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Editing gene: AXIN1 (CAeditome ID:8312)

Gene summary for AXIN1

Gene summary

Gene information	Gene symbol	AXIN1
	Gene ID	8312
	Gene name	axin 1
	Synonyms	AXIN\|PPP1R49
	Cytomap	16p13.3
	Type of gene	protein-coding
	Description	axin-1axis inhibition protein 1axis inhibitor 1fused, mouse, homolog ofprotein phosphatase 1, regulatory subunit 49
	Modification date	20210518
	UniProtAcc	O15169
	Context	- 33811251(Evaluation of AXIN1 and AXIN2 as targets of tankyrase inhibition in hepatocellular carcinoma cell lines)

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
AXIN1	GO:0008013	Axin-1	10644691
AXIN1	GO:0060090	Axin-1	9601641
AXIN1	GO:0060090	Axin-1	9601641
AXIN1	GO:0001934	Axin-1	9601641
AXIN1	GO:0032147	Axin-1	9601641
AXIN1	GO:0034622	Axin-1	16601693
AXIN1	GO:0045732	Axin-1	9601641
AXIN1	GO:0090090	Axin-1	10644691
AXIN1	GO:0005634	Axin-1	12072559
AXIN1	GO:0005634	Axin-1	21383061
AXIN1	GO:0005737	Axin-1	12072559
AXIN1	GO:0005737	Axin-1	17569865
AXIN1	GO:0005737	Axin-1	21383061
AXIN1	GO:0016328	Axin-1	12072559
AXIN1	GO:0048471	Axin-1	19038973
AXIN1	GO:0071944	Axin-1	19038973
AXIN1	GO:0030877	Axin-1	16188939
AXIN1	GO:0030877	Axin-1	16188939
AXIN1	GO:0030877	Axin-1	19759537
AXIN1	GO:0030877	Axin-1	9601641

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RNA A-to-I events for AXIN1

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000103126.13

RNA A-to-I editing events in Cancer.

CAediting_1076698(291878, -), CAediting_1076699(295269, -), CAediting_1076700(295276, -), CAediting_1076701(295279, -), CAediting_1076702(299490, -), CAediting_1076703(299534, -), CAediting_1076704(300051, -), CAediting_1076705(300055, -), CAediting_1076706(300068, -), CAediting_1076707(300077, -), CAediting_1076708(300169, -), CAediting_1076709(300193, -), CAediting_1076710(300221, -), CAediting_1076711(300303, -), CAediting_1076712(300310, -), CAediting_1076713(300337, -), CAediting_1076714(300353, -), CAediting_1076715(300399, -), CAediting_1076716(300401, -), CAediting_1076717(300403, -), CAediting_1076718(300418, -), CAediting_1076719(300423, -), CAediting_1076720(300427, -), CAediting_1076721(300443, -), CAediting_1076722(300444, -), CAediting_1076723(300446, -), CAediting_1076724(300448, -), CAediting_1076725(300450, -), CAediting_1076726(300451, -), CAediting_1076727(300479, -), CAediting_1076728(300481, -), CAediting_1076729(300491, -), CAediting_1076730(300500, -), CAediting_1076731(301027, -), CAediting_1076732(301556, -), CAediting_1076733(301573, -), CAediting_1076734(301597, -), CAediting_1076735(301603, -), CAediting_1076736(301625, -), CAediting_1076737(302986, -), CAediting_1076738(304565, -), CAediting_1076739(304603, -), CAediting_1076740(304618, -), CAediting_1076741(304620, -), CAediting_1076742(304663, -), CAediting_1076743(304667, -), CAediting_1076744(304673, -), CAediting_1076745(304679, -), CAediting_1076746(304695, -), CAediting_1076747(304699, -), CAediting_1076748(304708, -), CAediting_1076749(304713, -), CAediting_1076750(304736, -), CAediting_1076751(304738, -), CAediting_1076752(304739, -), CAediting_1076753(304767, -), CAediting_1076754(304802, -), CAediting_1076755(304808, -), CAediting_1076756(304814, -), CAediting_1076757(305222, -), CAediting_1076758(305223, -), CAediting_1076759(305224, -), CAediting_1076760(305246, -), CAediting_1076761(305247, -), CAediting_1076762(305251, -), CAediting_1076763(305296, -), CAediting_1076764(305301, -), CAediting_1076765(305346, -), CAediting_1076766(305351, -), CAediting_1076767(305352, -), CAediting_1076768(305358, -), CAediting_1076769(305362, -), CAediting_1076770(305370, -), CAediting_1076771(305375, -), CAediting_1076772(305432, -), CAediting_1076773(305438, -), CAediting_1076774(305462, -), CAediting_1076775(305676, -), CAediting_1076776(305943, -), CAediting_1076777(305945, -), CAediting_1076778(309218, -), CAediting_1076779(311236, -), CAediting_1076780(328293, -), CAediting_1076781(329019, -), CAediting_1076782(344198, -), CAediting_1076783(344626, -), CAediting_1076784(344627, -), CAediting_1076785(350062, -),

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RNA editing positional annotations for AXIN1 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_1076698	chr16_291878_-	ncRNA_exonic
CAediting_1076699	chr16_295269_-	ncRNA_intronic
CAediting_1076700	chr16_295276_-	ncRNA_intronic
CAediting_1076701	chr16_295279_-	ncRNA_intronic
CAediting_1076702	chr16_299490_-	ncRNA_intronic
CAediting_1076703	chr16_299534_-	ncRNA_intronic
CAediting_1076704	chr16_300051_-	ncRNA_intronic
CAediting_1076705	chr16_300055_-	ncRNA_intronic
CAediting_1076706	chr16_300068_-	ncRNA_intronic
CAediting_1076707	chr16_300077_-	ncRNA_intronic
CAediting_1076708	chr16_300169_-	ncRNA_intronic
CAediting_1076709	chr16_300193_-	ncRNA_intronic
CAediting_1076710	chr16_300221_-	ncRNA_intronic
CAediting_1076711	chr16_300303_-	ncRNA_intronic
CAediting_1076712	chr16_300310_-	ncRNA_intronic
CAediting_1076713	chr16_300337_-	ncRNA_intronic
CAediting_1076714	chr16_300353_-	ncRNA_intronic
CAediting_1076715	chr16_300399_-	ncRNA_intronic
CAediting_1076716	chr16_300401_-	ncRNA_intronic
CAediting_1076717	chr16_300403_-	ncRNA_intronic
CAediting_1076718	chr16_300418_-	ncRNA_intronic
CAediting_1076719	chr16_300423_-	ncRNA_intronic
CAediting_1076720	chr16_300427_-	ncRNA_intronic
CAediting_1076721	chr16_300443_-	ncRNA_intronic
CAediting_1076722	chr16_300444_-	ncRNA_intronic
CAediting_1076723	chr16_300446_-	ncRNA_intronic
CAediting_1076724	chr16_300448_-	ncRNA_intronic
CAediting_1076725	chr16_300450_-	ncRNA_intronic
CAediting_1076726	chr16_300451_-	ncRNA_intronic
CAediting_1076727	chr16_300479_-	ncRNA_intronic
CAediting_1076728	chr16_300481_-	ncRNA_intronic
CAediting_1076729	chr16_300491_-	ncRNA_intronic
CAediting_1076730	chr16_300500_-	ncRNA_intronic
CAediting_1076731	chr16_301027_-	ncRNA_intronic
CAediting_1076732	chr16_301556_-	ncRNA_intronic
CAediting_1076733	chr16_301573_-	ncRNA_intronic
CAediting_1076734	chr16_301597_-	ncRNA_intronic
CAediting_1076735	chr16_301603_-	ncRNA_intronic
CAediting_1076736	chr16_301625_-	ncRNA_intronic
CAediting_1076737	chr16_302986_-	ncRNA_intronic
CAediting_1076738	chr16_304565_-	ncRNA_intronic
CAediting_1076739	chr16_304603_-	ncRNA_intronic
CAediting_1076740	chr16_304618_-	ncRNA_intronic
CAediting_1076741	chr16_304620_-	ncRNA_intronic
CAediting_1076742	chr16_304663_-	ncRNA_intronic
CAediting_1076743	chr16_304667_-	ncRNA_intronic
CAediting_1076744	chr16_304673_-	ncRNA_intronic
CAediting_1076745	chr16_304679_-	ncRNA_intronic
CAediting_1076746	chr16_304695_-	ncRNA_intronic
CAediting_1076747	chr16_304699_-	ncRNA_intronic
CAediting_1076748	chr16_304708_-	ncRNA_intronic
CAediting_1076749	chr16_304713_-	ncRNA_intronic
CAediting_1076750	chr16_304736_-	ncRNA_intronic
CAediting_1076751	chr16_304738_-	ncRNA_intronic
CAediting_1076752	chr16_304739_-	ncRNA_intronic
CAediting_1076753	chr16_304767_-	ncRNA_intronic
CAediting_1076754	chr16_304802_-	ncRNA_intronic
CAediting_1076755	chr16_304808_-	ncRNA_intronic
CAediting_1076756	chr16_304814_-	ncRNA_intronic
CAediting_1076757	chr16_305222_-	ncRNA_intronic
CAediting_1076758	chr16_305223_-	ncRNA_intronic
CAediting_1076759	chr16_305224_-	ncRNA_intronic
CAediting_1076760	chr16_305246_-	ncRNA_intronic
CAediting_1076761	chr16_305247_-	ncRNA_intronic
CAediting_1076762	chr16_305251_-	ncRNA_intronic
CAediting_1076763	chr16_305296_-	ncRNA_intronic
CAediting_1076764	chr16_305301_-	ncRNA_intronic
CAediting_1076765	chr16_305346_-	ncRNA_intronic
CAediting_1076766	chr16_305351_-	ncRNA_intronic
CAediting_1076767	chr16_305352_-	ncRNA_intronic
CAediting_1076768	chr16_305358_-	ncRNA_intronic
CAediting_1076769	chr16_305362_-	ncRNA_intronic
CAediting_1076770	chr16_305370_-	ncRNA_intronic
CAediting_1076771	chr16_305375_-	ncRNA_intronic
CAediting_1076772	chr16_305432_-	ncRNA_intronic
CAediting_1076773	chr16_305438_-	ncRNA_intronic
CAediting_1076774	chr16_305462_-	ncRNA_intronic
CAediting_1076775	chr16_305676_-	ncRNA_intronic
CAediting_1076776	chr16_305943_-	ncRNA_intronic
CAediting_1076777	chr16_305945_-	ncRNA_intronic
CAediting_1076778	chr16_309218_-	ncRNA_intronic
CAediting_1076779	chr16_311236_-	ncRNA_intronic
CAediting_1076780	chr16_328293_-	ncRNA_intronic
CAediting_1076781	chr16_329019_-	ncRNA_intronic
CAediting_1076782	chr16_344198_-	ncRNA_intronic
CAediting_1076783	chr16_344626_-	ncRNA_intronic
CAediting_1076784	chr16_344627_-	ncRNA_intronic
CAediting_1076785	chr16_350062_-	ncRNA_intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_1076699	chr16_295269_-	SINE	Alu	AluSq2
CAediting_1076700	chr16_295276_-	SINE	Alu	AluSq2
CAediting_1076701	chr16_295279_-	SINE	Alu	AluSq2
CAediting_1076702	chr16_299490_-	SINE	Alu	AluSx
CAediting_1076703	chr16_299534_-	SINE	Alu	AluSx
CAediting_1076704	chr16_300051_-	SINE	Alu	AluSq2
CAediting_1076705	chr16_300055_-	SINE	Alu	AluSq2
CAediting_1076706	chr16_300068_-	SINE	Alu	AluSq2
CAediting_1076707	chr16_300077_-	SINE	Alu	AluSq2
CAediting_1076708	chr16_300169_-	SINE	Alu	AluSq2
CAediting_1076709	chr16_300193_-	SINE	Alu	AluSq2
CAediting_1076710	chr16_300221_-	SINE	Alu	AluSq2
CAediting_1076711	chr16_300303_-	SINE	Alu	AluJb
CAediting_1076712	chr16_300310_-	SINE	Alu	AluJb
CAediting_1076713	chr16_300337_-	SINE	Alu	AluJb
CAediting_1076714	chr16_300353_-	SINE	Alu	AluJb
CAediting_1076715	chr16_300399_-	SINE	Alu	AluJb
CAediting_1076716	chr16_300401_-	SINE	Alu	AluJb
CAediting_1076717	chr16_300403_-	SINE	Alu	AluJb
CAediting_1076718	chr16_300418_-	SINE	Alu	AluJb
CAediting_1076719	chr16_300423_-	SINE	Alu	AluJb
CAediting_1076720	chr16_300427_-	SINE	Alu	AluJb
CAediting_1076721	chr16_300443_-	SINE	Alu	AluJb
CAediting_1076722	chr16_300444_-	SINE	Alu	AluJb
CAediting_1076723	chr16_300446_-	SINE	Alu	AluJb
CAediting_1076724	chr16_300448_-	SINE	Alu	AluJb
CAediting_1076725	chr16_300450_-	SINE	Alu	AluJb
CAediting_1076726	chr16_300451_-	SINE	Alu	AluJb
CAediting_1076727	chr16_300479_-	SINE	Alu	AluJb
CAediting_1076728	chr16_300481_-	SINE	Alu	AluJb
CAediting_1076729	chr16_300491_-	SINE	Alu	AluJb
CAediting_1076731	chr16_301027_-	SINE	Alu	AluY
CAediting_1076732	chr16_301556_-	SINE	Alu	AluJr
CAediting_1076733	chr16_301573_-	SINE	Alu	AluJr
CAediting_1076734	chr16_301597_-	SINE	Alu	AluJr
CAediting_1076735	chr16_301603_-	SINE	Alu	AluJr
CAediting_1076736	chr16_301625_-	SINE	Alu	AluJr
CAediting_1076737	chr16_302986_-	SINE	Alu	AluJb
CAediting_1076738	chr16_304565_-	SINE	Alu	AluSx1
CAediting_1076739	chr16_304603_-	SINE	Alu	AluSx1
CAediting_1076740	chr16_304618_-	SINE	Alu	AluSx1
CAediting_1076741	chr16_304620_-	SINE	Alu	AluSx1
CAediting_1076742	chr16_304663_-	SINE	Alu	AluSx1
CAediting_1076743	chr16_304667_-	SINE	Alu	AluSx1
CAediting_1076744	chr16_304673_-	SINE	Alu	AluSx1
CAediting_1076745	chr16_304679_-	SINE	Alu	AluSx1
CAediting_1076746	chr16_304695_-	SINE	Alu	AluSx1
CAediting_1076747	chr16_304699_-	SINE	Alu	AluSx1
CAediting_1076748	chr16_304708_-	SINE	Alu	AluSx1
CAediting_1076749	chr16_304713_-	SINE	Alu	AluSx1
CAediting_1076750	chr16_304736_-	SINE	Alu	AluSx1
CAediting_1076751	chr16_304738_-	SINE	Alu	AluSx1
CAediting_1076752	chr16_304739_-	SINE	Alu	AluSx1
CAediting_1076753	chr16_304767_-	SINE	Alu	AluSx1
CAediting_1076754	chr16_304802_-	SINE	Alu	AluSx1
CAediting_1076755	chr16_304808_-	SINE	Alu	AluSx1
CAediting_1076756	chr16_304814_-	SINE	Alu	AluSx1
CAediting_1076757	chr16_305222_-	SINE	Alu	AluJb
CAediting_1076758	chr16_305223_-	SINE	Alu	AluJb
CAediting_1076759	chr16_305224_-	SINE	Alu	AluJb
CAediting_1076760	chr16_305246_-	SINE	Alu	AluJb
CAediting_1076761	chr16_305247_-	SINE	Alu	AluJb
CAediting_1076762	chr16_305251_-	SINE	Alu	AluJb
CAediting_1076763	chr16_305296_-	SINE	Alu	AluJb
CAediting_1076764	chr16_305301_-	SINE	Alu	AluJb
CAediting_1076765	chr16_305346_-	SINE	Alu	AluJb
CAediting_1076766	chr16_305351_-	SINE	Alu	AluJb
CAediting_1076767	chr16_305352_-	SINE	Alu	AluJb
CAediting_1076768	chr16_305358_-	SINE	Alu	AluJb
CAediting_1076769	chr16_305362_-	SINE	Alu	AluJb
CAediting_1076770	chr16_305370_-	SINE	Alu	AluJb
CAediting_1076771	chr16_305375_-	SINE	Alu	AluJb
CAediting_1076772	chr16_305432_-	SINE	Alu	AluJb
CAediting_1076773	chr16_305438_-	SINE	Alu	AluJb
CAediting_1076774	chr16_305462_-	SINE	Alu	AluJb
CAediting_1076775	chr16_305676_-	SINE	Alu	AluY
CAediting_1076776	chr16_305943_-	SINE	Alu	FLAM_C
CAediting_1076777	chr16_305945_-	SINE	Alu	FLAM_C
CAediting_1076778	chr16_309218_-	SINE	Alu	AluY
CAediting_1076779	chr16_311236_-	SINE	Alu	AluY
CAediting_1076780	chr16_328293_-	SINE	Alu	AluJb
CAediting_1076781	chr16_329019_-	SINE	Alu	AluSg
CAediting_1076782	chr16_344198_-	SINE	Alu	AluY
CAediting_1076783	chr16_344626_-	SINE	Alu	AluSq2
CAediting_1076784	chr16_344627_-	SINE	Alu	AluSq2
CAediting_1076785	chr16_350062_-	SINE	Alu	AluJb

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RNA A-to-I editing events in the alternative splicing sites for AXIN1

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000103126.13.AXIN1.

Correlation between RNA A-to-I editing and PSI for ENSG00000103126.13.AXIN1.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for AXIN1

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for AXIN1

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for AXIN1

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1524209	chrX_134546392_-	ENSG00000103126.13	ENST00000262320	hsa-miR-503-5p	287848	287854	7mer-1a	287848	287868	146	-25.09
CAediting_1524209	chrX_134546392_-	ENSG00000103126.13	ENST00000354866	hsa-miR-503-5p	287848	287854	7mer-1a	287848	287868	146	-25.09

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1054808	chr15_66496985_-	ENSG00000103126.13	ENST00000262320	hsa-miR-4512	288084	288090	7mer-m8	288083	288106	154	-21.28
CAediting_468389	chr6_31355314_-	ENSG00000103126.13	ENST00000262320	hsa-miR-6891-5p	287588	287594	7mer-m8	287587	287605	141	-19.89
CAediting_1054808	chr15_66496985_-	ENSG00000103126.13	ENST00000354866	hsa-miR-4512	288084	288090	7mer-m8	288083	288106	154	-21.28
CAediting_468389	chr6_31355314_-	ENSG00000103126.13	ENST00000354866	hsa-miR-6891-5p	287588	287594	7mer-m8	287587	287605	141	-19.89

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for AXIN1

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for AXIN1

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for AXIN1

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for AXIN1

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for AXIN1

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for AXIN1

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
AXIN1	C2239176	Liver carcinoma	2	CGI;CTD_human;UNIPROT
AXIN1	C0279607	Adult Hepatocellular Carcinoma	1	ORPHANET

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene