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Editing gene: VKORC1 (CAeditome ID:79001)

Gene summary for VKORC1

Gene summary

Gene information	Gene symbol	VKORC1
	Gene ID	79001
	Gene name	vitamin K epoxide reductase complex subunit 1
	Synonyms	EDTP308\|MST134\|MST576\|VKCFD2\|VKOR
	Cytomap	16p11.2
	Type of gene	protein-coding
	Description	vitamin K epoxide reductase complex subunit 1phylloquinone epoxide reductasevitamin K dependent clotting factors deficiency 2vitamin K1 2,3-epoxide reductase subunit 1vitamin K1 epoxide reductase (warfarin-sensitive)
	Modification date	20210518
	UniProtAcc	Q9BQB6
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
VKORC1	GO:0047057	Vitamin K epoxide reductase complex subunit 1	16270630
VKORC1	GO:0042373	Vitamin K epoxide reductase complex subunit 1	16270630
VKORC1	GO:0005783	Vitamin K epoxide reductase complex subunit 1	0000052

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RNA A-to-I events for VKORC1

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000167397.13

RNA A-to-I editing events in Cancer.

CAediting_1112285(31090849, -), CAediting_1112286(31090854, -), CAediting_1112287(31090857, -), CAediting_1112288(31090858, -), CAediting_1112289(31090863, -), CAediting_1112290(31090873, -), CAediting_1112291(31090896, -), CAediting_1112292(31090913, -), CAediting_1112293(31090914, -), CAediting_1112294(31090915, -), CAediting_1112295(31091530, -), CAediting_1112296(31091534, -), CAediting_1112297(31091540, -), CAediting_1112298(31091558, -), CAediting_1112299(31091721, -), CAediting_1112300(31091724, -), CAediting_1112301(31091787, -), CAediting_1112302(31091810, -), CAediting_1112303(31091823, -), CAediting_1112304(31091824, -), CAediting_1112305(31091852, -), CAediting_1112306(31091859, -), CAediting_1112307(31092381, -), CAediting_1112308(31092413, -), CAediting_1112309(31092503, -), CAediting_1112310(31092786, -), CAediting_1112311(31092788, -), CAediting_1112312(31092803, -), CAediting_1112313(31092805, -), CAediting_1112314(31092826, -), CAediting_1112315(31092827, -), CAediting_1112316(31092851, -), CAediting_1112317(31092942, -), CAediting_1112318(31092947, -),

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RNA editing positional annotations for VKORC1 using Annovar

Protein coding RNA editing(s).

CAeditome ID	Position	Variant type	ENST	NTchange	AAchange	SIFT_score	Polyphen2_HVAR_score	PROVEAN_pred
CAediting_1112310	chr16_31092786_-	nonsynonymous SNV	ENST00000319788.10	c.A362G	p.Q121R	D	B	N

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_1112285	chr16_31090849_-	UTR3
CAediting_1112286	chr16_31090854_-	UTR3
CAediting_1112287	chr16_31090857_-	UTR3
CAediting_1112288	chr16_31090858_-	UTR3
CAediting_1112289	chr16_31090863_-	UTR3
CAediting_1112290	chr16_31090873_-	UTR3
CAediting_1112291	chr16_31090896_-	UTR3
CAediting_1112292	chr16_31090913_-	UTR3
CAediting_1112293	chr16_31090914_-	UTR3
CAediting_1112294	chr16_31090915_-	UTR3
CAediting_1112295	chr16_31091530_-	intronic
CAediting_1112296	chr16_31091534_-	intronic
CAediting_1112297	chr16_31091540_-	intronic
CAediting_1112298	chr16_31091558_-	intronic
CAediting_1112299	chr16_31091721_-	intronic
CAediting_1112300	chr16_31091724_-	intronic
CAediting_1112301	chr16_31091787_-	intronic
CAediting_1112302	chr16_31091810_-	intronic
CAediting_1112303	chr16_31091823_-	intronic
CAediting_1112304	chr16_31091824_-	intronic
CAediting_1112305	chr16_31091852_-	intronic
CAediting_1112306	chr16_31091859_-	intronic
CAediting_1112307	chr16_31092381_-	intronic
CAediting_1112308	chr16_31092413_-	intronic
CAediting_1112309	chr16_31092503_-	intronic
CAediting_1112310	chr16_31092786_-	exonic
CAediting_1112311	chr16_31092788_-	exonic
CAediting_1112312	chr16_31092803_-	exonic
CAediting_1112313	chr16_31092805_-	exonic
CAediting_1112314	chr16_31092826_-	exonic
CAediting_1112315	chr16_31092827_-	exonic
CAediting_1112316	chr16_31092851_-	exonic
CAediting_1112317	chr16_31092942_-	intronic
CAediting_1112318	chr16_31092947_-	intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_1112295	chr16_31091530_-	SINE	Alu	AluJr4
CAediting_1112296	chr16_31091534_-	SINE	Alu	AluJr4
CAediting_1112297	chr16_31091540_-	SINE	Alu	AluJr4
CAediting_1112298	chr16_31091558_-	SINE	Alu	AluJr4
CAediting_1112299	chr16_31091721_-	SINE	Alu	AluSq
CAediting_1112300	chr16_31091724_-	SINE	Alu	AluSq
CAediting_1112301	chr16_31091787_-	SINE	Alu	AluSq
CAediting_1112302	chr16_31091810_-	SINE	Alu	AluSq
CAediting_1112303	chr16_31091823_-	SINE	Alu	AluSq
CAediting_1112304	chr16_31091824_-	SINE	Alu	AluSq
CAediting_1112305	chr16_31091852_-	SINE	Alu	AluSq
CAediting_1112306	chr16_31091859_-	SINE	Alu	AluSq
CAediting_1112310	chr16_31092786_-	SINE	Alu	AluSg
CAediting_1112311	chr16_31092788_-	SINE	Alu	AluSg
CAediting_1112312	chr16_31092803_-	SINE	Alu	AluSg
CAediting_1112313	chr16_31092805_-	SINE	Alu	AluSg
CAediting_1112314	chr16_31092826_-	SINE	Alu	AluSg
CAediting_1112315	chr16_31092827_-	SINE	Alu	AluSg
CAediting_1112316	chr16_31092851_-	SINE	Alu	AluSg
CAediting_1112317	chr16_31092942_-	SINE	Alu	AluSg
CAediting_1112318	chr16_31092947_-	SINE	Alu	AluSg

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RNA A-to-I editing events in the alternative splicing sites for VKORC1

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000167397.13.VKORC1.

Correlation between RNA A-to-I editing and PSI for ENSG00000167397.13.VKORC1.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for VKORC1

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for VKORC1

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for VKORC1

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1112285	chr16_31090849_-	ENSG00000167397.13	ENST00000300851	hsa-miR-3064-5p	31090849	31090855	7mer-m8	31090848	31090867	152.00	-20.05
CAediting_1112285	chr16_31090849_-	ENSG00000167397.13	ENST00000300851	hsa-miR-3085-3p	31090849	31090855	7mer-m8	31090848	31090867	146.00	-16.15
CAediting_1112285	chr16_31090849_-	ENSG00000167397.13	ENST00000300851	hsa-miR-3661	31090846	31090852	7mer-m8	31090845	31090866	140.00	-16.51
CAediting_1112285	chr16_31090849_-	ENSG00000167397.13	ENST00000300851	hsa-miR-631	31090846	31090852	7mer-m8	31090845	31090867	150.00	-19.91
CAediting_1112285	chr16_31090849_-	ENSG00000167397.13	ENST00000300851	hsa-miR-6504-5p	31090849	31090855	7mer-m8	31090848	31090870	151.00	-17.22
CAediting_1112285	chr16_31090849_-	ENSG00000167397.13	ENST00000319788	hsa-miR-3064-5p	31090849	31090855	7mer-m8	31090848	31090867	152.00	-20.05
CAediting_1112285	chr16_31090849_-	ENSG00000167397.13	ENST00000319788	hsa-miR-3085-3p	31090849	31090855	7mer-m8	31090848	31090867	146.00	-16.15
CAediting_1112285	chr16_31090849_-	ENSG00000167397.13	ENST00000319788	hsa-miR-3661	31090846	31090852	7mer-m8	31090845	31090866	140.00	-16.51
CAediting_1112285	chr16_31090849_-	ENSG00000167397.13	ENST00000319788	hsa-miR-631	31090846	31090852	7mer-m8	31090845	31090867	150.00	-19.91
CAediting_1112285	chr16_31090849_-	ENSG00000167397.13	ENST00000319788	hsa-miR-6504-5p	31090849	31090855	7mer-m8	31090848	31090870	151.00	-17.22
CAediting_1112285	chr16_31090849_-	ENSG00000167397.13	ENST00000354895	hsa-miR-3064-5p	31090849	31090855	7mer-m8	31090848	31090867	152.00	-20.05
CAediting_1112285	chr16_31090849_-	ENSG00000167397.13	ENST00000354895	hsa-miR-3085-3p	31090849	31090855	7mer-m8	31090848	31090867	146.00	-16.15
CAediting_1112285	chr16_31090849_-	ENSG00000167397.13	ENST00000354895	hsa-miR-3661	31090846	31090852	7mer-m8	31090845	31090866	140.00	-16.51
CAediting_1112285	chr16_31090849_-	ENSG00000167397.13	ENST00000354895	hsa-miR-631	31090846	31090852	7mer-m8	31090845	31090867	150.00	-19.91
CAediting_1112285	chr16_31090849_-	ENSG00000167397.13	ENST00000354895	hsa-miR-6504-5p	31090849	31090855	7mer-m8	31090848	31090870	151.00	-17.22
CAediting_1112285	chr16_31090849_-	ENSG00000167397.13	ENST00000420057	hsa-miR-3064-5p	31090849	31090855	7mer-m8	31090848	31090867	152.00	-20.05
CAediting_1112285	chr16_31090849_-	ENSG00000167397.13	ENST00000420057	hsa-miR-3085-3p	31090849	31090855	7mer-m8	31090848	31090867	146.00	-16.15
CAediting_1112285	chr16_31090849_-	ENSG00000167397.13	ENST00000420057	hsa-miR-3661	31090846	31090852	7mer-m8	31090845	31090866	140.00	-16.51
CAediting_1112285	chr16_31090849_-	ENSG00000167397.13	ENST00000420057	hsa-miR-631	31090846	31090852	7mer-m8	31090845	31090867	150.00	-19.91
CAediting_1112285	chr16_31090849_-	ENSG00000167397.13	ENST00000420057	hsa-miR-6504-5p	31090849	31090855	7mer-m8	31090848	31090870	151.00	-17.22
CAediting_1112289	chr16_31090863_-	ENSG00000167397.13	ENST00000300851	hsa-miR-640	31090857	31090864	8mer-1a	31090857	31090877	163.00	-17.29
CAediting_1112289	chr16_31090863_-	ENSG00000167397.13	ENST00000319788	hsa-miR-640	31090857	31090864	8mer-1a	31090857	31090877	163.00	-17.29
CAediting_1112289	chr16_31090863_-	ENSG00000167397.13	ENST00000354895	hsa-miR-640	31090857	31090864	8mer-1a	31090857	31090877	163.00	-17.29
CAediting_1112289	chr16_31090863_-	ENSG00000167397.13	ENST00000420057	hsa-miR-640	31090857	31090864	8mer-1a	31090857	31090877	163.00	-17.29
CAediting_1112287	chr16_31090857_-	ENSG00000167397.13	ENST00000300851	hsa-miR-3136-5p	31090854	31090860	7mer-m8	31090853	31090876	148.00	-16.33
CAediting_1112287	chr16_31090857_-	ENSG00000167397.13	ENST00000300851	hsa-miR-4439	31090854	31090860	7mer-m8	31090853	31090872	157.00	-17.75
CAediting_1112287	chr16_31090857_-	ENSG00000167397.13	ENST00000319788	hsa-miR-3136-5p	31090854	31090860	7mer-m8	31090853	31090876	148.00	-16.33
CAediting_1112287	chr16_31090857_-	ENSG00000167397.13	ENST00000319788	hsa-miR-4439	31090854	31090860	7mer-m8	31090853	31090872	157.00	-17.75
CAediting_1112287	chr16_31090857_-	ENSG00000167397.13	ENST00000354895	hsa-miR-3136-5p	31090854	31090860	7mer-m8	31090853	31090876	148.00	-16.33
CAediting_1112287	chr16_31090857_-	ENSG00000167397.13	ENST00000354895	hsa-miR-4439	31090854	31090860	7mer-m8	31090853	31090872	157.00	-17.75
CAediting_1112287	chr16_31090857_-	ENSG00000167397.13	ENST00000420057	hsa-miR-3136-5p	31090854	31090860	7mer-m8	31090853	31090876	148.00	-16.33
CAediting_1112287	chr16_31090857_-	ENSG00000167397.13	ENST00000420057	hsa-miR-4439	31090854	31090860	7mer-m8	31090853	31090872	157.00	-17.75
CAediting_1112290	chr16_31090873_-	ENSG00000167397.13	ENST00000300851	hsa-miR-1912-5p	31090871	31090878	8mer-1a	31090871	31090892	145.00	-11.69
CAediting_1112290	chr16_31090873_-	ENSG00000167397.13	ENST00000319788	hsa-miR-1912-5p	31090871	31090878	8mer-1a	31090871	31090892	145.00	-11.69
CAediting_1112290	chr16_31090873_-	ENSG00000167397.13	ENST00000354895	hsa-miR-1912-5p	31090871	31090878	8mer-1a	31090871	31090892	145.00	-11.69
CAediting_1112290	chr16_31090873_-	ENSG00000167397.13	ENST00000420057	hsa-miR-1912-5p	31090871	31090878	8mer-1a	31090871	31090892	145.00	-11.69
CAediting_1112291	chr16_31090896_-	ENSG00000167397.13	ENST00000300851	hsa-miR-5587-3p	31090892	31090899	8mer-1a	31090892	31090912	164.00	-29.27
CAediting_1112291	chr16_31090896_-	ENSG00000167397.13	ENST00000300851	hsa-miR-6763-3p	31090892	31090898	7mer-m8	31090891	31090911	146.00	-21.65
CAediting_1112291	chr16_31090896_-	ENSG00000167397.13	ENST00000319788	hsa-miR-5587-3p	31090892	31090899	8mer-1a	31090892	31090912	164.00	-29.27
CAediting_1112291	chr16_31090896_-	ENSG00000167397.13	ENST00000319788	hsa-miR-6763-3p	31090892	31090898	7mer-m8	31090891	31090911	146.00	-21.65
CAediting_1112291	chr16_31090896_-	ENSG00000167397.13	ENST00000354895	hsa-miR-5587-3p	31090892	31090899	8mer-1a	31090892	31090912	164.00	-29.27
CAediting_1112291	chr16_31090896_-	ENSG00000167397.13	ENST00000354895	hsa-miR-6763-3p	31090892	31090898	7mer-m8	31090891	31090911	146.00	-21.65
CAediting_1112291	chr16_31090896_-	ENSG00000167397.13	ENST00000420057	hsa-miR-5587-3p	31090892	31090899	8mer-1a	31090892	31090912	164.00	-29.27
CAediting_1112291	chr16_31090896_-	ENSG00000167397.13	ENST00000420057	hsa-miR-6763-3p	31090892	31090898	7mer-m8	31090891	31090911	146.00	-21.65
CAediting_1112293	chr16_31090914_-	ENSG00000167397.13	ENST00000300851	hsa-miR-516b-5p	31090913	31090919	7mer-m8	31090912	31090933	149.00	-17.43
CAediting_1112293	chr16_31090914_-	ENSG00000167397.13	ENST00000300851	hsa-miR-516b-5p	31090913	31090919	7mer-m8	31090912	31090933	149.00	-17.43
CAediting_1112293	chr16_31090914_-	ENSG00000167397.13	ENST00000300851	hsa-miR-518c-5p	31090912	31090918	7mer-m8	31090911	31090933	159.00	-22.56
CAediting_1112293	chr16_31090914_-	ENSG00000167397.13	ENST00000319788	hsa-miR-516b-5p	31090913	31090919	7mer-m8	31090912	31090933	149.00	-17.43
CAediting_1112293	chr16_31090914_-	ENSG00000167397.13	ENST00000319788	hsa-miR-516b-5p	31090913	31090919	7mer-m8	31090912	31090933	149.00	-17.43
CAediting_1112293	chr16_31090914_-	ENSG00000167397.13	ENST00000319788	hsa-miR-518c-5p	31090912	31090918	7mer-m8	31090911	31090933	159.00	-22.56
CAediting_1112293	chr16_31090914_-	ENSG00000167397.13	ENST00000354895	hsa-miR-516b-5p	31090913	31090919	7mer-m8	31090912	31090933	149.00	-17.43
CAediting_1112293	chr16_31090914_-	ENSG00000167397.13	ENST00000354895	hsa-miR-516b-5p	31090913	31090919	7mer-m8	31090912	31090933	149.00	-17.43
CAediting_1112293	chr16_31090914_-	ENSG00000167397.13	ENST00000354895	hsa-miR-518c-5p	31090912	31090918	7mer-m8	31090911	31090933	159.00	-22.56
CAediting_1112293	chr16_31090914_-	ENSG00000167397.13	ENST00000420057	hsa-miR-516b-5p	31090913	31090919	7mer-m8	31090912	31090933	149.00	-17.43
CAediting_1112293	chr16_31090914_-	ENSG00000167397.13	ENST00000420057	hsa-miR-516b-5p	31090913	31090919	7mer-m8	31090912	31090933	149.00	-17.43
CAediting_1112293	chr16_31090914_-	ENSG00000167397.13	ENST00000420057	hsa-miR-518c-5p	31090912	31090918	7mer-m8	31090911	31090933	159.00	-22.56
CAediting_1112294	chr16_31090915_-	ENSG00000167397.13	ENST00000300851	hsa-miR-5091	31090914	31090921	8mer-1a	31090914	31090933	147.00	-17.77
CAediting_1112294	chr16_31090915_-	ENSG00000167397.13	ENST00000319788	hsa-miR-5091	31090914	31090921	8mer-1a	31090914	31090933	147.00	-17.77
CAediting_1112294	chr16_31090915_-	ENSG00000167397.13	ENST00000354895	hsa-miR-5091	31090914	31090921	8mer-1a	31090914	31090933	147.00	-17.77
CAediting_1112294	chr16_31090915_-	ENSG00000167397.13	ENST00000420057	hsa-miR-5091	31090914	31090921	8mer-1a	31090914	31090933	147.00	-17.77

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1112293	chr16_31090914_-	ENSG00000167397.13	ENST00000300851	hsa-miR-12131	31090913	31090920	8mer-1a	31090913	31090932	140	-15.39
CAediting_1112294	chr16_31090915_-	ENSG00000167397.13	ENST00000300851	hsa-miR-12131	31090913	31090920	8mer-1a	31090913	31090932	140	-15.39
CAediting_1112291	chr16_31090896_-	ENSG00000167397.13	ENST00000300851	hsa-miR-1285-3p	31090895	31090901	7mer-m8	31090894	31090915	154	-19.75
CAediting_1112291	chr16_31090896_-	ENSG00000167397.13	ENST00000300851	hsa-miR-1285-3p	31090895	31090901	7mer-m8	31090894	31090915	154	-19.75
CAediting_1112290	chr16_31090873_-	ENSG00000167397.13	ENST00000300851	hsa-miR-137-3p	31090872	31090879	8mer-1a	31090872	31090893	153	-14.53
CAediting_1112291	chr16_31090896_-	ENSG00000167397.13	ENST00000300851	hsa-miR-3187-5p	31090895	31090901	7mer-m8	31090894	31090916	144	-22.57
CAediting_1112291	chr16_31090896_-	ENSG00000167397.13	ENST00000300851	hsa-miR-4292	31090892	31090899	8mer-1a	31090892	31090909	145	-19.76
CAediting_1112291	chr16_31090896_-	ENSG00000167397.13	ENST00000300851	hsa-miR-5189-5p	31090895	31090901	7mer-m8	31090894	31090916	145	-21.19
CAediting_1112291	chr16_31090896_-	ENSG00000167397.13	ENST00000300851	hsa-miR-612	31090895	31090901	7mer-m8	31090894	31090917	147	-23.83
CAediting_1112291	chr16_31090896_-	ENSG00000167397.13	ENST00000300851	hsa-miR-6791-5p	31090892	31090899	8mer-1a	31090892	31090914	153	-24.28
CAediting_1112291	chr16_31090896_-	ENSG00000167397.13	ENST00000300851	hsa-miR-6860	31090895	31090901	7mer-m8	31090894	31090922	147	-24.31
CAediting_1112291	chr16_31090896_-	ENSG00000167397.13	ENST00000300851	hsa-miR-7113-3p	31090891	31090897	7mer-m8	31090890	31090912	140	-18.24
CAediting_1112291	chr16_31090896_-	ENSG00000167397.13	ENST00000300851	hsa-miR-939-3p	31090894	31090900	7mer-m8	31090893	31090913	140	-20.43
CAediting_1112293	chr16_31090914_-	ENSG00000167397.13	ENST00000319788	hsa-miR-12131	31090913	31090920	8mer-1a	31090913	31090932	140	-15.39
CAediting_1112294	chr16_31090915_-	ENSG00000167397.13	ENST00000319788	hsa-miR-12131	31090913	31090920	8mer-1a	31090913	31090932	140	-15.39
CAediting_1112291	chr16_31090896_-	ENSG00000167397.13	ENST00000319788	hsa-miR-1285-3p	31090895	31090901	7mer-m8	31090894	31090915	154	-19.75
CAediting_1112291	chr16_31090896_-	ENSG00000167397.13	ENST00000319788	hsa-miR-1285-3p	31090895	31090901	7mer-m8	31090894	31090915	154	-19.75
CAediting_1112290	chr16_31090873_-	ENSG00000167397.13	ENST00000319788	hsa-miR-137-3p	31090872	31090879	8mer-1a	31090872	31090893	153	-14.53
CAediting_1112291	chr16_31090896_-	ENSG00000167397.13	ENST00000319788	hsa-miR-3187-5p	31090895	31090901	7mer-m8	31090894	31090916	144	-22.57
CAediting_1112291	chr16_31090896_-	ENSG00000167397.13	ENST00000319788	hsa-miR-4292	31090892	31090899	8mer-1a	31090892	31090909	145	-19.76
CAediting_1112291	chr16_31090896_-	ENSG00000167397.13	ENST00000319788	hsa-miR-5189-5p	31090895	31090901	7mer-m8	31090894	31090916	145	-21.19
CAediting_1112291	chr16_31090896_-	ENSG00000167397.13	ENST00000319788	hsa-miR-612	31090895	31090901	7mer-m8	31090894	31090917	147	-23.83
CAediting_1112291	chr16_31090896_-	ENSG00000167397.13	ENST00000319788	hsa-miR-6791-5p	31090892	31090899	8mer-1a	31090892	31090914	153	-24.28
CAediting_1112291	chr16_31090896_-	ENSG00000167397.13	ENST00000319788	hsa-miR-6860	31090895	31090901	7mer-m8	31090894	31090922	147	-24.31
CAediting_1112291	chr16_31090896_-	ENSG00000167397.13	ENST00000319788	hsa-miR-7113-3p	31090891	31090897	7mer-m8	31090890	31090912	140	-18.24
CAediting_1112291	chr16_31090896_-	ENSG00000167397.13	ENST00000319788	hsa-miR-939-3p	31090894	31090900	7mer-m8	31090893	31090913	140	-20.43
CAediting_1112293	chr16_31090914_-	ENSG00000167397.13	ENST00000354895	hsa-miR-12131	31090913	31090920	8mer-1a	31090913	31090932	140	-15.39
CAediting_1112294	chr16_31090915_-	ENSG00000167397.13	ENST00000354895	hsa-miR-12131	31090913	31090920	8mer-1a	31090913	31090932	140	-15.39
CAediting_1112291	chr16_31090896_-	ENSG00000167397.13	ENST00000354895	hsa-miR-1285-3p	31090895	31090901	7mer-m8	31090894	31090915	154	-19.75
CAediting_1112291	chr16_31090896_-	ENSG00000167397.13	ENST00000354895	hsa-miR-1285-3p	31090895	31090901	7mer-m8	31090894	31090915	154	-19.75
CAediting_1112290	chr16_31090873_-	ENSG00000167397.13	ENST00000354895	hsa-miR-137-3p	31090872	31090879	8mer-1a	31090872	31090893	153	-14.53
CAediting_1112291	chr16_31090896_-	ENSG00000167397.13	ENST00000354895	hsa-miR-3187-5p	31090895	31090901	7mer-m8	31090894	31090916	144	-22.57
CAediting_1112291	chr16_31090896_-	ENSG00000167397.13	ENST00000354895	hsa-miR-4292	31090892	31090899	8mer-1a	31090892	31090909	145	-19.76
CAediting_1112291	chr16_31090896_-	ENSG00000167397.13	ENST00000354895	hsa-miR-5189-5p	31090895	31090901	7mer-m8	31090894	31090916	145	-21.19
CAediting_1112291	chr16_31090896_-	ENSG00000167397.13	ENST00000354895	hsa-miR-612	31090895	31090901	7mer-m8	31090894	31090917	147	-23.83
CAediting_1112291	chr16_31090896_-	ENSG00000167397.13	ENST00000354895	hsa-miR-6791-5p	31090892	31090899	8mer-1a	31090892	31090914	153	-24.28
CAediting_1112291	chr16_31090896_-	ENSG00000167397.13	ENST00000354895	hsa-miR-6860	31090895	31090901	7mer-m8	31090894	31090922	147	-24.31
CAediting_1112291	chr16_31090896_-	ENSG00000167397.13	ENST00000354895	hsa-miR-7113-3p	31090891	31090897	7mer-m8	31090890	31090912	140	-18.24
CAediting_1112291	chr16_31090896_-	ENSG00000167397.13	ENST00000354895	hsa-miR-939-3p	31090894	31090900	7mer-m8	31090893	31090913	140	-20.43
CAediting_1112293	chr16_31090914_-	ENSG00000167397.13	ENST00000420057	hsa-miR-12131	31090913	31090920	8mer-1a	31090913	31090932	140	-15.39
CAediting_1112294	chr16_31090915_-	ENSG00000167397.13	ENST00000420057	hsa-miR-12131	31090913	31090920	8mer-1a	31090913	31090932	140	-15.39
CAediting_1112291	chr16_31090896_-	ENSG00000167397.13	ENST00000420057	hsa-miR-1285-3p	31090895	31090901	7mer-m8	31090894	31090915	154	-19.75
CAediting_1112291	chr16_31090896_-	ENSG00000167397.13	ENST00000420057	hsa-miR-1285-3p	31090895	31090901	7mer-m8	31090894	31090915	154	-19.75
CAediting_1112290	chr16_31090873_-	ENSG00000167397.13	ENST00000420057	hsa-miR-137-3p	31090872	31090879	8mer-1a	31090872	31090893	153	-14.53
CAediting_1112291	chr16_31090896_-	ENSG00000167397.13	ENST00000420057	hsa-miR-3187-5p	31090895	31090901	7mer-m8	31090894	31090916	144	-22.57
CAediting_1112291	chr16_31090896_-	ENSG00000167397.13	ENST00000420057	hsa-miR-4292	31090892	31090899	8mer-1a	31090892	31090909	145	-19.76
CAediting_1112291	chr16_31090896_-	ENSG00000167397.13	ENST00000420057	hsa-miR-5189-5p	31090895	31090901	7mer-m8	31090894	31090916	145	-21.19
CAediting_1112291	chr16_31090896_-	ENSG00000167397.13	ENST00000420057	hsa-miR-612	31090895	31090901	7mer-m8	31090894	31090917	147	-23.83
CAediting_1112291	chr16_31090896_-	ENSG00000167397.13	ENST00000420057	hsa-miR-6791-5p	31090892	31090899	8mer-1a	31090892	31090914	153	-24.28
CAediting_1112291	chr16_31090896_-	ENSG00000167397.13	ENST00000420057	hsa-miR-6860	31090895	31090901	7mer-m8	31090894	31090922	147	-24.31
CAediting_1112291	chr16_31090896_-	ENSG00000167397.13	ENST00000420057	hsa-miR-7113-3p	31090891	31090897	7mer-m8	31090890	31090912	140	-18.24
CAediting_1112291	chr16_31090896_-	ENSG00000167397.13	ENST00000420057	hsa-miR-939-3p	31090894	31090900	7mer-m8	31090893	31090913	140	-20.43

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_442554	chr5_154685830_+	ENSG00000167397.13	ENST00000300851	hsa-miR-1303	31090913	31090920	8mer-1a	31090913	31090934	158	-20.94
CAediting_442554	chr5_154685830_+	ENSG00000167397.13	ENST00000319788	hsa-miR-1303	31090913	31090920	8mer-1a	31090913	31090934	158	-20.94
CAediting_442554	chr5_154685830_+	ENSG00000167397.13	ENST00000354895	hsa-miR-1303	31090913	31090920	8mer-1a	31090913	31090934	158	-20.94
CAediting_442554	chr5_154685830_+	ENSG00000167397.13	ENST00000420057	hsa-miR-1303	31090913	31090920	8mer-1a	31090913	31090934	158	-20.94
CAediting_468389	chr6_31355314_-	ENSG00000167397.13	ENST00000300851	hsa-miR-6891-5p	31091012	31091018	7mer-m8	31091011	31091028	157	-24.33
CAediting_468389	chr6_31355314_-	ENSG00000167397.13	ENST00000319788	hsa-miR-6891-5p	31091012	31091018	7mer-m8	31091011	31091028	157	-24.33
CAediting_468389	chr6_31355314_-	ENSG00000167397.13	ENST00000354895	hsa-miR-6891-5p	31091012	31091018	7mer-m8	31091011	31091028	157	-24.33
CAediting_468389	chr6_31355314_-	ENSG00000167397.13	ENST00000420057	hsa-miR-6891-5p	31091012	31091018	7mer-m8	31091011	31091028	157	-24.33

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

Top

The effects of the RNA editing to the stability of the RNA structures for VKORC1

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

Top

Relation with ADAR for VKORC1

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
BRCA	CAediting_1112286	chr16_31090854_-	.	.	1.24871714418994e-05	0.575153629896753	.	.
CESC	CAediting_1112289	chr16_31090863_-	0.0208028112921568	0.256511723147139	.	.	.	.
LUAD	CAediting_1112289	chr16_31090863_-	0.020907571211362	0.240539400779851	.	.	.	.

Top

Relation with cancer stages for VKORC1

Correlation between Cancer stages and RNA editing frequency

Cancer	Stage_type	CAeditomID	position	P-val	Coeff.
CESC	clinical_stage	CAediting_1112289	chr16_31090863_-	0.00924112312314248	0.287555754176715

Top

Relation with survival for VKORC1

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

Top

RelatedDrugs for VKORC1

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
VKORC1	Q9BQB6	DB00266	Dicoumarol	Vitamin K epoxide reductase complex subunit 1	SmallMoleculeDrug	approved
VKORC1	Q9BQB6	DB00682	Warfarin	Vitamin K epoxide reductase complex subunit 1	SmallMoleculeDrug	approved
VKORC1	Q9BQB6	DB00498	Phenindione	Vitamin K epoxide reductase complex subunit 1	SmallMoleculeDrug	approved\|investigational
VKORC1	Q9BQB6	DB00946	Phenprocoumon	Vitamin K epoxide reductase complex subunit 1	SmallMoleculeDrug	approved\|investigational
VKORC1	Q9BQB6	DB01418	Acenocoumarol	Vitamin K epoxide reductase complex subunit 1	SmallMoleculeDrug	approved\|investigational
VKORC1	Q9BQB6	DB00170	Menadione	Vitamin K epoxide reductase complex subunit 1	SmallMoleculeDrug	approved\|nutraceutical

Top

RelatedDiseases for VKORC1

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
VKORC1	C1843832	VITAMIN K-DEPENDENT CLOTTING FACTORS, COMBINED DEFICIENCY OF, 2	3	CTD_human;GENOMICS_ENGLAND;UNIPROT
VKORC1	C0019080	Hemorrhage	2	CTD_human
VKORC1	C0750384	Coumarin Resistance	2	CTD_human;GENOMICS_ENGLAND;UNIPROT
VKORC1	C0003496	Aortic Rupture	1	CTD_human
VKORC1	C0005779	Blood Coagulation Disorders	1	CTD_human
VKORC1	C0010068	Coronary heart disease	1	CTD_human
VKORC1	C0013221	Drug toxicity	1	CTD_human
VKORC1	C0038454	Cerebrovascular accident	1	CTD_human
VKORC1	C0040053	Thrombosis	1	CTD_human
VKORC1	C0041755	Adverse reaction to drug	1	CTD_human
VKORC1	C0042373	Vascular Diseases	1	CTD_human
VKORC1	C0087086	Thrombus	1	CTD_human
VKORC1	C0741160	Aortic Aneurysm, Ruptured	1	CTD_human
VKORC1	C0751956	Acute Cerebrovascular Accidents	1	CTD_human
VKORC1	C1848534	VITAMIN K-DEPENDENT CLOTTING FACTORS, COMBINED DEFICIENCY OF, 1	1	ORPHANET

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene