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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: ZNF140 (CAeditome ID:7699)

Gene summary for ZNF140

check button Gene summary
Gene informationGene symbol

ZNF140

Gene ID

7699

Gene namezinc finger protein 140
SynonymspHZ-39
Cytomap

12q24.33

Type of geneprotein-coding
Descriptionzinc finger protein 140
Modification date20210518
UniProtAcc

P52738

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
ZNF140

GO:0001227

Zinc finger protein 140

11470777

ZNF140

GO:0043565

Zinc finger protein 140

28473536

ZNF140

GO:1990837

Zinc finger protein 140

28473536

ZNF140

GO:1990837

Zinc finger protein 140

28473536

ZNF140

GO:0000122

Zinc finger protein 140

11470777

ZNF140

GO:0000122

Zinc finger protein 140

7649249


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RNA A-to-I events for ZNF140

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000196387.8

check button RNA A-to-I editing events in Cancer.
CAediting_950161(133085094, +), CAediting_950162(133085099, +), CAediting_950163(133085105, +), CAediting_950164(133085125, +), CAediting_950165(133085129, +), CAediting_950166(133085142, +), CAediting_950167(133085154, +), CAediting_950168(133085155, +), CAediting_950169(133085164, +), CAediting_950170(133085208, +), CAediting_950171(133085225, +), CAediting_950172(133085247, +), CAediting_950173(133085253, +), CAediting_950174(133085284, +), CAediting_950175(133085285, +), CAediting_950176(133085299, +), CAediting_950177(133085759, +), CAediting_950178(133085762, +), CAediting_950179(133085807, +), CAediting_950180(133085815, +), CAediting_950181(133085821, +), CAediting_950182(133085835, +), CAediting_950183(133085859, +), CAediting_950184(133085896, +), CAediting_950185(133085915, +), CAediting_950186(133085968, +), CAediting_950187(133086006, +), CAediting_950188(133087970, +), CAediting_950189(133087974, +), CAediting_950190(133087983, +), CAediting_950191(133088009, +), CAediting_950192(133088010, +), CAediting_950193(133088019, +), CAediting_950194(133088026, +), CAediting_950195(133088039, +), CAediting_950196(133088050, +), CAediting_950197(133088055, +), CAediting_950198(133088062, +), CAediting_950199(133088074, +), CAediting_950200(133088115, +), CAediting_950201(133089414, +), CAediting_950202(133089442, +), CAediting_950203(133089449, +), CAediting_950204(133089476, +), CAediting_950205(133089491, +), CAediting_950206(133090058, +), CAediting_950207(133090084, +), CAediting_950208(133090191, +), CAediting_950209(133090378, +), CAediting_950210(133090382, +), CAediting_950211(133090386, +), CAediting_950212(133097388, +), CAediting_950213(133097389, +), CAediting_950214(133097400, +), CAediting_950215(133097410, +), CAediting_950216(133097411, +), CAediting_950217(133097481, +), CAediting_950218(133097482, +), CAediting_950219(133097496, +), CAediting_950220(133097522, +), CAediting_950221(133098108, +), CAediting_950222(133098298, +), CAediting_950223(133098354, +), CAediting_950224(133098366, +), CAediting_950225(133098378, +), CAediting_950226(133098420, +), CAediting_950227(133098429, +), CAediting_950228(133098449, +), CAediting_950229(133098478, +), CAediting_950230(133098502, +), CAediting_950231(133099078, +), CAediting_950232(133099669, +), CAediting_950233(133100199, +), CAediting_950234(133100242, +), CAediting_950235(133102527, +), CAediting_950236(133102606, +), CAediting_950237(133102638, +), CAediting_950238(133102698, +), CAediting_950239(133103359, +), CAediting_950240(133103511, +), CAediting_950241(133103528, +), CAediting_950242(133105901, +), CAediting_950243(133106106, +), CAediting_950244(133106174, +), CAediting_950245(133106403, +), CAediting_950246(133106407, +),

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RNA editing positional annotations for ZNF140 using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred
CAediting_950245chr12_133106403_+nonsynonymous SNVENST00000355557.5c.A1126Gp.T376ADBN
CAediting_950245chr12_133106403_+nonsynonymous SNVENST00000544426.4c.A817Gp.T273ADBN

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_950161chr12_133085094_+intronic
CAediting_950162chr12_133085099_+intronic
CAediting_950163chr12_133085105_+intronic
CAediting_950164chr12_133085125_+intronic
CAediting_950165chr12_133085129_+intronic
CAediting_950166chr12_133085142_+intronic
CAediting_950167chr12_133085154_+intronic
CAediting_950168chr12_133085155_+intronic
CAediting_950169chr12_133085164_+intronic
CAediting_950170chr12_133085208_+intronic
CAediting_950171chr12_133085225_+intronic
CAediting_950172chr12_133085247_+intronic
CAediting_950173chr12_133085253_+intronic
CAediting_950174chr12_133085284_+intronic
CAediting_950175chr12_133085285_+intronic
CAediting_950176chr12_133085299_+intronic
CAediting_950177chr12_133085759_+intronic
CAediting_950178chr12_133085762_+intronic
CAediting_950179chr12_133085807_+intronic
CAediting_950180chr12_133085815_+intronic
CAediting_950181chr12_133085821_+intronic
CAediting_950182chr12_133085835_+intronic
CAediting_950183chr12_133085859_+intronic
CAediting_950184chr12_133085896_+intronic
CAediting_950185chr12_133085915_+intronic
CAediting_950186chr12_133085968_+intronic
CAediting_950187chr12_133086006_+intronic
CAediting_950188chr12_133087970_+intronic
CAediting_950189chr12_133087974_+intronic
CAediting_950190chr12_133087983_+intronic
CAediting_950191chr12_133088009_+intronic
CAediting_950192chr12_133088010_+intronic
CAediting_950193chr12_133088019_+intronic
CAediting_950194chr12_133088026_+intronic
CAediting_950195chr12_133088039_+intronic
CAediting_950196chr12_133088050_+intronic
CAediting_950197chr12_133088055_+intronic
CAediting_950198chr12_133088062_+intronic
CAediting_950199chr12_133088074_+intronic
CAediting_950200chr12_133088115_+intronic
CAediting_950201chr12_133089414_+intronic
CAediting_950202chr12_133089442_+intronic
CAediting_950203chr12_133089449_+intronic
CAediting_950204chr12_133089476_+intronic
CAediting_950205chr12_133089491_+intronic
CAediting_950206chr12_133090058_+intronic
CAediting_950207chr12_133090084_+intronic
CAediting_950208chr12_133090191_+intronic
CAediting_950209chr12_133090378_+intronic
CAediting_950210chr12_133090382_+intronic
CAediting_950211chr12_133090386_+intronic
CAediting_950212chr12_133097388_+intronic
CAediting_950213chr12_133097389_+intronic
CAediting_950214chr12_133097400_+intronic
CAediting_950215chr12_133097410_+intronic
CAediting_950216chr12_133097411_+intronic
CAediting_950217chr12_133097481_+intronic
CAediting_950218chr12_133097482_+intronic
CAediting_950219chr12_133097496_+intronic
CAediting_950220chr12_133097522_+intronic
CAediting_950221chr12_133098108_+intronic
CAediting_950222chr12_133098298_+intronic
CAediting_950223chr12_133098354_+intronic
CAediting_950224chr12_133098366_+intronic
CAediting_950225chr12_133098378_+intronic
CAediting_950226chr12_133098420_+intronic
CAediting_950227chr12_133098429_+intronic
CAediting_950228chr12_133098449_+intronic
CAediting_950229chr12_133098478_+intronic
CAediting_950230chr12_133098502_+intronic
CAediting_950231chr12_133099078_+intronic
CAediting_950232chr12_133099669_+intronic
CAediting_950233chr12_133100199_+intronic
CAediting_950234chr12_133100242_+intronic
CAediting_950235chr12_133102527_+intronic
CAediting_950236chr12_133102606_+intronic
CAediting_950237chr12_133102638_+intronic
CAediting_950238chr12_133102698_+intronic
CAediting_950239chr12_133103359_+intronic
CAediting_950240chr12_133103511_+intronic
CAediting_950241chr12_133103528_+intronic
CAediting_950242chr12_133105901_+exonic
CAediting_950243chr12_133106106_+exonic
CAediting_950244chr12_133106174_+exonic
CAediting_950245chr12_133106403_+exonic
CAediting_950246chr12_133106407_+exonic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_950161chr12_133085094_+SINEAluAluSq10
CAediting_950162chr12_133085099_+SINEAluAluSq10
CAediting_950163chr12_133085105_+SINEAluAluSq10
CAediting_950164chr12_133085125_+SINEAluAluSq10
CAediting_950165chr12_133085129_+SINEAluAluSq10
CAediting_950166chr12_133085142_+SINEAluAluSq10
CAediting_950167chr12_133085154_+SINEAluAluSq10
CAediting_950168chr12_133085155_+SINEAluAluSq10
CAediting_950169chr12_133085164_+SINEAluAluSq10
CAediting_950170chr12_133085208_+SINEAluAluSq10
CAediting_950171chr12_133085225_+SINEAluAluSq10
CAediting_950172chr12_133085247_+SINEAluAluSq10
CAediting_950173chr12_133085253_+SINEAluAluSq10
CAediting_950174chr12_133085284_+SINEAluAluSq10
CAediting_950175chr12_133085285_+SINEAluAluSq10
CAediting_950176chr12_133085299_+SINEAluAluSq10
CAediting_950177chr12_133085759_+SINEAluAluJr4
CAediting_950178chr12_133085762_+SINEAluAluJr4
CAediting_950179chr12_133085807_+SINEAluAluJr4
CAediting_950180chr12_133085815_+SINEAluAluJr4
CAediting_950181chr12_133085821_+SINEAluAluJr4
CAediting_950182chr12_133085835_+SINEAluAluJr4
CAediting_950183chr12_133085859_+SINEAluAluJr4
CAediting_950184chr12_133085896_+SINEAluAluJr4
CAediting_950185chr12_133085915_+SINEAluAluJr4
CAediting_950186chr12_133085968_+SINEAluAluJr4
CAediting_950187chr12_133086006_+SINEAluAluJr4
CAediting_950188chr12_133087970_+SINEAluAluSx
CAediting_950189chr12_133087974_+SINEAluAluSx
CAediting_950190chr12_133087983_+SINEAluAluSx
CAediting_950191chr12_133088009_+SINEAluAluSx
CAediting_950192chr12_133088010_+SINEAluAluSx
CAediting_950193chr12_133088019_+SINEAluAluSx
CAediting_950194chr12_133088026_+SINEAluAluSx
CAediting_950195chr12_133088039_+SINEAluAluSx
CAediting_950196chr12_133088050_+SINEAluAluSx
CAediting_950197chr12_133088055_+SINEAluAluSx
CAediting_950198chr12_133088062_+SINEAluAluSx
CAediting_950199chr12_133088074_+SINEAluAluSx
CAediting_950200chr12_133088115_+SINEAluAluSx
CAediting_950201chr12_133089414_+SINEAluAluJb
CAediting_950202chr12_133089442_+SINEAluAluJb
CAediting_950203chr12_133089449_+SINEAluAluJb
CAediting_950204chr12_133089476_+SINEAluAluJb
CAediting_950205chr12_133089491_+SINEAluAluJb
CAediting_950206chr12_133090058_+SINEAluAluSq2
CAediting_950207chr12_133090084_+SINEAluAluSq2
CAediting_950208chr12_133090191_+SINEAluAluJr4
CAediting_950209chr12_133090378_+SINEAluAluJr4
CAediting_950210chr12_133090382_+SINEAluAluJr4
CAediting_950211chr12_133090386_+SINEAluAluJr4
CAediting_950212chr12_133097388_+SINEAluAluY
CAediting_950213chr12_133097389_+SINEAluAluY
CAediting_950214chr12_133097400_+SINEAluAluY
CAediting_950215chr12_133097410_+SINEAluAluY
CAediting_950216chr12_133097411_+SINEAluAluY
CAediting_950217chr12_133097481_+SINEAluAluY
CAediting_950218chr12_133097482_+SINEAluAluY
CAediting_950219chr12_133097496_+SINEAluAluY
CAediting_950220chr12_133097522_+SINEAluAluY
CAediting_950221chr12_133098108_+SINEAluAluSx1
CAediting_950222chr12_133098298_+SINEAluAluSz
CAediting_950223chr12_133098354_+SINEAluAluSz
CAediting_950224chr12_133098366_+SINEAluAluSz
CAediting_950225chr12_133098378_+SINEAluAluSz
CAediting_950226chr12_133098420_+SINEAluAluSz
CAediting_950227chr12_133098429_+SINEAluAluSz
CAediting_950228chr12_133098449_+SINEAluAluSz
CAediting_950229chr12_133098478_+SINEAluAluSz
CAediting_950230chr12_133098502_+SINEAluAluSz
CAediting_950231chr12_133099078_+SINEAluAluSx4
CAediting_950232chr12_133099669_+SINEAluFRAM
CAediting_950233chr12_133100199_+SINEAluAluJr
CAediting_950234chr12_133100242_+SINEAluAluJr
CAediting_950235chr12_133102527_+SINEAluAluSx
CAediting_950236chr12_133102606_+SINEAluAluSx
CAediting_950237chr12_133102638_+SINEAluAluSx
CAediting_950238chr12_133102698_+SINEAluAluSx
CAediting_950239chr12_133103359_+SINEAluAluJr
CAediting_950240chr12_133103511_+SINEAluAluJr
CAediting_950241chr12_133103528_+SINEAluAluJr

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RNA A-to-I editing events in the alternative splicing sites for ZNF140

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000196387.8.ZNF140.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000196387.8.ZNF140.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for ZNF140

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

check button Correlation between RNA A-to-I editing and gene expression.

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for ZNF140

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.
all structure


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The effects of the RNA editing to the miRNA binding sites for ZNF140

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_950242chr12_133105901_+ENSG00000196387.8ENST00000440550hsa-miR-79781331058941331059018mer-1a133105881133105901147.00-17.42
CAediting_950242chr12_133105901_+ENSG00000196387.8ENST00000536790hsa-miR-79781331058941331059018mer-1a133105881133105901147.00-17.42
CAediting_950243chr12_133106106_+ENSG00000196387.8ENST00000440550hsa-miR-39381331061021331061087mer-m8133106087133106109155.00-9.62
CAediting_950243chr12_133106106_+ENSG00000196387.8ENST00000536790hsa-miR-39381331061021331061087mer-m8133106087133106109155.00-9.62
CAediting_950244chr12_133106174_+ENSG00000196387.8ENST00000440550hsa-miR-103a-1-5p1331061691331061746mer133106154133106175148.00-22.33
CAediting_950244chr12_133106174_+ENSG00000196387.8ENST00000440550hsa-miR-103a-2-5p1331061691331061746mer133106154133106175148.00-18.48
CAediting_950244chr12_133106174_+ENSG00000196387.8ENST00000440550hsa-miR-6815-3p1331061691331061757mer-m8133106157133106176152.00-20.31
CAediting_950244chr12_133106174_+ENSG00000196387.8ENST00000440550hsa-miR-942-5p1331061671331061737mer-m8133106153133106174140.00-15.82
CAediting_950244chr12_133106174_+ENSG00000196387.8ENST00000536790hsa-miR-103a-1-5p1331061691331061746mer133106154133106175148.00-22.33
CAediting_950244chr12_133106174_+ENSG00000196387.8ENST00000536790hsa-miR-103a-2-5p1331061691331061746mer133106154133106175148.00-18.48
CAediting_950244chr12_133106174_+ENSG00000196387.8ENST00000536790hsa-miR-6815-3p1331061691331061757mer-m8133106157133106176152.00-20.31
CAediting_950244chr12_133106174_+ENSG00000196387.8ENST00000536790hsa-miR-942-5p1331061671331061737mer-m8133106153133106174140.00-15.82

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_950243chr12_133106106_+ENSG00000196387.8ENST00000440550hsa-miR-36851331061001331061078mer-1a133106086133106107140-10.03
CAediting_950242chr12_133105901_+ENSG00000196387.8ENST00000440550hsa-miR-5002-5p1331058961331059027mer-m8133105877133105903150-12.03
CAediting_950245chr12_133106403_+ENSG00000196387.8ENST00000440550hsa-miR-5671331063971331064037mer-m8133106382133106404140-9.39
CAediting_950242chr12_133105901_+ENSG00000196387.8ENST00000440550hsa-miR-579-3p1331058981331059047mer-m8133105883133105905152-14.34
CAediting_950242chr12_133105901_+ENSG00000196387.8ENST00000440550hsa-miR-664b-3p1331058981331059047mer-m8133105884133105905140-6.71
CAediting_950243chr12_133106106_+ENSG00000196387.8ENST00000536790hsa-miR-36851331061001331061078mer-1a133106086133106107140-10.03
CAediting_950242chr12_133105901_+ENSG00000196387.8ENST00000536790hsa-miR-5002-5p1331058961331059027mer-m8133105877133105903150-12.03
CAediting_950245chr12_133106403_+ENSG00000196387.8ENST00000536790hsa-miR-5671331063971331064037mer-m8133106382133106404140-9.39
CAediting_950242chr12_133105901_+ENSG00000196387.8ENST00000536790hsa-miR-579-3p1331058981331059047mer-m8133105883133105905152-14.34
CAediting_950242chr12_133105901_+ENSG00000196387.8ENST00000536790hsa-miR-664b-3p1331058981331059047mer-m8133105884133105905140-6.71

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_980496chr14_31014685_-ENSG00000196387.8ENST00000536790hsa-miR-624-3p1331056091331056146mer133105596133105615144-18.96

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_748296chr10_51299626_+ENSG00000196387.8ENST00000544426hsa-miR-605-3p1331071371331071448mer-1a133107123133107144154-12.46
CAediting_228905chr2_188297554_+ENSG00000196387.8ENST00000440550hsa-miR-561-3p1331057791331057857mer-m8133105762133105786141-7.82
CAediting_393chr1_1167164_+ENSG00000196387.8ENST00000536790hsa-miR-200b-3p1331055741331055807mer-m8133105558133105581150-10.98
CAediting_228905chr2_188297554_+ENSG00000196387.8ENST00000536790hsa-miR-561-3p1331057791331057857mer-m8133105762133105786141-7.82
CAediting_748296chr10_51299626_+ENSG00000196387.8ENST00000536790hsa-miR-605-3p1331071371331071448mer-1a133107123133107144154-12.46
CAediting_748296chr10_51299626_+ENSG00000196387.8ENST00000536790hsa-miR-605-3p1331064531331064597mer-1a133106438133106459140-18.41
CAediting_980496chr14_31014685_-ENSG00000196387.8ENST00000536790hsa-miR-624-3p1331058841331058907mer-m8133105872133105891155-16.75

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for ZNF140

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for ZNF140

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)

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Relation with cancer stages for ZNF140

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.

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Relation with survival for ZNF140

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR

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RelatedDrugs for ZNF140

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ZNF140

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource