_intronic
CAediting_1305769chr19_13767461_+ncRNA_intronic
CAediting_1305770chr19_13767493_+ncRNA_intronic
CAediting_1305771chr19_13767499_+ncRNA_intronic
CAediting_1305772chr19_13767501_+ncRNA_intronic
CAediting_1305773chr19_13767513_+ncRNA_intronic
CAediting_1305774chr19_13767514_+ncRNA_intronic
CAediting_1305775chr19_13767518_+ncRNA_intronic
CAediting_1305776chr19_13767521_+ncRNA_intronic
CAediting_1305777chr19_13767522_+ncRNA_intronic
CAediting_1305778chr19_13767549_+ncRNA_intronic
CAediting_1305779chr19_13767550_+ncRNA_intronic
CAediting_1305780chr19_13767555_+ncRNA_intronic
CAediting_1305781chr19_13767558_+ncRNA_intronic
CAediting_1305782chr19_13767571_+ncRNA_intronic
CAediting_1305783chr19_13767572_+ncRNA_intronic
CAediting_1305784chr19_13767595_+ncRNA_intronic
CAediting_1305785chr19_13767603_+ncRNA_intronic
CAediting_1305786chr19_13767605_+ncRNA_intronic
CAediting_1305787chr19_13767606_+ncRNA_intronic
CAediting_1305788chr19_13767609_+ncRNA_intronic
CAediting_1305789chr19_13767626_+ncRNA_intronic
CAediting_1305790chr19_13767627_+ncRNA_intronic
CAediting_1305791chr19_13767629_+ncRNA_intronic
CAediting_1305792chr19_13767640_+ncRNA_intronic
CAediting_1305793chr19_13767645_+ncRNA_intronic
CAediting_1305794chr19_13767646_+ncRNA_intronic
CAediting_1305795chr19_13767647_+ncRNA_intronic
CAediting_1305796chr19_13767653_+ncRNA_intronic
CAediting_1305797chr19_13767654_+ncRNA_intronic
CAediting_1305798chr19_13767655_+ncRNA_intronic
CAediting_1305799chr19_13767658_+ncRNA_intronic
CAediting_1305800chr19_13767694_+ncRNA_intronic
CAediting_1305801chr19_13767712_+ncRNA_intronic
CAediting_1305802chr19_13767749_+ncRNA_intronic
CAediting_1305803chr19_13767753_+ncRNA_intronic
CAediting_1305804chr19_13767786_+ncRNA_intronic
CAediting_1305805chr19_13767794_+ncRNA_intronic
CAediting_1305806chr19_13767892_+ncRNA_intronic
CAediting_1305807chr19_13768067_+ncRNA_intronic
CAediting_1305808chr19_13768079_+ncRNA_intronic
CAediting_1305809chr19_13768111_+ncRNA_intronic
CAediting_1305810chr19_13768119_+ncRNA_intronic
CAediting_1305811chr19_13768128_+ncRNA_intronic
CAediting_1305812chr19_13768129_+ncRNA_intronic
CAediting_1305813chr19_13768130_+ncRNA_intronic
CAediting_1305814chr19_13768142_+ncRNA_intronic
CAediting_1305815chr19_13769347_+intronic
CAediting_1305816chr19_13769644_+intronic
CAediting_1305817chr19_13769660_+intronic
CAediting_1305818chr19_13769667_+intronic
CAediting_1305819chr19_13769738_+intronic
CAediting_1305820chr19_13769764_+intronic
CAediting_1305821chr19_13769773_+intronic
CAediting_1305822chr19_13769813_+intronic
CAediting_1305823chr19_13769841_+intronic
CAediting_1305824chr19_13769990_+intronic
CAediting_1305825chr19_13770021_+intronic
CAediting_1305826chr19_13770036_+intronic
CAediting_1305827chr19_13770053_+intronic
CAediting_1305828chr19_13770062_+intronic
CAediting_1305829chr19_13770070_+intronic
CAediting_1305830chr19_13770508_+intronic
CAediting_1305831chr19_13770980_+intronic
CAediting_1305832chr19_13771247_+intronic
CAediting_1305833chr19_13771322_+intronic
CAediting_1305834chr19_13771357_+intronic
CAediting_1305835chr19_13771388_+intronic
CAediting_1305836chr19_13771424_+intronic
CAediting_1305837chr19_13771434_+intronic
CAediting_1305838chr19_13771470_+intronic
CAediting_1305839chr19_13771736_+intronic
CAediting_1305840chr19_13771741_+intronic
CAediting_1305841chr19_13771745_+intronic
CAediting_1305842chr19_13771847_+intronic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_1305749chr19_13767074_+SINEAluAluSx
CAediting_1305750chr19_13767124_+SINEAluAluSx
CAediting_1305751chr19_13767146_+SINEAluAluSx
CAediting_1305752chr19_13767147_+SINEAluAluSx
CAediting_1305753chr19_13767149_+SINEAluAluSx
CAediting_1305754chr19_13767164_+SINEAluAluSx
CAediting_1305755chr19_13767186_+SINEAluAluSx
CAediting_1305756chr19_13767195_+SINEAluAluSx
CAediting_1305757chr19_13767202_+SINEAluAluSx
CAediting_1305758chr19_13767213_+SINEAluAluSx
CAediting_1305759chr19_13767227_+SINEAluAluSx
CAediting_1305760chr19_13767281_+SINEAluAluSx
CAediting_1305761chr19_13767307_+SINEAluAluSx
CAediting_1305762chr19_13767321_+SINEAluAluSx
CAediting_1305763chr19_13767330_+SINEAluAluSx
CAediting_1305764chr19_13767429_+SINEAluAluJo
CAediting_1305765chr19_13767435_+SINEAluAluJo
CAediting_1305766chr19_13767446_+SINEAluAluJo
CAediting_1305767chr19_13767455_+SINEAluAluJo
CAediting_1305768chr19_13767458_+SINEAluAluJo
CAediting_1305769chr19_13767461_+SINEAluAluJo
CAediting_1305770chr19_13767493_+SINEAluAluJo
CAediting_1305771chr19_13767499_+SINEAluAluJo
CAediting_1305772chr19_13767501_+SINEAluAluJo
CAediting_1305773chr19_13767513_+SINEAluAluJo
CAediting_1305774chr19_13767514_+SINEAluAluJo
CAediting_1305775chr19_13767518_+SINEAluAluJo
CAediting_1305776chr19_13767521_+SINEAluAluJo
CAediting_1305777chr19_13767522_+SINEAluAluJo
CAediting_1305778chr19_13767549_+SINEAluAluJo
CAediting_1305779chr19_13767550_+SINEAluAluJo
CAediting_1305780chr19_13767555_+SINEAluAluJo
CAediting_1305781chr19_13767558_+SINEAluAluJo
CAediting_1305782chr19_13767571_+SINEAluAluJo
CAediting_1305783chr19_13767572_+SINEAluAluJo
CAediting_1305784chr19_13767595_+SINEAluAluJo
CAediting_1305785chr19_13767603_+SINEAluAluJo
CAediting_1305786chr19_13767605_+SINEAluAluJo
CAediting_1305787chr19_13767606_+SINEAluAluJo
CAediting_1305788chr19_13767609_+SINEAluAluJo
CAediting_1305789chr19_13767626_+SINEAluAluJo
CAediting_1305790chr19_13767627_+SINEAluAluJo
CAediting_1305791chr19_13767629_+SINEAluAluJo
CAediting_1305792chr19_13767640_+SINEAluAluJo
CAediting_1305793chr19_13767645_+SINEAluAluJo
CAediting_1305794chr19_13767646_+SINEAluAluJo
CAediting_1305795chr19_13767647_+SINEAluAluJo
CAediting_1305796chr19_13767653_+SINEAluAluJo
CAediting_1305797chr19_13767654_+SINEAluAluJo
CAediting_1305798chr19_13767655_+SINEAluAluJo
CAediting_1305799chr19_13767658_+SINEAluAluJo
CAediting_1305800chr19_13767694_+SINEAluAluJo
CAediting_1305801chr19_13767712_+SINEAluAluJo
CAediting_1305802chr19_13767749_+SINEAluAluSz6
CAediting_1305803chr19_13767753_+SINEAluAluSz6
CAediting_1305804chr19_13767786_+SINEAluAluSz6
CAediting_1305805chr19_13767794_+SINEAluAluSz6
CAediting_1305806chr19_13767892_+SINEAluAluY
CAediting_1305807chr19_13768067_+SINEAluAluY
CAediting_1305808chr19_13768079_+SINEAluAluY
CAediting_1305809chr19_13768111_+SINEAluAluY
CAediting_1305810chr19_13768119_+SINEAluAluY
CAediting_1305811chr19_13768128_+SINEAluAluY
CAediting_1305812chr19_13768129_+SINEAluAluY
CAediting_1305813chr19_13768130_+SINEAluAluY
CAediting_1305814chr19_13768142_+SINEAluAluY
CAediting_1305815chr19_13769347_+SINEAluAluSz
CAediting_1305816chr19_13769644_+SINEAluAluSg
CAediting_1305817chr19_13769660_+SINEAluAluSg
CAediting_1305818chr19_13769667_+SINEAluAluSg
CAediting_1305819chr19_13769738_+SINEAluAluSg
CAediting_1305820chr19_13769764_+SINEAluAluSg
CAediting_1305821chr19_13769773_+SINEAluAluSg
CAediting_1305822chr19_13769813_+SINEAluAluSg
CAediting_1305823chr19_13769841_+SINEAluAluSg
CAediting_1305824chr19_13769990_+SINEAluAluJr4
CAediting_1305825chr19_13770021_+SINEAluAluJr4
CAediting_1305826chr19_13770036_+SINEAluAluJr4
CAediting_1305827chr19_13770053_+SINEAluAluJr4
CAediting_1305828chr19_13770062_+SINEAluAluJr4
CAediting_1305829chr19_13770070_+SINEAluAluJr4
CAediting_1305830chr19_13770508_+SINEAluAluSz
CAediting_1305831chr19_13770980_+SINEAluAluJr4
CAediting_1305832chr19_13771247_+SINEAluAluSq2
CAediting_1305833chr19_13771322_+SINEAluAluSq2
CAediting_1305834chr19_13771357_+SINEAluAluSq2
CAediting_1305835chr19_13771388_+SINEAluAluJr4
CAediting_1305836chr19_13771424_+SINEAluAluJr4
CAediting_1305837chr19_13771434_+SINEAluAluJr4
CAediting_1305838chr19_13771470_+SINEAluAluJr4
CAediting_1305839chr19_13771736_+SINEAluAluSp
CAediting_1305840chr19_13771741_+SINEAluAluSp
CAediting_1305841chr19_13771745_+SINEAluAluSp
CAediting_1305842chr19_13771847_+SINEAluAluSp

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RNA A-to-I editing events in the alternative splicing sites for MRI1

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000037757.12.MRI1.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000037757.12.MRI1.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for MRI1

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.
boxplot

check button Correlation between RNA A-to-I editing and gene expression.
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for MRI1

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for MRI1

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_1229413chr17_67471544_+ENSG00000037757.12ENST00000319545hsa-miR-548aa13772515137725217mer-m81377249913772522141-9.94
CAediting_1399425chr20_1392958_-ENSG00000037757.12ENST00000319545hsa-miR-6869-5p13772338137723458mer-1a1377232413772345142-16.03
CAediting_442554chr5_154685830_+ENSG00000037757.12ENST00000319545hsa-miR-130313773866137738727mer-m81377385213773873152-16.38
CAediting_604450chr7_133034877_-ENSG00000037757.12ENST00000319545hsa-miR-365413772355137723617mer-m81377234613772362141-20.84
CAediting_573000chr7_92204081_-ENSG00000037757.12ENST00000319545hsa-miR-1285-5p13773067137730737mer-m81377305313773074150-24.82

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_228905chr2_188297554_+ENSG00000037757.12ENST00000319545hsa-miR-561-3p13774026137740338mer-1a1377401213774033147-6.93
CAediting_1399425chr20_1392958_-ENSG00000037757.12ENST00000319545hsa-miR-6869-5p13773518137735247mer-m81377350313773525155-21.11

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for MRI1

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for MRI1

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
BRCACAediting_1305764chr19_13767429_+8.83960207569036e-050.286460523621634....
LUSCCAediting_1305764chr19_13767429_+0.01696569102544410.237113243546636..0.03598617795976680.208959150317302
BRCACAediting_1305775chr19_13767518_+0.04527711944347820.193079250701637....

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Relation with cancer stages for MRI1

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.
BLCApathologic_stageCAediting_1305764chr19_13767429_+0.04645063714741160.282981026669218
BRCApathologic_stageCAediting_1305764chr19_13767429_+0.04557252978321990.149642885803635
KIRCpathologic_stageCAediting_1305764chr19_13767429_+0.01419656347049230.231161687150161
KIRPclinical_stageCAediting_1305764chr19_13767429_+0.004758955866781350.486427478600581
KIRPpathologic_stageCAediting_1305764chr19_13767429_+0.004966591641570710.40307537053764

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Relation with survival for MRI1

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR

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RelatedDrugs for MRI1

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MRI1

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource