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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: SHARPIN (CAeditome ID:81858)

Gene summary for SHARPIN

check button Gene summary
Gene informationGene symbol

SHARPIN

Gene ID

81858

Gene nameSHANK associated RH domain interactor
SynonymsSIPL1
Cytomap

8q24.3

Type of geneprotein-coding
DescriptionsharpinhSIPL1shank-associated RH domain-interacting proteinshank-interacting protein-like 1
Modification date20210531
UniProtAcc

Q9H0F6

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
SHARPIN

GO:0031593

Sharpin

21455173

SHARPIN

GO:0031593

Sharpin

21455181

SHARPIN

GO:0010803

Sharpin

21455173

SHARPIN

GO:0043123

Sharpin

21455173

SHARPIN

GO:0097039

Sharpin

21455173

SHARPIN

GO:0097039

Sharpin

21455180

SHARPIN

GO:0097039

Sharpin

21455181

SHARPIN

GO:2000348

Sharpin

21455173

SHARPIN

GO:0005829

Sharpin

20179993

SHARPIN

GO:0071797

Sharpin

21455173

SHARPIN

GO:0071797

Sharpin

21455180

SHARPIN

GO:0071797

Sharpin

21455181

SHARPIN

GO:0071797

Sharpin

24726323

SHARPIN

GO:0071797

Sharpin

27523608


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RNA A-to-I events for SHARPIN

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000179526.15
boxplot

check button RNA A-to-I editing events in Cancer.
CAediting_670776(144100893, -), CAediting_670777(144100898, -), CAediting_670778(144100901, -), CAediting_670779(144100925, -), CAediting_670780(144100928, -), CAediting_670781(144100942, -), CAediting_670782(144100951, -), CAediting_670783(144100960, -), CAediting_670784(144100973, -), CAediting_670785(144101000, -), CAediting_670786(144101005, -), CAediting_670787(144101008, -), CAediting_670788(144101017, -), CAediting_670789(144101038, -), CAediting_670790(144101042, -), CAediting_670791(144101054, -), CAediting_670792(144101284, -), CAediting_670793(144101294, -), CAediting_670794(144101320, -), CAediting_670795(144101334, -), CAediting_670796(144101339, -), CAediting_670797(144101345, -), CAediting_670798(144101352, -), CAediting_670799(144101358, -), CAediting_670800(144101374, -), CAediting_670801(144101391, -), CAediting_670802(144101476, -), CAediting_670803(144101481, -), CAediting_670804(144101498, -), CAediting_670805(144101501, -), CAediting_670806(144101506, -), CAediting_670807(144101515, -), CAediting_670808(144101524, -), CAediting_670809(144101537, -), CAediting_670810(144101547, -), CAediting_670811(144101642, -), CAediting_670812(144101658, -), CAediting_670813(144101688, -), CAediting_670814(144102108, -), CAediting_670815(144102121, -), CAediting_670816(144102130, -), CAediting_670817(144102143, -), CAediting_670818(144102160, -), CAediting_670819(144102168, -), CAediting_670820(144102173, -), CAediting_670821(144102177, -), CAediting_670822(144102178, -), CAediting_670823(144102189, -), CAediting_670824(144102204, -), CAediting_670825(144102208, -), CAediting_670826(144102222, -), CAediting_670827(144102223, -), CAediting_670828(144102266, -), CAediting_670829(144102331, -), CAediting_670830(144102339, -), CAediting_670831(144102341, -), CAediting_670832(144102346, -), CAediting_670833(144102359, -), CAediting_670834(144102375, -), CAediting_670835(144102402, -), CAediting_670836(144102434, -), CAediting_670837(144102438, -), CAediting_670838(144102474, -), CAediting_670839(144102501, -), CAediting_670840(144102523, -), CAediting_670841(144102545, -), CAediting_670842(144102546, -),

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RNA editing positional annotations for SHARPIN using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_670776chr8_144100893_-ncRNA_intronic
CAediting_670777chr8_144100898_-ncRNA_intronic
CAediting_670778chr8_144100901_-ncRNA_intronic
CAediting_670779chr8_144100925_-ncRNA_intronic
CAediting_670780chr8_144100928_-ncRNA_intronic
CAediting_670781chr8_144100942_-ncRNA_intronic
CAediting_670782chr8_144100951_-ncRNA_intronic
CAediting_670783chr8_144100960_-ncRNA_intronic
CAediting_670784chr8_144100973_-ncRNA_intronic
CAediting_670785chr8_144101000_-ncRNA_intronic
CAediting_670786chr8_144101005_-ncRNA_intronic
CAediting_670787chr8_144101008_-ncRNA_intronic
CAediting_670788chr8_144101017_-ncRNA_intronic
CAediting_670789chr8_144101038_-ncRNA_intronic
CAediting_670790chr8_144101042_-ncRNA_intronic
CAediting_670791chr8_144101054_-ncRNA_intronic
CAediting_670792chr8_144101284_-ncRNA_intronic
CAediting_670793chr8_144101294_-ncRNA_intronic
CAediting_670794chr8_144101320_-ncRNA_intronic
CAediting_670795chr8_144101334_-ncRNA_intronic
CAediting_670796chr8_144101339_-ncRNA_intronic
CAediting_670797chr8_144101345_-ncRNA_intronic
CAediting_670798chr8_144101352_-ncRNA_intronic
CAediting_670799chr8_144101358_-ncRNA_intronic
CAediting_670800chr8_144101374_-ncRNA_intronic
CAediting_670801chr8_144101391_-ncRNA_intronic
CAediting_670802chr8_144101476_-ncRNA_intronic
CAediting_670803chr8_144101481_-ncRNA_intronic
CAediting_670804chr8_144101498_-ncRNA_intronic
CAediting_670805chr8_144101501_-ncRNA_intronic
CAediting_670806chr8_144101506_-ncRNA_intronic
CAediting_670807chr8_144101515_-ncRNA_intronic
CAediting_670808chr8_144101524_-ncRNA_intronic
CAediting_670809chr8_144101537_-ncRNA_intronic
CAediting_670810chr8_144101547_-ncRNA_intronic
CAediting_670811chr8_144101642_-ncRNA_intronic
CAediting_670812chr8_144101658_-ncRNA_intronic
CAediting_670813chr8_144101688_-ncRNA_intronic
CAediting_670814chr8_144102108_-ncRNA_intronic
CAediting_670815chr8_144102121_-ncRNA_intronic
CAediting_670816chr8_144102130_-ncRNA_intronic
CAediting_670817chr8_144102143_-ncRNA_intronic
CAediting_670818chr8_144102160_-ncRNA_intronic
CAediting_670819chr8_144102168_-ncRNA_intronic
CAediting_670820chr8_144102173_-ncRNA_intronic
CAediting_670821chr8_144102177_-ncRNA_intronic
CAediting_670822chr8_144102178_-ncRNA_intronic
CAediting_670823chr8_144102189_-ncRNA_intronic
CAediting_670824chr8_144102204_-ncRNA_intronic
CAediting_670825chr8_144102208_-ncRNA_intronic
CAediting_670826chr8_144102222_-ncRNA_intronic
CAediting_670827chr8_144102223_-ncRNA_intronic
CAediting_670828chr8_144102266_-ncRNA_intronic
CAediting_670829chr8_144102331_-ncRNA_intronic
CAediting_670830chr8_144102339_-ncRNA_intronic
CAediting_670831chr8_144102341_-ncRNA_intronic
CAediting_670832chr8_144102346_-ncRNA_intronic
CAediting_670833chr8_144102359_-ncRNA_intronic
CAediting_670834chr8_144102375_-ncRNA_intronic
CAediting_670835chr8_144102402_-ncRNA_intronic
CAediting_670836chr8_144102434_-ncRNA_intronic
CAediting_670837chr8_144102438_-ncRNA_intronic
CAediting_670838chr8_144102474_-ncRNA_intronic
CAediting_670839chr8_144102501_-ncRNA_intronic
CAediting_670840chr8_144102523_-ncRNA_intronic
CAediting_670841chr8_144102545_-ncRNA_intronic
CAediting_670842chr8_144102546_-ncRNA_intronic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_670776chr8_144100893_-SINEAluAluSp
CAediting_670777chr8_144100898_-SINEAluAluSp
CAediting_670778chr8_144100901_-SINEAluAluSp
CAediting_670779chr8_144100925_-SINEAluAluSp
CAediting_670780chr8_144100928_-SINEAluAluSp
CAediting_670781chr8_144100942_-SINEAluAluSp
CAediting_670782chr8_144100951_-SINEAluAluSp
CAediting_670783chr8_144100960_-SINEAluAluSp
CAediting_670784chr8_144100973_-SINEAluAluSp
CAediting_670785chr8_144101000_-SINEAluAluSp
CAediting_670786chr8_144101005_-SINEAluAluSp
CAediting_670787chr8_144101008_-SINEAluAluSp
CAediting_670788chr8_144101017_-SINEAluAluSp
CAediting_670789chr8_144101038_-SINEAluAluSp
CAediting_670790chr8_144101042_-SINEAluAluSp
CAediting_670791chr8_144101054_-SINEAluAluSp
CAediting_670792chr8_144101284_-SINEAluAluJr
CAediting_670793chr8_144101294_-SINEAluAluJr
CAediting_670794chr8_144101320_-SINEAluAluJr
CAediting_670795chr8_144101334_-SINEAluAluJr
CAediting_670796chr8_144101339_-SINEAluAluJr
CAediting_670797chr8_144101345_-SINEAluAluJr
CAediting_670798chr8_144101352_-SINEAluAluJr
CAediting_670799chr8_144101358_-SINEAluAluJr
CAediting_670800chr8_144101374_-SINEAluAluJr
CAediting_670801chr8_144101391_-SINEAluAluJr
CAediting_670802chr8_144101476_-SINEAluAluY
CAediting_670803chr8_144101481_-SINEAluAluY
CAediting_670804chr8_144101498_-SINEAluAluY
CAediting_670805chr8_144101501_-SINEAluAluY
CAediting_670806chr8_144101506_-SINEAluAluY
CAediting_670807chr8_144101515_-SINEAluAluY
CAediting_670808chr8_144101524_-SINEAluAluY
CAediting_670809chr8_144101537_-SINEAluAluY
CAediting_670810chr8_144101547_-SINEAluAluY
CAediting_670811chr8_144101642_-SINEAluAluY
CAediting_670812chr8_144101658_-SINEAluAluY
CAediting_670813chr8_144101688_-SINEAluAluY
CAediting_670814chr8_144102108_-SINEAluAluJo
CAediting_670815chr8_144102121_-SINEAluAluJo
CAediting_670816chr8_144102130_-SINEAluAluJo
CAediting_670817chr8_144102143_-SINEAluAluJo
CAediting_670818chr8_144102160_-SINEAluAluJo
CAediting_670819chr8_144102168_-SINEAluAluJo
CAediting_670820chr8_144102173_-SINEAluAluJo
CAediting_670821chr8_144102177_-SINEAluAluJo
CAediting_670822chr8_144102178_-SINEAluAluJo
CAediting_670823chr8_144102189_-SINEAluAluJo
CAediting_670824chr8_144102204_-SINEAluAluJo
CAediting_670825chr8_144102208_-SINEAluAluJo
CAediting_670826chr8_144102222_-SINEAluAluJo
CAediting_670827chr8_144102223_-SINEAluAluJo
CAediting_670829chr8_144102331_-SINEAluAluSx
CAediting_670830chr8_144102339_-SINEAluAluSx
CAediting_670831chr8_144102341_-SINEAluAluSx
CAediting_670832chr8_144102346_-SINEAluAluSx
CAediting_670833chr8_144102359_-SINEAluAluSx
CAediting_670834chr8_144102375_-SINEAluAluSx
CAediting_670835chr8_144102402_-SINEAluAluSx
CAediting_670836chr8_144102434_-SINEAluAluSx
CAediting_670837chr8_144102438_-SINEAluAluSx
CAediting_670838chr8_144102474_-SINEAluAluSx
CAediting_670839chr8_144102501_-SINEAluAluSx
CAediting_670840chr8_144102523_-SINEAluAluSx
CAediting_670841chr8_144102545_-SINEAluAluSx
CAediting_670842chr8_144102546_-SINEAluAluSx

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RNA A-to-I editing events in the alternative splicing sites for SHARPIN

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength
ESCAediting_670785chr8_144101000_-144100996:1441010183SS0+2iTACTAAAAATACAAAATTAGCCG-2.49TACTAAAAATACAAAATTGGCCG-10.45
MEX_1CAediting_670785chr8_144101000_-144100996:1441010183SS0+2iTACTAAAAATACAAAATTAGCCG-2.49TACTAAAAATACAAAATTGGCCG-10.45
ESCAediting_670786chr8_144101005_-144100996:1441010183SS0+7iTACTAAAAATACAAAATTAGCCG-2.49TACTAAAAATACAGAATTAGCCG-8.57
MEX_1CAediting_670786chr8_144101005_-144100996:1441010183SS0+7iTACTAAAAATACAAAATTAGCCG-2.49TACTAAAAATACAGAATTAGCCG-8.57
ESCAediting_670787chr8_144101008_-144100996:1441010183SS0+10iTACTAAAAATACAAAATTAGCCG-2.49TACTAAAAATGCAAAATTAGCCG-3.19
MEX_1CAediting_670787chr8_144101008_-144100996:1441010183SS0+10iTACTAAAAATACAAAATTAGCCG-2.49TACTAAAAATGCAAAATTAGCCG-3.19
ESCAediting_670788chr8_144101017_-144100996:1441010183SS0+19iTACTAAAAATACAAAATTAGCCG-2.49TGCTAAAAATACAAAATTAGCCG-2.1
MEX_1CAediting_670788chr8_144101017_-144100996:1441010183SS0+19iTACTAAAAATACAAAATTAGCCG-2.49TGCTAAAAATACAAAATTAGCCG-2.1

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000179526.15.SHARPIN.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000179526.15.SHARPIN.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for SHARPIN

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.
boxplot

check button Correlation between RNA A-to-I editing and gene expression.
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.
LAML.CAediting_670823.ENSG00000179526.SHARPIN.png
Soverview

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Protein coding region RNA A-to-I editings for SHARPIN

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for SHARPIN

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_1054808chr15_66496985_-ENSG00000179526.15ENST00000532536hsa-miR-45121440987371440987437mer-m8144098736144098757146-16.89
CAediting_1368054chr19_46709310_-ENSG00000179526.15ENST00000532536hsa-miR-320e1440988001440988067mer-m8144098799144098816152-18.2
CAediting_1054808chr15_66496985_-ENSG00000179526.15ENST00000398712hsa-miR-45121440987371440987437mer-m8144098736144098757146-16.89
CAediting_1054808chr15_66496985_-ENSG00000179526.15ENST00000359551hsa-miR-45121440987371440987437mer-m8144098736144098757146-16.89

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for SHARPIN

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for SHARPIN

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
BLCACAediting_670823chr8_144102189_-7.83484452283489e-090.498690316645798....
LGGCAediting_670823chr8_144102189_-0.03137789316764110.2632361680341070.009091760259384180.3164106227694160.008487399162714030.319106096254101
BRCACAediting_670823chr8_144102189_-4.98449507349188e-240.413704162955579....
CESCCAediting_670823chr8_144102189_-6.7066469854736e-070.537256036891974....
LUADCAediting_670823chr8_144102189_-0.000115038512894060.308699742775813....
COADCAediting_670823chr8_144102189_-0.009446497755628710.31963578760756....
LUSCCAediting_670823chr8_144102189_-3.06009476608115e-090.430447902947376....
PRADCAediting_670823chr8_144102189_-6.09983338930399e-050.416153654250934....
HNSCCAediting_670823chr8_144102189_-0.000625451910973590.331479518120805....
STADCAediting_670823chr8_144102189_-0.006297560774122320.233170266690225....
THCACAediting_670823chr8_144102189_-0.003418151193670050.2383622874554....
KIRPCAediting_670823chr8_144102189_-0.006511783503466360.33674607522239....
OVCAediting_670823chr8_144102189_-2.46831509778289e-050.284664027300992....
SKCMCAediting_670823chr8_144102189_-2.31114761095697e-080.581852789999204....

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Relation with cancer stages for SHARPIN

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.
BRCApathologic_stageCAediting_670828chr8_144102266_-0.04471028072732960.25798581294318
ESCApathologic_stageCAediting_670823chr8_144102189_-0.002904950608572710.341485524567185
KIRCpathologic_stageCAediting_670823chr8_144102189_-0.0008980037506181780.272876018840516
KIRPclinical_stageCAediting_670823chr8_144102189_-0.02513388444072890.31339384758246
KIRPpathologic_stageCAediting_670823chr8_144102189_-0.006028218973882620.353472057857454

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Relation with survival for SHARPIN

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR

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RelatedDrugs for SHARPIN

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SHARPIN

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource
SHARPINC0011603Dermatitis1CTD_human
SHARPINC0014457Eosinophilia1CTD_human
SHARPINC0014458Eosinophilia, Tropical1CTD_human