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Editing gene: MIS12 (CAeditome ID:79003)

Gene summary for MIS12

Gene summary

Gene information	Gene symbol	MIS12
	Gene ID	79003
	Gene name	MIS12 kinetochore complex component
	Synonyms	2510025F08Rik\|KNTC2AP\|MTW1\|hMis12
	Cytomap	17p13.2
	Type of gene	protein-coding
	Description	protein MIS12 homologMIS12 homologMIS12, MIND kinetochore complex component, homologhomolog of yeast Mis12
	Modification date	20210518
	UniProtAcc	Q9H081
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
MIS12	GO:0051382	Protein MIS12 homolog	16585270
MIS12	GO:0000776	Protein MIS12 homolog	15371340
MIS12	GO:0005634	Protein MIS12 homolog	0000054
MIS12	GO:0000444	Protein MIS12 homolog	16585270

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RNA A-to-I events for MIS12

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000167842.14

RNA A-to-I editing events in Cancer.

CAediting_1159667(5487143, +), CAediting_1159668(5487144, +), CAediting_1159669(5487149, +), CAediting_1159670(5487153, +), CAediting_1159671(5487166, +), CAediting_1159672(5487171, +), CAediting_1159673(5487179, +), CAediting_1159674(5487185, +), CAediting_1159675(5487189, +), CAediting_1159676(5487192, +), CAediting_1159677(5487196, +), CAediting_1159678(5487214, +), CAediting_1159679(5487221, +), CAediting_1159680(5487246, +), CAediting_1159681(5487264, +), CAediting_1159682(5487266, +), CAediting_1159683(5487269, +), CAediting_1159684(5487271, +), CAediting_1159685(5487272, +), CAediting_1159686(5487285, +), CAediting_1159687(5487286, +), CAediting_1159688(5487289, +), CAediting_1159689(5487293, +), CAediting_1159690(5487297, +), CAediting_1159691(5487309, +), CAediting_1159692(5487332, +), CAediting_1159693(5487334, +), CAediting_1159694(5487338, +), CAediting_1159695(5487345, +), CAediting_1159696(5487377, +), CAediting_1159697(5487401, +), CAediting_1159698(5487418, +), CAediting_1159699(5487439, +), CAediting_1159700(5487557, +), CAediting_1159701(5487593, +), CAediting_1159702(5487595, +), CAediting_1159703(5487596, +), CAediting_1159704(5487606, +), CAediting_1159705(5487611, +), CAediting_1159706(5487612, +), CAediting_1159707(5487661, +), CAediting_1159708(5487674, +), CAediting_1159709(5487677, +), CAediting_1159710(5487721, +), CAediting_1159711(5487792, +), CAediting_1159712(5487793, +), CAediting_1159713(5489868, +), CAediting_1159714(5489871, +), CAediting_1159715(5489874, +), CAediting_1159716(5489884, +), CAediting_1159717(5489889, +), CAediting_1159718(5489904, +), CAediting_1159719(5489913, +), CAediting_1159720(5489920, +), CAediting_1159721(5489933, +), CAediting_1159722(5489944, +), CAediting_1159723(5489949, +), CAediting_1159724(5489970, +), CAediting_1159725(5489974, +), CAediting_1159726(5489995, +), CAediting_1159727(5489996, +), CAediting_1159728(5489999, +), CAediting_1159729(5490003, +), CAediting_1159730(5490009, +), CAediting_1159731(5490022, +), CAediting_1159732(5490053, +),

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RNA editing positional annotations for MIS12 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_1159667	chr17_5487143_+	ncRNA_exonic
CAediting_1159668	chr17_5487144_+	ncRNA_exonic
CAediting_1159669	chr17_5487149_+	ncRNA_exonic
CAediting_1159670	chr17_5487153_+	ncRNA_exonic
CAediting_1159671	chr17_5487166_+	intronic
CAediting_1159672	chr17_5487171_+	intronic
CAediting_1159673	chr17_5487179_+	intronic
CAediting_1159674	chr17_5487185_+	intronic
CAediting_1159675	chr17_5487189_+	intronic
CAediting_1159676	chr17_5487192_+	intronic
CAediting_1159677	chr17_5487196_+	intronic
CAediting_1159678	chr17_5487214_+	intronic
CAediting_1159679	chr17_5487221_+	intronic
CAediting_1159680	chr17_5487246_+	intronic
CAediting_1159681	chr17_5487264_+	intronic
CAediting_1159682	chr17_5487266_+	intronic
CAediting_1159683	chr17_5487269_+	intronic
CAediting_1159684	chr17_5487271_+	intronic
CAediting_1159685	chr17_5487272_+	intronic
CAediting_1159686	chr17_5487285_+	intronic
CAediting_1159687	chr17_5487286_+	intronic
CAediting_1159688	chr17_5487289_+	intronic
CAediting_1159689	chr17_5487293_+	intronic
CAediting_1159690	chr17_5487297_+	intronic
CAediting_1159691	chr17_5487309_+	intronic
CAediting_1159692	chr17_5487332_+	intronic
CAediting_1159693	chr17_5487334_+	intronic
CAediting_1159694	chr17_5487338_+	intronic
CAediting_1159695	chr17_5487345_+	intronic
CAediting_1159696	chr17_5487377_+	intronic
CAediting_1159697	chr17_5487401_+	intronic
CAediting_1159698	chr17_5487418_+	intronic
CAediting_1159699	chr17_5487439_+	intronic
CAediting_1159700	chr17_5487557_+	UTR5
CAediting_1159701	chr17_5487593_+	UTR5
CAediting_1159702	chr17_5487595_+	UTR5
CAediting_1159703	chr17_5487596_+	UTR5
CAediting_1159704	chr17_5487606_+	UTR5
CAediting_1159705	chr17_5487611_+	UTR5
CAediting_1159706	chr17_5487612_+	UTR5
CAediting_1159707	chr17_5487661_+	UTR5
CAediting_1159708	chr17_5487674_+	UTR5
CAediting_1159709	chr17_5487677_+	UTR5
CAediting_1159710	chr17_5487721_+	intronic
CAediting_1159711	chr17_5487792_+	intronic
CAediting_1159712	chr17_5487793_+	intronic
CAediting_1159713	chr17_5489868_+	UTR3
CAediting_1159714	chr17_5489871_+	UTR3
CAediting_1159715	chr17_5489874_+	UTR3
CAediting_1159716	chr17_5489884_+	UTR3
CAediting_1159717	chr17_5489889_+	UTR3
CAediting_1159718	chr17_5489904_+	UTR3
CAediting_1159719	chr17_5489913_+	UTR3
CAediting_1159720	chr17_5489920_+	UTR3
CAediting_1159721	chr17_5489933_+	UTR3
CAediting_1159722	chr17_5489944_+	UTR3
CAediting_1159723	chr17_5489949_+	UTR3
CAediting_1159724	chr17_5489970_+	UTR3
CAediting_1159725	chr17_5489974_+	UTR3
CAediting_1159726	chr17_5489995_+	UTR3
CAediting_1159727	chr17_5489996_+	UTR3
CAediting_1159728	chr17_5489999_+	UTR3
CAediting_1159729	chr17_5490003_+	UTR3
CAediting_1159730	chr17_5490009_+	UTR3
CAediting_1159731	chr17_5490022_+	UTR3
CAediting_1159732	chr17_5490053_+	UTR3

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_1159667	chr17_5487143_+	SINE	Alu	AluJb
CAediting_1159668	chr17_5487144_+	SINE	Alu	AluJb
CAediting_1159669	chr17_5487149_+	SINE	Alu	AluJb
CAediting_1159670	chr17_5487153_+	SINE	Alu	AluJb
CAediting_1159671	chr17_5487166_+	SINE	Alu	AluJb
CAediting_1159672	chr17_5487171_+	SINE	Alu	AluJb
CAediting_1159673	chr17_5487179_+	SINE	Alu	AluJb
CAediting_1159674	chr17_5487185_+	SINE	Alu	AluJb
CAediting_1159675	chr17_5487189_+	SINE	Alu	AluJb
CAediting_1159676	chr17_5487192_+	SINE	Alu	AluJb
CAediting_1159677	chr17_5487196_+	SINE	Alu	AluJb
CAediting_1159678	chr17_5487214_+	SINE	Alu	AluJb
CAediting_1159679	chr17_5487221_+	SINE	Alu	AluJb
CAediting_1159680	chr17_5487246_+	SINE	Alu	AluJb
CAediting_1159681	chr17_5487264_+	SINE	Alu	AluJb
CAediting_1159682	chr17_5487266_+	SINE	Alu	AluJb
CAediting_1159683	chr17_5487269_+	SINE	Alu	AluJb
CAediting_1159684	chr17_5487271_+	SINE	Alu	AluJb
CAediting_1159685	chr17_5487272_+	SINE	Alu	AluJb
CAediting_1159686	chr17_5487285_+	SINE	Alu	AluJb
CAediting_1159687	chr17_5487286_+	SINE	Alu	AluJb
CAediting_1159688	chr17_5487289_+	SINE	Alu	AluJb
CAediting_1159689	chr17_5487293_+	SINE	Alu	AluJb
CAediting_1159690	chr17_5487297_+	SINE	Alu	AluJb
CAediting_1159691	chr17_5487309_+	SINE	Alu	AluJb
CAediting_1159692	chr17_5487332_+	SINE	Alu	AluJb
CAediting_1159693	chr17_5487334_+	SINE	Alu	AluJb
CAediting_1159694	chr17_5487338_+	SINE	Alu	AluJb
CAediting_1159695	chr17_5487345_+	SINE	Alu	AluJb
CAediting_1159696	chr17_5487377_+	SINE	Alu	AluJb
CAediting_1159697	chr17_5487401_+	SINE	Alu	AluJb
CAediting_1159698	chr17_5487418_+	SINE	Alu	AluJb
CAediting_1159699	chr17_5487439_+	SINE	Alu	AluJb
CAediting_1159700	chr17_5487557_+	SINE	Alu	AluSx1
CAediting_1159701	chr17_5487593_+	SINE	Alu	AluSx1
CAediting_1159702	chr17_5487595_+	SINE	Alu	AluSx1
CAediting_1159703	chr17_5487596_+	SINE	Alu	AluSx1
CAediting_1159704	chr17_5487606_+	SINE	Alu	AluSx1
CAediting_1159705	chr17_5487611_+	SINE	Alu	AluSx1
CAediting_1159706	chr17_5487612_+	SINE	Alu	AluSx1
CAediting_1159707	chr17_5487661_+	SINE	Alu	AluSx1
CAediting_1159708	chr17_5487674_+	SINE	Alu	AluSx1
CAediting_1159709	chr17_5487677_+	SINE	Alu	AluSx1
CAediting_1159710	chr17_5487721_+	SINE	Alu	AluSx1
CAediting_1159711	chr17_5487792_+	SINE	Alu	AluSx1
CAediting_1159712	chr17_5487793_+	SINE	Alu	AluSx1
CAediting_1159716	chr17_5489884_+	SINE	Alu	AluJr4
CAediting_1159717	chr17_5489889_+	SINE	Alu	AluJr4
CAediting_1159718	chr17_5489904_+	SINE	Alu	AluJr4
CAediting_1159719	chr17_5489913_+	SINE	Alu	AluJr4
CAediting_1159720	chr17_5489920_+	SINE	Alu	AluJr4
CAediting_1159721	chr17_5489933_+	SINE	Alu	AluJr4
CAediting_1159722	chr17_5489944_+	SINE	Alu	AluJr4
CAediting_1159723	chr17_5489949_+	SINE	Alu	AluJr4
CAediting_1159724	chr17_5489970_+	SINE	Alu	AluJr4
CAediting_1159725	chr17_5489974_+	SINE	Alu	AluJr4
CAediting_1159726	chr17_5489995_+	SINE	Alu	AluJr4
CAediting_1159727	chr17_5489996_+	SINE	Alu	AluJr4
CAediting_1159728	chr17_5489999_+	SINE	Alu	AluJr4
CAediting_1159729	chr17_5490003_+	SINE	Alu	AluJr4
CAediting_1159730	chr17_5490009_+	SINE	Alu	AluJr4
CAediting_1159731	chr17_5490022_+	SINE	Alu	AluJr4
CAediting_1159732	chr17_5490053_+	SINE	Alu	AluJr4

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RNA A-to-I editing events in the alternative splicing sites for MIS12

RNA A-to-I editing(s) in the alternative splicing sites.

AStype	CAeditomID	Editing position	AS position	AS direction	Exonic location	Wildtype sequence	Wildtype splicing strength	RNA edited sequence	RNA edited splicing strength
ES	CAediting_1159694	chr17_5487338_+	5487337:5487345	5SS	2+0i	GAGGTGGGA	4.3	GGGGTGGGA	-0.25
MEX_1	CAediting_1159694	chr17_5487338_+	5487337:5487345	5SS	2+0i	GAGGTGGGA	4.3	GGGGTGGGA	-0.25
ES	CAediting_1159695	chr17_5487345_+	5487337:5487345	5SS	0+6i	GAGGTGGGA	4.3	GAGGTGGGG	4.41
MEX_1	CAediting_1159695	chr17_5487345_+	5487337:5487345	5SS	0+6i	GAGGTGGGA	4.3	GAGGTGGGG	4.41
ES	CAediting_1159700	chr17_5487557_+	5487536:5487558	3SS	2+0i	TTATTTTATTTTTTGAGACAGAG	-15.12	TTATTTTATTTTTTGAGACAGGG	-15.11
MEX_2	CAediting_1159700	chr17_5487557_+	5487536:5487558	3SS	2+0i	TTATTTTATTTTTTGAGACAGAG	-15.12	TTATTTTATTTTTTGAGACAGGG	-15.11

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000167842.14.MIS12.

Correlation between RNA A-to-I editing and PSI for ENSG00000167842.14.MIS12.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for MIS12

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

KIRP.CAediting_1159708.ENSG00000167842.MIS12.png
Soverview

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Protein coding region RNA A-to-I editings for MIS12

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for MIS12

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1159718	chr17_5489904_+	ENSG00000167842.14	ENST00000573759	hsa-miR-1273c	5489899	5489904	6mer	5489884	5489905	144.00	-24.54
CAediting_1159718	chr17_5489904_+	ENSG00000167842.14	ENST00000573759	hsa-miR-1285-3p	5489903	5489908	6mer	5489888	5489909	140.00	-25.05
CAediting_1159718	chr17_5489904_+	ENSG00000167842.14	ENST00000573759	hsa-miR-1285-3p	5489903	5489908	6mer	5489888	5489909	140.00	-25.05
CAediting_1159718	chr17_5489904_+	ENSG00000167842.14	ENST00000573759	hsa-miR-4486	5489902	5489908	7mer-m8	5489893	5489909	145.00	-18.47
CAediting_1159718	chr17_5489904_+	ENSG00000167842.14	ENST00000381165	hsa-miR-1273c	5489899	5489904	6mer	5489884	5489905	144.00	-24.54
CAediting_1159718	chr17_5489904_+	ENSG00000167842.14	ENST00000381165	hsa-miR-1285-3p	5489903	5489908	6mer	5489888	5489909	140.00	-25.05
CAediting_1159718	chr17_5489904_+	ENSG00000167842.14	ENST00000381165	hsa-miR-1285-3p	5489903	5489908	6mer	5489888	5489909	140.00	-25.05
CAediting_1159718	chr17_5489904_+	ENSG00000167842.14	ENST00000381165	hsa-miR-4486	5489902	5489908	7mer-m8	5489893	5489909	145.00	-18.47
CAediting_1159724	chr17_5489970_+	ENSG00000167842.14	ENST00000573759	hsa-miR-3622a-3p	5489966	5489973	8mer-1a	5489952	5489973	148.00	-19.86
CAediting_1159724	chr17_5489970_+	ENSG00000167842.14	ENST00000573759	hsa-miR-3622b-3p	5489966	5489973	8mer-1a	5489953	5489973	156.00	-23.59
CAediting_1159724	chr17_5489970_+	ENSG00000167842.14	ENST00000573759	hsa-miR-6751-3p	5489963	5489969	7mer-m8	5489950	5489970	141.00	-15.51
CAediting_1159724	chr17_5489970_+	ENSG00000167842.14	ENST00000381165	hsa-miR-3622a-3p	5489966	5489973	8mer-1a	5489952	5489973	148.00	-19.86
CAediting_1159724	chr17_5489970_+	ENSG00000167842.14	ENST00000381165	hsa-miR-3622b-3p	5489966	5489973	8mer-1a	5489953	5489973	156.00	-23.59
CAediting_1159724	chr17_5489970_+	ENSG00000167842.14	ENST00000381165	hsa-miR-6751-3p	5489963	5489969	7mer-m8	5489950	5489970	141.00	-15.51
CAediting_1159715	chr17_5489874_+	ENSG00000167842.14	ENST00000573759	hsa-miR-196a-1-3p	5489872	5489878	7mer-m8	5489859	5489879	152.00	-6.53
CAediting_1159715	chr17_5489874_+	ENSG00000167842.14	ENST00000573759	hsa-miR-3529-3p	5489871	5489877	7mer-m8	5489855	5489878	151.00	-7.60
CAediting_1159715	chr17_5489874_+	ENSG00000167842.14	ENST00000381165	hsa-miR-196a-1-3p	5489872	5489878	7mer-m8	5489859	5489879	152.00	-6.53
CAediting_1159715	chr17_5489874_+	ENSG00000167842.14	ENST00000381165	hsa-miR-3529-3p	5489871	5489877	7mer-m8	5489855	5489878	151.00	-7.60
CAediting_1159716	chr17_5489884_+	ENSG00000167842.14	ENST00000573759	hsa-miR-4433b-5p	5489881	5489888	8mer-1a	5489868	5489888	140.00	-10.60
CAediting_1159716	chr17_5489884_+	ENSG00000167842.14	ENST00000573759	hsa-miR-4646-3p	5489882	5489888	7mer-m8	5489869	5489889	140.00	-10.34
CAediting_1159716	chr17_5489884_+	ENSG00000167842.14	ENST00000381165	hsa-miR-4433b-5p	5489881	5489888	8mer-1a	5489868	5489888	140.00	-10.60
CAediting_1159716	chr17_5489884_+	ENSG00000167842.14	ENST00000381165	hsa-miR-4646-3p	5489882	5489888	7mer-m8	5489869	5489889	140.00	-10.34
CAediting_1159717	chr17_5489889_+	ENSG00000167842.14	ENST00000573759	hsa-miR-10a-5p	5489885	5489891	7mer-m8	5489872	5489892	142.00	-12.59
CAediting_1159717	chr17_5489889_+	ENSG00000167842.14	ENST00000573759	hsa-miR-10b-5p	5489885	5489891	7mer-m8	5489867	5489892	147.00	-12.87
CAediting_1159717	chr17_5489889_+	ENSG00000167842.14	ENST00000573759	hsa-miR-339-5p	5489884	5489890	7mer-m8	5489870	5489891	150.00	-19.40
CAediting_1159717	chr17_5489889_+	ENSG00000167842.14	ENST00000573759	hsa-miR-4421	5489883	5489889	7mer-m8	5489870	5489890	152.00	-14.20
CAediting_1159717	chr17_5489889_+	ENSG00000167842.14	ENST00000573759	hsa-miR-4725-5p	5489886	5489892	7mer-m8	5489873	5489893	140.00	-14.16
CAediting_1159717	chr17_5489889_+	ENSG00000167842.14	ENST00000573759	hsa-miR-504-5p	5489886	5489892	7mer-m8	5489874	5489893	147.00	-16.35
CAediting_1159717	chr17_5489889_+	ENSG00000167842.14	ENST00000573759	hsa-miR-5699-3p	5489883	5489889	7mer-m8	5489869	5489890	141.00	-16.39
CAediting_1159717	chr17_5489889_+	ENSG00000167842.14	ENST00000381165	hsa-miR-10a-5p	5489885	5489891	7mer-m8	5489872	5489892	142.00	-12.59
CAediting_1159717	chr17_5489889_+	ENSG00000167842.14	ENST00000381165	hsa-miR-10b-5p	5489885	5489891	7mer-m8	5489867	5489892	147.00	-12.87
CAediting_1159717	chr17_5489889_+	ENSG00000167842.14	ENST00000381165	hsa-miR-339-5p	5489884	5489890	7mer-m8	5489870	5489891	150.00	-19.40
CAediting_1159717	chr17_5489889_+	ENSG00000167842.14	ENST00000381165	hsa-miR-4421	5489883	5489889	7mer-m8	5489870	5489890	152.00	-14.20
CAediting_1159717	chr17_5489889_+	ENSG00000167842.14	ENST00000381165	hsa-miR-4725-5p	5489886	5489892	7mer-m8	5489873	5489893	140.00	-14.16
CAediting_1159717	chr17_5489889_+	ENSG00000167842.14	ENST00000381165	hsa-miR-504-5p	5489886	5489892	7mer-m8	5489874	5489893	147.00	-16.35
CAediting_1159717	chr17_5489889_+	ENSG00000167842.14	ENST00000381165	hsa-miR-5699-3p	5489883	5489889	7mer-m8	5489869	5489890	141.00	-16.39
CAediting_1159719	chr17_5489913_+	ENSG00000167842.14	ENST00000573759	hsa-miR-3145-5p	5489910	5489917	8mer-1a	5489896	5489917	142.00	-10.65
CAediting_1159719	chr17_5489913_+	ENSG00000167842.14	ENST00000573759	hsa-miR-4714-3p	5489907	5489912	6mer	5489893	5489913	141.00	-27.65
CAediting_1159719	chr17_5489913_+	ENSG00000167842.14	ENST00000381165	hsa-miR-3145-5p	5489910	5489917	8mer-1a	5489896	5489917	142.00	-10.65
CAediting_1159719	chr17_5489913_+	ENSG00000167842.14	ENST00000381165	hsa-miR-4714-3p	5489907	5489912	6mer	5489893	5489913	141.00	-27.65
CAediting_1159725	chr17_5489974_+	ENSG00000167842.14	ENST00000573759	hsa-miR-1255b-2-3p	5489968	5489974	7mer-m8	5489954	5489975	140.00	-14.03
CAediting_1159725	chr17_5489974_+	ENSG00000167842.14	ENST00000573759	hsa-miR-4751	5489972	5489978	7mer-m8	5489956	5489979	150.00	-20.40
CAediting_1159725	chr17_5489974_+	ENSG00000167842.14	ENST00000381165	hsa-miR-1255b-2-3p	5489968	5489974	7mer-m8	5489954	5489975	140.00	-14.03
CAediting_1159725	chr17_5489974_+	ENSG00000167842.14	ENST00000381165	hsa-miR-4751	5489972	5489978	7mer-m8	5489956	5489979	150.00	-20.40
CAediting_1159726	chr17_5489995_+	ENSG00000167842.14	ENST00000573759	hsa-miR-6771-5p	5489989	5489995	7mer-m8	5489977	5489996	160.00	-34.33
CAediting_1159726	chr17_5489995_+	ENSG00000167842.14	ENST00000381165	hsa-miR-6771-5p	5489989	5489995	7mer-m8	5489977	5489996	160.00	-34.33
CAediting_1159727	chr17_5489996_+	ENSG00000167842.14	ENST00000573759	hsa-miR-6852-5p	5489991	5489996	6mer	5489978	5489997	149.00	-26.62
CAediting_1159727	chr17_5489996_+	ENSG00000167842.14	ENST00000381165	hsa-miR-6852-5p	5489991	5489996	6mer	5489978	5489997	149.00	-26.62
CAediting_1159729	chr17_5490003_+	ENSG00000167842.14	ENST00000573759	hsa-miR-5690	5489996	5490002	7mer-m8	5489983	5490003	145.00	-16.74
CAediting_1159729	chr17_5490003_+	ENSG00000167842.14	ENST00000573759	hsa-miR-7977	5489999	5490005	7mer-m8	5489989	5490006	142.00	-12.24
CAediting_1159729	chr17_5490003_+	ENSG00000167842.14	ENST00000381165	hsa-miR-5690	5489996	5490002	7mer-m8	5489983	5490003	145.00	-16.74
CAediting_1159729	chr17_5490003_+	ENSG00000167842.14	ENST00000381165	hsa-miR-7977	5489999	5490005	7mer-m8	5489989	5490006	142.00	-12.24
CAediting_1159713	chr17_5489868_+	ENSG00000167842.14	ENST00000573759	hsa-miR-16-2-3p	5489861	5489867	7mer-m8	5489846	5489868	151.00	-11.01
CAediting_1159713	chr17_5489868_+	ENSG00000167842.14	ENST00000573759	hsa-miR-195-3p	5489861	5489867	7mer-m8	5489847	5489868	156.00	-15.53
CAediting_1159713	chr17_5489868_+	ENSG00000167842.14	ENST00000573759	hsa-miR-338-5p	5489862	5489868	7mer-m8	5489847	5489869	141.00	-12.24
CAediting_1159713	chr17_5489868_+	ENSG00000167842.14	ENST00000381165	hsa-miR-16-2-3p	5489861	5489867	7mer-m8	5489846	5489868	151.00	-11.01
CAediting_1159713	chr17_5489868_+	ENSG00000167842.14	ENST00000381165	hsa-miR-195-3p	5489861	5489867	7mer-m8	5489847	5489868	156.00	-15.53
CAediting_1159713	chr17_5489868_+	ENSG00000167842.14	ENST00000381165	hsa-miR-338-5p	5489862	5489868	7mer-m8	5489847	5489869	141.00	-12.24
CAediting_1159728	chr17_5489999_+	ENSG00000167842.14	ENST00000573759	hsa-miR-3614-5p	5489992	5489998	7mer-m8	5489976	5489999	152.00	-25.27
CAediting_1159728	chr17_5489999_+	ENSG00000167842.14	ENST00000381165	hsa-miR-3614-5p	5489992	5489998	7mer-m8	5489976	5489999	152.00	-25.27

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1159726	chr17_5489995_+	ENSG00000167842.14	ENST00000573759	hsa-miR-12126	5489991	5489998	8mer-1a	5489975	5489998	147	-13.08
CAediting_1159727	chr17_5489996_+	ENSG00000167842.14	ENST00000573759	hsa-miR-12126	5489991	5489998	8mer-1a	5489975	5489998	147	-13.08
CAediting_1159718	chr17_5489904_+	ENSG00000167842.14	ENST00000573759	hsa-miR-1262	5489901	5489907	7mer-m8	5489892	5489908	142	-17.82
CAediting_1159726	chr17_5489995_+	ENSG00000167842.14	ENST00000573759	hsa-miR-30b-3p	5489988	5489995	8mer-1a	5489974	5489995	151	-15.38
CAediting_1159722	chr17_5489944_+	ENSG00000167842.14	ENST00000573759	hsa-miR-3174	5489940	5489945	6mer	5489925	5489946	141	-20.38
CAediting_1159726	chr17_5489995_+	ENSG00000167842.14	ENST00000573759	hsa-miR-3689a-3p	5489988	5489995	8mer-1a	5489975	5489995	147	-18.72
CAediting_1159726	chr17_5489995_+	ENSG00000167842.14	ENST00000573759	hsa-miR-3689b-3p	5489988	5489995	8mer-1a	5489975	5489995	147	-17.55
CAediting_1159726	chr17_5489995_+	ENSG00000167842.14	ENST00000573759	hsa-miR-3689c	5489988	5489995	8mer-1a	5489975	5489995	147	-17.55
CAediting_1159716	chr17_5489884_+	ENSG00000167842.14	ENST00000573759	hsa-miR-371b-5p	5489878	5489885	8mer-1a	5489862	5489885	143	-8.5
CAediting_1159716	chr17_5489884_+	ENSG00000167842.14	ENST00000573759	hsa-miR-373-5p	5489878	5489885	8mer-1a	5489864	5489885	140	-8.35
CAediting_1159723	chr17_5489949_+	ENSG00000167842.14	ENST00000573759	hsa-miR-377-5p	5489947	5489953	7mer-m8	5489933	5489954	155	-19.35
CAediting_1159718	chr17_5489904_+	ENSG00000167842.14	ENST00000573759	hsa-miR-4701-3p	5489901	5489907	7mer-m8	5489889	5489908	153	-19.05
CAediting_1159718	chr17_5489904_+	ENSG00000167842.14	ENST00000573759	hsa-miR-542-3p	5489898	5489904	7mer-m8	5489884	5489905	150	-14.16
CAediting_1159719	chr17_5489913_+	ENSG00000167842.14	ENST00000573759	hsa-miR-5684	5489911	5489917	7mer-1a	5489898	5489917	150	-22.01
CAediting_1159723	chr17_5489949_+	ENSG00000167842.14	ENST00000573759	hsa-miR-6086	5489947	5489953	7mer-m8	5489935	5489954	148	-19
CAediting_1159716	chr17_5489884_+	ENSG00000167842.14	ENST00000573759	hsa-miR-616-5p	5489878	5489885	8mer-1a	5489865	5489885	149	-10.02
CAediting_1159723	chr17_5489949_+	ENSG00000167842.14	ENST00000573759	hsa-miR-6516-5p	5489943	5489949	7mer-m8	5489925	5489950	152	-16.76
CAediting_1159717	chr17_5489889_+	ENSG00000167842.14	ENST00000573759	hsa-miR-659-5p	5489887	5489893	7mer-m8	5489871	5489894	154	-14.61
CAediting_1159718	chr17_5489904_+	ENSG00000167842.14	ENST00000573759	hsa-miR-6736-5p	5489901	5489907	7mer-m8	5489888	5489908	145	-21.95
CAediting_1159726	chr17_5489995_+	ENSG00000167842.14	ENST00000573759	hsa-miR-6779-5p	5489988	5489995	8mer-1a	5489977	5489995	148	-22.58
CAediting_1159722	chr17_5489944_+	ENSG00000167842.14	ENST00000573759	hsa-miR-6807-5p	5489937	5489943	7mer-m8	5489925	5489944	145	-17.12
CAediting_1159726	chr17_5489995_+	ENSG00000167842.14	ENST00000573759	hsa-miR-887-5p	5489989	5489995	7mer-m8	5489977	5489996	143	-19.73
CAediting_1159727	chr17_5489996_+	ENSG00000167842.14	ENST00000573759	hsa-miR-887-5p	5489989	5489995	7mer-m8	5489977	5489996	143	-19.73
CAediting_1159726	chr17_5489995_+	ENSG00000167842.14	ENST00000381165	hsa-miR-12126	5489991	5489998	8mer-1a	5489975	5489998	147	-13.08
CAediting_1159727	chr17_5489996_+	ENSG00000167842.14	ENST00000381165	hsa-miR-12126	5489991	5489998	8mer-1a	5489975	5489998	147	-13.08
CAediting_1159718	chr17_5489904_+	ENSG00000167842.14	ENST00000381165	hsa-miR-1262	5489901	5489907	7mer-m8	5489892	5489908	142	-17.82
CAediting_1159726	chr17_5489995_+	ENSG00000167842.14	ENST00000381165	hsa-miR-30b-3p	5489988	5489995	8mer-1a	5489974	5489995	151	-15.38
CAediting_1159722	chr17_5489944_+	ENSG00000167842.14	ENST00000381165	hsa-miR-3174	5489940	5489945	6mer	5489925	5489946	141	-20.38
CAediting_1159726	chr17_5489995_+	ENSG00000167842.14	ENST00000381165	hsa-miR-3689a-3p	5489988	5489995	8mer-1a	5489975	5489995	147	-18.72
CAediting_1159726	chr17_5489995_+	ENSG00000167842.14	ENST00000381165	hsa-miR-3689b-3p	5489988	5489995	8mer-1a	5489975	5489995	147	-17.55
CAediting_1159726	chr17_5489995_+	ENSG00000167842.14	ENST00000381165	hsa-miR-3689c	5489988	5489995	8mer-1a	5489975	5489995	147	-17.55
CAediting_1159716	chr17_5489884_+	ENSG00000167842.14	ENST00000381165	hsa-miR-371b-5p	5489878	5489885	8mer-1a	5489862	5489885	143	-8.5
CAediting_1159716	chr17_5489884_+	ENSG00000167842.14	ENST00000381165	hsa-miR-373-5p	5489878	5489885	8mer-1a	5489864	5489885	140	-8.35
CAediting_1159723	chr17_5489949_+	ENSG00000167842.14	ENST00000381165	hsa-miR-377-5p	5489947	5489953	7mer-m8	5489933	5489954	155	-19.35
CAediting_1159718	chr17_5489904_+	ENSG00000167842.14	ENST00000381165	hsa-miR-4701-3p	5489901	5489907	7mer-m8	5489889	5489908	153	-19.05
CAediting_1159718	chr17_5489904_+	ENSG00000167842.14	ENST00000381165	hsa-miR-542-3p	5489898	5489904	7mer-m8	5489884	5489905	150	-14.16
CAediting_1159719	chr17_5489913_+	ENSG00000167842.14	ENST00000381165	hsa-miR-5684	5489911	5489917	7mer-1a	5489898	5489917	150	-22.01
CAediting_1159723	chr17_5489949_+	ENSG00000167842.14	ENST00000381165	hsa-miR-6086	5489947	5489953	7mer-m8	5489935	5489954	148	-19
CAediting_1159716	chr17_5489884_+	ENSG00000167842.14	ENST00000381165	hsa-miR-616-5p	5489878	5489885	8mer-1a	5489865	5489885	149	-10.02
CAediting_1159723	chr17_5489949_+	ENSG00000167842.14	ENST00000381165	hsa-miR-6516-5p	5489943	5489949	7mer-m8	5489925	5489950	152	-16.76
CAediting_1159717	chr17_5489889_+	ENSG00000167842.14	ENST00000381165	hsa-miR-659-5p	5489887	5489893	7mer-m8	5489871	5489894	154	-14.61
CAediting_1159718	chr17_5489904_+	ENSG00000167842.14	ENST00000381165	hsa-miR-6736-5p	5489901	5489907	7mer-m8	5489888	5489908	145	-21.95
CAediting_1159726	chr17_5489995_+	ENSG00000167842.14	ENST00000381165	hsa-miR-6779-5p	5489988	5489995	8mer-1a	5489977	5489995	148	-22.58
CAediting_1159722	chr17_5489944_+	ENSG00000167842.14	ENST00000381165	hsa-miR-6807-5p	5489937	5489943	7mer-m8	5489925	5489944	145	-17.12
CAediting_1159726	chr17_5489995_+	ENSG00000167842.14	ENST00000381165	hsa-miR-887-5p	5489989	5489995	7mer-m8	5489977	5489996	143	-19.73
CAediting_1159727	chr17_5489996_+	ENSG00000167842.14	ENST00000381165	hsa-miR-887-5p	5489989	5489995	7mer-m8	5489977	5489996	143	-19.73

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_748296	chr10_51299626_+	ENSG00000167842.14	ENST00000573759	hsa-miR-605-3p	5490499	5490506	8mer-1a	5490486	5490506	161	-14.12
CAediting_748296	chr10_51299626_+	ENSG00000167842.14	ENST00000573759	hsa-miR-605-3p	5490629	5490635	7mer-m8	5490616	5490636	141	-17.06
CAediting_748296	chr10_51299626_+	ENSG00000167842.14	ENST00000381165	hsa-miR-605-3p	5490499	5490506	8mer-1a	5490486	5490506	161	-14.12
CAediting_748296	chr10_51299626_+	ENSG00000167842.14	ENST00000381165	hsa-miR-605-3p	5490629	5490635	7mer-m8	5490616	5490636	141	-17.06
CAediting_604450	chr7_133034877_-	ENSG00000167842.14	ENST00000573759	hsa-miR-3654	5490299	5490306	8mer-1a	5490290	5490306	146	-21.06
CAediting_604450	chr7_133034877_-	ENSG00000167842.14	ENST00000381165	hsa-miR-3654	5490299	5490306	8mer-1a	5490290	5490306	146	-21.06

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1229413	chr17_67471544_+	ENSG00000167842.14	ENST00000573759	hsa-miR-548aa	5490434	5490440	7mer-m8	5490418	5490441	148	-5.82
CAediting_1229413	chr17_67471544_+	ENSG00000167842.14	ENST00000381165	hsa-miR-548aa	5490434	5490440	7mer-m8	5490418	5490441	148	-5.82

Differentially expressed gene-miRNA network

Top

The effects of the RNA editing to the stability of the RNA structures for MIS12

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

Top

Relation with ADAR for MIS12

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
STAD	CAediting_1159696	chr17_5487377_+	.	.	0.0451422661274462	0.164941281831333	.	.
KIRC	CAediting_1159696	chr17_5487377_+	.	.	0.030610902924342	0.284201132562035	.	.
KIRP	CAediting_1159696	chr17_5487377_+	0.0198042645411591	0.258493787571097	.	.	.	.
OV	CAediting_1159696	chr17_5487377_+	0.0127729539396311	0.202888846170063	.	.	.	.
OV	CAediting_1159703	chr17_5487596_+	0.00459523403649075	0.34988854289488	.	.	.	.

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Relation with cancer stages for MIS12

Correlation between Cancer stages and RNA editing frequency

Cancer	Stage_type	CAeditomID	position	P-val	Coeff.
KIRC	pathologic_stage	CAediting_1159696	chr17_5487377_+	0.043338903151348	0.266281021632913
KIRP	clinical_stage	CAediting_1159696	chr17_5487377_+	0.0133564534890862	0.334742439180174
STAD	pathologic_stage	CAediting_1159702	chr17_5487595_+	0.00184770946021696	0.407082224146952

Top

Relation with survival for MIS12

Correlation between RNA editing and survival

Cancer	CAeditomID	position	KMpvalue	Coxpvalue	CoxHR
LGG	CAediting_1159696	chr17_5487377_+	0.00742797463827927	0.0421304	0.0185487

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RelatedDrugs for MIS12

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

RelatedDiseases for MIS12

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
MIS12	C0023893	Liver Cirrhosis, Experimental	1	CTD_human

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene