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Editing gene: TMEM222 (CAeditome ID:84065)

Gene summary for TMEM222

Gene summary

Gene information	Gene symbol	TMEM222
	Gene ID	84065
	Gene name	transmembrane protein 222
	Synonyms	C1orf160
	Cytomap	1p36.11
	Type of gene	protein-coding
	Description	transmembrane protein 222
	Modification date	20210518
	UniProtAcc	Q9H0R3
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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RNA A-to-I events for TMEM222

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000186501.13

RNA A-to-I editing events in Cancer.

CAediting_30659(27323702, +), CAediting_30660(27324070, +), CAediting_30661(27325456, +), CAediting_30662(27326425, +), CAediting_30663(27327412, +), CAediting_30664(27327458, +), CAediting_30665(27327488, +), CAediting_30666(27327489, +), CAediting_30667(27327506, +), CAediting_30668(27327518, +), CAediting_30669(27327528, +), CAediting_30670(27327578, +), CAediting_30671(27327735, +), CAediting_30672(27327780, +), CAediting_30673(27327816, +), CAediting_30674(27327841, +), CAediting_30675(27327881, +), CAediting_30676(27327903, +), CAediting_30677(27330165, +), CAediting_30678(27330226, +), CAediting_30679(27330232, +), CAediting_30680(27330276, +), CAediting_30681(27330299, +), CAediting_30682(27330318, +),

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RNA editing positional annotations for TMEM222 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_30659	chr1_27323702_+	intronic
CAediting_30660	chr1_27324070_+	intronic
CAediting_30661	chr1_27325456_+	ncRNA_exonic
CAediting_30662	chr1_27326425_+	intronic
CAediting_30663	chr1_27327412_+	intronic
CAediting_30664	chr1_27327458_+	intronic
CAediting_30665	chr1_27327488_+	intronic
CAediting_30666	chr1_27327489_+	intronic
CAediting_30667	chr1_27327506_+	intronic
CAediting_30668	chr1_27327518_+	intronic
CAediting_30669	chr1_27327528_+	intronic
CAediting_30670	chr1_27327578_+	intronic
CAediting_30671	chr1_27327735_+	intronic
CAediting_30672	chr1_27327780_+	intronic
CAediting_30673	chr1_27327816_+	intronic
CAediting_30674	chr1_27327841_+	intronic
CAediting_30675	chr1_27327881_+	intronic
CAediting_30676	chr1_27327903_+	intronic
CAediting_30677	chr1_27330165_+	intronic
CAediting_30678	chr1_27330226_+	intronic
CAediting_30679	chr1_27330232_+	intronic
CAediting_30680	chr1_27330276_+	intronic
CAediting_30681	chr1_27330299_+	intronic
CAediting_30682	chr1_27330318_+	intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_30659	chr1_27323702_+	SINE	Alu	AluSg
CAediting_30660	chr1_27324070_+	SINE	Alu	AluSp
CAediting_30663	chr1_27327412_+	SINE	Alu	AluSz6
CAediting_30664	chr1_27327458_+	SINE	Alu	AluSz6
CAediting_30665	chr1_27327488_+	SINE	Alu	AluSz6
CAediting_30666	chr1_27327489_+	SINE	Alu	AluSz6
CAediting_30667	chr1_27327506_+	SINE	Alu	AluSz6
CAediting_30668	chr1_27327518_+	SINE	Alu	AluSz6
CAediting_30669	chr1_27327528_+	SINE	Alu	AluSz6
CAediting_30670	chr1_27327578_+	SINE	Alu	AluSz6
CAediting_30671	chr1_27327735_+	SINE	Alu	AluJo
CAediting_30672	chr1_27327780_+	SINE	Alu	AluJo
CAediting_30673	chr1_27327816_+	SINE	Alu	AluJo
CAediting_30674	chr1_27327841_+	SINE	Alu	AluJo
CAediting_30675	chr1_27327881_+	SINE	Alu	AluJo
CAediting_30676	chr1_27327903_+	SINE	Alu	AluJo
CAediting_30677	chr1_27330165_+	SINE	Alu	AluSc
CAediting_30678	chr1_27330226_+	SINE	Alu	AluSc
CAediting_30679	chr1_27330232_+	SINE	Alu	AluSc
CAediting_30680	chr1_27330276_+	SINE	Alu	AluSc
CAediting_30681	chr1_27330299_+	SINE	Alu	AluSc
CAediting_30682	chr1_27330318_+	SINE	Alu	AluSc

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RNA A-to-I editing events in the alternative splicing sites for TMEM222

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000186501.13.TMEM222.

Correlation between RNA A-to-I editing and PSI for ENSG00000186501.13.TMEM222.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for TMEM222

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for TMEM222

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for TMEM222

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_980496	chr14_31014685_-	ENSG00000186501.13	ENST00000611517	hsa-miR-624-3p	27335663	27335669	7mer-m8	27335650	27335670	143	-12.32
CAediting_980496	chr14_31014685_-	ENSG00000186501.13	ENST00000611517	hsa-miR-624-3p	27336314	27336319	6mer	27336299	27336320	150	-22.11
CAediting_393	chr1_1167164_+	ENSG00000186501.13	ENST00000611517	hsa-miR-200b-3p	27336076	27336082	7mer-m8	27336062	27336083	154	-16.14
CAediting_980496	chr14_31014685_-	ENSG00000186501.13	ENST00000374076	hsa-miR-624-3p	27335663	27335669	7mer-m8	27335650	27335670	143	-12.32
CAediting_980496	chr14_31014685_-	ENSG00000186501.13	ENST00000374076	hsa-miR-624-3p	27336314	27336319	6mer	27336299	27336320	150	-22.11
CAediting_393	chr1_1167164_+	ENSG00000186501.13	ENST00000374076	hsa-miR-200b-3p	27336076	27336082	7mer-m8	27336062	27336083	154	-16.14
CAediting_980496	chr14_31014685_-	ENSG00000186501.13	ENST00000464720	hsa-miR-624-3p	27335663	27335669	7mer-m8	27335650	27335670	143	-12.32
CAediting_980496	chr14_31014685_-	ENSG00000186501.13	ENST00000464720	hsa-miR-624-3p	27336314	27336319	6mer	27336299	27336320	150	-22.11
CAediting_393	chr1_1167164_+	ENSG00000186501.13	ENST00000464720	hsa-miR-200b-3p	27336076	27336082	7mer-m8	27336062	27336083	154	-16.14
CAediting_980496	chr14_31014685_-	ENSG00000186501.13	ENST00000608611	hsa-miR-624-3p	27335663	27335669	7mer-m8	27335650	27335670	143	-12.32
CAediting_980496	chr14_31014685_-	ENSG00000186501.13	ENST00000608611	hsa-miR-624-3p	27336314	27336319	6mer	27336299	27336320	150	-22.11
CAediting_393	chr1_1167164_+	ENSG00000186501.13	ENST00000608611	hsa-miR-200b-3p	27336076	27336082	7mer-m8	27336062	27336083	154	-16.14
CAediting_980496	chr14_31014685_-	ENSG00000186501.13	ENST00000478104	hsa-miR-624-3p	27335663	27335669	7mer-m8	27335650	27335670	143	-12.32
CAediting_1368054	chr19_46709310_-	ENSG00000186501.13	ENST00000611517	hsa-miR-320e	27336285	27336291	7mer-m8	27336275	27336292	150	-18.04
CAediting_77128	chr1_85133844_+	ENSG00000186501.13	ENST00000611517	hsa-miR-4423-3p	27335792	27335798	7mer-m8	27335779	27335799	140	-12.68
CAediting_77128	chr1_85133844_+	ENSG00000186501.13	ENST00000611517	hsa-miR-4423-3p	27336008	27336014	7mer-m8	27335994	27336015	141	-16.33
CAediting_524911	chr7_5495852_-	ENSG00000186501.13	ENST00000611517	hsa-miR-589-3p	27336339	27336345	7mer-m8	27336323	27336346	140	-14.23
CAediting_1368054	chr19_46709310_-	ENSG00000186501.13	ENST00000374076	hsa-miR-320e	27336285	27336291	7mer-m8	27336275	27336292	150	-18.04
CAediting_77128	chr1_85133844_+	ENSG00000186501.13	ENST00000374076	hsa-miR-4423-3p	27335792	27335798	7mer-m8	27335779	27335799	140	-12.68
CAediting_77128	chr1_85133844_+	ENSG00000186501.13	ENST00000374076	hsa-miR-4423-3p	27336008	27336014	7mer-m8	27335994	27336015	141	-16.33
CAediting_524911	chr7_5495852_-	ENSG00000186501.13	ENST00000374076	hsa-miR-589-3p	27336339	27336345	7mer-m8	27336323	27336346	140	-14.23
CAediting_1229414	chr17_67471546_+	ENSG00000186501.13	ENST00000464720	hsa-miR-548aa	27335446	27335452	7mer-m8	27335429	27335453	143	-10.3
CAediting_1368054	chr19_46709310_-	ENSG00000186501.13	ENST00000464720	hsa-miR-320e	27336285	27336291	7mer-m8	27336275	27336292	150	-18.04
CAediting_77128	chr1_85133844_+	ENSG00000186501.13	ENST00000464720	hsa-miR-4423-3p	27335792	27335798	7mer-m8	27335779	27335799	140	-12.68
CAediting_77128	chr1_85133844_+	ENSG00000186501.13	ENST00000464720	hsa-miR-4423-3p	27336008	27336014	7mer-m8	27335994	27336015	141	-16.33
CAediting_524911	chr7_5495852_-	ENSG00000186501.13	ENST00000464720	hsa-miR-589-3p	27336339	27336345	7mer-m8	27336323	27336346	140	-14.23
CAediting_1368054	chr19_46709310_-	ENSG00000186501.13	ENST00000608611	hsa-miR-320e	27336285	27336291	7mer-m8	27336275	27336292	150	-18.04
CAediting_77128	chr1_85133844_+	ENSG00000186501.13	ENST00000608611	hsa-miR-4423-3p	27335792	27335798	7mer-m8	27335779	27335799	140	-12.68
CAediting_77128	chr1_85133844_+	ENSG00000186501.13	ENST00000608611	hsa-miR-4423-3p	27336008	27336014	7mer-m8	27335994	27336015	141	-16.33
CAediting_524911	chr7_5495852_-	ENSG00000186501.13	ENST00000608611	hsa-miR-589-3p	27336339	27336345	7mer-m8	27336323	27336346	140	-14.23
CAediting_1229414	chr17_67471546_+	ENSG00000186501.13	ENST00000486082	hsa-miR-548aa	27335446	27335452	7mer-m8	27335429	27335453	143	-10.3
CAediting_1229415	chr17_67471547_+	ENSG00000186501.13	ENST00000464813	hsa-miR-548aa	27334856	27334862	7mer-m8	27334838	27334863	152	-12.43
CAediting_1368054	chr19_46709310_-	ENSG00000186501.13	ENST00000464813	hsa-miR-320e	27334468	27334474	7mer-m8	27334457	27334475	151	-17.97
CAediting_442554	chr5_154685830_+	ENSG00000186501.13	ENST00000464813	hsa-miR-1303	27334775	27334781	7mer-m8	27334761	27334782	155	-21.07
CAediting_604450	chr7_133034877_-	ENSG00000186501.13	ENST00000464813	hsa-miR-3654	27334466	27334472	7mer-m8	27334453	27334473	143	-18.71
CAediting_573001	chr7_92204086_-	ENSG00000186501.13	ENST00000464813	hsa-miR-1285-5p	27334513	27334519	7mer-m8	27334500	27334520	140	-19.16
CAediting_1229414	chr17_67471546_+	ENSG00000186501.13	ENST00000478104	hsa-miR-548aa	27335446	27335452	7mer-m8	27335429	27335453	143	-10.3
CAediting_77128	chr1_85133844_+	ENSG00000186501.13	ENST00000478104	hsa-miR-4423-3p	27335792	27335798	7mer-m8	27335779	27335799	140	-12.68
CAediting_468389	chr6_31355314_-	ENSG00000186501.13	ENST00000611517	hsa-miR-6891-5p	27335672	27335678	7mer-m8	27335662	27335679	155	-30.05
CAediting_468389	chr6_31355314_-	ENSG00000186501.13	ENST00000374076	hsa-miR-6891-5p	27335672	27335678	7mer-m8	27335662	27335679	155	-30.05
CAediting_468389	chr6_31355314_-	ENSG00000186501.13	ENST00000464720	hsa-miR-6891-5p	27335672	27335678	7mer-m8	27335662	27335679	155	-30.05
CAediting_468389	chr6_31355314_-	ENSG00000186501.13	ENST00000608611	hsa-miR-6891-5p	27335672	27335678	7mer-m8	27335662	27335679	155	-30.05
CAediting_468389	chr6_31355314_-	ENSG00000186501.13	ENST00000478104	hsa-miR-6891-5p	27335672	27335678	7mer-m8	27335662	27335679	155	-30.05

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1054808	chr15_66496985_-	ENSG00000186501.13	ENST00000464720	hsa-miR-4512	27336311	27336317	7mer-m8	27336296	27336318	145	-21.03

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for TMEM222

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for TMEM222

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for TMEM222

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for TMEM222

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for TMEM222

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for TMEM222

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene