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Editing gene: CA9 (CAeditome ID:768)

Gene summary for CA9

Gene summary

Gene information	Gene symbol	CA9
	Gene ID	768
	Gene name	carbonic anhydrase 9
	Synonyms	CAIX\|MN
	Cytomap	9p13.3
	Type of gene	protein-coding
	Description	carbonic anhydrase 9CA-IXP54/58NRCC-associated antigen G250RCC-associated protein G250carbonate dehydratase IXcarbonic anhydrase IXcarbonic dehydratasemembrane antigen MNpMW1renal cell carcinoma-associated antigen G250
	Modification date	20210518
	UniProtAcc	Q16790
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
CA9	GO:0005886	Carbonic anhydrase 9	22087255

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RNA A-to-I events for CA9

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000107159.11

RNA A-to-I editing events in Cancer.

CAediting_684580(35676584, +), CAediting_684581(35676982, +), CAediting_684582(35677075, +), CAediting_684583(35677127, +), CAediting_684584(35677130, +), CAediting_684585(35678073, +), CAediting_684586(35678091, +), CAediting_684587(35678174, +), CAediting_684588(35678225, +), CAediting_684589(35678231, +), CAediting_684590(35678252, +), CAediting_684591(35678727, +), CAediting_684592(35678729, +), CAediting_684593(35678733, +), CAediting_684594(35678741, +), CAediting_684595(35678746, +), CAediting_684596(35678765, +), CAediting_684597(35679456, +), CAediting_684598(35679609, +), CAediting_684599(35680380, +), CAediting_684600(35680386, +), CAediting_684601(35680456, +),

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RNA editing positional annotations for CA9 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_684580	chr9_35676584_+	ncRNA_intronic
CAediting_684581	chr9_35676982_+	ncRNA_intronic
CAediting_684582	chr9_35677075_+	ncRNA_intronic
CAediting_684583	chr9_35677127_+	ncRNA_intronic
CAediting_684584	chr9_35677130_+	ncRNA_intronic
CAediting_684585	chr9_35678073_+	ncRNA_intronic
CAediting_684586	chr9_35678091_+	ncRNA_intronic
CAediting_684587	chr9_35678174_+	ncRNA_intronic
CAediting_684588	chr9_35678225_+	ncRNA_intronic
CAediting_684589	chr9_35678231_+	ncRNA_intronic
CAediting_684590	chr9_35678252_+	ncRNA_intronic
CAediting_684591	chr9_35678727_+	ncRNA_intronic
CAediting_684592	chr9_35678729_+	ncRNA_intronic
CAediting_684593	chr9_35678733_+	ncRNA_intronic
CAediting_684594	chr9_35678741_+	ncRNA_intronic
CAediting_684595	chr9_35678746_+	ncRNA_intronic
CAediting_684596	chr9_35678765_+	ncRNA_intronic
CAediting_684597	chr9_35679456_+	ncRNA_intronic
CAediting_684598	chr9_35679609_+	ncRNA_intronic
CAediting_684599	chr9_35680380_+	ncRNA_intronic
CAediting_684600	chr9_35680386_+	ncRNA_intronic
CAediting_684601	chr9_35680456_+	ncRNA_intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_684580	chr9_35676584_+	LINE	L2	L2c
CAediting_684581	chr9_35676982_+	SINE	Alu	AluSz
CAediting_684582	chr9_35677075_+	SINE	Alu	AluSz
CAediting_684583	chr9_35677127_+	SINE	Alu	AluSz
CAediting_684584	chr9_35677130_+	SINE	Alu	AluSz
CAediting_684585	chr9_35678073_+	SINE	Alu	AluY
CAediting_684586	chr9_35678091_+	SINE	Alu	AluY
CAediting_684587	chr9_35678174_+	SINE	Alu	AluY
CAediting_684588	chr9_35678225_+	SINE	Alu	AluY
CAediting_684589	chr9_35678231_+	SINE	Alu	AluY
CAediting_684590	chr9_35678252_+	SINE	Alu	AluY
CAediting_684591	chr9_35678727_+	SINE	Alu	AluSx4
CAediting_684592	chr9_35678729_+	SINE	Alu	AluSx4
CAediting_684593	chr9_35678733_+	SINE	Alu	AluSx4
CAediting_684594	chr9_35678741_+	SINE	Alu	AluSx4
CAediting_684595	chr9_35678746_+	SINE	Alu	AluSx4
CAediting_684596	chr9_35678765_+	SINE	Alu	AluSx4
CAediting_684597	chr9_35679456_+	SINE	Alu	AluJo
CAediting_684598	chr9_35679609_+	SINE	Alu	AluJo
CAediting_684599	chr9_35680380_+	SINE	Alu	FRAM
CAediting_684600	chr9_35680386_+	SINE	Alu	FRAM
CAediting_684601	chr9_35680456_+	SINE	Alu	FRAM

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RNA A-to-I editing events in the alternative splicing sites for CA9

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000107159.11.CA9.

Correlation between RNA A-to-I editing and PSI for ENSG00000107159.11.CA9.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for CA9

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for CA9

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for CA9

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for CA9

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for CA9

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for CA9

Correlation between Cancer stages and RNA editing frequency

Cancer	Stage_type	CAeditomID	position	P-val	Coeff.
KIRC	pathologic_stage	CAediting_684591	chr9_35678727_+	0.00180197792289493	0.260603792800633

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Relation with survival for CA9

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for CA9

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
CA9	Q16790	DB00562	Benzthiazide	Carbonic anhydrase 9	SmallMoleculeDrug	approved
CA9	Q16790	DB00606	Cyclothiazide	Carbonic anhydrase 9	SmallMoleculeDrug	approved
CA9	Q16790	DB09460	Sodium carbonate	Carbonic anhydrase 9	SmallMoleculeDrug	approved
CA9	Q16790	DB00909	Zonisamide	Carbonic anhydrase 9	SmallMoleculeDrug	approved\|investigational
CA9	Q16790	DB00774	Hydroflumethiazide	Carbonic anhydrase 9	SmallMoleculeDrug	approved\|investigational\|withdrawn

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RelatedDiseases for CA9

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
CA9	C0002793	Anaplasia	1	CTD_human
CA9	C0003129	Anoxemia	1	CTD_human
CA9	C0003130	Anoxia	1	CTD_human
CA9	C0007124	Noninfiltrating Intraductal Carcinoma	1	CTD_human
CA9	C0007131	Non-Small Cell Lung Carcinoma	1	CTD_human
CA9	C0020542	Pulmonary Hypertension	1	CTD_human
CA9	C0023473	Myeloid Leukemia, Chronic	1	CTD_human
CA9	C0242184	Hypoxia	1	CTD_human
CA9	C0700292	Hypoxemia	1	CTD_human
CA9	C1176475	Ductal Carcinoma	1	CTD_human
CA9	C1332347	Atypical Ductal Breast Hyperplasia	1	CTD_human

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene