CAeditome Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: COG3 (CAeditome ID:83548)

Gene summary for COG3

check button Gene summary
Gene informationGene symbol

COG3

Gene ID

83548

Gene namecomponent of oligomeric golgi complex 3
SynonymsSEC34
Cytomap

13q14.13

Type of geneprotein-coding
Descriptionconserved oligomeric Golgi complex subunit 3COG complex subunit 3p94tethering factor SEC34vesicle-docking protein SEC34 homolog
Modification date20210518
UniProtAcc

Q96JB2

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
COG3

GO:0006888

Conserved oligomeric Golgi complex subunit 3

11929878

COG3

GO:0006891

Conserved oligomeric Golgi complex subunit 3

11929878

COG3

GO:0005794

Conserved oligomeric Golgi complex subunit 3

0000052

COG3

GO:0005794

Conserved oligomeric Golgi complex subunit 3

11980916

COG3

GO:0005829

Conserved oligomeric Golgi complex subunit 3

0000052

COG3

GO:0005886

Conserved oligomeric Golgi complex subunit 3

0000052

COG3

GO:0017119

Conserved oligomeric Golgi complex subunit 3

11292827

COG3

GO:0017119

Conserved oligomeric Golgi complex subunit 3

15047703


Top

RNA A-to-I events for COG3

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000136152.13
boxplot

check button RNA A-to-I editing events in Cancer.
CAediting_962806(45466302, +), CAediting_962807(45467337, +), CAediting_962808(45471222, +), CAediting_962809(45471299, +), CAediting_962810(45471376, +), CAediting_962811(45475736, +), CAediting_962812(45489076, +), CAediting_962813(45494087, +), CAediting_962814(45494092, +), CAediting_962815(45494164, +), CAediting_962816(45494165, +), CAediting_962817(45494167, +), CAediting_962818(45494169, +), CAediting_962819(45494178, +), CAediting_962820(45494182, +), CAediting_962821(45494202, +), CAediting_962822(45494204, +), CAediting_962823(45494205, +), CAediting_962824(45494231, +), CAediting_962825(45494246, +), CAediting_962826(45494253, +), CAediting_962827(45494270, +), CAediting_962828(45494288, +), CAediting_962829(45495409, +), CAediting_962830(45496459, +), CAediting_962831(45497528, +), CAediting_962832(45497529, +), CAediting_962833(45497568, +), CAediting_962834(45497582, +), CAediting_962835(45497741, +), CAediting_962836(45507645, +), CAediting_962837(45507814, +), CAediting_962838(45507884, +), CAediting_962839(45507903, +), CAediting_962840(45507909, +), CAediting_962841(45507918, +), CAediting_962842(45507919, +), CAediting_962843(45507922, +), CAediting_962844(45507938, +), CAediting_962845(45507941, +), CAediting_962846(45507962, +), CAediting_962847(45507984, +), CAediting_962848(45509169, +), CAediting_962849(45516231, +), CAediting_962850(45516235, +), CAediting_962851(45516236, +), CAediting_962852(45518300, +), CAediting_962853(45518304, +), CAediting_962854(45518311, +), CAediting_962855(45518316, +), CAediting_962856(45518317, +), CAediting_962857(45520017, +), CAediting_962858(45520023, +), CAediting_962859(45520024, +), CAediting_962860(45520050, +), CAediting_962861(45520101, +), CAediting_962862(45520102, +), CAediting_962863(45520106, +), CAediting_962864(45520110, +), CAediting_962865(45520123, +), CAediting_962866(45520126, +), CAediting_962867(45520127, +), CAediting_962868(45520128, +), CAediting_962869(45520130, +), CAediting_962870(45520142, +), CAediting_962871(45520152, +), CAediting_962872(45520166, +), CAediting_962873(45520174, +), CAediting_962874(45520178, +), CAediting_962875(45520199, +), CAediting_962876(45520209, +), CAediting_962877(45520217, +), CAediting_962878(45520229, +), CAediting_962879(45520233, +), CAediting_962880(45520237, +), CAediting_962881(45520238, +), CAediting_962882(45520243, +), CAediting_962883(45520253, +), CAediting_962884(45520258, +), CAediting_962885(45520272, +), CAediting_962886(45521063, +), CAediting_962887(45521116, +), CAediting_962888(45521877, +), CAediting_962889(45521907, +), CAediting_962890(45521937, +), CAediting_962891(45532687, +),

Top

RNA editing positional annotations for COG3 using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_962806chr13_45466302_+intronic
CAediting_962807chr13_45467337_+intronic
CAediting_962808chr13_45471222_+intronic
CAediting_962809chr13_45471299_+intronic
CAediting_962810chr13_45471376_+intronic
CAediting_962811chr13_45475736_+intronic
CAediting_962812chr13_45489076_+intronic
CAediting_962813chr13_45494087_+ncRNA_intronic
CAediting_962814chr13_45494092_+ncRNA_intronic
CAediting_962815chr13_45494164_+ncRNA_intronic
CAediting_962816chr13_45494165_+ncRNA_intronic
CAediting_962817chr13_45494167_+ncRNA_intronic
CAediting_962818chr13_45494169_+ncRNA_intronic
CAediting_962819chr13_45494178_+ncRNA_intronic
CAediting_962820chr13_45494182_+ncRNA_intronic
CAediting_962821chr13_45494202_+ncRNA_intronic
CAediting_962822chr13_45494204_+ncRNA_intronic
CAediting_962823chr13_45494205_+ncRNA_intronic
CAediting_962824chr13_45494231_+ncRNA_intronic
CAediting_962825chr13_45494246_+ncRNA_intronic
CAediting_962826chr13_45494253_+ncRNA_intronic
CAediting_962827chr13_45494270_+ncRNA_intronic
CAediting_962828chr13_45494288_+ncRNA_intronic
CAediting_962829chr13_45495409_+ncRNA_intronic
CAediting_962830chr13_45496459_+ncRNA_intronic
CAediting_962831chr13_45497528_+ncRNA_intronic
CAediting_962832chr13_45497529_+ncRNA_intronic
CAediting_962833chr13_45497568_+ncRNA_intronic
CAediting_962834chr13_45497582_+ncRNA_intronic
CAediting_962835chr13_45497741_+ncRNA_intronic
CAediting_962836chr13_45507645_+ncRNA_intronic
CAediting_962837chr13_45507814_+ncRNA_intronic
CAediting_962838chr13_45507884_+ncRNA_intronic
CAediting_962839chr13_45507903_+ncRNA_intronic
CAediting_962840chr13_45507909_+ncRNA_intronic
CAediting_962841chr13_45507918_+ncRNA_intronic
CAediting_962842chr13_45507919_+ncRNA_intronic
CAediting_962843chr13_45507922_+ncRNA_intronic
CAediting_962844chr13_45507938_+ncRNA_intronic
CAediting_962845chr13_45507941_+ncRNA_intronic
CAediting_962846chr13_45507962_+ncRNA_intronic
CAediting_962847chr13_45507984_+ncRNA_intronic
CAediting_962848chr13_45509169_+ncRNA_intronic
CAediting_962849chr13_45516231_+exonic
CAediting_962850chr13_45516235_+exonic
CAediting_962851chr13_45516236_+exonic
CAediting_962852chr13_45518300_+intronic
CAediting_962853chr13_45518304_+intronic
CAediting_962854chr13_45518311_+intronic
CAediting_962855chr13_45518316_+intronic
CAediting_962856chr13_45518317_+intronic
CAediting_962857chr13_45520017_+intronic
CAediting_962858chr13_45520023_+intronic
CAediting_962859chr13_45520024_+intronic
CAediting_962860chr13_45520050_+intronic
CAediting_962861chr13_45520101_+intronic
CAediting_962862chr13_45520102_+intronic
CAediting_962863chr13_45520106_+intronic
CAediting_962864chr13_45520110_+intronic
CAediting_962865chr13_45520123_+intronic
CAediting_962866chr13_45520126_+intronic
CAediting_962867chr13_45520127_+intronic
CAediting_962868chr13_45520128_+intronic
CAediting_962869chr13_45520130_+intronic
CAediting_962870chr13_45520142_+intronic
CAediting_962871chr13_45520152_+intronic
CAediting_962872chr13_45520166_+intronic
CAediting_962873chr13_45520174_+intronic
CAediting_962874chr13_45520178_+intronic
CAediting_962875chr13_45520199_+intronic
CAediting_962876chr13_45520209_+intronic
CAediting_962877chr13_45520217_+intronic
CAediting_962878chr13_45520229_+intronic
CAediting_962879chr13_45520233_+intronic
CAediting_962880chr13_45520237_+intronic
CAediting_962881chr13_45520238_+intronic
CAediting_962882chr13_45520243_+intronic
CAediting_962883chr13_45520253_+intronic
CAediting_962884chr13_45520258_+intronic
CAediting_962885chr13_45520272_+intronic
CAediting_962886chr13_45521063_+intronic
CAediting_962887chr13_45521116_+intronic
CAediting_962888chr13_45521877_+intronic
CAediting_962889chr13_45521907_+intronic
CAediting_962890chr13_45521937_+intronic
CAediting_962891chr13_45532687_+intronic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_962806chr13_45466302_+SINEAluAluSx1
CAediting_962807chr13_45467337_+SINEAluAluSz6
CAediting_962808chr13_45471222_+SINEAluAluJo
CAediting_962809chr13_45471299_+SINEAluAluJo
CAediting_962810chr13_45471376_+SINEAluAluJo
CAediting_962811chr13_45475736_+SINEAluAluJb
CAediting_962812chr13_45489076_+SINEAluAluJb
CAediting_962813chr13_45494087_+SINEAluAluSq2
CAediting_962814chr13_45494092_+SINEAluAluSq2
CAediting_962815chr13_45494164_+SINEAluAluSq2
CAediting_962816chr13_45494165_+SINEAluAluSq2
CAediting_962817chr13_45494167_+SINEAluAluSq2
CAediting_962818chr13_45494169_+SINEAluAluSq2
CAediting_962819chr13_45494178_+SINEAluAluSq2
CAediting_962820chr13_45494182_+SINEAluAluSq2
CAediting_962821chr13_45494202_+SINEAluAluSq2
CAediting_962822chr13_45494204_+SINEAluAluSq2
CAediting_962823chr13_45494205_+SINEAluAluSq2
CAediting_962824chr13_45494231_+SINEAluAluSq2
CAediting_962825chr13_45494246_+SINEAluAluSq2
CAediting_962826chr13_45494253_+SINEAluAluSq2
CAediting_962827chr13_45494270_+SINEAluAluSq2
CAediting_962828chr13_45494288_+SINEAluAluSq2
CAediting_962829chr13_45495409_+SINEAluAluJb
CAediting_962830chr13_45496459_+SINEAluAluJb
CAediting_962831chr13_45497528_+SINEAluAluJb
CAediting_962832chr13_45497529_+SINEAluAluJb
CAediting_962833chr13_45497568_+SINEAluAluJb
CAediting_962834chr13_45497582_+SINEAluAluJb
CAediting_962835chr13_45497741_+SINEAluAluJb
CAediting_962836chr13_45507645_+SINEAluAluSz6
CAediting_962837chr13_45507814_+SINEAluAluSc8
CAediting_962838chr13_45507884_+SINEAluAluSc8
CAediting_962839chr13_45507903_+SINEAluAluSc8
CAediting_962840chr13_45507909_+SINEAluAluSc8
CAediting_962841chr13_45507918_+SINEAluAluSc8
CAediting_962842chr13_45507919_+SINEAluAluSc8
CAediting_962843chr13_45507922_+SINEAluAluSc8
CAediting_962844chr13_45507938_+SINEAluAluSc8
CAediting_962845chr13_45507941_+SINEAluAluSc8
CAediting_962846chr13_45507962_+SINEAluAluSc8
CAediting_962847chr13_45507984_+SINEAluAluSc8
CAediting_962848chr13_45509169_+SINEAluAluSx4
CAediting_962857chr13_45520017_+SINEAluAluJb
CAediting_962858chr13_45520023_+SINEAluAluJb
CAediting_962859chr13_45520024_+SINEAluAluJb
CAediting_962860chr13_45520050_+SINEAluAluJb
CAediting_962861chr13_45520101_+SINEAluAluJb
CAediting_962862chr13_45520102_+SINEAluAluJb
CAediting_962863chr13_45520106_+SINEAluAluJb
CAediting_962864chr13_45520110_+SINEAluAluJb
CAediting_962865chr13_45520123_+SINEAluAluJb
CAediting_962866chr13_45520126_+SINEAluAluJb
CAediting_962867chr13_45520127_+SINEAluAluJb
CAediting_962868chr13_45520128_+SINEAluAluJb
CAediting_962869chr13_45520130_+SINEAluAluJb
CAediting_962870chr13_45520142_+SINEAluAluJb
CAediting_962871chr13_45520152_+SINEAluAluJb
CAediting_962872chr13_45520166_+SINEAluAluJb
CAediting_962873chr13_45520174_+SINEAluAluJb
CAediting_962874chr13_45520178_+SINEAluAluJb
CAediting_962875chr13_45520199_+SINEAluAluJb
CAediting_962876chr13_45520209_+SINEAluAluJb
CAediting_962877chr13_45520217_+SINEAluAluJb
CAediting_962878chr13_45520229_+SINEAluAluJb
CAediting_962879chr13_45520233_+SINEAluAluJb
CAediting_962880chr13_45520237_+SINEAluAluJb
CAediting_962881chr13_45520238_+SINEAluAluJb
CAediting_962882chr13_45520243_+SINEAluAluJb
CAediting_962883chr13_45520253_+SINEAluAluJb
CAediting_962884chr13_45520258_+SINEAluAluJb
CAediting_962885chr13_45520272_+SINEAluAluJb
CAediting_962886chr13_45521063_+SINEAluFLAM_A
CAediting_962887chr13_45521116_+SINEAluFLAM_A
CAediting_962888chr13_45521877_+SINEAluAluSz
CAediting_962889chr13_45521907_+SINEAluAluSz
CAediting_962890chr13_45521937_+SINEAluAluSz
CAediting_962891chr13_45532687_+SINEAluAluY

Top

RNA A-to-I editing events in the alternative splicing sites for COG3

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000136152.13.COG3.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000136152.13.COG3.

Top

Differntial gene expression between RNA A-to-I edited versus non-edited samples for COG3

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.
boxplot

check button Correlation between RNA A-to-I editing and gene expression.
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.
PRAD.CAediting_962851.ENSG00000136152.COG3.png
Soverview
STAD.CAediting_962851.ENSG00000136152.COG3.png
Soverview

Top

Protein coding region RNA A-to-I editings for COG3

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.
all structure


Top

The effects of the RNA editing to the miRNA binding sites for COG3

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button Differentially expressed gene-miRNA network

Top

The effects of the RNA editing to the stability of the RNA structures for COG3

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

Top

Relation with ADAR for COG3

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
BLCACAediting_962851chr13_45516236_+..8.49594688405335e-060.387979921896953..
LGGCAediting_962851chr13_45516236_+0.001907963583566650.143440089980856....
BRCACAediting_962851chr13_45516236_+..1.82226517907257e-090.219893449964708..
LIHCCAediting_962851chr13_45516236_+..0.01276113304805030.195286270246593..
LUADCAediting_962851chr13_45516236_+..0.0009470793167542360.1947952579759..
LUSCCAediting_962851chr13_45516236_+..1.8516914714808e-120.421683852667716..
GBMCAediting_962851chr13_45516236_+0.002346420953824620.2542613179187020.02217942915677120.192531814244569..
HNSCCAediting_962851chr13_45516236_+..7.61460393752488e-070.289925801352701..
STADCAediting_962851chr13_45516236_+..0.001841355464958090.300502411984016..
KIRCCAediting_962851chr13_45516236_+..9.98527939668509e-130.3213498542307..
KIRPCAediting_962851chr13_45516236_+..0.002030236671643390.259574437522516..
PAADCAediting_962851chr13_45516236_+..4.52734852054114e-090.527343629020809..
PCPGCAediting_962851chr13_45516236_+....0.003103920754076670.305099712251576
SKCMCAediting_962851chr13_45516236_+..3.45335216028695e-250.507179786964249..
MESOCAediting_962851chr13_45516236_+..0.0114840800221210.304836516123986..
SARCCAediting_962851chr13_45516236_+..3.18315197064202e-050.31599280060857..

Top

Relation with cancer stages for COG3

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.
STADpathologic_stageCAediting_962863chr13_45520106_+0.007338251855214960.303267562130564
STADpathologic_stageCAediting_962876chr13_45520209_+0.03716566562683850.205646283323722
THCApathologic_stageCAediting_962851chr13_45516236_+0.01506612366228530.178008023587346

Top

Relation with survival for COG3

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR

Top

RelatedDrugs for COG3

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for COG3

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource