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Editing gene: ZNF221 (CAeditome ID:7638)

Gene summary for ZNF221

Gene summary

Gene information	Gene symbol	ZNF221
	Gene ID	7638
	Gene name	zinc finger protein 221
	Synonyms	-
	Cytomap	19q13.31
	Type of gene	protein-coding
	Description	zinc finger protein 221
	Modification date	20210518
	UniProtAcc	Q9UK13
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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RNA A-to-I events for ZNF221

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000159905.13

RNA A-to-I editing events in Cancer.

CAediting_1359534(43953995, +), CAediting_1359535(43953997, +), CAediting_1359536(43954002, +), CAediting_1359537(43954003, +), CAediting_1359538(43954015, +), CAediting_1359539(43967206, +), CAediting_1359540(43967543, +), CAediting_1359541(43967553, +), CAediting_1359542(43967572, +), CAediting_1359543(43967578, +), CAediting_1359544(43967685, +),

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RNA editing positional annotations for ZNF221 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_1359534	chr19_43953995_+	intronic
CAediting_1359535	chr19_43953997_+	intronic
CAediting_1359536	chr19_43954002_+	intronic
CAediting_1359537	chr19_43954003_+	intronic
CAediting_1359538	chr19_43954015_+	intronic
CAediting_1359539	chr19_43967206_+	exonic
CAediting_1359540	chr19_43967543_+	UTR3
CAediting_1359541	chr19_43967553_+	UTR3
CAediting_1359542	chr19_43967572_+	UTR3
CAediting_1359543	chr19_43967578_+	UTR3
CAediting_1359544	chr19_43967685_+	UTR3

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_1359534	chr19_43953995_+	SINE	Alu	AluSx
CAediting_1359535	chr19_43953997_+	SINE	Alu	AluSx
CAediting_1359536	chr19_43954002_+	SINE	Alu	AluSx
CAediting_1359537	chr19_43954003_+	SINE	Alu	AluSx
CAediting_1359538	chr19_43954015_+	SINE	Alu	AluSx
CAediting_1359540	chr19_43967543_+	SINE	Alu	AluYk4
CAediting_1359541	chr19_43967553_+	SINE	Alu	AluYk4
CAediting_1359542	chr19_43967572_+	SINE	Alu	AluYk4
CAediting_1359543	chr19_43967578_+	SINE	Alu	AluYk4
CAediting_1359544	chr19_43967685_+	SINE	Alu	AluYk4

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RNA A-to-I editing events in the alternative splicing sites for ZNF221

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000159905.13.ZNF221.

Correlation between RNA A-to-I editing and PSI for ENSG00000159905.13.ZNF221.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for ZNF221

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for ZNF221

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for ZNF221

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1359540	chr19_43967543_+	ENSG00000159905.13	ENST00000251269	hsa-miR-2277-3p	43967538	43967544	7mer-m8	43967524	43967545	161.00	-26.01
CAediting_1359540	chr19_43967543_+	ENSG00000159905.13	ENST00000251269	hsa-miR-4524a-3p	43967540	43967547	8mer-1a	43967525	43967547	153.00	-21.79
CAediting_1359540	chr19_43967543_+	ENSG00000159905.13	ENST00000592350	hsa-miR-2277-3p	43967538	43967544	7mer-m8	43967524	43967545	161.00	-26.01
CAediting_1359540	chr19_43967543_+	ENSG00000159905.13	ENST00000592350	hsa-miR-4524a-3p	43967540	43967547	8mer-1a	43967525	43967547	153.00	-21.79
CAediting_1359540	chr19_43967543_+	ENSG00000159905.13	ENST00000622072	hsa-miR-2277-3p	43967538	43967544	7mer-m8	43967524	43967545	161.00	-26.01
CAediting_1359540	chr19_43967543_+	ENSG00000159905.13	ENST00000622072	hsa-miR-4524a-3p	43967540	43967547	8mer-1a	43967525	43967547	153.00	-21.79
CAediting_1359543	chr19_43967578_+	ENSG00000159905.13	ENST00000251269	hsa-miR-4634	43967575	43967582	8mer-1a	43967563	43967582	144.00	-25.01
CAediting_1359543	chr19_43967578_+	ENSG00000159905.13	ENST00000592350	hsa-miR-4634	43967575	43967582	8mer-1a	43967563	43967582	144.00	-25.01
CAediting_1359543	chr19_43967578_+	ENSG00000159905.13	ENST00000622072	hsa-miR-4634	43967575	43967582	8mer-1a	43967563	43967582	144.00	-25.01
CAediting_1359544	chr19_43967685_+	ENSG00000159905.13	ENST00000251269	hsa-miR-3190-5p	43967683	43967689	7mer-m8	43967672	43967690	152.00	-22.63
CAediting_1359544	chr19_43967685_+	ENSG00000159905.13	ENST00000251269	hsa-miR-548s	43967682	43967688	7mer-m8	43967667	43967689	149.00	-13.99
CAediting_1359542	chr19_43967572_+	ENSG00000159905.13	ENST00000251269	hsa-miR-1247-3p	43967567	43967573	7mer-m8	43967552	43967574	152.00	-26.23
CAediting_1359542	chr19_43967572_+	ENSG00000159905.13	ENST00000592350	hsa-miR-1247-3p	43967567	43967573	7mer-m8	43967552	43967574	152.00	-26.23
CAediting_1359542	chr19_43967572_+	ENSG00000159905.13	ENST00000622072	hsa-miR-1247-3p	43967567	43967573	7mer-m8	43967552	43967574	152.00	-26.23

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1359544	chr19_43967685_+	ENSG00000159905.13	ENST00000251269	hsa-miR-3064-5p	43967684	43967689	6mer	43967670	43967690	144	-24.26
CAediting_1359541	chr19_43967553_+	ENSG00000159905.13	ENST00000251269	hsa-miR-3174	43967549	43967554	6mer	43967534	43967555	146	-24.89
CAediting_1359542	chr19_43967572_+	ENSG00000159905.13	ENST00000251269	hsa-miR-3689a-3p	43967565	43967571	7mer-m8	43967552	43967572	150	-24.97
CAediting_1359542	chr19_43967572_+	ENSG00000159905.13	ENST00000251269	hsa-miR-4646-5p	43967567	43967572	6mer	43967552	43967573	140	-24.75
CAediting_1359544	chr19_43967685_+	ENSG00000159905.13	ENST00000251269	hsa-miR-4794	43967683	43967689	7mer-m8	43967668	43967690	151	-21.79
CAediting_1359542	chr19_43967572_+	ENSG00000159905.13	ENST00000251269	hsa-miR-490-3p	43967569	43967575	7mer-m8	43967554	43967576	146	-17.97
CAediting_1359544	chr19_43967685_+	ENSG00000159905.13	ENST00000251269	hsa-miR-664a-5p	43967683	43967689	7mer-m8	43967667	43967690	141	-16.08
CAediting_1359542	chr19_43967572_+	ENSG00000159905.13	ENST00000251269	hsa-miR-6780a-5p	43967565	43967571	7mer-m8	43967548	43967572	147	-25
CAediting_1359541	chr19_43967553_+	ENSG00000159905.13	ENST00000592350	hsa-miR-3174	43967549	43967554	6mer	43967534	43967555	146	-24.89
CAediting_1359542	chr19_43967572_+	ENSG00000159905.13	ENST00000592350	hsa-miR-3689a-3p	43967565	43967571	7mer-m8	43967552	43967572	150	-24.97
CAediting_1359542	chr19_43967572_+	ENSG00000159905.13	ENST00000592350	hsa-miR-4646-5p	43967567	43967572	6mer	43967552	43967573	140	-24.75
CAediting_1359542	chr19_43967572_+	ENSG00000159905.13	ENST00000592350	hsa-miR-490-3p	43967569	43967575	7mer-m8	43967554	43967576	146	-17.97
CAediting_1359542	chr19_43967572_+	ENSG00000159905.13	ENST00000592350	hsa-miR-6780a-5p	43967565	43967571	7mer-m8	43967548	43967572	147	-25
CAediting_1359541	chr19_43967553_+	ENSG00000159905.13	ENST00000622072	hsa-miR-3174	43967549	43967554	6mer	43967534	43967555	146	-24.89
CAediting_1359542	chr19_43967572_+	ENSG00000159905.13	ENST00000622072	hsa-miR-3689a-3p	43967565	43967571	7mer-m8	43967552	43967572	150	-24.97
CAediting_1359542	chr19_43967572_+	ENSG00000159905.13	ENST00000622072	hsa-miR-4646-5p	43967567	43967572	6mer	43967552	43967573	140	-24.75
CAediting_1359542	chr19_43967572_+	ENSG00000159905.13	ENST00000622072	hsa-miR-490-3p	43967569	43967575	7mer-m8	43967554	43967576	146	-17.97
CAediting_1359542	chr19_43967572_+	ENSG00000159905.13	ENST00000622072	hsa-miR-6780a-5p	43967565	43967571	7mer-m8	43967548	43967572	147	-25

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for ZNF221

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for ZNF221

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for ZNF221

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for ZNF221

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for ZNF221

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for ZNF221

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene