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![]() | Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples |
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![]() | The effects of the RNA editing to the stability of the RNA structures |
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Editing gene: ADAMTS12 (CAeditome ID:81792) |
Gene summary for ADAMTS12 |
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Gene information | Gene symbol | ADAMTS12 | Gene ID | 81792 |
Gene name | ADAM metallopeptidase with thrombospondin type 1 motif 12 | |
Synonyms | PRO4389 | |
Cytomap | 5p13.3-p13.2 | |
Type of gene | protein-coding | |
Description | A disintegrin and metalloproteinase with thrombospondin motifs 12ADAM-TS 12ADAM-TS12ADAMTS-12a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 12 | |
Modification date | 20210518 | |
UniProtAcc | P58397 | |
Context |
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Gene | GO ID | GO term | PubMed ID |
ADAMTS12 | GO:0004222 | A disintegrin and metalloproteinase with thrombospondin motifs 12 | 16611630 |
ADAMTS12 | GO:0004222 | A disintegrin and metalloproteinase with thrombospondin motifs 12 | 17895370 |
ADAMTS12 | GO:0004222 | A disintegrin and metalloproteinase with thrombospondin motifs 12 | 18485748 |
ADAMTS12 | GO:0030167 | A disintegrin and metalloproteinase with thrombospondin motifs 12 | 17895370 |
ADAMTS12 | GO:0032331 | A disintegrin and metalloproteinase with thrombospondin motifs 12 | 22247065 |
ADAMTS12 | GO:0050727 | A disintegrin and metalloproteinase with thrombospondin motifs 12 | 23019333 |
ADAMTS12 | GO:0051603 | A disintegrin and metalloproteinase with thrombospondin motifs 12 | 16611630 |
ADAMTS12 | GO:0071773 | A disintegrin and metalloproteinase with thrombospondin motifs 12 | 22247065 |
ADAMTS12 | GO:1901509 | A disintegrin and metalloproteinase with thrombospondin motifs 12 | 17895370 |
ADAMTS12 | GO:1902203 | A disintegrin and metalloproteinase with thrombospondin motifs 12 | 17895370 |
ADAMTS12 | GO:1902548 | A disintegrin and metalloproteinase with thrombospondin motifs 12 | 17895370 |
ADAMTS12 | GO:2001113 | A disintegrin and metalloproteinase with thrombospondin motifs 12 | 17895370 |
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RNA A-to-I events for ADAMTS12 |
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CAediting_400974(33606033, -), CAediting_400975(33606086, -), CAediting_400976(33621317, -), CAediting_400977(33621318, -), CAediting_400978(33666590, -), CAediting_400979(33751477, -), CAediting_400980(33792083, -), CAediting_400981(33798539, -), |
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RNA editing positional annotations for ADAMTS12 using Annovar |
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CAeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
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CAeditome ID | Position | Variant type |
CAediting_400974 | chr5_33606033_- | ncRNA_intronic |
CAediting_400975 | chr5_33606086_- | ncRNA_intronic |
CAediting_400976 | chr5_33621317_- | ncRNA_intronic |
CAediting_400977 | chr5_33621318_- | ncRNA_intronic |
CAediting_400978 | chr5_33666590_- | ncRNA_intronic |
CAediting_400979 | chr5_33751477_- | exonic |
CAediting_400980 | chr5_33792083_- | ncRNA_intronic |
CAediting_400981 | chr5_33798539_- | ncRNA_intronic |
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CAeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
CAediting_400974 | chr5_33606033_- | SINE | Alu | AluSx |
CAediting_400975 | chr5_33606086_- | SINE | Alu | AluSx |
CAediting_400976 | chr5_33621317_- | SINE | Alu | AluSg |
CAediting_400977 | chr5_33621318_- | SINE | Alu | AluSg |
CAediting_400978 | chr5_33666590_- | SINE | Alu | AluSc |
CAediting_400980 | chr5_33792083_- | SINE | Alu | AluSx1 |
CAediting_400981 | chr5_33798539_- | SINE | Alu | AluSx1 |
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RNA A-to-I editing events in the alternative splicing sites for ADAMTS12 |
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AStype | CAeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for ADAMTS12 |
![]() * The grey color means N/A. |
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Protein coding region RNA A-to-I editings for ADAMTS12 |
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The effects of the RNA editing to the miRNA binding sites for ADAMTS12 |
**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page. |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
CAediting_748296 | chr10_51299626_+ | ENSG00000151388.9 | ENST00000504830 | hsa-miR-605-3p | 33523673 | 33523679 | 7mer-m8 | 33523672 | 33523691 | 146 | -14.23 |
CAediting_688080 | chr9_63819626_+ | ENSG00000151388.9 | ENST00000504830 | hsa-miR-4477b | 33523622 | 33523628 | 7mer-m8 | 33523621 | 33523642 | 142 | -10.85 |
CAediting_1160181 | chr17_7017644_- | ENSG00000151388.9 | ENST00000504830 | hsa-miR-195-3p | 33525255 | 33525261 | 7mer-m8 | 33525254 | 33525274 | 144 | -8.41 |
CAediting_1160181 | chr17_7017644_- | ENSG00000151388.9 | ENST00000504830 | hsa-miR-195-3p | 33524826 | 33524832 | 7mer-m8 | 33524825 | 33524848 | 146 | -15.53 |
CAediting_1368054 | chr19_46709310_- | ENSG00000151388.9 | ENST00000504830 | hsa-miR-320e | 33526223 | 33526229 | 7mer-m8 | 33526222 | 33526239 | 142 | -18.86 |
CAediting_1399425 | chr20_1392958_- | ENSG00000151388.9 | ENST00000504830 | hsa-miR-6869-5p | 33523726 | 33523732 | 7mer-m8 | 33523725 | 33523746 | 144 | -15.96 |
CAediting_1399425 | chr20_1392958_- | ENSG00000151388.9 | ENST00000504830 | hsa-miR-6869-5p | 33523632 | 33523638 | 7mer-m8 | 33523631 | 33523652 | 145 | -19.39 |
CAediting_228905 | chr2_188297554_+ | ENSG00000151388.9 | ENST00000504830 | hsa-miR-561-3p | 33525544 | 33525550 | 7mer-m8 | 33525543 | 33525566 | 152 | -10.2 |
CAediting_228905 | chr2_188297554_+ | ENSG00000151388.9 | ENST00000504830 | hsa-miR-561-3p | 33523988 | 33523994 | 7mer-m8 | 33523987 | 33524010 | 153 | -14.31 |
CAediting_396018 | chr5_1062918_- | ENSG00000151388.9 | ENST00000504830 | hsa-miR-4635 | 33526832 | 33526839 | 8mer-1a | 33526832 | 33526851 | 146 | -16.65 |
CAediting_396018 | chr5_1062918_- | ENSG00000151388.9 | ENST00000504830 | hsa-miR-4635 | 33523621 | 33523627 | 7mer-m8 | 33523620 | 33523640 | 140 | -12.87 |
CAediting_468389 | chr6_31355314_- | ENSG00000151388.9 | ENST00000504830 | hsa-miR-6891-5p | 33523623 | 33523630 | 8mer-1a | 33523623 | 33523643 | 152 | -30.09 |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
CAediting_393 | chr1_1167164_+ | ENSG00000151388.9 | ENST00000504830 | hsa-miR-200b-3p | 33524654 | 33524660 | 7mer-m8 | 33524653 | 33524674 | 152 | -9.66 |
CAediting_393 | chr1_1167164_+ | ENSG00000151388.9 | ENST00000504830 | hsa-miR-200b-3p | 33523775 | 33523780 | 6mer | 33523774 | 33523793 | 144 | -10.37 |
CAediting_1368054 | chr19_46709310_- | ENSG00000151388.9 | ENST00000504830 | hsa-miR-320e | 33527075 | 33527080 | 6mer | 33527074 | 33527092 | 142 | -15.87 |
CAediting_1368054 | chr19_46709310_- | ENSG00000151388.9 | ENST00000504830 | hsa-miR-320e | 33527168 | 33527173 | 6mer | 33527167 | 33527184 | 147 | -11.74 |
CAediting_1229414 | chr17_67471546_+ | ENSG00000151388.9 | ENST00000504830 | hsa-miR-548aa | 33525220 | 33525226 | 7mer-m8 | 33525219 | 33525244 | 151 | -10.89 |
CAediting_468389 | chr6_31355314_- | ENSG00000151388.9 | ENST00000504830 | hsa-miR-6891-5p | 33524210 | 33524216 | 7mer-m8 | 33524209 | 33524226 | 143 | -17.6 |
CAediting_468389 | chr6_31355314_- | ENSG00000151388.9 | ENST00000504830 | hsa-miR-6891-5p | 33523937 | 33523942 | 6mer | 33523936 | 33523955 | 140 | -19.18 |
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The effects of the RNA editing to the stability of the RNA structures for ADAMTS12 |
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CAeditom_ID | ENST | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
CAediting_400979 | ENST00000352040.6 | chr5_33751477_- | -1644.30 | -1643.30 | -1644.30 |
CAediting_400979 | ENST00000504582.4 | chr5_33751477_- | -933.30 | -931.40 | -933.30 |
CAediting_400979 | ENST00000504830.4 | chr5_33751477_- | -2936.00 | -2935.00 | -2936.00 |
CAediting_400979 | ENST00000515401.1 | chr5_33751477_- | -341.80 | -340.80 | -341.80 |
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Relation with ADAR for ADAMTS12 |
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Cancer | CAeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
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Relation with cancer stages for ADAMTS12 |
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Cancer | Stage_type | CAeditomID | position | P-val | Coeff. |
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Relation with survival for ADAMTS12 |
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Cancer | CAeditomID | position | KMpvalue | Coxpvalue | CoxHR |
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RelatedDrugs for ADAMTS12 |
![]() (DrugBank Version 5.1.8 2021-01-03) |
Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ADAMTS12 |
![]() (DisGeNet 7.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |
ADAMTS12 | C0036341 | Schizophrenia | 1 | PSYGENET |