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Editing gene: AHNAK (CAeditome ID:79026)

Gene summary for AHNAK

Gene summary

Gene information	Gene symbol	AHNAK
	Gene ID	79026
	Gene name	AHNAK nucleoprotein
	Synonyms	AHNAKRS\|PM227
	Cytomap	11q12.3
	Type of gene	protein-coding
	Description	neuroblast differentiation-associated protein AHNAKAHNAK-relateddesmoyokin
	Modification date	20210518
	UniProtAcc	Q09666
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
AHNAK	GO:0045121	Neuroblast differentiation-associated protein AHNAK	14699089
AHNAK	GO:0005737	Neuroblast differentiation-associated protein AHNAK	22057634
AHNAK	GO:0005829	Neuroblast differentiation-associated protein AHNAK	0000052
AHNAK	GO:0005886	Neuroblast differentiation-associated protein AHNAK	0000052
AHNAK	GO:0005886	Neuroblast differentiation-associated protein AHNAK	21940993
AHNAK	GO:0005886	Neuroblast differentiation-associated protein AHNAK	22057634
AHNAK	GO:0015629	Neuroblast differentiation-associated protein AHNAK	21940993
AHNAK	GO:0031982	Neuroblast differentiation-associated protein AHNAK	21940993
AHNAK	GO:0042383	Neuroblast differentiation-associated protein AHNAK	22057634
AHNAK	GO:0044291	Neuroblast differentiation-associated protein AHNAK	21940993
AHNAK	GO:0070062	Neuroblast differentiation-associated protein AHNAK	22057634

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RNA A-to-I events for AHNAK

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000124942.12

RNA A-to-I editing events in Cancer.

CAediting_818191(62434831, -), CAediting_818192(62435478, -), CAediting_818193(62435798, -), CAediting_818194(62435799, -), CAediting_818195(62437922, -), CAediting_818196(62439156, -), CAediting_818197(62442330, -), CAediting_818198(62442355, -), CAediting_818199(62442376, -), CAediting_818200(62442436, -), CAediting_818201(62442439, -), CAediting_818202(62450015, -), CAediting_818203(62450396, -), CAediting_818204(62450397, -), CAediting_818205(62450472, -), CAediting_818206(62451163, -), CAediting_818207(62451481, -), CAediting_818208(62452858, -), CAediting_818209(62452903, -), CAediting_818210(62454291, -), CAediting_818211(62455049, -), CAediting_818212(62455939, -), CAediting_818213(62460959, -), CAediting_818214(62464257, -), CAediting_818215(62467109, -), CAediting_818216(62468146, -), CAediting_818217(62469154, -), CAediting_818218(62469260, -), CAediting_818219(62469747, -), CAediting_818220(62472861, -), CAediting_818221(62473289, -), CAediting_818222(62473905, -), CAediting_818223(62475690, -), CAediting_818224(62475737, -), CAediting_818225(62476391, -), CAediting_818226(62479014, -), CAediting_818227(62479035, -), CAediting_818228(62481243, -), CAediting_818229(62481244, -), CAediting_818230(62482291, -), CAediting_818231(62482303, -), CAediting_818232(62484852, -), CAediting_818233(62484886, -), CAediting_818234(62484954, -), CAediting_818235(62485155, -), CAediting_818236(62488494, -), CAediting_818237(62488498, -), CAediting_818238(62488499, -), CAediting_818239(62488526, -), CAediting_818240(62488529, -), CAediting_818241(62488539, -), CAediting_818242(62488563, -), CAediting_818243(62488606, -), CAediting_818244(62488607, -), CAediting_818245(62488608, -), CAediting_818246(62488611, -), CAediting_818247(62489192, -), CAediting_818248(62490340, -), CAediting_818249(62490383, -), CAediting_818250(62490403, -), CAediting_818251(62490404, -), CAediting_818252(62490428, -), CAediting_818253(62490482, -), CAediting_818254(62490967, -), CAediting_818255(62490970, -), CAediting_818256(62490987, -), CAediting_818257(62490996, -), CAediting_818258(62491059, -), CAediting_818259(62491060, -), CAediting_818260(62492756, -), CAediting_818261(62492796, -), CAediting_818262(62493102, -), CAediting_818263(62493109, -), CAediting_818264(62493150, -), CAediting_818265(62493241, -), CAediting_818266(62493278, -), CAediting_818267(62493431, -), CAediting_818268(62493454, -), CAediting_818269(62493463, -), CAediting_818270(62493474, -), CAediting_818271(62493737, -), CAediting_818272(62493752, -), CAediting_818273(62508081, -), CAediting_818274(62511338, -), CAediting_818275(62511349, -), CAediting_818276(62511390, -), CAediting_818277(62511417, -), CAediting_818278(62512644, -), CAediting_818279(62520486, -), CAediting_818280(62528038, -),

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RNA editing positional annotations for AHNAK using Annovar

Protein coding RNA editing(s).

CAeditome ID	Position	Variant type	ENST	NTchange	AAchange	SIFT_score	Polyphen2_HVAR_score	PROVEAN_pred
CAediting_818280	chr11_62528038_-	nonsynonymous SNV	ENST00000378024.7	c.A6379G	p.K2127E	T	D	N

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_818191	chr11_62434831_-	ncRNA_intronic
CAediting_818192	chr11_62435478_-	ncRNA_intronic
CAediting_818193	chr11_62435798_-	ncRNA_intronic
CAediting_818194	chr11_62435799_-	ncRNA_intronic
CAediting_818195	chr11_62437922_-	ncRNA_intronic
CAediting_818196	chr11_62439156_-	ncRNA_intronic
CAediting_818197	chr11_62442330_-	ncRNA_intronic
CAediting_818198	chr11_62442355_-	ncRNA_intronic
CAediting_818199	chr11_62442376_-	ncRNA_intronic
CAediting_818200	chr11_62442436_-	ncRNA_intronic
CAediting_818201	chr11_62442439_-	ncRNA_intronic
CAediting_818202	chr11_62450015_-	ncRNA_intronic
CAediting_818203	chr11_62450396_-	ncRNA_intronic
CAediting_818204	chr11_62450397_-	ncRNA_intronic
CAediting_818205	chr11_62450472_-	ncRNA_intronic
CAediting_818206	chr11_62451163_-	ncRNA_intronic
CAediting_818207	chr11_62451481_-	ncRNA_intronic
CAediting_818208	chr11_62452858_-	ncRNA_intronic
CAediting_818209	chr11_62452903_-	ncRNA_intronic
CAediting_818210	chr11_62454291_-	ncRNA_intronic
CAediting_818211	chr11_62455049_-	ncRNA_intronic
CAediting_818212	chr11_62455939_-	ncRNA_intronic
CAediting_818213	chr11_62460959_-	ncRNA_intronic
CAediting_818214	chr11_62464257_-	ncRNA_intronic
CAediting_818215	chr11_62467109_-	ncRNA_intronic
CAediting_818216	chr11_62468146_-	ncRNA_intronic
CAediting_818217	chr11_62469154_-	ncRNA_intronic
CAediting_818218	chr11_62469260_-	ncRNA_intronic
CAediting_818219	chr11_62469747_-	ncRNA_intronic
CAediting_818220	chr11_62472861_-	ncRNA_intronic
CAediting_818221	chr11_62473289_-	ncRNA_intronic
CAediting_818222	chr11_62473905_-	ncRNA_intronic
CAediting_818223	chr11_62475690_-	ncRNA_intronic
CAediting_818224	chr11_62475737_-	ncRNA_intronic
CAediting_818225	chr11_62476391_-	ncRNA_intronic
CAediting_818226	chr11_62479014_-	ncRNA_intronic
CAediting_818227	chr11_62479035_-	ncRNA_intronic
CAediting_818228	chr11_62481243_-	ncRNA_intronic
CAediting_818229	chr11_62481244_-	ncRNA_intronic
CAediting_818230	chr11_62482291_-	ncRNA_intronic
CAediting_818231	chr11_62482303_-	ncRNA_intronic
CAediting_818232	chr11_62484852_-	ncRNA_intronic
CAediting_818233	chr11_62484886_-	ncRNA_intronic
CAediting_818234	chr11_62484954_-	ncRNA_intronic
CAediting_818235	chr11_62485155_-	ncRNA_intronic
CAediting_818236	chr11_62488494_-	ncRNA_intronic
CAediting_818237	chr11_62488498_-	ncRNA_intronic
CAediting_818238	chr11_62488499_-	ncRNA_intronic
CAediting_818239	chr11_62488526_-	ncRNA_intronic
CAediting_818240	chr11_62488529_-	ncRNA_intronic
CAediting_818241	chr11_62488539_-	ncRNA_intronic
CAediting_818242	chr11_62488563_-	ncRNA_intronic
CAediting_818243	chr11_62488606_-	ncRNA_intronic
CAediting_818244	chr11_62488607_-	ncRNA_intronic
CAediting_818245	chr11_62488608_-	ncRNA_intronic
CAediting_818246	chr11_62488611_-	ncRNA_intronic
CAediting_818247	chr11_62489192_-	ncRNA_intronic
CAediting_818248	chr11_62490340_-	ncRNA_intronic
CAediting_818249	chr11_62490383_-	ncRNA_intronic
CAediting_818250	chr11_62490403_-	ncRNA_intronic
CAediting_818251	chr11_62490404_-	ncRNA_intronic
CAediting_818252	chr11_62490428_-	ncRNA_intronic
CAediting_818253	chr11_62490482_-	ncRNA_intronic
CAediting_818254	chr11_62490967_-	ncRNA_intronic
CAediting_818255	chr11_62490970_-	ncRNA_intronic
CAediting_818256	chr11_62490987_-	ncRNA_intronic
CAediting_818257	chr11_62490996_-	ncRNA_intronic
CAediting_818258	chr11_62491059_-	ncRNA_intronic
CAediting_818259	chr11_62491060_-	ncRNA_intronic
CAediting_818260	chr11_62492756_-	ncRNA_intronic
CAediting_818261	chr11_62492796_-	ncRNA_intronic
CAediting_818262	chr11_62493102_-	ncRNA_intronic
CAediting_818263	chr11_62493109_-	ncRNA_intronic
CAediting_818264	chr11_62493150_-	ncRNA_intronic
CAediting_818265	chr11_62493241_-	ncRNA_intronic
CAediting_818266	chr11_62493278_-	ncRNA_intronic
CAediting_818267	chr11_62493431_-	ncRNA_intronic
CAediting_818268	chr11_62493454_-	ncRNA_intronic
CAediting_818269	chr11_62493463_-	ncRNA_intronic
CAediting_818270	chr11_62493474_-	ncRNA_intronic
CAediting_818271	chr11_62493737_-	ncRNA_intronic
CAediting_818272	chr11_62493752_-	ncRNA_intronic
CAediting_818273	chr11_62508081_-	ncRNA_intronic
CAediting_818274	chr11_62511338_-	ncRNA_intronic
CAediting_818275	chr11_62511349_-	ncRNA_intronic
CAediting_818276	chr11_62511390_-	ncRNA_intronic
CAediting_818277	chr11_62511417_-	ncRNA_intronic
CAediting_818278	chr11_62512644_-	ncRNA_intronic
CAediting_818279	chr11_62520486_-	exonic
CAediting_818280	chr11_62528038_-	exonic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_818191	chr11_62434831_-	SINE	Alu	AluSx
CAediting_818192	chr11_62435478_-	SINE	Alu	AluYe5
CAediting_818193	chr11_62435798_-	SINE	Alu	FLAM_C
CAediting_818194	chr11_62435799_-	SINE	Alu	FLAM_C
CAediting_818195	chr11_62437922_-	SINE	Alu	AluJr
CAediting_818196	chr11_62439156_-	SINE	Alu	AluY
CAediting_818197	chr11_62442330_-	SINE	Alu	AluJb
CAediting_818198	chr11_62442355_-	SINE	Alu	AluJb
CAediting_818199	chr11_62442376_-	SINE	Alu	AluJb
CAediting_818200	chr11_62442436_-	SINE	Alu	AluJb
CAediting_818201	chr11_62442439_-	SINE	Alu	AluJb
CAediting_818202	chr11_62450015_-	SINE	Alu	AluJo
CAediting_818203	chr11_62450396_-	SINE	Alu	AluSq2
CAediting_818204	chr11_62450397_-	SINE	Alu	AluSq2
CAediting_818205	chr11_62450472_-	SINE	Alu	AluSq2
CAediting_818206	chr11_62451163_-	SINE	Alu	AluSg7
CAediting_818207	chr11_62451481_-	SINE	Alu	AluSz
CAediting_818208	chr11_62452858_-	SINE	Alu	AluSz
CAediting_818209	chr11_62452903_-	SINE	Alu	AluSz
CAediting_818210	chr11_62454291_-	SINE	Alu	AluY
CAediting_818211	chr11_62455049_-	SINE	Alu	AluSq
CAediting_818212	chr11_62455939_-	SINE	Alu	AluSq
CAediting_818213	chr11_62460959_-	SINE	Alu	AluY
CAediting_818214	chr11_62464257_-	SINE	Alu	AluJb
CAediting_818215	chr11_62467109_-	SINE	Alu	AluJb
CAediting_818216	chr11_62468146_-	SINE	Alu	AluSz6
CAediting_818217	chr11_62469154_-	SINE	Alu	AluSz
CAediting_818218	chr11_62469260_-	SINE	Alu	AluSz
CAediting_818219	chr11_62469747_-	SINE	Alu	AluSz6
CAediting_818220	chr11_62472861_-	SINE	Alu	AluSz
CAediting_818221	chr11_62473289_-	SINE	Alu	AluSx3
CAediting_818222	chr11_62473905_-	SINE	Alu	AluJb
CAediting_818223	chr11_62475690_-	SINE	Alu	AluSx1
CAediting_818224	chr11_62475737_-	SINE	Alu	AluSx1
CAediting_818225	chr11_62476391_-	SINE	Alu	AluSx
CAediting_818226	chr11_62479014_-	SINE	Alu	AluSc8
CAediting_818227	chr11_62479035_-	SINE	Alu	AluSc8
CAediting_818228	chr11_62481243_-	SINE	Alu	AluSq
CAediting_818229	chr11_62481244_-	SINE	Alu	AluSq
CAediting_818230	chr11_62482291_-	SINE	Alu	AluSz
CAediting_818231	chr11_62482303_-	SINE	Alu	AluSz
CAediting_818232	chr11_62484852_-	SINE	Alu	AluSp
CAediting_818233	chr11_62484886_-	SINE	Alu	AluSp
CAediting_818234	chr11_62484954_-	SINE	Alu	AluSp
CAediting_818235	chr11_62485155_-	SINE	Alu	AluJr
CAediting_818236	chr11_62488494_-	SINE	Alu	AluSq2
CAediting_818237	chr11_62488498_-	SINE	Alu	AluSq2
CAediting_818238	chr11_62488499_-	SINE	Alu	AluSq2
CAediting_818239	chr11_62488526_-	SINE	Alu	AluSq2
CAediting_818240	chr11_62488529_-	SINE	Alu	AluSq2
CAediting_818241	chr11_62488539_-	SINE	Alu	AluSq2
CAediting_818242	chr11_62488563_-	SINE	Alu	AluSq2
CAediting_818243	chr11_62488606_-	SINE	Alu	AluSq2
CAediting_818244	chr11_62488607_-	SINE	Alu	AluSq2
CAediting_818245	chr11_62488608_-	SINE	Alu	AluSq2
CAediting_818246	chr11_62488611_-	SINE	Alu	AluSq2
CAediting_818247	chr11_62489192_-	SINE	Alu	AluSx3
CAediting_818248	chr11_62490340_-	SINE	Alu	AluSg
CAediting_818249	chr11_62490383_-	SINE	Alu	AluSg
CAediting_818250	chr11_62490403_-	SINE	Alu	AluSg
CAediting_818251	chr11_62490404_-	SINE	Alu	AluSg
CAediting_818252	chr11_62490428_-	SINE	Alu	AluSg
CAediting_818253	chr11_62490482_-	SINE	Alu	AluSg
CAediting_818254	chr11_62490967_-	SINE	Alu	AluSx1
CAediting_818255	chr11_62490970_-	SINE	Alu	AluSx1
CAediting_818256	chr11_62490987_-	SINE	Alu	AluSx1
CAediting_818257	chr11_62490996_-	SINE	Alu	AluSx1
CAediting_818258	chr11_62491059_-	SINE	Alu	AluSx1
CAediting_818259	chr11_62491060_-	SINE	Alu	AluSx1
CAediting_818260	chr11_62492756_-	SINE	Alu	AluJb
CAediting_818261	chr11_62492796_-	SINE	Alu	AluJb
CAediting_818262	chr11_62493102_-	SINE	Alu	AluSx
CAediting_818263	chr11_62493109_-	SINE	Alu	AluSx
CAediting_818264	chr11_62493150_-	SINE	Alu	AluSx
CAediting_818265	chr11_62493241_-	SINE	Alu	AluSx
CAediting_818266	chr11_62493278_-	SINE	Alu	AluSx
CAediting_818267	chr11_62493431_-	SINE	Alu	AluSx
CAediting_818268	chr11_62493454_-	SINE	Alu	AluSx
CAediting_818269	chr11_62493463_-	SINE	Alu	AluSx
CAediting_818270	chr11_62493474_-	SINE	Alu	AluSx
CAediting_818271	chr11_62493737_-	SINE	Alu	FLAM_C
CAediting_818272	chr11_62493752_-	SINE	Alu	FLAM_C
CAediting_818273	chr11_62508081_-	SINE	Alu	FRAM
CAediting_818274	chr11_62511338_-	SINE	Alu	AluSz
CAediting_818275	chr11_62511349_-	SINE	Alu	AluSz
CAediting_818276	chr11_62511390_-	SINE	Alu	AluSz
CAediting_818277	chr11_62511417_-	SINE	Alu	AluSz
CAediting_818278	chr11_62512644_-	SINE	Alu	AluJb

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RNA A-to-I editing events in the alternative splicing sites for AHNAK

RNA A-to-I editing(s) in the alternative splicing sites.

AStype	CAeditomID	Editing position	AS position	AS direction	Exonic location	Wildtype sequence	Wildtype splicing strength	RNA edited sequence	RNA edited splicing strength
IR	CAediting_818279	chr11_62520486_-	62520481:62520503	3SS	0+3i	CCCAGATGTGGACGTTCAAGGCC	-1.55	CCCAGATGTGGACGTTCGAGGCC	-4.84
MEX_1	CAediting_818279	chr11_62520486_-	62520481:62520503	3SS	0+3i	CCCAGATGTGGACGTTCAAGGCC	-1.55	CCCAGATGTGGACGTTCGAGGCC	-4.84

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000124942.12.AHNAK.

Correlation between RNA A-to-I editing and PSI for ENSG00000124942.12.AHNAK.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for AHNAK

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for AHNAK

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for AHNAK

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for AHNAK

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for AHNAK

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for AHNAK

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for AHNAK

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for AHNAK

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for AHNAK

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
AHNAK	C0007134	Renal Cell Carcinoma	1	CTD_human
AHNAK	C0023893	Liver Cirrhosis, Experimental	1	CTD_human
AHNAK	C0027626	Neoplasm Invasiveness	1	CTD_human
AHNAK	C0263454	Chloracne	1	CTD_human
AHNAK	C0279702	Conventional (Clear Cell) Renal Cell Carcinoma	1	CTD_human
AHNAK	C1266042	Chromophobe Renal Cell Carcinoma	1	CTD_human
AHNAK	C1266043	Sarcomatoid Renal Cell Carcinoma	1	CTD_human
AHNAK	C1266044	Collecting Duct Carcinoma of the Kidney	1	CTD_human
AHNAK	C1306837	Papillary Renal Cell Carcinoma	1	CTD_human

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene