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Editing gene: EFCAB1 (CAeditome ID:79645)

Gene summary for EFCAB1

Gene summary

Gene information	Gene symbol	EFCAB1
	Gene ID	79645
	Gene name	EF-hand calcium binding domain 1
	Synonyms	-
	Cytomap	8q11.21
	Type of gene	protein-coding
	Description	EF-hand calcium-binding domain-containing protein 1calaxin
	Modification date	20210518
	UniProtAcc	Q9HAE3
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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RNA A-to-I events for EFCAB1

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000034239.9

RNA A-to-I editing events in Cancer.

CAediting_637857(48722624, -), CAediting_637858(48722635, -), CAediting_637859(48722655, -), CAediting_637860(48722656, -), CAediting_637861(48722659, -), CAediting_637862(48722660, -), CAediting_637863(48722672, -), CAediting_637864(48722681, -), CAediting_637865(48722710, -), CAediting_637866(48722745, -), CAediting_637867(48722748, -), CAediting_637868(48722750, -), CAediting_637869(48723809, -), CAediting_637870(48723811, -), CAediting_637871(48723845, -), CAediting_637872(48723871, -), CAediting_637873(48723890, -), CAediting_637874(48723891, -), CAediting_637875(48723892, -), CAediting_637876(48723903, -), CAediting_637877(48723912, -), CAediting_637878(48723924, -), CAediting_637879(48723926, -), CAediting_637880(48723957, -),

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RNA editing positional annotations for EFCAB1 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_637857	chr8_48722624_-	ncRNA_intronic
CAediting_637858	chr8_48722635_-	ncRNA_intronic
CAediting_637859	chr8_48722655_-	ncRNA_intronic
CAediting_637860	chr8_48722656_-	ncRNA_intronic
CAediting_637861	chr8_48722659_-	ncRNA_intronic
CAediting_637862	chr8_48722660_-	ncRNA_intronic
CAediting_637863	chr8_48722672_-	ncRNA_intronic
CAediting_637864	chr8_48722681_-	ncRNA_intronic
CAediting_637865	chr8_48722710_-	ncRNA_intronic
CAediting_637866	chr8_48722745_-	ncRNA_intronic
CAediting_637867	chr8_48722748_-	ncRNA_intronic
CAediting_637868	chr8_48722750_-	ncRNA_intronic
CAediting_637869	chr8_48723809_-	ncRNA_intronic
CAediting_637870	chr8_48723811_-	ncRNA_intronic
CAediting_637871	chr8_48723845_-	ncRNA_intronic
CAediting_637872	chr8_48723871_-	ncRNA_intronic
CAediting_637873	chr8_48723890_-	ncRNA_intronic
CAediting_637874	chr8_48723891_-	ncRNA_intronic
CAediting_637875	chr8_48723892_-	ncRNA_intronic
CAediting_637876	chr8_48723903_-	ncRNA_intronic
CAediting_637877	chr8_48723912_-	ncRNA_intronic
CAediting_637878	chr8_48723924_-	ncRNA_intronic
CAediting_637879	chr8_48723926_-	ncRNA_intronic
CAediting_637880	chr8_48723957_-	ncRNA_intronic

Repat-regional RNA editing(s).

CAeditome ID

Position

Repeat family

Repeat sub family

Repeat name

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RNA A-to-I editing events in the alternative splicing sites for EFCAB1

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000034239.9.EFCAB1.

Correlation between RNA A-to-I editing and PSI for ENSG00000034239.9.EFCAB1.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for EFCAB1

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for EFCAB1

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for EFCAB1

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1054808	chr15_66496985_-	ENSG00000034239.9	ENST00000433756	hsa-miR-4512	48716283	48716289	7mer-m8	48716282	48716302	146	-26.96
CAediting_1054808	chr15_66496985_-	ENSG00000034239.9	ENST00000521701	hsa-miR-4512	48716283	48716289	7mer-m8	48716282	48716302	146	-26.96
CAediting_468389	chr6_31355314_-	ENSG00000034239.9	ENST00000433756	hsa-miR-6891-5p	48716491	48716497	7mer-m8	48716490	48716513	146	-27.15
CAediting_468389	chr6_31355314_-	ENSG00000034239.9	ENST00000521701	hsa-miR-6891-5p	48716491	48716497	7mer-m8	48716490	48716513	146	-27.15

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for EFCAB1

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000262103.6	protein_coding

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID	ENST	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
CAediting_637869	ENST00000262103.6	chr8_48723809_-	-574.40	-573.10	-589.80
CAediting_637870	ENST00000262103.6	chr8_48723811_-	-575.70	-573.10	-589.80
CAediting_637871	ENST00000262103.6	chr8_48723845_-	-573.60	-573.10	-589.80
CAediting_637872	ENST00000262103.6	chr8_48723871_-	-572.70	-573.10	-589.80
CAediting_637873	ENST00000262103.6	chr8_48723890_-	-573.20	-573.10	-589.80
CAediting_637874	ENST00000262103.6	chr8_48723891_-	-573.50	-573.10	-589.80
CAediting_637875	ENST00000262103.6	chr8_48723892_-	-572.80	-573.10	-589.80
CAediting_637876	ENST00000262103.6	chr8_48723903_-	-573.90	-573.10	-589.80
CAediting_637877	ENST00000262103.6	chr8_48723912_-	-575.10	-573.10	-589.80
CAediting_637878	ENST00000262103.6	chr8_48723924_-	-575.90	-573.10	-589.80
CAediting_637879	ENST00000262103.6	chr8_48723926_-	-578.10	-573.10	-589.80
CAediting_637880	ENST00000262103.6	chr8_48723957_-	-573.70	-573.10	-589.80

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Relation with ADAR for EFCAB1

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
BLCA	CAediting_637873	chr8_48723890_-	0.0234530386474617	0.320070919709513	.	.	.	.
LUAD	CAediting_637873	chr8_48723890_-	0.0168856112585294	0.232735635609665	.	.	0.0479573959283508	0.193496276723297
UCEC	CAediting_637873	chr8_48723890_-	8.47626576580707e-06	0.320023802620307	0.0022336929195533	0.222845792133327	.	.
SARC	CAediting_637873	chr8_48723890_-	0.000300350900401773	0.454375088515492	0.0168456799464713	0.31008169570309	.	.

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Relation with cancer stages for EFCAB1

Correlation between Cancer stages and RNA editing frequency

Cancer	Stage_type	CAeditomID	position	P-val	Coeff.
HNSC	clinical_stage	CAediting_637873	chr8_48723890_-	0.0393091055744446	0.284005238733169
UCEC	clinical_stage	CAediting_637869	chr8_48723809_-	0.0459507293946336	-0.283603662493216

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Relation with survival for EFCAB1

Correlation between RNA editing and survival

Cancer	CAeditomID	position	KMpvalue	Coxpvalue	CoxHR
HNSC	CAediting_637873	chr8_48723890_-	0.0261720944595565	0.005038	0.000175095

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RelatedDrugs for EFCAB1

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for EFCAB1

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene