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Editing gene: CACNA1D (CAeditome ID:776)

Gene summary for CACNA1D

Gene summary

Gene information	Gene symbol	CACNA1D
	Gene ID	776
	Gene name	calcium voltage-gated channel subunit alpha1 D
	Synonyms	CACH3\|CACN4\|CACNL1A2\|CCHL1A2\|Cav1.3\|PASNA\|SANDD
	Cytomap	3p21.1
	Type of gene	protein-coding
	Description	voltage-dependent L-type calcium channel subunit alpha-1Dcalcium channel, L type, alpha-1 polypeptidecalcium channel, neuroendocrine/brain-type, alpha 1 subunitcalcium channel, voltage-dependent, L type, alpha 1D subunitvoltage-gated calcium channel a
	Modification date	20210518
	UniProtAcc	Q01668
	Context	- 28781648(Voltage-gated calcium channels: Novel targets for cancer therapy)

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
CACNA1D	GO:0008331	Voltage-dependent L-type calcium channel subunit alpha-1D	1309651
CACNA1D	GO:0005245	Voltage-dependent L-type calcium channel subunit alpha-1D	11160515
CACNA1D	GO:0005245	Voltage-dependent L-type calcium channel subunit alpha-1D	21131953
CACNA1D	GO:0006816	Voltage-dependent L-type calcium channel subunit alpha-1D	11160515
CACNA1D	GO:0051928	Voltage-dependent L-type calcium channel subunit alpha-1D	1309651
CACNA1D	GO:0070509	Voltage-dependent L-type calcium channel subunit alpha-1D	1309651
CACNA1D	GO:0005891	Voltage-dependent L-type calcium channel subunit alpha-1D	11160515
CACNA1D	GO:1990454	Voltage-dependent L-type calcium channel subunit alpha-1D	1309651

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RNA A-to-I events for CACNA1D

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000157388.12

RNA A-to-I editing events in Cancer.

CAediting_286146(53500231, +), CAediting_286147(53500310, +), CAediting_286148(53500316, +), CAediting_286149(53500355, +), CAediting_286150(53500376, +), CAediting_286151(53500379, +), CAediting_286152(53500380, +), CAediting_286153(53500385, +), CAediting_286154(53507340, +), CAediting_286155(53507407, +), CAediting_286156(53507409, +), CAediting_286157(53521093, +), CAediting_286158(53521119, +), CAediting_286159(53521120, +), CAediting_286160(53521144, +), CAediting_286161(53521157, +), CAediting_286162(53521173, +), CAediting_286163(53521179, +), CAediting_286164(53521227, +), CAediting_286165(53521243, +), CAediting_286166(53521252, +), CAediting_286167(53521253, +), CAediting_286168(53521254, +), CAediting_286169(53521278, +), CAediting_286170(53521304, +), CAediting_286171(53521887, +), CAediting_286172(53521889, +), CAediting_286173(53521895, +), CAediting_286174(53521927, +), CAediting_286175(53521937, +), CAediting_286176(53521938, +), CAediting_286177(53521939, +), CAediting_286178(53521941, +), CAediting_286179(53521989, +), CAediting_286180(53522011, +), CAediting_286181(53522025, +), CAediting_286182(53522029, +), CAediting_286183(53522032, +), CAediting_286184(53539315, +), CAediting_286185(53539382, +), CAediting_286186(53540167, +), CAediting_286187(53540258, +), CAediting_286188(53542418, +), CAediting_286189(53542543, +), CAediting_286190(53542777, +), CAediting_286191(53552450, +), CAediting_286192(53552474, +), CAediting_286193(53552546, +), CAediting_286194(53552581, +), CAediting_286195(53552642, +), CAediting_286196(53553941, +), CAediting_286197(53554116, +), CAediting_286198(53556771, +), CAediting_286199(53556926, +), CAediting_286200(53556951, +), CAediting_286201(53556990, +), CAediting_286202(53557241, +), CAediting_286203(53557280, +), CAediting_286204(53557305, +), CAediting_286205(53557308, +), CAediting_286206(53557309, +), CAediting_286207(53557336, +), CAediting_286208(53557344, +), CAediting_286209(53557347, +), CAediting_286210(53563290, +), CAediting_286211(53563291, +), CAediting_286212(53563304, +), CAediting_286213(53563309, +), CAediting_286214(53563322, +), CAediting_286215(53563323, +), CAediting_286216(53563329, +), CAediting_286217(53563359, +), CAediting_286218(53563362, +), CAediting_286219(53563364, +), CAediting_286220(53563403, +), CAediting_286221(53563413, +), CAediting_286222(53563430, +), CAediting_286223(53563444, +), CAediting_286224(53563445, +), CAediting_286225(53564225, +), CAediting_286226(53564261, +), CAediting_286227(53564262, +), CAediting_286228(53598334, +), CAediting_286229(53598385, +), CAediting_286230(53598464, +), CAediting_286231(53598494, +), CAediting_286232(53601810, +), CAediting_286233(53601811, +), CAediting_286234(53601850, +), CAediting_286235(53611291, +), CAediting_286236(53620317, +), CAediting_286237(53620424, +), CAediting_286238(53640058, +), CAediting_286239(53640124, +), CAediting_286240(53662318, +), CAediting_286241(53662326, +), CAediting_286242(53662345, +), CAediting_286243(53662367, +), CAediting_286244(53662387, +), CAediting_286245(53663349, +), CAediting_286246(53663351, +), CAediting_286247(53663372, +), CAediting_286248(53663376, +), CAediting_286249(53663380, +), CAediting_286250(53663386, +), CAediting_286251(53663450, +), CAediting_286252(53663476, +), CAediting_286253(53678992, +), CAediting_286254(53678996, +), CAediting_286255(53678998, +), CAediting_286256(53679012, +), CAediting_286257(53679020, +), CAediting_286258(53679041, +), CAediting_286259(53679050, +), CAediting_286260(53679055, +), CAediting_286261(53679057, +), CAediting_286262(53679060, +), CAediting_286263(53679105, +), CAediting_286264(53679108, +), CAediting_286265(53679109, +), CAediting_286266(53679110, +), CAediting_286267(53679111, +), CAediting_286268(53679112, +), CAediting_286269(53679120, +), CAediting_286270(53679123, +), CAediting_286271(53679149, +), CAediting_286272(53679150, +), CAediting_286273(53679176, +), CAediting_286274(53679185, +), CAediting_286275(53679190, +), CAediting_286276(53679191, +), CAediting_286277(53679194, +), CAediting_286278(53679219, +), CAediting_286279(53679220, +), CAediting_286280(53682289, +), CAediting_286281(53682329, +), CAediting_286282(53682346, +), CAediting_286283(53682434, +), CAediting_286284(53682436, +), CAediting_286285(53682446, +), CAediting_286286(53682463, +), CAediting_286287(53682477, +), CAediting_286288(53682482, +), CAediting_286289(53682491, +), CAediting_286290(53682498, +), CAediting_286291(53682536, +), CAediting_286292(53689683, +), CAediting_286293(53689738, +), CAediting_286294(53689744, +), CAediting_286295(53689745, +), CAediting_286296(53689759, +), CAediting_286297(53689762, +), CAediting_286298(53689771, +), CAediting_286299(53689825, +), CAediting_286300(53689894, +), CAediting_286301(53689895, +), CAediting_286302(53689921, +), CAediting_286303(53689934, +), CAediting_286304(53692894, +), CAediting_286305(53692937, +), CAediting_286306(53692938, +), CAediting_286307(53695988, +), CAediting_286308(53696025, +), CAediting_286309(53696203, +), CAediting_286310(53696230, +), CAediting_286311(53763169, +), CAediting_286312(53783011, +), CAediting_286313(53786865, +),

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RNA editing positional annotations for CACNA1D using Annovar

Protein coding RNA editing(s).

CAeditome ID	Position	Variant type	ENST	NTchange	AAchange	SIFT_score	Polyphen2_HVAR_score	PROVEAN_pred
CAediting_286313	chr3_53786865_+	nonsynonymous SNV	ENST00000288139.7	c.A4896G	p.I1632M	D	P	D
CAediting_286313	chr3_53786865_+	nonsynonymous SNV	ENST00000350061.8	c.A4836G	p.I1612M	D	P	D
CAediting_286313	chr3_53786865_+	nonsynonymous SNV	ENST00000422281.5	c.A4791G	p.I1597M	D	P	D
CAediting_286313	chr3_53786865_+	nonsynonymous SNV	ENST00000481478.1	c.A3915G	p.I1305M	D	P	D

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_286146	chr3_53500231_+	intronic
CAediting_286147	chr3_53500310_+	intronic
CAediting_286148	chr3_53500316_+	intronic
CAediting_286149	chr3_53500355_+	intronic
CAediting_286150	chr3_53500376_+	intronic
CAediting_286151	chr3_53500379_+	intronic
CAediting_286152	chr3_53500380_+	intronic
CAediting_286153	chr3_53500385_+	intronic
CAediting_286154	chr3_53507340_+	intronic
CAediting_286155	chr3_53507407_+	intronic
CAediting_286156	chr3_53507409_+	intronic
CAediting_286157	chr3_53521093_+	intronic
CAediting_286158	chr3_53521119_+	intronic
CAediting_286159	chr3_53521120_+	intronic
CAediting_286160	chr3_53521144_+	intronic
CAediting_286161	chr3_53521157_+	intronic
CAediting_286162	chr3_53521173_+	intronic
CAediting_286163	chr3_53521179_+	intronic
CAediting_286164	chr3_53521227_+	intronic
CAediting_286165	chr3_53521243_+	intronic
CAediting_286166	chr3_53521252_+	intronic
CAediting_286167	chr3_53521253_+	intronic
CAediting_286168	chr3_53521254_+	intronic
CAediting_286169	chr3_53521278_+	intronic
CAediting_286170	chr3_53521304_+	intronic
CAediting_286171	chr3_53521887_+	intronic
CAediting_286172	chr3_53521889_+	intronic
CAediting_286173	chr3_53521895_+	intronic
CAediting_286174	chr3_53521927_+	intronic
CAediting_286175	chr3_53521937_+	intronic
CAediting_286176	chr3_53521938_+	intronic
CAediting_286177	chr3_53521939_+	intronic
CAediting_286178	chr3_53521941_+	intronic
CAediting_286179	chr3_53521989_+	intronic
CAediting_286180	chr3_53522011_+	intronic
CAediting_286181	chr3_53522025_+	intronic
CAediting_286182	chr3_53522029_+	intronic
CAediting_286183	chr3_53522032_+	intronic
CAediting_286184	chr3_53539315_+	intronic
CAediting_286185	chr3_53539382_+	intronic
CAediting_286186	chr3_53540167_+	intronic
CAediting_286187	chr3_53540258_+	intronic
CAediting_286188	chr3_53542418_+	intronic
CAediting_286189	chr3_53542543_+	intronic
CAediting_286190	chr3_53542777_+	intronic
CAediting_286191	chr3_53552450_+	intronic
CAediting_286192	chr3_53552474_+	intronic
CAediting_286193	chr3_53552546_+	intronic
CAediting_286194	chr3_53552581_+	intronic
CAediting_286195	chr3_53552642_+	intronic
CAediting_286196	chr3_53553941_+	intronic
CAediting_286197	chr3_53554116_+	intronic
CAediting_286198	chr3_53556771_+	intronic
CAediting_286199	chr3_53556926_+	intronic
CAediting_286200	chr3_53556951_+	intronic
CAediting_286201	chr3_53556990_+	intronic
CAediting_286202	chr3_53557241_+	intronic
CAediting_286203	chr3_53557280_+	intronic
CAediting_286204	chr3_53557305_+	intronic
CAediting_286205	chr3_53557308_+	intronic
CAediting_286206	chr3_53557309_+	intronic
CAediting_286207	chr3_53557336_+	intronic
CAediting_286208	chr3_53557344_+	intronic
CAediting_286209	chr3_53557347_+	intronic
CAediting_286210	chr3_53563290_+	intronic
CAediting_286211	chr3_53563291_+	intronic
CAediting_286212	chr3_53563304_+	intronic
CAediting_286213	chr3_53563309_+	intronic
CAediting_286214	chr3_53563322_+	intronic
CAediting_286215	chr3_53563323_+	intronic
CAediting_286216	chr3_53563329_+	intronic
CAediting_286217	chr3_53563359_+	intronic
CAediting_286218	chr3_53563362_+	intronic
CAediting_286219	chr3_53563364_+	intronic
CAediting_286220	chr3_53563403_+	intronic
CAediting_286221	chr3_53563413_+	intronic
CAediting_286222	chr3_53563430_+	intronic
CAediting_286223	chr3_53563444_+	intronic
CAediting_286224	chr3_53563445_+	intronic
CAediting_286225	chr3_53564225_+	intronic
CAediting_286226	chr3_53564261_+	intronic
CAediting_286227	chr3_53564262_+	intronic
CAediting_286228	chr3_53598334_+	intronic
CAediting_286229	chr3_53598385_+	intronic
CAediting_286230	chr3_53598464_+	intronic
CAediting_286231	chr3_53598494_+	intronic
CAediting_286232	chr3_53601810_+	intronic
CAediting_286233	chr3_53601811_+	intronic
CAediting_286234	chr3_53601850_+	intronic
CAediting_286235	chr3_53611291_+	intronic
CAediting_286236	chr3_53620317_+	intronic
CAediting_286237	chr3_53620424_+	intronic
CAediting_286238	chr3_53640058_+	intronic
CAediting_286239	chr3_53640124_+	intronic
CAediting_286240	chr3_53662318_+	intronic
CAediting_286241	chr3_53662326_+	intronic
CAediting_286242	chr3_53662345_+	intronic
CAediting_286243	chr3_53662367_+	intronic
CAediting_286244	chr3_53662387_+	intronic
CAediting_286245	chr3_53663349_+	intronic
CAediting_286246	chr3_53663351_+	intronic
CAediting_286247	chr3_53663372_+	intronic
CAediting_286248	chr3_53663376_+	intronic
CAediting_286249	chr3_53663380_+	intronic
CAediting_286250	chr3_53663386_+	intronic
CAediting_286251	chr3_53663450_+	intronic
CAediting_286252	chr3_53663476_+	intronic
CAediting_286253	chr3_53678992_+	ncRNA_splicing
CAediting_286254	chr3_53678996_+	ncRNA_exonic
CAediting_286255	chr3_53678998_+	ncRNA_exonic
CAediting_286256	chr3_53679012_+	ncRNA_exonic
CAediting_286257	chr3_53679020_+	ncRNA_exonic
CAediting_286258	chr3_53679041_+	ncRNA_exonic
CAediting_286259	chr3_53679050_+	ncRNA_exonic
CAediting_286260	chr3_53679055_+	ncRNA_exonic
CAediting_286261	chr3_53679057_+	ncRNA_exonic
CAediting_286262	chr3_53679060_+	ncRNA_exonic
CAediting_286263	chr3_53679105_+	ncRNA_exonic
CAediting_286264	chr3_53679108_+	ncRNA_exonic
CAediting_286265	chr3_53679109_+	ncRNA_exonic
CAediting_286266	chr3_53679110_+	ncRNA_exonic
CAediting_286267	chr3_53679111_+	ncRNA_exonic
CAediting_286268	chr3_53679112_+	ncRNA_exonic
CAediting_286269	chr3_53679120_+	ncRNA_exonic
CAediting_286270	chr3_53679123_+	ncRNA_exonic
CAediting_286271	chr3_53679149_+	ncRNA_exonic
CAediting_286272	chr3_53679150_+	ncRNA_exonic
CAediting_286273	chr3_53679176_+	ncRNA_exonic
CAediting_286274	chr3_53679185_+	ncRNA_exonic
CAediting_286275	chr3_53679190_+	ncRNA_exonic
CAediting_286276	chr3_53679191_+	ncRNA_exonic
CAediting_286277	chr3_53679194_+	ncRNA_exonic
CAediting_286278	chr3_53679219_+	ncRNA_exonic
CAediting_286279	chr3_53679220_+	ncRNA_exonic
CAediting_286280	chr3_53682289_+	intronic
CAediting_286281	chr3_53682329_+	intronic
CAediting_286282	chr3_53682346_+	intronic
CAediting_286283	chr3_53682434_+	intronic
CAediting_286284	chr3_53682436_+	intronic
CAediting_286285	chr3_53682446_+	intronic
CAediting_286286	chr3_53682463_+	intronic
CAediting_286287	chr3_53682477_+	intronic
CAediting_286288	chr3_53682482_+	intronic
CAediting_286289	chr3_53682491_+	intronic
CAediting_286290	chr3_53682498_+	intronic
CAediting_286291	chr3_53682536_+	intronic
CAediting_286292	chr3_53689683_+	intronic
CAediting_286293	chr3_53689738_+	intronic
CAediting_286294	chr3_53689744_+	intronic
CAediting_286295	chr3_53689745_+	intronic
CAediting_286296	chr3_53689759_+	intronic
CAediting_286297	chr3_53689762_+	intronic
CAediting_286298	chr3_53689771_+	intronic
CAediting_286299	chr3_53689825_+	intronic
CAediting_286300	chr3_53689894_+	intronic
CAediting_286301	chr3_53689895_+	intronic
CAediting_286302	chr3_53689921_+	intronic
CAediting_286303	chr3_53689934_+	intronic
CAediting_286304	chr3_53692894_+	intronic
CAediting_286305	chr3_53692937_+	intronic
CAediting_286306	chr3_53692938_+	intronic
CAediting_286307	chr3_53695988_+	intronic
CAediting_286308	chr3_53696025_+	intronic
CAediting_286309	chr3_53696203_+	intronic
CAediting_286310	chr3_53696230_+	intronic
CAediting_286311	chr3_53763169_+	intronic
CAediting_286312	chr3_53783011_+	intronic
CAediting_286313	chr3_53786865_+	exonic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_286146	chr3_53500231_+	SINE	Alu	AluSz6
CAediting_286147	chr3_53500310_+	SINE	Alu	AluSz6
CAediting_286148	chr3_53500316_+	SINE	Alu	AluSz6
CAediting_286149	chr3_53500355_+	SINE	Alu	AluSz6
CAediting_286150	chr3_53500376_+	SINE	Alu	AluSz6
CAediting_286151	chr3_53500379_+	SINE	Alu	AluSz6
CAediting_286152	chr3_53500380_+	SINE	Alu	AluSz6
CAediting_286153	chr3_53500385_+	SINE	Alu	AluSz6
CAediting_286154	chr3_53507340_+	SINE	Alu	AluJr
CAediting_286155	chr3_53507407_+	SINE	Alu	AluJr
CAediting_286156	chr3_53507409_+	SINE	Alu	AluJr
CAediting_286157	chr3_53521093_+	SINE	Alu	AluJr4
CAediting_286158	chr3_53521119_+	SINE	Alu	AluJr4
CAediting_286159	chr3_53521120_+	SINE	Alu	AluJr4
CAediting_286160	chr3_53521144_+	SINE	Alu	AluJr4
CAediting_286161	chr3_53521157_+	SINE	Alu	AluJr4
CAediting_286162	chr3_53521173_+	SINE	Alu	AluJr4
CAediting_286163	chr3_53521179_+	SINE	Alu	AluJr4
CAediting_286164	chr3_53521227_+	SINE	Alu	AluJr4
CAediting_286165	chr3_53521243_+	SINE	Alu	AluJr4
CAediting_286166	chr3_53521252_+	SINE	Alu	AluJr4
CAediting_286167	chr3_53521253_+	SINE	Alu	AluJr4
CAediting_286168	chr3_53521254_+	SINE	Alu	AluJr4
CAediting_286169	chr3_53521278_+	SINE	Alu	AluJr4
CAediting_286170	chr3_53521304_+	SINE	Alu	AluJr4
CAediting_286171	chr3_53521887_+	SINE	Alu	AluJr4
CAediting_286172	chr3_53521889_+	SINE	Alu	AluJr4
CAediting_286173	chr3_53521895_+	SINE	Alu	AluJr4
CAediting_286174	chr3_53521927_+	SINE	Alu	AluJr4
CAediting_286175	chr3_53521937_+	SINE	Alu	AluJr4
CAediting_286176	chr3_53521938_+	SINE	Alu	AluJr4
CAediting_286177	chr3_53521939_+	SINE	Alu	AluJr4
CAediting_286178	chr3_53521941_+	SINE	Alu	AluJr4
CAediting_286179	chr3_53521989_+	SINE	Alu	AluJr4
CAediting_286180	chr3_53522011_+	SINE	Alu	AluJr4
CAediting_286181	chr3_53522025_+	SINE	Alu	AluJr4
CAediting_286182	chr3_53522029_+	SINE	Alu	AluJr4
CAediting_286183	chr3_53522032_+	SINE	Alu	AluJr4
CAediting_286184	chr3_53539315_+	SINE	Alu	AluSg
CAediting_286185	chr3_53539382_+	SINE	Alu	AluSg
CAediting_286186	chr3_53540167_+	SINE	Alu	AluSz
CAediting_286187	chr3_53540258_+	SINE	Alu	AluSz
CAediting_286188	chr3_53542418_+	SINE	Alu	AluJo
CAediting_286189	chr3_53542543_+	SINE	Alu	AluJo
CAediting_286190	chr3_53542777_+	SINE	Alu	AluSp
CAediting_286191	chr3_53552450_+	SINE	Alu	AluSz
CAediting_286192	chr3_53552474_+	SINE	Alu	AluSz
CAediting_286193	chr3_53552546_+	SINE	Alu	AluSz
CAediting_286194	chr3_53552581_+	SINE	Alu	AluSz
CAediting_286195	chr3_53552642_+	SINE	Alu	AluSz
CAediting_286196	chr3_53553941_+	SINE	Alu	AluY
CAediting_286197	chr3_53554116_+	SINE	Alu	AluY
CAediting_286198	chr3_53556771_+	SINE	Alu	AluSz
CAediting_286199	chr3_53556926_+	SINE	Alu	AluSz
CAediting_286200	chr3_53556951_+	SINE	Alu	AluSz
CAediting_286201	chr3_53556990_+	SINE	Alu	AluSz
CAediting_286202	chr3_53557241_+	SINE	Alu	AluSp
CAediting_286203	chr3_53557280_+	SINE	Alu	AluSp
CAediting_286204	chr3_53557305_+	SINE	Alu	AluSp
CAediting_286205	chr3_53557308_+	SINE	Alu	AluSp
CAediting_286206	chr3_53557309_+	SINE	Alu	AluSp
CAediting_286207	chr3_53557336_+	SINE	Alu	AluSp
CAediting_286208	chr3_53557344_+	SINE	Alu	AluSp
CAediting_286209	chr3_53557347_+	SINE	Alu	AluSp
CAediting_286210	chr3_53563290_+	SINE	Alu	AluSx1
CAediting_286211	chr3_53563291_+	SINE	Alu	AluSx1
CAediting_286212	chr3_53563304_+	SINE	Alu	AluSx1
CAediting_286213	chr3_53563309_+	SINE	Alu	AluSx1
CAediting_286214	chr3_53563322_+	SINE	Alu	AluSx1
CAediting_286215	chr3_53563323_+	SINE	Alu	AluSx1
CAediting_286216	chr3_53563329_+	SINE	Alu	AluSx1
CAediting_286217	chr3_53563359_+	SINE	Alu	AluSx1
CAediting_286218	chr3_53563362_+	SINE	Alu	AluSx1
CAediting_286219	chr3_53563364_+	SINE	Alu	AluSx1
CAediting_286220	chr3_53563403_+	SINE	Alu	AluSx1
CAediting_286221	chr3_53563413_+	SINE	Alu	AluSx1
CAediting_286222	chr3_53563430_+	SINE	Alu	AluSx1
CAediting_286223	chr3_53563444_+	SINE	Alu	AluSx1
CAediting_286224	chr3_53563445_+	SINE	Alu	AluSx1
CAediting_286225	chr3_53564225_+	SINE	Alu	AluSz
CAediting_286226	chr3_53564261_+	SINE	Alu	AluSz
CAediting_286227	chr3_53564262_+	SINE	Alu	AluSz
CAediting_286228	chr3_53598334_+	SINE	Alu	AluSz6
CAediting_286229	chr3_53598385_+	SINE	Alu	AluSz6
CAediting_286230	chr3_53598464_+	SINE	Alu	AluSz6
CAediting_286231	chr3_53598494_+	SINE	Alu	AluSz6
CAediting_286232	chr3_53601810_+	SINE	Alu	AluSx1
CAediting_286233	chr3_53601811_+	SINE	Alu	AluSx1
CAediting_286234	chr3_53601850_+	SINE	Alu	AluSx1
CAediting_286235	chr3_53611291_+	SINE	Alu	AluJr
CAediting_286236	chr3_53620317_+	SINE	Alu	AluJo
CAediting_286237	chr3_53620424_+	SINE	Alu	AluJo
CAediting_286238	chr3_53640058_+	SINE	Alu	AluSx
CAediting_286239	chr3_53640124_+	SINE	Alu	AluSx
CAediting_286246	chr3_53663351_+	Low_complexity	Low_complexity	GA-rich
CAediting_286247	chr3_53663372_+	Low_complexity	Low_complexity	GA-rich
CAediting_286248	chr3_53663376_+	Low_complexity	Low_complexity	GA-rich
CAediting_286249	chr3_53663380_+	Low_complexity	Low_complexity	GA-rich
CAediting_286250	chr3_53663386_+	Low_complexity	Low_complexity	GA-rich
CAediting_286253	chr3_53678992_+	SINE	Alu	AluSq2
CAediting_286254	chr3_53678996_+	SINE	Alu	AluSq2
CAediting_286255	chr3_53678998_+	SINE	Alu	AluSq2
CAediting_286256	chr3_53679012_+	SINE	Alu	AluSq2
CAediting_286257	chr3_53679020_+	SINE	Alu	AluSq2
CAediting_286258	chr3_53679041_+	SINE	Alu	AluSq2
CAediting_286259	chr3_53679050_+	SINE	Alu	AluSq2
CAediting_286260	chr3_53679055_+	SINE	Alu	AluSq2
CAediting_286261	chr3_53679057_+	SINE	Alu	AluSq2
CAediting_286262	chr3_53679060_+	SINE	Alu	AluSq2
CAediting_286263	chr3_53679105_+	SINE	Alu	AluSq2
CAediting_286264	chr3_53679108_+	SINE	Alu	AluSq2
CAediting_286265	chr3_53679109_+	SINE	Alu	AluSq2
CAediting_286266	chr3_53679110_+	SINE	Alu	AluSq2
CAediting_286267	chr3_53679111_+	SINE	Alu	AluSq2
CAediting_286268	chr3_53679112_+	SINE	Alu	AluSq2
CAediting_286269	chr3_53679120_+	SINE	Alu	AluSq2
CAediting_286270	chr3_53679123_+	SINE	Alu	AluSq2
CAediting_286271	chr3_53679149_+	SINE	Alu	AluSq2
CAediting_286272	chr3_53679150_+	SINE	Alu	AluSq2
CAediting_286273	chr3_53679176_+	SINE	Alu	AluSq2
CAediting_286274	chr3_53679185_+	SINE	Alu	AluSq2
CAediting_286275	chr3_53679190_+	SINE	Alu	AluSq2
CAediting_286276	chr3_53679191_+	SINE	Alu	AluSq2
CAediting_286277	chr3_53679194_+	SINE	Alu	AluSq2
CAediting_286278	chr3_53679219_+	SINE	Alu	AluSq2
CAediting_286279	chr3_53679220_+	SINE	Alu	AluSq2
CAediting_286280	chr3_53682289_+	SINE	Alu	AluJr
CAediting_286281	chr3_53682329_+	SINE	Alu	AluJr
CAediting_286282	chr3_53682346_+	SINE	Alu	AluJr
CAediting_286283	chr3_53682434_+	SINE	Alu	AluJr
CAediting_286284	chr3_53682436_+	SINE	Alu	AluJr
CAediting_286285	chr3_53682446_+	SINE	Alu	AluJr
CAediting_286286	chr3_53682463_+	SINE	Alu	AluJr
CAediting_286287	chr3_53682477_+	SINE	Alu	AluJr
CAediting_286288	chr3_53682482_+	SINE	Alu	AluJr
CAediting_286289	chr3_53682491_+	SINE	Alu	AluJr
CAediting_286290	chr3_53682498_+	SINE	Alu	AluJr
CAediting_286291	chr3_53682536_+	SINE	Alu	AluJr
CAediting_286292	chr3_53689683_+	SINE	Alu	AluJr
CAediting_286293	chr3_53689738_+	SINE	Alu	AluJr
CAediting_286294	chr3_53689744_+	SINE	Alu	AluJr
CAediting_286295	chr3_53689745_+	SINE	Alu	AluJr
CAediting_286296	chr3_53689759_+	SINE	Alu	AluJr
CAediting_286297	chr3_53689762_+	SINE	Alu	AluJr
CAediting_286298	chr3_53689771_+	SINE	Alu	AluJr
CAediting_286299	chr3_53689825_+	SINE	Alu	AluJr
CAediting_286300	chr3_53689894_+	SINE	Alu	AluJr
CAediting_286301	chr3_53689895_+	SINE	Alu	AluJr
CAediting_286302	chr3_53689921_+	SINE	Alu	AluJr
CAediting_286303	chr3_53689934_+	SINE	Alu	AluJr
CAediting_286304	chr3_53692894_+	SINE	Alu	AluSz6
CAediting_286305	chr3_53692937_+	SINE	Alu	AluSz6
CAediting_286306	chr3_53692938_+	SINE	Alu	AluSz6
CAediting_286307	chr3_53695988_+	SINE	Alu	AluJr4
CAediting_286308	chr3_53696025_+	SINE	Alu	AluJr4
CAediting_286309	chr3_53696203_+	SINE	Alu	AluJr4
CAediting_286310	chr3_53696230_+	SINE	Alu	AluJr4

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RNA A-to-I editing events in the alternative splicing sites for CACNA1D

RNA A-to-I editing(s) in the alternative splicing sites.

AStype	CAeditomID	Editing position	AS position	AS direction	Exonic location	Wildtype sequence	Wildtype splicing strength	RNA edited sequence	RNA edited splicing strength
ES	CAediting_286313	chr3_53786865_+	53786848:53786870	3SS	0+3i	TATGCCACTTTCCTGATACAGGA	-11.67	TATGCCACTTTCCTGATGCAGGA	-26.04
ES	CAediting_286313	chr3_53786865_+	53786859:53786881	3SS	0+14i	CCTGATACAGGACTACTTTAGGA	-20.51	CCTGATGCAGGACTACTTTAGGA	-20.22

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000157388.12.CACNA1D.

Correlation between RNA A-to-I editing and PSI for ENSG00000157388.12.CACNA1D.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for CACNA1D

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for CACNA1D

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for CACNA1D

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1054808	chr15_66496985_-	ENSG00000157388.12	ENST00000288139	hsa-miR-4512	53811639	53811645	7mer-m8	53811626	53811646	155	-26.34
CAediting_1351755	chr19_40282625_-	ENSG00000157388.12	ENST00000288139	hsa-miR-641	53813529	53813534	6mer	53813512	53813535	141	-19.76
CAediting_396018	chr5_1062918_-	ENSG00000157388.12	ENST00000288139	hsa-miR-4635	53811547	53811554	8mer-1a	53811534	53811554	145	-15.42
CAediting_604450	chr7_133034877_-	ENSG00000157388.12	ENST00000288139	hsa-miR-3654	53812618	53812624	7mer-m8	53812607	53812625	149	-18.84
CAediting_524911	chr7_5495852_-	ENSG00000157388.12	ENST00000288139	hsa-miR-589-3p	53812629	53812635	7mer-m8	53812616	53812636	150	-22.27

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_846604	chr11_93733708_-	ENSG00000157388.12	ENST00000288139	hsa-miR-1304-3p	53813363	53813370	8mer-1a	53813349	53813370	140	-15.12
CAediting_396018	chr5_1062918_-	ENSG00000157388.12	ENST00000288139	hsa-miR-4635	53813233	53813239	7mer-m8	53813220	53813240	145	-12.53
CAediting_524911	chr7_5495852_-	ENSG00000157388.12	ENST00000288139	hsa-miR-589-3p	53811922	53811929	8mer-1a	53811905	53811929	145	-20.68

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for CACNA1D

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000288139.7	protein_coding
ENST00000350061.8	protein_coding
ENST00000422281.5	protein_coding
ENST00000481478.1	protein_coding
ENST00000498251.1	processed_transcript

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID	ENST	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
CAediting_286313	ENST00000288139.7	chr3_53786865_+	-2854.30	-2853.30	-2854.30
CAediting_286313	ENST00000350061.8	chr3_53786865_+	-2506.30	-2506.20	-2506.30
CAediting_286313	ENST00000422281.5	chr3_53786865_+	-2042.40	-2042.30	-2042.40
CAediting_286313	ENST00000481478.1	chr3_53786865_+	-1870.40	-1870.30	-1870.40
CAediting_286254	ENST00000498251.1	chr3_53678996_+	-231.60	-231.60	-259.90
CAediting_286255	ENST00000498251.1	chr3_53678998_+	-231.60	-231.60	-259.90
CAediting_286256	ENST00000498251.1	chr3_53679012_+	-231.60	-231.60	-259.90
CAediting_286257	ENST00000498251.1	chr3_53679020_+	-230.90	-231.60	-259.90
CAediting_286258	ENST00000498251.1	chr3_53679041_+	-232.00	-231.60	-259.90
CAediting_286259	ENST00000498251.1	chr3_53679050_+	-232.10	-231.60	-259.90
CAediting_286260	ENST00000498251.1	chr3_53679055_+	-234.90	-231.60	-259.90
CAediting_286261	ENST00000498251.1	chr3_53679057_+	-235.10	-231.60	-259.90
CAediting_286262	ENST00000498251.1	chr3_53679060_+	-235.40	-231.60	-259.90
CAediting_286263	ENST00000498251.1	chr3_53679105_+	-234.90	-231.60	-259.90
CAediting_286264	ENST00000498251.1	chr3_53679108_+	-231.40	-231.60	-259.90
CAediting_286265	ENST00000498251.1	chr3_53679109_+	-231.60	-231.60	-259.90
CAediting_286266	ENST00000498251.1	chr3_53679110_+	-231.60	-231.60	-259.90
CAediting_286267	ENST00000498251.1	chr3_53679111_+	-231.60	-231.60	-259.90
CAediting_286268	ENST00000498251.1	chr3_53679112_+	-232.30	-231.60	-259.90
CAediting_286269	ENST00000498251.1	chr3_53679120_+	-231.60	-231.60	-259.90
CAediting_286270	ENST00000498251.1	chr3_53679123_+	-232.70	-231.60	-259.90
CAediting_286271	ENST00000498251.1	chr3_53679149_+	-232.10	-231.60	-259.90
CAediting_286272	ENST00000498251.1	chr3_53679150_+	-232.50	-231.60	-259.90
CAediting_286273	ENST00000498251.1	chr3_53679176_+	-232.20	-231.60	-259.90
CAediting_286274	ENST00000498251.1	chr3_53679185_+	-231.90	-231.60	-259.90
CAediting_286275	ENST00000498251.1	chr3_53679190_+	-232.60	-231.60	-259.90
CAediting_286276	ENST00000498251.1	chr3_53679191_+	-232.70	-231.60	-259.90
CAediting_286277	ENST00000498251.1	chr3_53679194_+	-232.60	-231.60	-259.90
CAediting_286278	ENST00000498251.1	chr3_53679219_+	-232.60	-231.60	-259.90
CAediting_286279	ENST00000498251.1	chr3_53679220_+	-237.10	-231.60	-259.90

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Relation with ADAR for CACNA1D

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for CACNA1D

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for CACNA1D

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for CACNA1D

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
CACNA1D	Q01668	DB00273	Topiramate	Voltage-dependent L-type calcium channel subunit alpha-1D	SmallMoleculeDrug	approved
CACNA1D	Q01668	DB00401	Nisoldipine	Voltage-dependent L-type calcium channel subunit alpha-1D	SmallMoleculeDrug	approved
CACNA1D	Q01668	DB00421	Spironolactone	Voltage-dependent L-type calcium channel subunit alpha-1D	SmallMoleculeDrug	approved
CACNA1D	Q01668	DB00825	Levomenthol	Voltage-dependent L-type calcium channel subunit alpha-1D	SmallMoleculeDrug	approved
CACNA1D	Q01668	DB00898	Ethanol	Voltage-dependent L-type calcium channel subunit alpha-1D	SmallMoleculeDrug	approved
CACNA1D	Q01668	DB01115	Nifedipine	Voltage-dependent L-type calcium channel subunit alpha-1D	SmallMoleculeDrug	approved
CACNA1D	Q01668	DB04855	Dronedarone	Voltage-dependent L-type calcium channel subunit alpha-1D	SmallMoleculeDrug	approved
CACNA1D	Q01668	DB09089	Trimebutine	Voltage-dependent L-type calcium channel subunit alpha-1D	SmallMoleculeDrug	approved
CACNA1D	Q01668	DB13746	Bioallethrin	Voltage-dependent L-type calcium channel subunit alpha-1D	SmallMoleculeDrug	approved\|experimental
CACNA1D	Q01668	DB00243	Ranolazine	Voltage-dependent L-type calcium channel subunit alpha-1D	SmallMoleculeDrug	approved\|investigational
CACNA1D	Q01668	DB00270	Isradipine	Voltage-dependent L-type calcium channel subunit alpha-1D	SmallMoleculeDrug	approved\|investigational
CACNA1D	Q01668	DB00393	Nimodipine	Voltage-dependent L-type calcium channel subunit alpha-1D	SmallMoleculeDrug	approved\|investigational
CACNA1D	Q01668	DB00568	Cinnarizine	Voltage-dependent L-type calcium channel subunit alpha-1D	SmallMoleculeDrug	approved\|investigational
CACNA1D	Q01668	DB00622	Nicardipine	Voltage-dependent L-type calcium channel subunit alpha-1D	SmallMoleculeDrug	approved\|investigational
CACNA1D	Q01668	DB01023	Felodipine	Voltage-dependent L-type calcium channel subunit alpha-1D	SmallMoleculeDrug	approved\|investigational
CACNA1D	Q01668	DB01054	Nitrendipine	Voltage-dependent L-type calcium channel subunit alpha-1D	SmallMoleculeDrug	approved\|investigational
CACNA1D	Q01668	DB01118	Amiodarone	Voltage-dependent L-type calcium channel subunit alpha-1D	SmallMoleculeDrug	approved\|investigational
CACNA1D	Q01668	DB04920	Clevidipine	Voltage-dependent L-type calcium channel subunit alpha-1D	SmallMoleculeDrug	approved\|investigational
CACNA1D	Q01668	DB06712	Nilvadipine	Voltage-dependent L-type calcium channel subunit alpha-1D	SmallMoleculeDrug	approved\|investigational
CACNA1D	Q01668	DB09236	Lacidipine	Voltage-dependent L-type calcium channel subunit alpha-1D	SmallMoleculeDrug	approved\|investigational
CACNA1D	Q01668	DB09237	Levamlodipine	Voltage-dependent L-type calcium channel subunit alpha-1D	SmallMoleculeDrug	approved\|investigational
CACNA1D	Q01668	DB09238	Manidipine	Voltage-dependent L-type calcium channel subunit alpha-1D	SmallMoleculeDrug	approved\|investigational
CACNA1D	Q01668	DB00228	Enflurane	Voltage-dependent L-type calcium channel subunit alpha-1D	SmallMoleculeDrug	approved\|investigational\|vet_approved
CACNA1D	Q01668	DB00653	Magnesium sulfate	Voltage-dependent L-type calcium channel subunit alpha-1D	SmallMoleculeDrug	approved\|investigational\|vet_approved
CACNA1D	Q01668	DB01110	Miconazole	Voltage-dependent L-type calcium channel subunit alpha-1D	SmallMoleculeDrug	approved\|investigational\|vet_approved
CACNA1D	Q01668	DB00153	Ergocalciferol	Voltage-dependent L-type calcium channel subunit alpha-1D	SmallMoleculeDrug	approved\|nutraceutical
CACNA1D	Q01668	DB13961	Fish oil	Voltage-dependent L-type calcium channel subunit alpha-1D	BiotechDrug	approved\|nutraceutical
CACNA1D	Q01668	DB00252	Phenytoin	Voltage-dependent L-type calcium channel subunit alpha-1D	SmallMoleculeDrug	approved\|vet_approved
CACNA1D	Q01668	DB11148	Butamben	Voltage-dependent L-type calcium channel subunit alpha-1D	SmallMoleculeDrug	approved\|withdrawn

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RelatedDiseases for CACNA1D

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
CACNA1D	C3554018	SINOATRIAL NODE DYSFUNCTION AND DEAFNESS	5	CLINGEN;GENOMICS_ENGLAND;ORPHANET
CACNA1D	C0001430	Adenoma	2	CTD_human
CACNA1D	C0205646	Adenoma, Basal Cell	2	CTD_human
CACNA1D	C0205647	Follicular adenoma	2	CTD_human
CACNA1D	C0205648	Adenoma, Microcystic	2	CTD_human
CACNA1D	C0205649	Adenoma, Monomorphic	2	CTD_human
CACNA1D	C0205650	Papillary adenoma	2	CTD_human
CACNA1D	C0205651	Adenoma, Trabecular	2	CTD_human
CACNA1D	C3809609	PRIMARY ALDOSTERONISM, SEIZURES, AND NEUROLOGIC ABNORMALITIES	2	GENOMICS_ENGLAND;ORPHANET;UNIPROT
CACNA1D	C0004331	Auriculo-Ventricular Dissociation	1	CTD_human
CACNA1D	C0005586	Bipolar Disorder	1	CTD_human
CACNA1D	C0005587	Depression, Bipolar	1	CTD_human
CACNA1D	C0011052	Prelingual Deafness	1	CTD_human
CACNA1D	C0011053	Deafness	1	CTD_human
CACNA1D	C0018794	Heart Block	1	CTD_human
CACNA1D	C0020428	Hyperaldosteronism	1	CTD_human
CACNA1D	C0024713	Manic Disorder	1	CTD_human
CACNA1D	C0037052	Sick Sinus Syndrome	1	CTD_human
CACNA1D	C0039240	Supraventricular tachycardia	1	CTD_human
CACNA1D	C0086395	Hearing Loss, Extreme	1	CTD_human
CACNA1D	C0338831	Manic	1	CTD_human
CACNA1D	C0428908	Sinus Node Dysfunction (disorder)	1	CTD_human
CACNA1D	C0428977	Bradycardia	1	CTD_human
CACNA1D	C0525045	Mood Disorders	1	PSYGENET
CACNA1D	C0581883	Complete Hearing Loss	1	CTD_human
CACNA1D	C0751068	Deafness, Acquired	1	CTD_human
CACNA1D	C1384514	Conn Syndrome	1	CTD_human
CACNA1D	C3665473	Bilateral Deafness	1	CTD_human
CACNA1D	C4082305	Deaf Mutism	1	CTD_human

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene