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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: PUS7L (CAeditome ID:83448)

Gene summary for PUS7L

check button Gene summary
Gene informationGene symbol

PUS7L

Gene ID

83448

Gene namepseudouridine synthase 7 like
Synonyms-
Cytomap

12q12

Type of geneprotein-coding
Descriptionpseudouridylate synthase 7 homolog-like proteinpseudouridylate synthase 7 like
Modification date20210518
UniProtAcc

Q9H0K6

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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RNA A-to-I events for PUS7L

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000129317.13
boxplot

check button RNA A-to-I editing events in Cancer.
CAediting_881415(43720238, -), CAediting_881416(43720239, -), CAediting_881417(43720240, -), CAediting_881418(43720255, -), CAediting_881419(43720279, -), CAediting_881420(43720281, -), CAediting_881421(43720301, -), CAediting_881422(43720304, -), CAediting_881423(43720309, -), CAediting_881424(43720316, -), CAediting_881425(43720318, -), CAediting_881426(43720321, -), CAediting_881427(43720327, -), CAediting_881428(43720336, -), CAediting_881429(43720360, -), CAediting_881430(43720362, -), CAediting_881431(43720375, -), CAediting_881432(43720397, -), CAediting_881433(43720401, -), CAediting_881434(43720402, -), CAediting_881435(43720422, -), CAediting_881436(43720427, -), CAediting_881437(43720437, -), CAediting_881438(43720440, -), CAediting_881439(43720457, -), CAediting_881440(43720462, -), CAediting_881441(43720489, -), CAediting_881442(43725460, -), CAediting_881443(43725462, -), CAediting_881444(43725469, -), CAediting_881445(43725488, -), CAediting_881446(43725492, -), CAediting_881447(43725505, -), CAediting_881448(43725512, -), CAediting_881449(43725513, -), CAediting_881450(43725521, -), CAediting_881451(43725531, -), CAediting_881452(43725544, -), CAediting_881453(43725553, -), CAediting_881454(43725557, -), CAediting_881455(43725562, -), CAediting_881456(43725565, -), CAediting_881457(43725566, -), CAediting_881458(43725567, -), CAediting_881459(43725568, -), CAediting_881460(43725571, -), CAediting_881461(43725582, -), CAediting_881462(43725583, -), CAediting_881463(43725584, -), CAediting_881464(43725590, -), CAediting_881465(43725592, -), CAediting_881466(43725602, -), CAediting_881467(43725605, -), CAediting_881468(43725607, -), CAediting_881469(43725608, -), CAediting_881470(43725616, -), CAediting_881471(43725624, -), CAediting_881472(43725654, -), CAediting_881473(43725655, -), CAediting_881474(43725661, -), CAediting_881475(43725679, -), CAediting_881476(43725683, -), CAediting_881477(43726549, -), CAediting_881478(43726555, -), CAediting_881479(43726565, -), CAediting_881480(43726571, -), CAediting_881481(43726574, -), CAediting_881482(43726577, -), CAediting_881483(43726583, -), CAediting_881484(43726585, -), CAediting_881485(43726587, -), CAediting_881486(43726610, -), CAediting_881487(43726616, -), CAediting_881488(43726623, -), CAediting_881489(43726624, -), CAediting_881490(43726625, -), CAediting_881491(43726636, -), CAediting_881492(43726648, -), CAediting_881493(43726662, -), CAediting_881494(43726665, -), CAediting_881495(43726680, -), CAediting_881496(43726745, -), CAediting_881497(43726746, -), CAediting_881498(43726765, -), CAediting_881499(43726771, -), CAediting_881500(43726806, -), CAediting_881501(43726820, -), CAediting_881502(43726826, -), CAediting_881503(43727099, -), CAediting_881504(43727105, -), CAediting_881505(43727247, -), CAediting_881506(43727328, -), CAediting_881507(43727331, -), CAediting_881508(43727403, -), CAediting_881509(43727481, -),

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RNA editing positional annotations for PUS7L using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_881415chr12_43720238_-UTR3
CAediting_881416chr12_43720239_-UTR3
CAediting_881417chr12_43720240_-UTR3
CAediting_881418chr12_43720255_-UTR3
CAediting_881419chr12_43720279_-UTR3
CAediting_881420chr12_43720281_-UTR3
CAediting_881421chr12_43720301_-UTR3
CAediting_881422chr12_43720304_-UTR3
CAediting_881423chr12_43720309_-UTR3
CAediting_881424chr12_43720316_-UTR3
CAediting_881425chr12_43720318_-UTR3
CAediting_881426chr12_43720321_-UTR3
CAediting_881427chr12_43720327_-UTR3
CAediting_881428chr12_43720336_-UTR3
CAediting_881429chr12_43720360_-UTR3
CAediting_881430chr12_43720362_-UTR3
CAediting_881431chr12_43720375_-UTR3
CAediting_881432chr12_43720397_-UTR3
CAediting_881433chr12_43720401_-UTR3
CAediting_881434chr12_43720402_-UTR3
CAediting_881435chr12_43720422_-UTR3
CAediting_881436chr12_43720427_-UTR3
CAediting_881437chr12_43720437_-UTR3
CAediting_881438chr12_43720440_-UTR3
CAediting_881439chr12_43720457_-UTR3
CAediting_881440chr12_43720462_-UTR3
CAediting_881441chr12_43720489_-UTR3
CAediting_881442chr12_43725460_-UTR3
CAediting_881443chr12_43725462_-UTR3
CAediting_881444chr12_43725469_-UTR3
CAediting_881445chr12_43725488_-UTR3
CAediting_881446chr12_43725492_-UTR3
CAediting_881447chr12_43725505_-UTR3
CAediting_881448chr12_43725512_-UTR3
CAediting_881449chr12_43725513_-UTR3
CAediting_881450chr12_43725521_-UTR3
CAediting_881451chr12_43725531_-UTR3
CAediting_881452chr12_43725544_-UTR3
CAediting_881453chr12_43725553_-UTR3
CAediting_881454chr12_43725557_-UTR3
CAediting_881455chr12_43725562_-UTR3
CAediting_881456chr12_43725565_-UTR3
CAediting_881457chr12_43725566_-UTR3
CAediting_881458chr12_43725567_-UTR3
CAediting_881459chr12_43725568_-UTR3
CAediting_881460chr12_43725571_-UTR3
CAediting_881461chr12_43725582_-UTR3
CAediting_881462chr12_43725583_-UTR3
CAediting_881463chr12_43725584_-UTR3
CAediting_881464chr12_43725590_-UTR3
CAediting_881465chr12_43725592_-UTR3
CAediting_881466chr12_43725602_-UTR3
CAediting_881467chr12_43725605_-UTR3
CAediting_881468chr12_43725607_-UTR3
CAediting_881469chr12_43725608_-UTR3
CAediting_881470chr12_43725616_-UTR3
CAediting_881471chr12_43725624_-UTR3
CAediting_881472chr12_43725654_-UTR3
CAediting_881473chr12_43725655_-UTR3
CAediting_881474chr12_43725661_-UTR3
CAediting_881475chr12_43725679_-UTR3
CAediting_881476chr12_43725683_-UTR3
CAediting_881477chr12_43726549_-UTR3
CAediting_881478chr12_43726555_-UTR3
CAediting_881479chr12_43726565_-UTR3
CAediting_881480chr12_43726571_-UTR3
CAediting_881481chr12_43726574_-UTR3
CAediting_881482chr12_43726577_-UTR3
CAediting_881483chr12_43726583_-UTR3
CAediting_881484chr12_43726585_-UTR3
CAediting_881485chr12_43726587_-UTR3
CAediting_881486chr12_43726610_-UTR3
CAediting_881487chr12_43726616_-UTR3
CAediting_881488chr12_43726623_-UTR3
CAediting_881489chr12_43726624_-UTR3
CAediting_881490chr12_43726625_-UTR3
CAediting_881491chr12_43726636_-UTR3
CAediting_881492chr12_43726648_-UTR3
CAediting_881493chr12_43726662_-UTR3
CAediting_881494chr12_43726665_-UTR3
CAediting_881495chr12_43726680_-UTR3
CAediting_881496chr12_43726745_-UTR3
CAediting_881497chr12_43726746_-UTR3
CAediting_881498chr12_43726765_-UTR3
CAediting_881499chr12_43726771_-UTR3
CAediting_881500chr12_43726806_-UTR3
CAediting_881501chr12_43726820_-UTR3
CAediting_881502chr12_43726826_-UTR3
CAediting_881503chr12_43727099_-UTR3
CAediting_881504chr12_43727105_-UTR3
CAediting_881505chr12_43727247_-UTR3
CAediting_881506chr12_43727328_-UTR3
CAediting_881507chr12_43727331_-UTR3
CAediting_881508chr12_43727403_-UTR3
CAediting_881509chr12_43727481_-UTR3

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_881415chr12_43720238_-SINEAluAluSz
CAediting_881416chr12_43720239_-SINEAluAluSz
CAediting_881417chr12_43720240_-SINEAluAluSz
CAediting_881418chr12_43720255_-SINEAluAluSz
CAediting_881419chr12_43720279_-SINEAluAluSz
CAediting_881420chr12_43720281_-SINEAluAluSz
CAediting_881421chr12_43720301_-SINEAluAluSz
CAediting_881422chr12_43720304_-SINEAluAluSz
CAediting_881423chr12_43720309_-SINEAluAluSz
CAediting_881424chr12_43720316_-SINEAluAluSz
CAediting_881425chr12_43720318_-SINEAluAluSz
CAediting_881426chr12_43720321_-SINEAluAluSz
CAediting_881427chr12_43720327_-SINEAluAluSz
CAediting_881428chr12_43720336_-SINEAluAluSz
CAediting_881429chr12_43720360_-SINEAluAluSz
CAediting_881430chr12_43720362_-SINEAluAluSz
CAediting_881431chr12_43720375_-SINEAluAluSz
CAediting_881432chr12_43720397_-SINEAluAluSz
CAediting_881433chr12_43720401_-SINEAluAluSz
CAediting_881434chr12_43720402_-SINEAluAluSz
CAediting_881435chr12_43720422_-SINEAluAluSz
CAediting_881436chr12_43720427_-SINEAluAluSz
CAediting_881437chr12_43720437_-SINEAluAluSz
CAediting_881438chr12_43720440_-SINEAluAluSz
CAediting_881439chr12_43720457_-SINEAluAluSz
CAediting_881440chr12_43720462_-SINEAluAluSz
CAediting_881441chr12_43720489_-SINEAluAluSz
CAediting_881442chr12_43725460_-SINEAluAluSg4
CAediting_881443chr12_43725462_-SINEAluAluSg4
CAediting_881444chr12_43725469_-SINEAluAluSg4
CAediting_881445chr12_43725488_-SINEAluAluSg4
CAediting_881446chr12_43725492_-SINEAluAluSg4
CAediting_881447chr12_43725505_-SINEAluAluSg4
CAediting_881448chr12_43725512_-SINEAluAluSg4
CAediting_881449chr12_43725513_-SINEAluAluSg4
CAediting_881450chr12_43725521_-SINEAluAluSg4
CAediting_881451chr12_43725531_-SINEAluAluSg4
CAediting_881452chr12_43725544_-SINEAluAluSg4
CAediting_881453chr12_43725553_-SINEAluAluSg4
CAediting_881454chr12_43725557_-SINEAluAluSg4
CAediting_881455chr12_43725562_-SINEAluAluSg4
CAediting_881456chr12_43725565_-SINEAluAluSg4
CAediting_881457chr12_43725566_-SINEAluAluSg4
CAediting_881458chr12_43725567_-SINEAluAluSg4
CAediting_881459chr12_43725568_-SINEAluAluSg4
CAediting_881460chr12_43725571_-SINEAluAluSg4
CAediting_881461chr12_43725582_-SINEAluAluSg4
CAediting_881462chr12_43725583_-SINEAluAluSg4
CAediting_881463chr12_43725584_-SINEAluAluSg4
CAediting_881464chr12_43725590_-SINEAluAluSg4
CAediting_881465chr12_43725592_-SINEAluAluSg4
CAediting_881466chr12_43725602_-SINEAluAluSg4
CAediting_881467chr12_43725605_-SINEAluAluSg4
CAediting_881468chr12_43725607_-SINEAluAluSg4
CAediting_881469chr12_43725608_-SINEAluAluSg4
CAediting_881470chr12_43725616_-SINEAluAluSg4
CAediting_881471chr12_43725624_-SINEAluAluSg4
CAediting_881472chr12_43725654_-SINEAluAluSg4
CAediting_881473chr12_43725655_-SINEAluAluSg4
CAediting_881474chr12_43725661_-SINEAluAluSg4
CAediting_881475chr12_43725679_-SINEAluAluSg4
CAediting_881476chr12_43725683_-SINEAluAluSg4
CAediting_881477chr12_43726549_-SINEAluAluSx1
CAediting_881478chr12_43726555_-SINEAluAluSx1
CAediting_881479chr12_43726565_-SINEAluAluSx1
CAediting_881480chr12_43726571_-SINEAluAluSx1
CAediting_881481chr12_43726574_-SINEAluAluSx1
CAediting_881482chr12_43726577_-SINEAluAluSx1
CAediting_881483chr12_43726583_-SINEAluAluSx1
CAediting_881484chr12_43726585_-SINEAluAluSx1
CAediting_881485chr12_43726587_-SINEAluAluSx1
CAediting_881486chr12_43726610_-SINEAluAluSx1
CAediting_881487chr12_43726616_-SINEAluAluSx1
CAediting_881488chr12_43726623_-SINEAluAluSx1
CAediting_881489chr12_43726624_-SINEAluAluSx1
CAediting_881490chr12_43726625_-SINEAluAluSx1
CAediting_881491chr12_43726636_-SINEAluAluSx1
CAediting_881492chr12_43726648_-SINEAluAluSx1
CAediting_881493chr12_43726662_-SINEAluAluSx1
CAediting_881494chr12_43726665_-SINEAluAluSx1
CAediting_881495chr12_43726680_-SINEAluAluSx1
CAediting_881496chr12_43726745_-SINEAluAluSx1
CAediting_881497chr12_43726746_-SINEAluAluSx1
CAediting_881498chr12_43726765_-SINEAluAluSx1
CAediting_881499chr12_43726771_-SINEAluAluSx1
CAediting_881500chr12_43726806_-SINEAluAluSx1
CAediting_881501chr12_43726820_-SINEAluAluSx1
CAediting_881502chr12_43726826_-SINEAluAluSx1
CAediting_881503chr12_43727099_-LINEL1L1PA15
CAediting_881504chr12_43727105_-LINEL1L1PA15
CAediting_881505chr12_43727247_-LINEL1L1PA15
CAediting_881506chr12_43727328_-LINEL1L1PA15
CAediting_881507chr12_43727331_-LINEL1L1PA15
CAediting_881508chr12_43727403_-LINEL1L1PA15
CAediting_881509chr12_43727481_-LINEL1L1PA15

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RNA A-to-I editing events in the alternative splicing sites for PUS7L

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000129317.13.PUS7L.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000129317.13.PUS7L.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for PUS7L

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.
boxplot

check button Correlation between RNA A-to-I editing and gene expression.
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for PUS7L

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for PUS7L

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_393chr1_1167164_+ENSG00000129317.13ENST00000416848hsa-miR-200b-3p43729167437291748mer-1a4372916743729190143-12.26
CAediting_1160181chr17_7017644_-ENSG00000129317.13ENST00000416848hsa-miR-195-3p43728844437288507mer-m84372884343728863155-16.51
CAediting_1160181chr17_7017644_-ENSG00000129317.13ENST00000416848hsa-miR-195-3p43729541437295477mer-m84372954043729559145-14.16
CAediting_1368054chr19_46709310_-ENSG00000129317.13ENST00000416848hsa-miR-320e43730022437300287mer-m84373002143730040147-16.17
CAediting_117844chr1_162342605_+ENSG00000129317.13ENST00000416848hsa-miR-556-3p43728627437286348mer-1a4372862743728647148-10.36
CAediting_77128chr1_85133844_+ENSG00000129317.13ENST00000416848hsa-miR-4423-3p43729535437295417mer-m84372953443729554142-13.6
CAediting_604450chr7_133034877_-ENSG00000129317.13ENST00000416848hsa-miR-365443729170437291778mer-1a4372917043729193141-18.71
CAediting_1160181chr17_7017644_-ENSG00000129317.13ENST00000551923hsa-miR-195-3p43729541437295477mer-m84372954043729559145-14.16
CAediting_1368054chr19_46709310_-ENSG00000129317.13ENST00000551923hsa-miR-320e43730022437300287mer-m84373002143730040147-16.17
CAediting_77128chr1_85133844_+ENSG00000129317.13ENST00000551923hsa-miR-4423-3p43729535437295417mer-m84372953443729554142-13.6
CAediting_1368054chr19_46709310_-ENSG00000129317.13ENST00000431332hsa-miR-320e43730022437300287mer-m84373002143730040147-16.17

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_1351755chr19_40282625_-ENSG00000129317.13ENST00000416848hsa-miR-64143730310437303178mer-1a4373031043730329141-14.28
CAediting_1351755chr19_40282625_-ENSG00000129317.13ENST00000551923hsa-miR-64143730310437303178mer-1a4373031043730329141-14.28
CAediting_1351755chr19_40282625_-ENSG00000129317.13ENST00000431332hsa-miR-64143730310437303178mer-1a4373031043730329141-14.28

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for PUS7L

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for PUS7L

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
LGGCAediting_881433chr12_43720401_-0.01174202228735460.237349085107333....
BRCACAediting_881433chr12_43720401_-..0.009876487652299390.15648793708059..
LGGCAediting_881434chr12_43720402_-0.00282357978908930.294205958155172....
BRCACAediting_881482chr12_43726577_-0.009039149539536470.256048857912957....

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Relation with cancer stages for PUS7L

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.
BLCApathologic_stageCAediting_881433chr12_43720401_-0.0341465804200490.297254562390521
THCApathologic_stageCAediting_881434chr12_43720402_-0.006191366389991260.265515198692534

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Relation with survival for PUS7L

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR

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RelatedDrugs for PUS7L

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PUS7L

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource