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Editing gene: STAM (CAeditome ID:8027)

Gene summary for STAM

Gene summary

Gene information	Gene symbol	STAM
	Gene ID	8027
	Gene name	signal transducing adaptor molecule
	Synonyms	STAM-1\|STAM1
	Cytomap	10p12.33
	Type of gene	protein-coding
	Description	signal transducing adapter molecule 1HSE1 homologsignal transducing adaptor molecule (SH3 domain and ITAM motif) 1
	Modification date	20210518
	UniProtAcc	Q92783
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
STAM	GO:0043231	Signal transducing adapter molecule 1	0000052
STAM	GO:0033565	Signal transducing adapter molecule 1	24790097

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RNA A-to-I events for STAM

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000136738.13

RNA A-to-I editing events in Cancer.

CAediting_732942(17649145, +), CAediting_732943(17649335, +), CAediting_732944(17656147, +), CAediting_732945(17656200, +), CAediting_732946(17659538, +), CAediting_732947(17660706, +), CAediting_732948(17675308, +), CAediting_732949(17675328, +), CAediting_732950(17686339, +), CAediting_732951(17686430, +), CAediting_732952(17686441, +), CAediting_732953(17686446, +), CAediting_732954(17686451, +), CAediting_732955(17686476, +), CAediting_732956(17686516, +), CAediting_732957(17686518, +), CAediting_732958(17686551, +), CAediting_732959(17686557, +), CAediting_732960(17686560, +), CAediting_732961(17686574, +), CAediting_732962(17686577, +), CAediting_732963(17686589, +), CAediting_732964(17686594, +), CAediting_732965(17686617, +), CAediting_732966(17686624, +), CAediting_732967(17686637, +), CAediting_732968(17686639, +), CAediting_732969(17686651, +), CAediting_732970(17686653, +), CAediting_732971(17686660, +), CAediting_732972(17687201, +), CAediting_732973(17687220, +), CAediting_732974(17687228, +), CAediting_732975(17687252, +), CAediting_732976(17687265, +), CAediting_732977(17687273, +), CAediting_732978(17687274, +), CAediting_732979(17687276, +), CAediting_732980(17687279, +), CAediting_732981(17687288, +), CAediting_732982(17687296, +), CAediting_732983(17687297, +), CAediting_732984(17687298, +), CAediting_732985(17687299, +), CAediting_732986(17687313, +), CAediting_732987(17687314, +), CAediting_732988(17687315, +), CAediting_732989(17687316, +), CAediting_732990(17687319, +), CAediting_732991(17687321, +), CAediting_732992(17687322, +), CAediting_732993(17687323, +), CAediting_732994(17687328, +), CAediting_732995(17687354, +), CAediting_732996(17687360, +), CAediting_732997(17687367, +), CAediting_732998(17687375, +), CAediting_732999(17687377, +), CAediting_733000(17687378, +), CAediting_733001(17687382, +), CAediting_733002(17687383, +), CAediting_733003(17687392, +), CAediting_733004(17687404, +), CAediting_733005(17687430, +), CAediting_733006(17687441, +), CAediting_733007(17687454, +), CAediting_733008(17687471, +), CAediting_733009(17687491, +), CAediting_733010(17687509, +), CAediting_733011(17688592, +), CAediting_733012(17702732, +), CAediting_733013(17702754, +), CAediting_733014(17702755, +), CAediting_733015(17702821, +), CAediting_733016(17702822, +), CAediting_733017(17702843, +), CAediting_733018(17702887, +), CAediting_733019(17702888, +), CAediting_733020(17702897, +), CAediting_733021(17702904, +), CAediting_733022(17702910, +), CAediting_733023(17702929, +), CAediting_733024(17702943, +), CAediting_733025(17702958, +), CAediting_733026(17702959, +), CAediting_733027(17704162, +),

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RNA editing positional annotations for STAM using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_732942	chr10_17649145_+	intronic
CAediting_732943	chr10_17649335_+	intronic
CAediting_732944	chr10_17656147_+	intronic
CAediting_732945	chr10_17656200_+	intronic
CAediting_732946	chr10_17659538_+	intronic
CAediting_732947	chr10_17660706_+	intronic
CAediting_732948	chr10_17675308_+	intronic
CAediting_732949	chr10_17675328_+	intronic
CAediting_732950	chr10_17686339_+	ncRNA_intronic
CAediting_732951	chr10_17686430_+	ncRNA_intronic
CAediting_732952	chr10_17686441_+	ncRNA_intronic
CAediting_732953	chr10_17686446_+	ncRNA_intronic
CAediting_732954	chr10_17686451_+	ncRNA_intronic
CAediting_732955	chr10_17686476_+	ncRNA_intronic
CAediting_732956	chr10_17686516_+	ncRNA_intronic
CAediting_732957	chr10_17686518_+	ncRNA_intronic
CAediting_732958	chr10_17686551_+	ncRNA_intronic
CAediting_732959	chr10_17686557_+	ncRNA_intronic
CAediting_732960	chr10_17686560_+	ncRNA_intronic
CAediting_732961	chr10_17686574_+	ncRNA_intronic
CAediting_732962	chr10_17686577_+	ncRNA_intronic
CAediting_732963	chr10_17686589_+	ncRNA_intronic
CAediting_732964	chr10_17686594_+	ncRNA_intronic
CAediting_732965	chr10_17686617_+	ncRNA_intronic
CAediting_732966	chr10_17686624_+	ncRNA_intronic
CAediting_732967	chr10_17686637_+	ncRNA_intronic
CAediting_732968	chr10_17686639_+	ncRNA_intronic
CAediting_732969	chr10_17686651_+	ncRNA_intronic
CAediting_732970	chr10_17686653_+	ncRNA_intronic
CAediting_732971	chr10_17686660_+	ncRNA_intronic
CAediting_732972	chr10_17687201_+	ncRNA_intronic
CAediting_732973	chr10_17687220_+	ncRNA_intronic
CAediting_732974	chr10_17687228_+	ncRNA_intronic
CAediting_732975	chr10_17687252_+	ncRNA_intronic
CAediting_732976	chr10_17687265_+	ncRNA_intronic
CAediting_732977	chr10_17687273_+	ncRNA_intronic
CAediting_732978	chr10_17687274_+	ncRNA_intronic
CAediting_732979	chr10_17687276_+	ncRNA_intronic
CAediting_732980	chr10_17687279_+	ncRNA_intronic
CAediting_732981	chr10_17687288_+	ncRNA_intronic
CAediting_732982	chr10_17687296_+	ncRNA_intronic
CAediting_732983	chr10_17687297_+	ncRNA_intronic
CAediting_732984	chr10_17687298_+	ncRNA_intronic
CAediting_732985	chr10_17687299_+	ncRNA_intronic
CAediting_732986	chr10_17687313_+	ncRNA_intronic
CAediting_732987	chr10_17687314_+	ncRNA_intronic
CAediting_732988	chr10_17687315_+	ncRNA_intronic
CAediting_732989	chr10_17687316_+	ncRNA_intronic
CAediting_732990	chr10_17687319_+	ncRNA_intronic
CAediting_732991	chr10_17687321_+	ncRNA_intronic
CAediting_732992	chr10_17687322_+	ncRNA_intronic
CAediting_732993	chr10_17687323_+	ncRNA_intronic
CAediting_732994	chr10_17687328_+	ncRNA_intronic
CAediting_732995	chr10_17687354_+	ncRNA_intronic
CAediting_732996	chr10_17687360_+	ncRNA_intronic
CAediting_732997	chr10_17687367_+	ncRNA_intronic
CAediting_732998	chr10_17687375_+	ncRNA_intronic
CAediting_732999	chr10_17687377_+	ncRNA_intronic
CAediting_733000	chr10_17687378_+	ncRNA_intronic
CAediting_733001	chr10_17687382_+	ncRNA_intronic
CAediting_733002	chr10_17687383_+	ncRNA_intronic
CAediting_733003	chr10_17687392_+	ncRNA_intronic
CAediting_733004	chr10_17687404_+	ncRNA_intronic
CAediting_733005	chr10_17687430_+	ncRNA_intronic
CAediting_733006	chr10_17687441_+	ncRNA_intronic
CAediting_733007	chr10_17687454_+	ncRNA_intronic
CAediting_733008	chr10_17687471_+	ncRNA_intronic
CAediting_733009	chr10_17687491_+	ncRNA_intronic
CAediting_733010	chr10_17687509_+	ncRNA_intronic
CAediting_733011	chr10_17688592_+	intronic
CAediting_733012	chr10_17702732_+	intronic
CAediting_733013	chr10_17702754_+	intronic
CAediting_733014	chr10_17702755_+	intronic
CAediting_733015	chr10_17702821_+	intronic
CAediting_733016	chr10_17702822_+	intronic
CAediting_733017	chr10_17702843_+	intronic
CAediting_733018	chr10_17702887_+	intronic
CAediting_733019	chr10_17702888_+	intronic
CAediting_733020	chr10_17702897_+	intronic
CAediting_733021	chr10_17702904_+	intronic
CAediting_733022	chr10_17702910_+	intronic
CAediting_733023	chr10_17702929_+	intronic
CAediting_733024	chr10_17702943_+	intronic
CAediting_733025	chr10_17702958_+	intronic
CAediting_733026	chr10_17702959_+	intronic
CAediting_733027	chr10_17704162_+	intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_732942	chr10_17649145_+	SINE	Alu	AluJr
CAediting_732943	chr10_17649335_+	SINE	Alu	AluJr
CAediting_732944	chr10_17656147_+	SINE	Alu	AluSc8
CAediting_732945	chr10_17656200_+	SINE	Alu	AluSc8
CAediting_732946	chr10_17659538_+	SINE	Alu	AluJr
CAediting_732947	chr10_17660706_+	SINE	Alu	AluJo
CAediting_732948	chr10_17675308_+	SINE	Alu	AluSx
CAediting_732949	chr10_17675328_+	SINE	Alu	AluSx
CAediting_732951	chr10_17686430_+	SINE	Alu	AluSg
CAediting_732952	chr10_17686441_+	SINE	Alu	AluSg
CAediting_732953	chr10_17686446_+	SINE	Alu	AluSg
CAediting_732954	chr10_17686451_+	SINE	Alu	AluSg
CAediting_732955	chr10_17686476_+	SINE	Alu	AluSg
CAediting_732956	chr10_17686516_+	SINE	Alu	AluSg
CAediting_732957	chr10_17686518_+	SINE	Alu	AluSg
CAediting_732958	chr10_17686551_+	SINE	Alu	AluSg
CAediting_732959	chr10_17686557_+	SINE	Alu	AluSg
CAediting_732960	chr10_17686560_+	SINE	Alu	AluSg
CAediting_732961	chr10_17686574_+	SINE	Alu	AluSg
CAediting_732962	chr10_17686577_+	SINE	Alu	AluSg
CAediting_732963	chr10_17686589_+	SINE	Alu	AluSg
CAediting_732964	chr10_17686594_+	SINE	Alu	AluSg
CAediting_732965	chr10_17686617_+	SINE	Alu	AluSg
CAediting_732966	chr10_17686624_+	SINE	Alu	AluSg
CAediting_732967	chr10_17686637_+	SINE	Alu	AluSg
CAediting_732968	chr10_17686639_+	SINE	Alu	AluSg
CAediting_732969	chr10_17686651_+	SINE	Alu	AluSg
CAediting_732970	chr10_17686653_+	SINE	Alu	AluSg
CAediting_732971	chr10_17686660_+	SINE	Alu	AluSg
CAediting_732972	chr10_17687201_+	SINE	Alu	AluSz
CAediting_732973	chr10_17687220_+	SINE	Alu	AluSz
CAediting_732974	chr10_17687228_+	SINE	Alu	AluSz
CAediting_732975	chr10_17687252_+	SINE	Alu	AluSz
CAediting_732976	chr10_17687265_+	SINE	Alu	AluSz
CAediting_732977	chr10_17687273_+	SINE	Alu	AluSz
CAediting_732978	chr10_17687274_+	SINE	Alu	AluSz
CAediting_732979	chr10_17687276_+	SINE	Alu	AluSz
CAediting_732980	chr10_17687279_+	SINE	Alu	AluSz
CAediting_732981	chr10_17687288_+	SINE	Alu	AluSz
CAediting_732982	chr10_17687296_+	SINE	Alu	AluSz
CAediting_732983	chr10_17687297_+	SINE	Alu	AluSz
CAediting_732984	chr10_17687298_+	SINE	Alu	AluSz
CAediting_732985	chr10_17687299_+	SINE	Alu	AluSz
CAediting_732986	chr10_17687313_+	SINE	Alu	AluSz
CAediting_732987	chr10_17687314_+	SINE	Alu	AluSz
CAediting_732988	chr10_17687315_+	SINE	Alu	AluSz
CAediting_732989	chr10_17687316_+	SINE	Alu	AluSz
CAediting_732990	chr10_17687319_+	SINE	Alu	AluSz
CAediting_732991	chr10_17687321_+	SINE	Alu	AluSz
CAediting_732992	chr10_17687322_+	SINE	Alu	AluSz
CAediting_732993	chr10_17687323_+	SINE	Alu	AluSz
CAediting_732994	chr10_17687328_+	SINE	Alu	AluSz
CAediting_732995	chr10_17687354_+	SINE	Alu	AluSz
CAediting_732996	chr10_17687360_+	SINE	Alu	AluSz
CAediting_732997	chr10_17687367_+	SINE	Alu	AluSz
CAediting_732998	chr10_17687375_+	SINE	Alu	AluSz
CAediting_732999	chr10_17687377_+	SINE	Alu	AluSz
CAediting_733000	chr10_17687378_+	SINE	Alu	AluSz
CAediting_733001	chr10_17687382_+	SINE	Alu	AluSz
CAediting_733002	chr10_17687383_+	SINE	Alu	AluSz
CAediting_733003	chr10_17687392_+	SINE	Alu	AluSz
CAediting_733004	chr10_17687404_+	SINE	Alu	AluSz
CAediting_733005	chr10_17687430_+	SINE	Alu	AluSz
CAediting_733006	chr10_17687441_+	SINE	Alu	AluSz
CAediting_733007	chr10_17687454_+	SINE	Alu	AluSz
CAediting_733008	chr10_17687471_+	SINE	Alu	AluSz
CAediting_733009	chr10_17687491_+	SINE	Alu	AluSz
CAediting_733010	chr10_17687509_+	SINE	Alu	AluSz
CAediting_733011	chr10_17688592_+	SINE	Alu	AluSx
CAediting_733012	chr10_17702732_+	SINE	Alu	AluSg
CAediting_733013	chr10_17702754_+	SINE	Alu	AluSg
CAediting_733014	chr10_17702755_+	SINE	Alu	AluSg
CAediting_733015	chr10_17702821_+	SINE	Alu	AluSg
CAediting_733016	chr10_17702822_+	SINE	Alu	AluSg
CAediting_733017	chr10_17702843_+	SINE	Alu	AluSg
CAediting_733018	chr10_17702887_+	SINE	Alu	AluSg
CAediting_733019	chr10_17702888_+	SINE	Alu	AluSg
CAediting_733020	chr10_17702897_+	SINE	Alu	AluSg
CAediting_733021	chr10_17702904_+	SINE	Alu	AluSg
CAediting_733022	chr10_17702910_+	SINE	Alu	AluSg
CAediting_733023	chr10_17702929_+	SINE	Alu	AluSg
CAediting_733024	chr10_17702943_+	SINE	Alu	AluSg
CAediting_733025	chr10_17702958_+	SINE	Alu	AluSg
CAediting_733026	chr10_17702959_+	SINE	Alu	AluSg
CAediting_733027	chr10_17704162_+	SINE	Alu	AluJr

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RNA A-to-I editing events in the alternative splicing sites for STAM

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000136738.13.STAM.

Correlation between RNA A-to-I editing and PSI for ENSG00000136738.13.STAM.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for STAM

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for STAM

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for STAM

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1368054	chr19_46709310_-	ENSG00000136738.13	ENST00000445846	hsa-miR-320e	17693245	17693251	7mer-m8	17693235	17693252	151	-20.83

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for STAM

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for STAM

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
STAD	CAediting_732977	chr10_17687273_+	0.0148792371156371	0.318334135815649	.	.	.	.
STAD	CAediting_732989	chr10_17687316_+	.	.	0.000354768530867907	0.453107312636428	.	.
STAD	CAediting_732995	chr10_17687354_+	0.0158373602200338	0.19736530652399	.	.	.	.

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Relation with cancer stages for STAM

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for STAM

Correlation between RNA editing and survival

Cancer	CAeditomID	position	KMpvalue	Coxpvalue	CoxHR
STAD	CAediting_733004	chr10_17687404_+	1.42997838484815e-05	8.2391e-05	280478

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RelatedDrugs for STAM

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for STAM

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene