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![]() | Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples |
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![]() | The effects of the RNA editing to the stability of the RNA structures |
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Editing gene: TRIM8 (CAeditome ID:81603) |
Gene summary for TRIM8 |
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Gene information | Gene symbol | TRIM8 | Gene ID | 81603 |
Gene name | tripartite motif containing 8 | |
Synonyms | GERP|RNF27 | |
Cytomap | 10q24.32 | |
Type of gene | protein-coding | |
Description | E3 ubiquitin-protein ligase TRIM8RING-type E3 ubiquitin transferase TRIM8glioblastoma-expressed RING finger proteinprobable E3 ubiquitin-protein ligase TRIM8ring finger protein 27tripartite motif protein TRIM8 | |
Modification date | 20210518 | |
UniProtAcc | Q9BZR9 | |
Context |
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Gene | GO ID | GO term | PubMed ID |
TRIM8 | GO:0003713 | E3 ubiquitin-protein ligase TRIM8 | 23077300 |
TRIM8 | GO:0043123 | E3 ubiquitin-protein ligase TRIM8 | 23077300 |
TRIM8 | GO:0045087 | E3 ubiquitin-protein ligase TRIM8 | 18248090 |
TRIM8 | GO:0051091 | E3 ubiquitin-protein ligase TRIM8 | 23077300 |
TRIM8 | GO:0051092 | E3 ubiquitin-protein ligase TRIM8 | 23077300 |
TRIM8 | GO:1902187 | E3 ubiquitin-protein ligase TRIM8 | 18248090 |
TRIM8 | GO:0016605 | E3 ubiquitin-protein ligase TRIM8 | 11331580 |
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RNA A-to-I events for TRIM8 |
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CAediting_779650(102644795, +), CAediting_779651(102644826, +), CAediting_779652(102644889, +), CAediting_779653(102652933, +), CAediting_779654(102652983, +), CAediting_779655(102654225, +), CAediting_779656(102654290, +), CAediting_779657(102654333, +), CAediting_779658(102654338, +), CAediting_779659(102654341, +), |
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RNA editing positional annotations for TRIM8 using Annovar |
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CAeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
CAediting_779651 | chr10_102644826_+ | nonsynonymous SNV | ENST00000302424.10 | c.A209G | p.K70R | T | D | N |
CAediting_779652 | chr10_102644889_+ | nonsynonymous SNV | ENST00000302424.10 | c.A272G | p.H91R | T | B | D |
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CAeditome ID | Position | Variant type |
CAediting_779650 | chr10_102644795_+ | exonic |
CAediting_779651 | chr10_102644826_+ | exonic |
CAediting_779652 | chr10_102644889_+ | exonic |
CAediting_779653 | chr10_102652933_+ | ncRNA_intronic |
CAediting_779654 | chr10_102652983_+ | ncRNA_intronic |
CAediting_779655 | chr10_102654225_+ | ncRNA_intronic |
CAediting_779656 | chr10_102654290_+ | ncRNA_intronic |
CAediting_779657 | chr10_102654333_+ | ncRNA_intronic |
CAediting_779658 | chr10_102654338_+ | ncRNA_intronic |
CAediting_779659 | chr10_102654341_+ | ncRNA_intronic |
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CAeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
CAediting_779653 | chr10_102652933_+ | SINE | Alu | AluSp |
CAediting_779654 | chr10_102652983_+ | SINE | Alu | AluSp |
CAediting_779655 | chr10_102654225_+ | SINE | Alu | AluSz |
CAediting_779656 | chr10_102654290_+ | SINE | Alu | AluSz |
CAediting_779657 | chr10_102654333_+ | SINE | Alu | AluSz |
CAediting_779658 | chr10_102654338_+ | SINE | Alu | AluSz |
CAediting_779659 | chr10_102654341_+ | SINE | Alu | AluSz |
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RNA A-to-I editing events in the alternative splicing sites for TRIM8 |
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AStype | CAeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for TRIM8 |
![]() * The grey color means N/A. |
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Protein coding region RNA A-to-I editings for TRIM8 |
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The effects of the RNA editing to the miRNA binding sites for TRIM8 |
**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page. |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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The effects of the RNA editing to the stability of the RNA structures for TRIM8 |
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ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
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CAeditom_ID | ENST | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for TRIM8 |
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Cancer | CAeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
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Relation with cancer stages for TRIM8 |
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Cancer | Stage_type | CAeditomID | position | P-val | Coeff. |
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Relation with survival for TRIM8 |
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Cancer | CAeditomID | position | KMpvalue | Coxpvalue | CoxHR |
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RelatedDrugs for TRIM8 |
![]() (DrugBank Version 5.1.8 2021-01-03) |
Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TRIM8 |
![]() (DisGeNet 7.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |
TRIM8 | C0036572 | Seizures | 1 | GENOMICS_ENGLAND |
TRIM8 | C0341106 | Eosinophilic esophagitis | 1 | GENOMICS_ENGLAND |
TRIM8 | C0393706 | Early infantile epileptic encephalopathy with suppression bursts | 1 | ORPHANET |
TRIM8 | C0557874 | Global developmental delay | 1 | GENOMICS_ENGLAND |
TRIM8 | C1865349 | Ethylmalonic encephalopathy | 1 | GENOMICS_ENGLAND |
TRIM8 | C3714756 | Intellectual Disability | 1 | GENOMICS_ENGLAND |