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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: TRIM26 (CAeditome ID:7726)

Gene summary for TRIM26

check button Gene summary
Gene informationGene symbol

TRIM26

Gene ID

7726

Gene nametripartite motif containing 26
SynonymsAFP|RNF95|ZNF173
Cytomap

6p22.1

Type of geneprotein-coding
Descriptiontripartite motif-containing protein 26RING finger protein 95acid finger proteinwidely expressed acid zinc finger proteinzinc finger protein 173
Modification date20210518
UniProtAcc

Q12899

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
TRIM26

GO:0045087

Tripartite motif-containing protein 26

18248090

TRIM26

GO:0046597

Tripartite motif-containing protein 26

18248090

TRIM26

GO:0051091

Tripartite motif-containing protein 26

23077300

TRIM26

GO:1902187

Tripartite motif-containing protein 26

18248090


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RNA A-to-I events for TRIM26

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000234127.7
boxplot

check button RNA A-to-I editing events in Cancer.
CAediting_467247(30192635, -), CAediting_467248(30192651, -), CAediting_467249(30192652, -), CAediting_467250(30192654, -), CAediting_467251(30192658, -), CAediting_467252(30193267, -), CAediting_467253(30193352, -), CAediting_467254(30193406, -), CAediting_467255(30193459, -), CAediting_467256(30194621, -), CAediting_467257(30194715, -), CAediting_467258(30194731, -), CAediting_467259(30194733, -), CAediting_467260(30194743, -), CAediting_467261(30194755, -), CAediting_467262(30194768, -), CAediting_467263(30194772, -), CAediting_467264(30194773, -), CAediting_467265(30194844, -), CAediting_467266(30194870, -), CAediting_467267(30194892, -), CAediting_467268(30194894, -), CAediting_467269(30199666, -), CAediting_467270(30199670, -), CAediting_467271(30199733, -), CAediting_467272(30199734, -), CAediting_467273(30199769, -), CAediting_467274(30199775, -), CAediting_467275(30199832, -), CAediting_467276(30199841, -), CAediting_467277(30199903, -), CAediting_467278(30200026, -), CAediting_467279(30200027, -), CAediting_467280(30200036, -), CAediting_467281(30200091, -), CAediting_467282(30200099, -), CAediting_467283(30200165, -), CAediting_467284(30200170, -), CAediting_467285(30200182, -), CAediting_467286(30200213, -), CAediting_467287(30200225, -), CAediting_467288(30200232, -), CAediting_467289(30200268, -), CAediting_467290(30200276, -), CAediting_467291(30201589, -), CAediting_467292(30201601, -), CAediting_467293(30201602, -), CAediting_467294(30201656, -), CAediting_467295(30201664, -), CAediting_467296(30201720, -), CAediting_467297(30201732, -), CAediting_467298(30201785, -), CAediting_467299(30201791, -), CAediting_467300(30203079, -), CAediting_467301(30203111, -), CAediting_467302(30203116, -), CAediting_467303(30203120, -), CAediting_467304(30203141, -), CAediting_467305(30203151, -), CAediting_467306(30203188, -), CAediting_467307(30203195, -), CAediting_467308(30203211, -), CAediting_467309(30203212, -), CAediting_467310(30203318, -), CAediting_467311(30203320, -), CAediting_467312(30203541, -), CAediting_467313(30203553, -), CAediting_467314(30203554, -), CAediting_467315(30203610, -), CAediting_467316(30203620, -), CAediting_467317(30203621, -), CAediting_467318(30203684, -), CAediting_467319(30203825, -), CAediting_467320(30205158, -), CAediting_467321(30205603, -), CAediting_467322(30205621, -), CAediting_467323(30205650, -), CAediting_467324(30209803, -),

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RNA editing positional annotations for TRIM26 using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_467247chr6_30192635_-intronic
CAediting_467248chr6_30192651_-intronic
CAediting_467249chr6_30192652_-intronic
CAediting_467250chr6_30192654_-intronic
CAediting_467251chr6_30192658_-intronic
CAediting_467252chr6_30193267_-intronic
CAediting_467253chr6_30193352_-intronic
CAediting_467254chr6_30193406_-intronic
CAediting_467255chr6_30193459_-intronic
CAediting_467256chr6_30194621_-intronic
CAediting_467257chr6_30194715_-intronic
CAediting_467258chr6_30194731_-intronic
CAediting_467259chr6_30194733_-intronic
CAediting_467260chr6_30194743_-intronic
CAediting_467261chr6_30194755_-intronic
CAediting_467262chr6_30194768_-intronic
CAediting_467263chr6_30194772_-intronic
CAediting_467264chr6_30194773_-intronic
CAediting_467265chr6_30194844_-intronic
CAediting_467266chr6_30194870_-intronic
CAediting_467267chr6_30194892_-intronic
CAediting_467268chr6_30194894_-intronic
CAediting_467269chr6_30199666_-ncRNA_intronic
CAediting_467270chr6_30199670_-ncRNA_intronic
CAediting_467271chr6_30199733_-ncRNA_intronic
CAediting_467272chr6_30199734_-ncRNA_intronic
CAediting_467273chr6_30199769_-ncRNA_intronic
CAediting_467274chr6_30199775_-ncRNA_intronic
CAediting_467275chr6_30199832_-ncRNA_intronic
CAediting_467276chr6_30199841_-ncRNA_intronic
CAediting_467277chr6_30199903_-ncRNA_intronic
CAediting_467278chr6_30200026_-ncRNA_intronic
CAediting_467279chr6_30200027_-ncRNA_intronic
CAediting_467280chr6_30200036_-ncRNA_intronic
CAediting_467281chr6_30200091_-ncRNA_intronic
CAediting_467282chr6_30200099_-ncRNA_intronic
CAediting_467283chr6_30200165_-ncRNA_intronic
CAediting_467284chr6_30200170_-ncRNA_intronic
CAediting_467285chr6_30200182_-ncRNA_intronic
CAediting_467286chr6_30200213_-ncRNA_intronic
CAediting_467287chr6_30200225_-ncRNA_intronic
CAediting_467288chr6_30200232_-ncRNA_intronic
CAediting_467289chr6_30200268_-ncRNA_intronic
CAediting_467290chr6_30200276_-ncRNA_intronic
CAediting_467291chr6_30201589_-ncRNA_intronic
CAediting_467292chr6_30201601_-ncRNA_intronic
CAediting_467293chr6_30201602_-ncRNA_intronic
CAediting_467294chr6_30201656_-ncRNA_intronic
CAediting_467295chr6_30201664_-ncRNA_intronic
CAediting_467296chr6_30201720_-ncRNA_intronic
CAediting_467297chr6_30201732_-ncRNA_intronic
CAediting_467298chr6_30201785_-ncRNA_intronic
CAediting_467299chr6_30201791_-ncRNA_intronic
CAediting_467300chr6_30203079_-ncRNA_intronic
CAediting_467301chr6_30203111_-ncRNA_intronic
CAediting_467302chr6_30203116_-ncRNA_intronic
CAediting_467303chr6_30203120_-ncRNA_intronic
CAediting_467304chr6_30203141_-ncRNA_intronic
CAediting_467305chr6_30203151_-ncRNA_intronic
CAediting_467306chr6_30203188_-ncRNA_intronic
CAediting_467307chr6_30203195_-ncRNA_intronic
CAediting_467308chr6_30203211_-ncRNA_intronic
CAediting_467309chr6_30203212_-ncRNA_intronic
CAediting_467310chr6_30203318_-ncRNA_intronic
CAediting_467311chr6_30203320_-ncRNA_intronic
CAediting_467312chr6_30203541_-ncRNA_intronic
CAediting_467313chr6_30203553_-ncRNA_intronic
CAediting_467314chr6_30203554_-ncRNA_intronic
CAediting_467315chr6_30203610_-ncRNA_intronic
CAediting_467316chr6_30203620_-ncRNA_intronic
CAediting_467317chr6_30203621_-ncRNA_intronic
CAediting_467318chr6_30203684_-ncRNA_intronic
CAediting_467319chr6_30203825_-ncRNA_intronic
CAediting_467320chr6_30205158_-ncRNA_intronic
CAediting_467321chr6_30205603_-ncRNA_intronic
CAediting_467322chr6_30205621_-ncRNA_intronic
CAediting_467323chr6_30205650_-ncRNA_intronic
CAediting_467324chr6_30209803_-ncRNA_intronic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_467247chr6_30192635_-SINEAluFLAM_C
CAediting_467248chr6_30192651_-SINEAluFLAM_C
CAediting_467249chr6_30192652_-SINEAluFLAM_C
CAediting_467250chr6_30192654_-SINEAluFLAM_C
CAediting_467251chr6_30192658_-SINEAluFLAM_C
CAediting_467252chr6_30193267_-SINEAluAluSg
CAediting_467253chr6_30193352_-SINEAluAluSg
CAediting_467254chr6_30193406_-SINEAluAluSg
CAediting_467255chr6_30193459_-SINEAluAluSg
CAediting_467256chr6_30194621_-SINEAluAluSx
CAediting_467257chr6_30194715_-SINEAluAluSx
CAediting_467258chr6_30194731_-SINEAluAluSx
CAediting_467259chr6_30194733_-SINEAluAluSx
CAediting_467260chr6_30194743_-SINEAluAluSx
CAediting_467261chr6_30194755_-SINEAluAluSx
CAediting_467262chr6_30194768_-SINEAluAluSx
CAediting_467263chr6_30194772_-SINEAluAluSx
CAediting_467264chr6_30194773_-SINEAluAluSx
CAediting_467265chr6_30194844_-SINEAluAluSx
CAediting_467266chr6_30194870_-SINEAluAluSx
CAediting_467267chr6_30194892_-SINEAluAluSx
CAediting_467268chr6_30194894_-SINEAluAluSx
CAediting_467269chr6_30199666_-SINEAluAluY
CAediting_467270chr6_30199670_-SINEAluAluY
CAediting_467271chr6_30199733_-SINEAluAluY
CAediting_467272chr6_30199734_-SINEAluAluY
CAediting_467273chr6_30199769_-SINEAluAluY
CAediting_467274chr6_30199775_-SINEAluAluY
CAediting_467275chr6_30199832_-SINEAluAluY
CAediting_467276chr6_30199841_-SINEAluAluY
CAediting_467277chr6_30199903_-SINEAluAluY
CAediting_467278chr6_30200026_-SINEAluAluJb
CAediting_467279chr6_30200027_-SINEAluAluJb
CAediting_467280chr6_30200036_-SINEAluAluJb
CAediting_467281chr6_30200091_-SINEAluAluJb
CAediting_467282chr6_30200099_-SINEAluAluJb
CAediting_467283chr6_30200165_-SINEAluAluJb
CAediting_467284chr6_30200170_-SINEAluAluJb
CAediting_467285chr6_30200182_-SINEAluAluJb
CAediting_467286chr6_30200213_-SINEAluAluJb
CAediting_467287chr6_30200225_-SINEAluAluJb
CAediting_467288chr6_30200232_-SINEAluAluJb
CAediting_467289chr6_30200268_-SINEAluAluJb
CAediting_467290chr6_30200276_-SINEAluAluJb
CAediting_467291chr6_30201589_-SINEAluAluSc8
CAediting_467292chr6_30201601_-SINEAluAluSc8
CAediting_467293chr6_30201602_-SINEAluAluSc8
CAediting_467294chr6_30201656_-SINEAluAluSc8
CAediting_467295chr6_30201664_-SINEAluAluSc8
CAediting_467296chr6_30201720_-SINEAluAluSc8
CAediting_467297chr6_30201732_-SINEAluAluSc8
CAediting_467298chr6_30201785_-SINEAluAluSc8
CAediting_467299chr6_30201791_-SINEAluAluSc8
CAediting_467300chr6_30203079_-SINEAluAluJb
CAediting_467301chr6_30203111_-SINEAluAluJb
CAediting_467302chr6_30203116_-SINEAluAluJb
CAediting_467303chr6_30203120_-SINEAluAluJb
CAediting_467304chr6_30203141_-SINEAluAluJb
CAediting_467305chr6_30203151_-SINEAluAluJb
CAediting_467306chr6_30203188_-SINEAluAluJb
CAediting_467307chr6_30203195_-SINEAluAluJb
CAediting_467308chr6_30203211_-SINEAluAluJb
CAediting_467309chr6_30203212_-SINEAluAluJb
CAediting_467310chr6_30203318_-SINEAluAluJb
CAediting_467311chr6_30203320_-SINEAluAluJb
CAediting_467312chr6_30203541_-SINEAluAluSq2
CAediting_467313chr6_30203553_-SINEAluAluSq2
CAediting_467314chr6_30203554_-SINEAluAluSq2
CAediting_467315chr6_30203610_-SINEAluAluSq2
CAediting_467316chr6_30203620_-SINEAluAluSq2
CAediting_467317chr6_30203621_-SINEAluAluSq2
CAediting_467318chr6_30203684_-SINEAluAluSq2
CAediting_467319chr6_30203825_-SINEAluAluYj4
CAediting_467320chr6_30205158_-SINEAluAluSp
CAediting_467321chr6_30205603_-SINEAluAluJb
CAediting_467322chr6_30205621_-SINEAluAluJb
CAediting_467323chr6_30205650_-SINEAluAluJb
CAediting_467324chr6_30209803_-SINEAluFLAM_C

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RNA A-to-I editing events in the alternative splicing sites for TRIM26

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000234127.7.TRIM26.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000234127.7.TRIM26.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for TRIM26

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

check button Correlation between RNA A-to-I editing and gene expression.

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for TRIM26

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for TRIM26

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_980496chr14_31014685_-ENSG00000234127.7ENST00000437089hsa-miR-624-3p30184692301846987mer-m83018469130184711150-14.31
CAediting_393chr1_1167164_+ENSG00000234127.7ENST00000437089hsa-miR-200b-3p30185547301855537mer-m83018554630185569151-14.05
CAediting_980496chr14_31014685_-ENSG00000234127.7ENST00000454678hsa-miR-624-3p30184692301846987mer-m83018469130184711150-14.31
CAediting_393chr1_1167164_+ENSG00000234127.7ENST00000454678hsa-miR-200b-3p30185547301855537mer-m83018554630185569151-14.05
CAediting_980496chr14_31014685_-ENSG00000234127.7ENST00000453195hsa-miR-624-3p30184692301846987mer-m83018469130184711150-14.31
CAediting_393chr1_1167164_+ENSG00000234127.7ENST00000453195hsa-miR-200b-3p30185547301855537mer-m83018554630185569151-14.05
CAediting_1229413chr17_67471544_+ENSG00000234127.7ENST00000437089hsa-miR-548aa30185652301856587mer-m83018565130185676141-8.78
CAediting_1229414chr17_67471546_+ENSG00000234127.7ENST00000437089hsa-miR-548aa30185202301852098mer-1a3018520230185226160-16.22
CAediting_1368054chr19_46709310_-ENSG00000234127.7ENST00000437089hsa-miR-320e30185581301855877mer-m83018558030185598149-23.12
CAediting_86358chr1_109598906_+ENSG00000234127.7ENST00000437089hsa-miR-197-5p30184695301847017mer-m83018469430184716145-19.2
CAediting_524911chr7_5495852_-ENSG00000234127.7ENST00000437089hsa-miR-589-3p30184732301847387mer-m83018473130184754144-13.8
CAediting_1229413chr17_67471544_+ENSG00000234127.7ENST00000454678hsa-miR-548aa30185652301856587mer-m83018565130185676141-8.78
CAediting_1229414chr17_67471546_+ENSG00000234127.7ENST00000454678hsa-miR-548aa30185202301852098mer-1a3018520230185226160-16.22
CAediting_1368054chr19_46709310_-ENSG00000234127.7ENST00000454678hsa-miR-320e30185581301855877mer-m83018558030185598149-23.12
CAediting_86358chr1_109598906_+ENSG00000234127.7ENST00000454678hsa-miR-197-5p30184695301847017mer-m83018469430184716145-19.2
CAediting_524911chr7_5495852_-ENSG00000234127.7ENST00000454678hsa-miR-589-3p30184732301847387mer-m83018473130184754144-13.8
CAediting_1229413chr17_67471544_+ENSG00000234127.7ENST00000453195hsa-miR-548aa30185652301856587mer-m83018565130185676141-8.78
CAediting_1229414chr17_67471546_+ENSG00000234127.7ENST00000453195hsa-miR-548aa30185202301852098mer-1a3018520230185226160-16.22
CAediting_1368054chr19_46709310_-ENSG00000234127.7ENST00000453195hsa-miR-320e30185581301855877mer-m83018558030185598149-23.12
CAediting_86358chr1_109598906_+ENSG00000234127.7ENST00000453195hsa-miR-197-5p30184695301847017mer-m83018469430184716145-19.2
CAediting_524911chr7_5495852_-ENSG00000234127.7ENST00000453195hsa-miR-589-3p30184732301847387mer-m83018473130184754144-13.8
CAediting_1524209chrX_134546392_-ENSG00000234127.7ENST00000437089hsa-miR-503-5p30185437301854426mer3018543630185459140-19.91
CAediting_1524209chrX_134546392_-ENSG00000234127.7ENST00000454678hsa-miR-503-5p30185437301854426mer3018543630185459140-19.91
CAediting_1524209chrX_134546392_-ENSG00000234127.7ENST00000453195hsa-miR-503-5p30185437301854426mer3018543630185459140-19.91

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_688081chr9_63819627_+ENSG00000234127.7ENST00000437089hsa-miR-4477b30185476301854838mer-1a3018547630185499154-15.47
CAediting_1351755chr19_40282625_-ENSG00000234127.7ENST00000437089hsa-miR-64130184853301848597mer-m83018485230184875140-15.42
CAediting_688081chr9_63819627_+ENSG00000234127.7ENST00000454678hsa-miR-4477b30185476301854838mer-1a3018547630185499154-15.47
CAediting_1351755chr19_40282625_-ENSG00000234127.7ENST00000454678hsa-miR-64130184853301848597mer-m83018485230184875140-15.42
CAediting_688081chr9_63819627_+ENSG00000234127.7ENST00000453195hsa-miR-4477b30185476301854838mer-1a3018547630185499154-15.47
CAediting_1351755chr19_40282625_-ENSG00000234127.7ENST00000453195hsa-miR-64130184853301848597mer-m83018485230184875140-15.42

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for TRIM26

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for TRIM26

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)

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Relation with cancer stages for TRIM26

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.
ESCAclinical_stageCAediting_467300chr6_30203079_-0.02697151676154910.534807146851806
STADpathologic_stageCAediting_467300chr6_30203079_-0.02786689052265850.197540255785309

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Relation with survival for TRIM26

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR

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RelatedDrugs for TRIM26

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TRIM26

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource