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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: CALM2 (CAeditome ID:805)

Gene summary for CALM2

check button Gene summary
Gene informationGene symbol

CALM2

Gene ID

805

Gene namecalmodulin 2
SynonymsCALM|CALML2|CAM1|CAM3|CAMC|CAMII|CAMIII|LQT15|PHKD|PHKD2|caM
Cytomap

2p21

Type of geneprotein-coding
Descriptioncalmodulin-2Calmodulin-1Calmodulin-3LP7057 proteincalmodulin 2 (phosphorylase kinase, delta)phosphorylase kinase deltaphosphorylase kinase subunit deltaprepro-calmodulin 2
Modification date20210518
UniProtAcc

P0DP24

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
CALM2

GO:0005509

Calmodulin-2

11807546

CALM2

GO:0005509

Calmodulin-2

23040497

CALM2

GO:0005509

Calmodulin-2

26164367

CALM2

GO:0005509

Calmodulin-2

26969752

CALM2

GO:0005509

Calmodulin-2

27516456

CALM2

GO:0005509

Calmodulin-2

7607248

CALM2

GO:0005509

Calmodulin-2

8631777

CALM2

GO:0010856

Calmodulin-2

11807546

CALM2

GO:0019855

Calmodulin-2

26969752

CALM2

GO:0072542

Calmodulin-2

8631777

CALM2

GO:0010880

Calmodulin-2

20226167

CALM2

GO:0032516

Calmodulin-2

8631777

CALM2

GO:0035307

Calmodulin-2

8631777

CALM2

GO:0051343

Calmodulin-2

8631777

CALM2

GO:0051592

Calmodulin-2

7607248

CALM2

GO:0060315

Calmodulin-2

26164367

CALM2

GO:0060316

Calmodulin-2

20226167

CALM2

GO:0000922

Calmodulin-2

16760425

CALM2

GO:0005737

Calmodulin-2

27165696

CALM2

GO:0005813

Calmodulin-2

16760425

CALM2

GO:0005876

Calmodulin-2

16760425

CALM2

GO:0030017

Calmodulin-2

20226167

CALM2

GO:0032991

Calmodulin-2

19855925

CALM2

GO:0034704

Calmodulin-2

23040497

CALM2

GO:1902494

Calmodulin-2

11807546


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RNA A-to-I events for CALM2

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000143933.15

check button RNA A-to-I editing events in Cancer.
CAediting_177568(47163460, -), CAediting_177569(47163471, -), CAediting_177570(47163493, -), CAediting_177571(47163498, -), CAediting_177572(47163538, -), CAediting_177573(47163539, -), CAediting_177574(47163548, -), CAediting_177575(47163570, -), CAediting_177576(47163571, -), CAediting_177577(47163597, -), CAediting_177578(47163614, -), CAediting_177579(47163635, -), CAediting_177580(47163636, -), CAediting_177581(47163639, -), CAediting_177582(47163650, -), CAediting_177583(47163664, -), CAediting_177584(47163669, -), CAediting_177585(47163678, -), CAediting_177586(47163684, -), CAediting_177587(47163704, -), CAediting_177588(47163867, -), CAediting_177589(47163897, -), CAediting_177590(47163901, -), CAediting_177591(47163981, -), CAediting_177592(47164475, -), CAediting_177593(47164485, -), CAediting_177594(47164559, -), CAediting_177595(47164570, -), CAediting_177596(47167511, -), CAediting_177597(47167562, -), CAediting_177598(47167594, -), CAediting_177599(47167653, -), CAediting_177600(47167656, -), CAediting_177601(47167830, -), CAediting_177602(47167833, -), CAediting_177603(47167900, -), CAediting_177604(47167907, -), CAediting_177605(47167923, -), CAediting_177606(47168480, -), CAediting_177607(47168504, -), CAediting_177608(47168522, -), CAediting_177609(47168547, -), CAediting_177610(47168571, -), CAediting_177611(47168573, -), CAediting_177612(47168576, -), CAediting_177613(47168611, -), CAediting_177614(47168902, -), CAediting_177615(47168915, -), CAediting_177616(47168942, -), CAediting_177617(47168954, -), CAediting_177618(47168956, -), CAediting_177619(47168966, -), CAediting_177620(47168971, -), CAediting_177621(47169359, -), CAediting_177622(47169406, -), CAediting_177623(47174290, -),

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RNA editing positional annotations for CALM2 using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred
CAediting_177596chr2_47167511_-nonsynonymous SNVENST00000409563.4c.A140Gp.H47RD.N
CAediting_177597chr2_47167562_-nonsynonymous SNVENST00000409563.4c.A89Gp.H30RD.N

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_177568chr2_47163460_-ncRNA_exonic
CAediting_177569chr2_47163471_-ncRNA_exonic
CAediting_177570chr2_47163493_-ncRNA_exonic
CAediting_177571chr2_47163498_-ncRNA_exonic
CAediting_177572chr2_47163538_-ncRNA_exonic
CAediting_177573chr2_47163539_-ncRNA_exonic
CAediting_177574chr2_47163548_-ncRNA_exonic
CAediting_177575chr2_47163570_-ncRNA_exonic
CAediting_177576chr2_47163571_-ncRNA_exonic
CAediting_177577chr2_47163597_-ncRNA_exonic
CAediting_177578chr2_47163614_-ncRNA_exonic
CAediting_177579chr2_47163635_-ncRNA_exonic
CAediting_177580chr2_47163636_-ncRNA_exonic
CAediting_177581chr2_47163639_-ncRNA_exonic
CAediting_177582chr2_47163650_-ncRNA_exonic
CAediting_177583chr2_47163664_-ncRNA_exonic
CAediting_177584chr2_47163669_-ncRNA_exonic
CAediting_177585chr2_47163678_-ncRNA_exonic
CAediting_177586chr2_47163684_-ncRNA_exonic
CAediting_177587chr2_47163704_-ncRNA_exonic
CAediting_177588chr2_47163867_-ncRNA_exonic
CAediting_177589chr2_47163897_-ncRNA_exonic
CAediting_177590chr2_47163901_-ncRNA_exonic
CAediting_177591chr2_47163981_-ncRNA_intronic
CAediting_177592chr2_47164475_-ncRNA_intronic
CAediting_177593chr2_47164485_-ncRNA_intronic
CAediting_177594chr2_47164559_-ncRNA_intronic
CAediting_177595chr2_47164570_-ncRNA_intronic
CAediting_177596chr2_47167511_-exonic
CAediting_177597chr2_47167562_-exonic
CAediting_177598chr2_47167594_-exonic
CAediting_177599chr2_47167653_-ncRNA_intronic
CAediting_177600chr2_47167656_-ncRNA_intronic
CAediting_177601chr2_47167830_-ncRNA_intronic
CAediting_177602chr2_47167833_-ncRNA_intronic
CAediting_177603chr2_47167900_-ncRNA_intronic
CAediting_177604chr2_47167907_-ncRNA_intronic
CAediting_177605chr2_47167923_-ncRNA_intronic
CAediting_177606chr2_47168480_-ncRNA_intronic
CAediting_177607chr2_47168504_-ncRNA_intronic
CAediting_177608chr2_47168522_-ncRNA_intronic
CAediting_177609chr2_47168547_-ncRNA_intronic
CAediting_177610chr2_47168571_-ncRNA_intronic
CAediting_177611chr2_47168573_-ncRNA_intronic
CAediting_177612chr2_47168576_-ncRNA_intronic
CAediting_177613chr2_47168611_-ncRNA_intronic
CAediting_177614chr2_47168902_-ncRNA_intronic
CAediting_177615chr2_47168915_-ncRNA_intronic
CAediting_177616chr2_47168942_-ncRNA_intronic
CAediting_177617chr2_47168954_-ncRNA_intronic
CAediting_177618chr2_47168956_-ncRNA_intronic
CAediting_177619chr2_47168966_-ncRNA_intronic
CAediting_177620chr2_47168971_-ncRNA_intronic
CAediting_177621chr2_47169359_-ncRNA_intronic
CAediting_177622chr2_47169406_-ncRNA_intronic
CAediting_177623chr2_47174290_-ncRNA_intronic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_177568chr2_47163460_-SINEAluAluSp
CAediting_177569chr2_47163471_-SINEAluAluSp
CAediting_177570chr2_47163493_-SINEAluAluSp
CAediting_177571chr2_47163498_-SINEAluAluSp
CAediting_177572chr2_47163538_-SINEAluAluSp
CAediting_177573chr2_47163539_-SINEAluAluSp
CAediting_177574chr2_47163548_-SINEAluAluSp
CAediting_177575chr2_47163570_-SINEAluAluSp
CAediting_177576chr2_47163571_-SINEAluAluSp
CAediting_177577chr2_47163597_-SINEAluAluSp
CAediting_177578chr2_47163614_-SINEAluAluSp
CAediting_177579chr2_47163635_-SINEAluAluSp
CAediting_177580chr2_47163636_-SINEAluAluSp
CAediting_177581chr2_47163639_-SINEAluAluSp
CAediting_177582chr2_47163650_-SINEAluAluSp
CAediting_177583chr2_47163664_-SINEAluAluSp
CAediting_177584chr2_47163669_-SINEAluAluSp
CAediting_177585chr2_47163678_-SINEAluAluSp
CAediting_177586chr2_47163684_-SINEAluAluSp
CAediting_177587chr2_47163704_-SINEAluAluSp
CAediting_177588chr2_47163867_-SINEAluAluSx
CAediting_177589chr2_47163897_-SINEAluAluSx
CAediting_177590chr2_47163901_-SINEAluAluSx
CAediting_177591chr2_47163981_-SINEAluAluYm1
CAediting_177592chr2_47164475_-SINEAluAluSx
CAediting_177593chr2_47164485_-SINEAluAluSx
CAediting_177594chr2_47164559_-SINEAluAluSx
CAediting_177595chr2_47164570_-SINEAluAluSx
CAediting_177596chr2_47167511_-SINEAluAluSx
CAediting_177597chr2_47167562_-SINEAluAluSx
CAediting_177598chr2_47167594_-SINEAluAluSx
CAediting_177599chr2_47167653_-SINEAluAluSx
CAediting_177600chr2_47167656_-SINEAluAluSx
CAediting_177601chr2_47167830_-SINEAluFLAM_C
CAediting_177602chr2_47167833_-SINEAluFLAM_C
CAediting_177603chr2_47167900_-SINEAluFLAM_C
CAediting_177604chr2_47167907_-SINEAluFLAM_C
CAediting_177605chr2_47167923_-SINEAluFLAM_C
CAediting_177606chr2_47168480_-SINEAluAluSp
CAediting_177607chr2_47168504_-SINEAluAluSp
CAediting_177608chr2_47168522_-SINEAluAluSp
CAediting_177609chr2_47168547_-SINEAluAluSp
CAediting_177610chr2_47168571_-SINEAluAluSp
CAediting_177611chr2_47168573_-SINEAluAluSp
CAediting_177612chr2_47168576_-SINEAluAluSp
CAediting_177613chr2_47168611_-SINEAluAluSp
CAediting_177614chr2_47168902_-SINEAluAluSz
CAediting_177615chr2_47168915_-SINEAluAluSz
CAediting_177616chr2_47168942_-SINEAluAluSz
CAediting_177617chr2_47168954_-SINEAluAluSz
CAediting_177618chr2_47168956_-SINEAluAluSz
CAediting_177619chr2_47168966_-SINEAluAluSz
CAediting_177620chr2_47168971_-SINEAluAluSz
CAediting_177621chr2_47169359_-SINEAluAluJo
CAediting_177622chr2_47169406_-SINEAluAluJo
CAediting_177623chr2_47174290_-SINEAluAluJo

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RNA A-to-I editing events in the alternative splicing sites for CALM2

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000143933.15.CALM2.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000143933.15.CALM2.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for CALM2

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

check button Correlation between RNA A-to-I editing and gene expression.

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for CALM2

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for CALM2

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_1229413chr17_67471544_+ENSG00000143933.15ENST00000628793hsa-miR-548aa47160091471600977mer-m84716009047160119148-12.98
CAediting_524911chr7_5495852_-ENSG00000143933.15ENST00000628793hsa-miR-589-3p47160153471601597mer-m84716015247160175150-14.85

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for CALM2

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.
ENST00000409563.4protein_codingSoverviewSoverview
ENST00000482532.4retained_intronSoverviewSoverview

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI
CAediting_177596ENST00000409563.4chr2_47167511_--201.00-201.40-210.10
CAediting_177597ENST00000409563.4chr2_47167562_--205.00-201.40-210.10
CAediting_177598ENST00000409563.4chr2_47167594_--204.20-201.40-210.10
CAediting_177599ENST00000409563.4chr2_47167653_--205.10-201.40-210.10
CAediting_177600ENST00000409563.4chr2_47167656_--203.30-201.40-210.10
CAediting_177568ENST00000482532.4chr2_47163460_--594.40-590.60-625.10
CAediting_177569ENST00000482532.4chr2_47163471_--591.40-590.60-625.10
CAediting_177570ENST00000482532.4chr2_47163493_--591.70-590.60-625.10
CAediting_177571ENST00000482532.4chr2_47163498_--590.60-590.60-625.10
CAediting_177572ENST00000482532.4chr2_47163538_--590.80-590.60-625.10
CAediting_177573ENST00000482532.4chr2_47163539_--590.60-590.60-625.10
CAediting_177574ENST00000482532.4chr2_47163548_--591.10-590.60-625.10
CAediting_177575ENST00000482532.4chr2_47163570_--590.60-590.60-625.10
CAediting_177576ENST00000482532.4chr2_47163571_--591.60-590.60-625.10
CAediting_177577ENST00000482532.4chr2_47163597_--594.10-590.60-625.10
CAediting_177578ENST00000482532.4chr2_47163614_--590.80-590.60-625.10
CAediting_177579ENST00000482532.4chr2_47163635_--590.60-590.60-625.10
CAediting_177580ENST00000482532.4chr2_47163636_--590.30-590.60-625.10
CAediting_177581ENST00000482532.4chr2_47163639_--589.70-590.60-625.10
CAediting_177582ENST00000482532.4chr2_47163650_--590.60-590.60-625.10
CAediting_177583ENST00000482532.4chr2_47163664_--589.70-590.60-625.10
CAediting_177584ENST00000482532.4chr2_47163669_--594.60-590.60-625.10
CAediting_177585ENST00000482532.4chr2_47163678_--595.40-590.60-625.10
CAediting_177586ENST00000482532.4chr2_47163684_--593.20-590.60-625.10
CAediting_177587ENST00000482532.4chr2_47163704_--590.60-590.60-625.10
CAediting_177588ENST00000482532.4chr2_47163867_--597.20-590.60-625.10
CAediting_177589ENST00000482532.4chr2_47163897_--594.40-590.60-625.10
CAediting_177590ENST00000482532.4chr2_47163901_--589.90-590.60-625.10

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Relation with ADAR for CALM2

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)

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Relation with cancer stages for CALM2

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.

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Relation with survival for CALM2

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR

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RelatedDrugs for CALM2

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
CALM2P0DP24DB11348Calcium PhosphateCalmodulin-2 SmallMoleculeDrugapproved
CALM2P0DP24DB14481Calcium phosphate dihydrateCalmodulin-2 SmallMoleculeDrugapproved
CALM2P0DP24DB11093Calcium citrateCalmodulin-2 SmallMoleculeDrugapproved|investigational

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RelatedDiseases for CALM2

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource
CALM2C4015695LONG QT SYNDROME 156CTD_human;GENOMICS_ENGLAND;UNIPROT
CALM2C0011570Mental Depression5PSYGENET
CALM2C0011581Depressive disorder5PSYGENET
CALM2C0005586Bipolar Disorder2PSYGENET
CALM2C0035828Romano-Ward Syndrome2ORPHANET
CALM2C0006868Cannabis Abuse1CTD_human
CALM2C0006870Cannabis Dependence1CTD_human
CALM2C0009171Cocaine Abuse1CTD_human
CALM2C0018614Hashish Abuse1CTD_human
CALM2C0024809Marijuana Abuse1CTD_human
CALM2C0031391Phencyclidine Abuse1CTD_human
CALM2C0236735Cannabis-Related Disorder1CTD_human
CALM2C0236736Cocaine-Related Disorders1CTD_human
CALM2C0236742Phencyclidine-Related Disorders1CTD_human
CALM2C0588008Severe depression1PSYGENET
CALM2C0600427Cocaine Dependence1CTD_human
CALM2C1142166Brugada Syndrome (disorder)1ORPHANET
CALM2C1631597VENTRICULAR TACHYCARDIA, CATECHOLAMINERGIC POLYMORPHIC, 1 (disorder)1ORPHANET