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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: TMEM254 (CAeditome ID:80195)

Gene summary for TMEM254

check button Gene summary
Gene informationGene symbol

TMEM254

Gene ID

80195

Gene nametransmembrane protein 254
SynonymsC10orf57|bA369J21.6
Cytomap

10q22.3

Type of geneprotein-coding
Descriptiontransmembrane protein 254transmembrane protein C10orf57
Modification date20210518
UniProtAcc

Q8TBM7

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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RNA A-to-I events for TMEM254

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000133678.12

check button RNA A-to-I editing events in Cancer.
CAediting_766567(80079752, +), CAediting_766568(80079792, +), CAediting_766569(80079793, +), CAediting_766570(80079806, +), CAediting_766571(80079812, +), CAediting_766572(80080692, +), CAediting_766573(80080793, +), CAediting_766574(80080857, +), CAediting_766575(80080860, +), CAediting_766576(80080865, +), CAediting_766577(80080920, +), CAediting_766578(80080921, +), CAediting_766579(80081008, +), CAediting_766580(80081019, +), CAediting_766581(80081032, +), CAediting_766582(80081055, +), CAediting_766583(80081056, +), CAediting_766584(80081234, +), CAediting_766585(80081539, +), CAediting_766586(80081681, +), CAediting_766587(80081682, +), CAediting_766588(80083208, +), CAediting_766589(80083243, +), CAediting_766590(80083835, +), CAediting_766591(80085304, +), CAediting_766592(80085456, +), CAediting_766593(80085460, +), CAediting_766594(80085488, +), CAediting_766595(80085530, +), CAediting_766596(80085550, +), CAediting_766597(80086587, +), CAediting_766598(80086588, +), CAediting_766599(80086734, +), CAediting_766600(80086985, +), CAediting_766601(80086986, +), CAediting_766602(80086988, +), CAediting_766603(80086999, +), CAediting_766604(80087036, +), CAediting_766605(80087037, +), CAediting_766606(80087054, +), CAediting_766607(80087062, +), CAediting_766608(80087066, +), CAediting_766609(80087067, +), CAediting_766610(80087387, +), CAediting_766611(80087388, +), CAediting_766612(80087402, +), CAediting_766613(80087404, +), CAediting_766614(80087532, +), CAediting_766615(80087533, +), CAediting_766616(80087546, +), CAediting_766617(80087559, +), CAediting_766618(80087637, +), CAediting_766619(80088858, +), CAediting_766620(80088859, +), CAediting_766621(80088860, +), CAediting_766622(80088868, +), CAediting_766623(80088872, +), CAediting_766624(80088874, +), CAediting_766625(80088942, +), CAediting_766626(80089416, +), CAediting_766627(80089488, +), CAediting_766628(80089575, +),

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RNA editing positional annotations for TMEM254 using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_766567chr10_80079752_+ncRNA_intronic
CAediting_766568chr10_80079792_+ncRNA_intronic
CAediting_766569chr10_80079793_+ncRNA_intronic
CAediting_766570chr10_80079806_+ncRNA_intronic
CAediting_766571chr10_80079812_+ncRNA_intronic
CAediting_766572chr10_80080692_+ncRNA_intronic
CAediting_766573chr10_80080793_+ncRNA_intronic
CAediting_766574chr10_80080857_+ncRNA_intronic
CAediting_766575chr10_80080860_+ncRNA_intronic
CAediting_766576chr10_80080865_+ncRNA_intronic
CAediting_766577chr10_80080920_+ncRNA_intronic
CAediting_766578chr10_80080921_+ncRNA_intronic
CAediting_766579chr10_80081008_+ncRNA_intronic
CAediting_766580chr10_80081019_+ncRNA_intronic
CAediting_766581chr10_80081032_+ncRNA_intronic
CAediting_766582chr10_80081055_+ncRNA_intronic
CAediting_766583chr10_80081056_+ncRNA_intronic
CAediting_766584chr10_80081234_+ncRNA_intronic
CAediting_766585chr10_80081539_+ncRNA_intronic
CAediting_766586chr10_80081681_+exonic
CAediting_766587chr10_80081682_+exonic
CAediting_766588chr10_80083208_+ncRNA_intronic
CAediting_766589chr10_80083243_+ncRNA_intronic
CAediting_766590chr10_80083835_+ncRNA_intronic
CAediting_766591chr10_80085304_+ncRNA_intronic
CAediting_766592chr10_80085456_+ncRNA_intronic
CAediting_766593chr10_80085460_+ncRNA_intronic
CAediting_766594chr10_80085488_+ncRNA_intronic
CAediting_766595chr10_80085530_+ncRNA_intronic
CAediting_766596chr10_80085550_+ncRNA_intronic
CAediting_766597chr10_80086587_+ncRNA_intronic
CAediting_766598chr10_80086588_+ncRNA_intronic
CAediting_766599chr10_80086734_+ncRNA_intronic
CAediting_766600chr10_80086985_+ncRNA_intronic
CAediting_766601chr10_80086986_+ncRNA_intronic
CAediting_766602chr10_80086988_+ncRNA_intronic
CAediting_766603chr10_80086999_+ncRNA_intronic
CAediting_766604chr10_80087036_+ncRNA_intronic
CAediting_766605chr10_80087037_+ncRNA_intronic
CAediting_766606chr10_80087054_+ncRNA_intronic
CAediting_766607chr10_80087062_+ncRNA_intronic
CAediting_766608chr10_80087066_+ncRNA_intronic
CAediting_766609chr10_80087067_+ncRNA_intronic
CAediting_766610chr10_80087387_+ncRNA_intronic
CAediting_766611chr10_80087388_+ncRNA_intronic
CAediting_766612chr10_80087402_+ncRNA_intronic
CAediting_766613chr10_80087404_+ncRNA_intronic
CAediting_766614chr10_80087532_+ncRNA_intronic
CAediting_766615chr10_80087533_+ncRNA_intronic
CAediting_766616chr10_80087546_+ncRNA_intronic
CAediting_766617chr10_80087559_+ncRNA_intronic
CAediting_766618chr10_80087637_+ncRNA_intronic
CAediting_766619chr10_80088858_+ncRNA_intronic
CAediting_766620chr10_80088859_+ncRNA_intronic
CAediting_766621chr10_80088860_+ncRNA_intronic
CAediting_766622chr10_80088868_+ncRNA_intronic
CAediting_766623chr10_80088872_+ncRNA_intronic
CAediting_766624chr10_80088874_+ncRNA_intronic
CAediting_766625chr10_80088942_+ncRNA_intronic
CAediting_766626chr10_80089416_+ncRNA_intronic
CAediting_766627chr10_80089488_+ncRNA_intronic
CAediting_766628chr10_80089575_+ncRNA_intronic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_766567chr10_80079752_+SINEAluAluSz
CAediting_766568chr10_80079792_+SINEAluAluSz
CAediting_766569chr10_80079793_+SINEAluAluSz
CAediting_766570chr10_80079806_+SINEAluAluSz
CAediting_766571chr10_80079812_+SINEAluAluSz
CAediting_766572chr10_80080692_+SINEAluAluJb
CAediting_766573chr10_80080793_+SINEAluAluJb
CAediting_766574chr10_80080857_+SINEAluAluSx
CAediting_766575chr10_80080860_+SINEAluAluSx
CAediting_766576chr10_80080865_+SINEAluAluSx
CAediting_766577chr10_80080920_+SINEAluAluSx
CAediting_766578chr10_80080921_+SINEAluAluSx
CAediting_766579chr10_80081008_+SINEAluAluSx
CAediting_766580chr10_80081019_+SINEAluAluSx
CAediting_766581chr10_80081032_+SINEAluAluSx
CAediting_766582chr10_80081055_+SINEAluAluSx
CAediting_766583chr10_80081056_+SINEAluAluSx
CAediting_766584chr10_80081234_+SINEAluAluJb
CAediting_766585chr10_80081539_+SINEAluAluJr
CAediting_766586chr10_80081681_+SINEAluAluJr
CAediting_766587chr10_80081682_+SINEAluAluJr
CAediting_766588chr10_80083208_+SINEAluAluSx1
CAediting_766589chr10_80083243_+SINEAluAluSx1
CAediting_766590chr10_80083835_+SINEAluAluSz6
CAediting_766591chr10_80085304_+SINEAluAluSx
CAediting_766592chr10_80085456_+SINEAluAluSx
CAediting_766593chr10_80085460_+SINEAluAluSx
CAediting_766594chr10_80085488_+SINEAluAluSx
CAediting_766595chr10_80085530_+SINEAluAluSx
CAediting_766596chr10_80085550_+SINEAluAluSx
CAediting_766597chr10_80086587_+SINEAluAluSx3
CAediting_766598chr10_80086588_+SINEAluAluSx3
CAediting_766599chr10_80086734_+SINEAluAluSx3
CAediting_766600chr10_80086985_+SINEAluFLAM_A
CAediting_766601chr10_80086986_+SINEAluFLAM_A
CAediting_766602chr10_80086988_+SINEAluFLAM_A
CAediting_766603chr10_80086999_+SINEAluFLAM_A
CAediting_766604chr10_80087036_+SINEAluFLAM_A
CAediting_766605chr10_80087037_+SINEAluFLAM_A
CAediting_766606chr10_80087054_+SINEAluFLAM_A
CAediting_766607chr10_80087062_+SINEAluFLAM_A
CAediting_766608chr10_80087066_+SINEAluFLAM_A
CAediting_766609chr10_80087067_+SINEAluFLAM_A
CAediting_766610chr10_80087387_+SINEAluAluSx1
CAediting_766611chr10_80087388_+SINEAluAluSx1
CAediting_766612chr10_80087402_+SINEAluAluSx1
CAediting_766613chr10_80087404_+SINEAluAluSx1
CAediting_766614chr10_80087532_+SINEAluAluSx1
CAediting_766615chr10_80087533_+SINEAluAluSx1
CAediting_766616chr10_80087546_+SINEAluAluSx1
CAediting_766617chr10_80087559_+SINEAluAluSx1
CAediting_766618chr10_80087637_+SINEAluAluSx1
CAediting_766619chr10_80088858_+SINEAluAluJo
CAediting_766620chr10_80088859_+SINEAluAluJo
CAediting_766621chr10_80088860_+SINEAluAluJo
CAediting_766622chr10_80088868_+SINEAluAluJo
CAediting_766623chr10_80088872_+SINEAluAluJo
CAediting_766624chr10_80088874_+SINEAluAluJo
CAediting_766625chr10_80088942_+SINEAluAluYj4
CAediting_766626chr10_80089416_+SINEAluAluJr
CAediting_766627chr10_80089488_+SINEAluAluJr
CAediting_766628chr10_80089575_+SINEAluAluJr

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RNA A-to-I editing events in the alternative splicing sites for TMEM254

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000133678.12.TMEM254.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000133678.12.TMEM254.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for TMEM254

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

check button Correlation between RNA A-to-I editing and gene expression.

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for TMEM254

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for TMEM254

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_1229413chr17_67471544_+ENSG00000133678.12ENST00000613758hsa-miR-548aa80091885800918917mer-m88009186880091892159-17.33
CAediting_1229414chr17_67471546_+ENSG00000133678.12ENST00000613758hsa-miR-548aa80092442800924487mer-m88009242480092449145-10.41
CAediting_1368054chr19_46709310_-ENSG00000133678.12ENST00000613758hsa-miR-320e80091960800919667mer-m88009195080091967147-18.7
CAediting_442554chr5_154685830_+ENSG00000133678.12ENST00000613758hsa-miR-130380091941800919488mer-1a8009192780091948150-13.42
CAediting_524911chr7_5495852_-ENSG00000133678.12ENST00000613758hsa-miR-589-3p80091077800910837mer-m88009106180091084148-14
CAediting_524911chr7_5495852_-ENSG00000133678.12ENST00000613758hsa-miR-589-3p80091210800912178mer-1a8009119480091217166-25.6
CAediting_524911chr7_5495852_-ENSG00000133678.12ENST00000613758hsa-miR-589-3p80091609800916157mer-m88009159080091616152-25.19
CAediting_524911chr7_5495852_-ENSG00000133678.12ENST00000372275hsa-miR-589-3p80091077800910837mer-m88009106180091084148-14
CAediting_524911chr7_5495852_-ENSG00000133678.12ENST00000372275hsa-miR-589-3p80091210800912178mer-1a8009119480091217166-25.6
CAediting_1229413chr17_67471544_+ENSG00000133678.12ENST00000372273hsa-miR-548aa80091885800918917mer-m88009186880091892159-17.33
CAediting_1229414chr17_67471546_+ENSG00000133678.12ENST00000372273hsa-miR-548aa80092442800924487mer-m88009242480092449145-10.41
CAediting_1368054chr19_46709310_-ENSG00000133678.12ENST00000372273hsa-miR-320e80091960800919667mer-m88009195080091967147-18.7
CAediting_442554chr5_154685830_+ENSG00000133678.12ENST00000372273hsa-miR-130380091941800919488mer-1a8009192780091948150-13.42
CAediting_524911chr7_5495852_-ENSG00000133678.12ENST00000372273hsa-miR-589-3p80091077800910837mer-m88009106180091084148-14
CAediting_524911chr7_5495852_-ENSG00000133678.12ENST00000372273hsa-miR-589-3p80091210800912178mer-1a8009119480091217166-25.6
CAediting_524911chr7_5495852_-ENSG00000133678.12ENST00000372273hsa-miR-589-3p80091609800916157mer-m88009159080091616152-25.19
CAediting_524911chr7_5495852_-ENSG00000133678.12ENST00000450179hsa-miR-589-3p80091077800910837mer-m88009106180091084148-14
CAediting_524911chr7_5495852_-ENSG00000133678.12ENST00000450179hsa-miR-589-3p80091210800912178mer-1a8009119480091217166-25.6

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_468389chr6_31355314_-ENSG00000133678.12ENST00000613758hsa-miR-6891-5p80091312800913176mer8009130080091318149-23.2
CAediting_468389chr6_31355314_-ENSG00000133678.12ENST00000372273hsa-miR-6891-5p80091312800913176mer8009130080091318149-23.2

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for TMEM254

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for TMEM254

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
BRCACAediting_766575chr10_80080860_+1.0568244495453e-050.547264757076494....

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Relation with cancer stages for TMEM254

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.

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Relation with survival for TMEM254

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR

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RelatedDrugs for TMEM254

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TMEM254

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource