Home

Download

Statistics

Examples

Help

Contact

Editing gene: PTGES2 (CAeditome ID:80142)

Gene summary for PTGES2

Gene summary

Gene information	Gene symbol	PTGES2
	Gene ID	80142
	Gene name	prostaglandin E synthase 2
	Synonyms	C9orf15\|GBF-1\|GBF1\|PGES2\|mPGES-2
	Cytomap	9q34.11
	Type of gene	protein-coding
	Description	prostaglandin E synthase 2GATE-binding factor 1gamma-interferon-activated transcriptional element-binding factor 1mPGE synthase-2membrane-associated prostaglandin E synthase 2microsomal prostaglandin E synthase-2prostaglandin-H(2) E-isomerase
	Modification date	20210518
	UniProtAcc	Q9H7Z7
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
PTGES2	GO:0016829	Prostaglandin E synthase 2	17585783
PTGES2	GO:0050220	Prostaglandin E synthase 2	12804604
PTGES2	GO:0006629	Prostaglandin E synthase 2	17585783
PTGES2	GO:0000139	Prostaglandin E synthase 2	12835322
PTGES2	GO:0005739	Prostaglandin E synthase 2	0000054
PTGES2	GO:0005829	Prostaglandin E synthase 2	12835322

Top

RNA A-to-I events for PTGES2

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000148334.13

RNA A-to-I editing events in Cancer.

CAediting_712029(128121647, -), CAediting_712030(128121739, -), CAediting_712031(128121741, -), CAediting_712032(128121837, -), CAediting_712033(128121899, -), CAediting_712034(128123361, -), CAediting_712035(128123379, -), CAediting_712036(128123407, -), CAediting_712037(128123465, -), CAediting_712038(128123822, -), CAediting_712039(128124266, -), CAediting_712040(128126003, -), CAediting_712041(128126004, -), CAediting_712042(128126640, -),

Top

RNA editing positional annotations for PTGES2 using Annovar

Protein coding RNA editing(s).

CAeditome ID	Position	Variant type	ENST	NTchange	AAchange	SIFT_score	Polyphen2_HVAR_score	PROVEAN_pred
CAediting_712038	chr9_128123822_-	nonsynonymous SNV	ENST00000338961.9	c.A566G	p.Y189C	D	D	D
CAediting_712038	chr9_128123822_-	nonsynonymous SNV	ENST00000449878.1	c.A461G	p.Y154C	D	D	D

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_712029	chr9_128121647_-	ncRNA_intronic
CAediting_712030	chr9_128121739_-	ncRNA_intronic
CAediting_712031	chr9_128121741_-	ncRNA_intronic
CAediting_712032	chr9_128121837_-	ncRNA_intronic
CAediting_712033	chr9_128121899_-	ncRNA_intronic
CAediting_712034	chr9_128123361_-	ncRNA_intronic
CAediting_712035	chr9_128123379_-	ncRNA_intronic
CAediting_712036	chr9_128123407_-	ncRNA_intronic
CAediting_712037	chr9_128123465_-	ncRNA_intronic
CAediting_712038	chr9_128123822_-	exonic
CAediting_712039	chr9_128124266_-	ncRNA_intronic
CAediting_712040	chr9_128126003_-	ncRNA_intronic
CAediting_712041	chr9_128126004_-	ncRNA_intronic
CAediting_712042	chr9_128126640_-	ncRNA_intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_712029	chr9_128121647_-	SINE	Alu	AluSx
CAediting_712030	chr9_128121739_-	SINE	Alu	AluSx
CAediting_712031	chr9_128121741_-	SINE	Alu	AluSx
CAediting_712032	chr9_128121837_-	SINE	Alu	AluSx
CAediting_712033	chr9_128121899_-	SINE	Alu	AluSx
CAediting_712034	chr9_128123361_-	SINE	Alu	AluSx
CAediting_712035	chr9_128123379_-	SINE	Alu	AluSx
CAediting_712036	chr9_128123407_-	SINE	Alu	AluSx
CAediting_712037	chr9_128123465_-	SINE	Alu	AluSx
CAediting_712039	chr9_128124266_-	SINE	Alu	AluSx1
CAediting_712040	chr9_128126003_-	SINE	Alu	AluJr
CAediting_712041	chr9_128126004_-	SINE	Alu	AluJr
CAediting_712042	chr9_128126640_-	SINE	Alu	AluSx1

Top

RNA A-to-I editing events in the alternative splicing sites for PTGES2

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000148334.13.PTGES2.

Correlation between RNA A-to-I editing and PSI for ENSG00000148334.13.PTGES2.

Top

Differntial gene expression between RNA A-to-I edited versus non-edited samples for PTGES2

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

Top

Protein coding region RNA A-to-I editings for PTGES2

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

Top

The effects of the RNA editing to the miRNA binding sites for PTGES2

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_580943	chr7_100356700_+	ENSG00000148334.13	ENST00000338961	hsa-miR-6840-3p	128120755	128120762	8mer-1a	128120755	128120777	155	-26.17
CAediting_524911	chr7_5495852_-	ENSG00000148334.13	ENST00000338961	hsa-miR-589-3p	128120901	128120907	7mer-m8	128120900	128120925	143	-15.73
CAediting_580943	chr7_100356700_+	ENSG00000148334.13	ENST00000617202	hsa-miR-6840-3p	128120755	128120762	8mer-1a	128120755	128120777	155	-26.17
CAediting_524911	chr7_5495852_-	ENSG00000148334.13	ENST00000617202	hsa-miR-589-3p	128120901	128120907	7mer-m8	128120900	128120925	143	-15.73
CAediting_580943	chr7_100356700_+	ENSG00000148334.13	ENST00000277462	hsa-miR-6840-3p	128120755	128120762	8mer-1a	128120755	128120777	155	-26.17
CAediting_524911	chr7_5495852_-	ENSG00000148334.13	ENST00000277462	hsa-miR-589-3p	128120901	128120907	7mer-m8	128120900	128120925	143	-15.73

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

Top

The effects of the RNA editing to the stability of the RNA structures for PTGES2

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

Top

Relation with ADAR for PTGES2

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

Top

Relation with cancer stages for PTGES2

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

Top

Relation with survival for PTGES2

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

Top

RelatedDrugs for PTGES2

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

RelatedDiseases for PTGES2

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
PTGES2	C0040136	Thyroid Neoplasm	1	CTD_human
PTGES2	C0151468	Thyroid Gland Follicular Adenoma	1	CTD_human
PTGES2	C0549473	Thyroid carcinoma	1	CTD_human

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene