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Editing gene: SLIRP (CAeditome ID:81892)

Gene summary for SLIRP

Gene summary

Gene information	Gene symbol	SLIRP
	Gene ID	81892
	Gene name	SRA stem-loop interacting RNA binding protein
	Synonyms	C14orf156\|DC50\|PD04872
	Cytomap	14q24.3
	Type of gene	protein-coding
	Description	SRA stem-loop-interacting RNA-binding protein, mitochondrial
	Modification date	20210518
	UniProtAcc	Q9GZT3
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
SLIRP	GO:0005739	SRA stem-loop-interacting RNA-binding protein, mitochondrial	0000052

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RNA A-to-I events for SLIRP

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000119705.8

RNA A-to-I editing events in Cancer.

CAediting_1008282(77714193, +), CAediting_1008283(77716043, +), CAediting_1008284(77716061, +), CAediting_1008285(77716067, +), CAediting_1008286(77716138, +), CAediting_1008287(77716139, +), CAediting_1008288(77716169, +), CAediting_1008289(77716195, +), CAediting_1008290(77716201, +), CAediting_1008291(77716212, +), CAediting_1008292(77716391, +), CAediting_1008293(77716392, +), CAediting_1008294(77716397, +), CAediting_1008295(77716431, +), CAediting_1008296(77716433, +), CAediting_1008297(77716471, +), CAediting_1008298(77716472, +), CAediting_1008299(77716496, +), CAediting_1008300(77716504, +), CAediting_1008301(77716536, +), CAediting_1008302(77716544, +), CAediting_1008303(77716547, +), CAediting_1008304(77716549, +), CAediting_1008305(77716557, +), CAediting_1008306(77716560, +), CAediting_1008307(77716567, +), CAediting_1008308(77716574, +), CAediting_1008309(77716583, +), CAediting_1008310(77716587, +), CAediting_1008311(77716592, +), CAediting_1008312(77716593, +), CAediting_1008313(77716810, +), CAediting_1008314(77716825, +), CAediting_1008315(77716826, +), CAediting_1008316(77716836, +), CAediting_1008317(77716862, +), CAediting_1008318(77716879, +), CAediting_1008319(77716888, +), CAediting_1008320(77716901, +), CAediting_1008321(77716907, +), CAediting_1008322(77716914, +), CAediting_1008323(77716917, +), CAediting_1008324(77716939, +), CAediting_1008325(77716945, +), CAediting_1008326(77716948, +), CAediting_1008327(77716950, +), CAediting_1008328(77716965, +), CAediting_1008329(77716974, +), CAediting_1008330(77716985, +), CAediting_1008331(77716987, +), CAediting_1008332(77717012, +), CAediting_1008333(77717027, +), CAediting_1008334(77717039, +), CAediting_1008335(77717041, +), CAediting_1008336(77717177, +), CAediting_1008337(77717209, +), CAediting_1008338(77717223, +), CAediting_1008339(77717226, +), CAediting_1008340(77717240, +), CAediting_1008341(77717248, +), CAediting_1008342(77717249, +), CAediting_1008343(77717250, +), CAediting_1008344(77717262, +), CAediting_1008345(77717264, +), CAediting_1008346(77717271, +),

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RNA editing positional annotations for SLIRP using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_1008282	chr14_77714193_+	ncRNA_intronic
CAediting_1008283	chr14_77716043_+	ncRNA_intronic
CAediting_1008284	chr14_77716061_+	ncRNA_intronic
CAediting_1008285	chr14_77716067_+	ncRNA_intronic
CAediting_1008286	chr14_77716138_+	ncRNA_intronic
CAediting_1008287	chr14_77716139_+	ncRNA_intronic
CAediting_1008288	chr14_77716169_+	ncRNA_intronic
CAediting_1008289	chr14_77716195_+	ncRNA_intronic
CAediting_1008290	chr14_77716201_+	ncRNA_intronic
CAediting_1008291	chr14_77716212_+	ncRNA_intronic
CAediting_1008292	chr14_77716391_+	ncRNA_intronic
CAediting_1008293	chr14_77716392_+	ncRNA_intronic
CAediting_1008294	chr14_77716397_+	ncRNA_intronic
CAediting_1008295	chr14_77716431_+	ncRNA_intronic
CAediting_1008296	chr14_77716433_+	ncRNA_intronic
CAediting_1008297	chr14_77716471_+	ncRNA_intronic
CAediting_1008298	chr14_77716472_+	ncRNA_intronic
CAediting_1008299	chr14_77716496_+	ncRNA_intronic
CAediting_1008300	chr14_77716504_+	ncRNA_intronic
CAediting_1008301	chr14_77716536_+	ncRNA_intronic
CAediting_1008302	chr14_77716544_+	ncRNA_intronic
CAediting_1008303	chr14_77716547_+	ncRNA_intronic
CAediting_1008304	chr14_77716549_+	ncRNA_intronic
CAediting_1008305	chr14_77716557_+	ncRNA_intronic
CAediting_1008306	chr14_77716560_+	ncRNA_intronic
CAediting_1008307	chr14_77716567_+	ncRNA_intronic
CAediting_1008308	chr14_77716574_+	ncRNA_intronic
CAediting_1008309	chr14_77716583_+	ncRNA_intronic
CAediting_1008310	chr14_77716587_+	ncRNA_intronic
CAediting_1008311	chr14_77716592_+	ncRNA_intronic
CAediting_1008312	chr14_77716593_+	ncRNA_intronic
CAediting_1008313	chr14_77716810_+	ncRNA_intronic
CAediting_1008314	chr14_77716825_+	ncRNA_intronic
CAediting_1008315	chr14_77716826_+	ncRNA_intronic
CAediting_1008316	chr14_77716836_+	ncRNA_intronic
CAediting_1008317	chr14_77716862_+	ncRNA_intronic
CAediting_1008318	chr14_77716879_+	ncRNA_intronic
CAediting_1008319	chr14_77716888_+	ncRNA_intronic
CAediting_1008320	chr14_77716901_+	ncRNA_intronic
CAediting_1008321	chr14_77716907_+	ncRNA_intronic
CAediting_1008322	chr14_77716914_+	ncRNA_intronic
CAediting_1008323	chr14_77716917_+	ncRNA_intronic
CAediting_1008324	chr14_77716939_+	ncRNA_intronic
CAediting_1008325	chr14_77716945_+	ncRNA_intronic
CAediting_1008326	chr14_77716948_+	ncRNA_intronic
CAediting_1008327	chr14_77716950_+	ncRNA_intronic
CAediting_1008328	chr14_77716965_+	ncRNA_intronic
CAediting_1008329	chr14_77716974_+	ncRNA_intronic
CAediting_1008330	chr14_77716985_+	ncRNA_intronic
CAediting_1008331	chr14_77716987_+	ncRNA_intronic
CAediting_1008332	chr14_77717012_+	ncRNA_intronic
CAediting_1008333	chr14_77717027_+	ncRNA_intronic
CAediting_1008334	chr14_77717039_+	ncRNA_intronic
CAediting_1008335	chr14_77717041_+	ncRNA_intronic
CAediting_1008336	chr14_77717177_+	ncRNA_intronic
CAediting_1008337	chr14_77717209_+	ncRNA_intronic
CAediting_1008338	chr14_77717223_+	ncRNA_intronic
CAediting_1008339	chr14_77717226_+	ncRNA_intronic
CAediting_1008340	chr14_77717240_+	ncRNA_intronic
CAediting_1008341	chr14_77717248_+	ncRNA_intronic
CAediting_1008342	chr14_77717249_+	ncRNA_intronic
CAediting_1008343	chr14_77717250_+	ncRNA_intronic
CAediting_1008344	chr14_77717262_+	ncRNA_intronic
CAediting_1008345	chr14_77717264_+	ncRNA_intronic
CAediting_1008346	chr14_77717271_+	ncRNA_intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_1008282	chr14_77714193_+	SINE	Alu	AluJb
CAediting_1008283	chr14_77716043_+	SINE	Alu	AluYe5
CAediting_1008284	chr14_77716061_+	SINE	Alu	AluYe5
CAediting_1008285	chr14_77716067_+	SINE	Alu	AluYe5
CAediting_1008286	chr14_77716138_+	SINE	Alu	AluYe5
CAediting_1008287	chr14_77716139_+	SINE	Alu	AluYe5
CAediting_1008288	chr14_77716169_+	SINE	Alu	AluYe5
CAediting_1008289	chr14_77716195_+	SINE	Alu	AluYe5
CAediting_1008290	chr14_77716201_+	SINE	Alu	AluYe5
CAediting_1008291	chr14_77716212_+	SINE	Alu	AluYe5
CAediting_1008292	chr14_77716391_+	SINE	Alu	AluSp
CAediting_1008293	chr14_77716392_+	SINE	Alu	AluSp
CAediting_1008294	chr14_77716397_+	SINE	Alu	AluSp
CAediting_1008295	chr14_77716431_+	SINE	Alu	AluSp
CAediting_1008296	chr14_77716433_+	SINE	Alu	AluSp
CAediting_1008297	chr14_77716471_+	SINE	Alu	AluSp
CAediting_1008298	chr14_77716472_+	SINE	Alu	AluSp
CAediting_1008299	chr14_77716496_+	SINE	Alu	AluSp
CAediting_1008300	chr14_77716504_+	SINE	Alu	AluSp
CAediting_1008301	chr14_77716536_+	SINE	Alu	AluSp
CAediting_1008302	chr14_77716544_+	SINE	Alu	AluSp
CAediting_1008303	chr14_77716547_+	SINE	Alu	AluSp
CAediting_1008304	chr14_77716549_+	SINE	Alu	AluSp
CAediting_1008305	chr14_77716557_+	SINE	Alu	AluSp
CAediting_1008306	chr14_77716560_+	SINE	Alu	AluSp
CAediting_1008307	chr14_77716567_+	SINE	Alu	AluSp
CAediting_1008308	chr14_77716574_+	SINE	Alu	AluSp
CAediting_1008309	chr14_77716583_+	SINE	Alu	AluSp
CAediting_1008310	chr14_77716587_+	SINE	Alu	AluSp
CAediting_1008311	chr14_77716592_+	SINE	Alu	AluSp
CAediting_1008312	chr14_77716593_+	SINE	Alu	AluSp
CAediting_1008313	chr14_77716810_+	SINE	Alu	AluSq2
CAediting_1008314	chr14_77716825_+	SINE	Alu	AluSq2
CAediting_1008315	chr14_77716826_+	SINE	Alu	AluSq2
CAediting_1008316	chr14_77716836_+	SINE	Alu	AluSq2
CAediting_1008317	chr14_77716862_+	SINE	Alu	AluSq2
CAediting_1008318	chr14_77716879_+	SINE	Alu	AluSq2
CAediting_1008319	chr14_77716888_+	SINE	Alu	AluSq2
CAediting_1008320	chr14_77716901_+	SINE	Alu	AluSq2
CAediting_1008321	chr14_77716907_+	SINE	Alu	AluSq2
CAediting_1008322	chr14_77716914_+	SINE	Alu	AluSq2
CAediting_1008323	chr14_77716917_+	SINE	Alu	AluSq2
CAediting_1008324	chr14_77716939_+	SINE	Alu	AluSq2
CAediting_1008325	chr14_77716945_+	SINE	Alu	AluSq2
CAediting_1008326	chr14_77716948_+	SINE	Alu	AluSq2
CAediting_1008327	chr14_77716950_+	SINE	Alu	AluSq2
CAediting_1008328	chr14_77716965_+	SINE	Alu	AluSq2
CAediting_1008329	chr14_77716974_+	SINE	Alu	AluSq2
CAediting_1008330	chr14_77716985_+	SINE	Alu	AluSq2
CAediting_1008331	chr14_77716987_+	SINE	Alu	AluSq2
CAediting_1008332	chr14_77717012_+	SINE	Alu	AluSq2
CAediting_1008333	chr14_77717027_+	SINE	Alu	AluSq2
CAediting_1008334	chr14_77717039_+	SINE	Alu	AluSq2
CAediting_1008335	chr14_77717041_+	SINE	Alu	AluSq2
CAediting_1008336	chr14_77717177_+	SINE	Alu	AluJr4
CAediting_1008337	chr14_77717209_+	SINE	Alu	AluJr4
CAediting_1008338	chr14_77717223_+	SINE	Alu	AluJr4
CAediting_1008339	chr14_77717226_+	SINE	Alu	AluJr4
CAediting_1008340	chr14_77717240_+	SINE	Alu	AluJr4
CAediting_1008341	chr14_77717248_+	SINE	Alu	AluJr4
CAediting_1008342	chr14_77717249_+	SINE	Alu	AluJr4
CAediting_1008343	chr14_77717250_+	SINE	Alu	AluJr4
CAediting_1008344	chr14_77717262_+	SINE	Alu	AluJr4
CAediting_1008345	chr14_77717264_+	SINE	Alu	AluJr4
CAediting_1008346	chr14_77717271_+	SINE	Alu	AluJr4

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RNA A-to-I editing events in the alternative splicing sites for SLIRP

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000119705.8.SLIRP.

Correlation between RNA A-to-I editing and PSI for ENSG00000119705.8.SLIRP.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for SLIRP

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

TGCT.CAediting_1008315.ENSG00000119705.SLIRP.png
Soverview

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Protein coding region RNA A-to-I editings for SLIRP

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for SLIRP

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1008284	chr14_77716061_+	ENSG00000119705.8	ENST00000556831	hsa-miR-513a-5p	77716055	77716061	7mer-m8	77716045	77716062	144.00	-16.68
CAediting_1008284	chr14_77716061_+	ENSG00000119705.8	ENST00000556831	hsa-miR-513a-5p	77716055	77716061	7mer-m8	77716045	77716062	144.00	-16.68
CAediting_1008284	chr14_77716061_+	ENSG00000119705.8	ENST00000556831	hsa-miR-638	77716060	77716066	7mer-1a	77716042	77716066	159.00	-35.56
CAediting_1008285	chr14_77716067_+	ENSG00000119705.8	ENST00000556831	hsa-miR-371a-3p	77716065	77716071	7mer-m8	77716050	77716072	145.00	-17.36
CAediting_1008287	chr14_77716139_+	ENSG00000119705.8	ENST00000556831	hsa-miR-412-3p	77716132	77716138	7mer-m8	77716117	77716139	151.00	-19.78
CAediting_1008287	chr14_77716139_+	ENSG00000119705.8	ENST00000556831	hsa-miR-4508	77716137	77716143	7mer-m8	77716129	77716144	141.00	-24.29
CAediting_1008287	chr14_77716139_+	ENSG00000119705.8	ENST00000556831	hsa-miR-6754-3p	77716132	77716138	7mer-m8	77716119	77716139	146.00	-16.46
CAediting_1008288	chr14_77716169_+	ENSG00000119705.8	ENST00000556831	hsa-miR-1972	77716167	77716173	7mer-m8	77716153	77716174	141.00	-18.06
CAediting_1008288	chr14_77716169_+	ENSG00000119705.8	ENST00000556831	hsa-miR-1972	77716167	77716173	7mer-m8	77716153	77716174	141.00	-18.06
CAediting_1008289	chr14_77716195_+	ENSG00000119705.8	ENST00000556831	hsa-miR-140-3p	77716190	77716196	7mer-m8	77716177	77716197	147.00	-22.25
CAediting_1008283	chr14_77716043_+	ENSG00000119705.8	ENST00000556831	hsa-miR-1292-3p	77716038	77716044	7mer-m8	77716026	77716045	159.00	-32.84
CAediting_1008286	chr14_77716138_+	ENSG00000119705.8	ENST00000556831	hsa-miR-1229-3p	77716132	77716138	7mer-m8	77716117	77716139	140.00	-13.50
CAediting_1008291	chr14_77716212_+	ENSG00000119705.8	ENST00000556831	hsa-miR-3943	77716209	77716215	7mer-m8	77716196	77716216	150.00	-22.28

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1008284	chr14_77716061_+	ENSG00000119705.8	ENST00000556831	hsa-miR-10399-5p	77716056	77716062	7mer-m8	77716042	77716063	144	-11.21
CAediting_1008286	chr14_77716138_+	ENSG00000119705.8	ENST00000556831	hsa-miR-193b-5p	77716136	77716142	7mer-m8	77716122	77716143	142	-17.8
CAediting_1008287	chr14_77716139_+	ENSG00000119705.8	ENST00000556831	hsa-miR-193b-5p	77716136	77716142	7mer-m8	77716122	77716143	142	-17.8
CAediting_1008288	chr14_77716169_+	ENSG00000119705.8	ENST00000556831	hsa-miR-4735-5p	77716163	77716169	7mer-m8	77716149	77716170	140	-4.28
CAediting_1008285	chr14_77716067_+	ENSG00000119705.8	ENST00000556831	hsa-miR-5089-5p	77716060	77716066	7mer-m8	77716045	77716067	148	-14.13
CAediting_1008285	chr14_77716067_+	ENSG00000119705.8	ENST00000556831	hsa-miR-512-3p	77716065	77716071	7mer-m8	77716051	77716072	149	-15.51
CAediting_1008285	chr14_77716067_+	ENSG00000119705.8	ENST00000556831	hsa-miR-512-3p	77716065	77716071	7mer-m8	77716051	77716072	149	-15.51
CAediting_1008284	chr14_77716061_+	ENSG00000119705.8	ENST00000556831	hsa-miR-6504-3p	77716056	77716062	7mer-m8	77716042	77716063	148	-14.35
CAediting_1008285	chr14_77716067_+	ENSG00000119705.8	ENST00000556831	hsa-miR-6506-5p	77716061	77716067	7mer-m8	77716046	77716068	144	-13.78
CAediting_1008291	chr14_77716212_+	ENSG00000119705.8	ENST00000556831	hsa-miR-6778-3p	77716208	77716214	7mer-m8	77716196	77716215	141	-15.45
CAediting_1008284	chr14_77716061_+	ENSG00000119705.8	ENST00000556831	hsa-miR-7151-3p	77716054	77716061	8mer-1a	77716041	77716061	144	-16.51
CAediting_1008289	chr14_77716195_+	ENSG00000119705.8	ENST00000556831	hsa-miR-7151-3p	77716188	77716194	7mer-m8	77716175	77716195	140	-16.5
CAediting_1008289	chr14_77716195_+	ENSG00000119705.8	ENST00000556831	hsa-miR-8052	77716194	77716200	7mer-1a	77716180	77716200	141	-23.11

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_846604	chr11_93733708_-	ENSG00000119705.8	ENST00000556831	hsa-miR-1304-3p	77716298	77716304	7mer-1a	77716283	77716304	144	-21.32
CAediting_228905	chr2_188297554_+	ENSG00000119705.8	ENST00000557623	hsa-miR-561-3p	77720857	77720863	7mer-m8	77720843	77720864	143	-7.91
CAediting_1368054	chr19_46709310_-	ENSG00000119705.8	ENST00000556310	hsa-miR-320e	77733971	77733978	8mer-1a	77733961	77733978	152	-12.92

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for SLIRP

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for SLIRP

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for SLIRP

Correlation between Cancer stages and RNA editing frequency

Cancer	Stage_type	CAeditomID	position	P-val	Coeff.
BRCA	pathologic_stage	CAediting_1008340	chr14_77717240_+	0.0327434247895733	0.253744163344941

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Relation with survival for SLIRP

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for SLIRP

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for SLIRP

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene