![]() |
||||||
|
![]() | |
![]() | |
![]() | Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples |
![]() | |
![]() | |
![]() | The effects of the RNA editing to the stability of the RNA structures |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Editing gene: BEST1 (CAeditome ID:7439) |
Gene summary for BEST1 |
![]() |
Gene information | Gene symbol | BEST1 | Gene ID | 7439 |
Gene name | bestrophin 1 | |
Synonyms | ARB|BEST|BMD|Best1V1Delta2|RP50|TU15B|VMD2 | |
Cytomap | 11q12.3 | |
Type of gene | protein-coding | |
Description | bestrophin-1Best diseasevitelliform macular dystrophy protein 2 | |
Modification date | 20210529 | |
UniProtAcc | O76090 | |
Context |
![]() |
Gene | GO ID | GO term | PubMed ID |
BEST1 | GO:0006821 | Bestrophin-1 | 17003041 |
BEST1 | GO:0005254 | Bestrophin-1 | 17003041 |
BEST1 | GO:0005254 | Bestrophin-1 | 17003041 |
BEST1 | GO:0030321 | Bestrophin-1 | 17003041 |
BEST1 | GO:0016323 | Bestrophin-1 | 11050159 |
BEST1 | GO:0016323 | Bestrophin-1 | 19853238 |
BEST1 | GO:0009925 | Bestrophin-1 | 31791063 |
BEST1 | GO:0034707 | Bestrophin-1 | 17003041 |
Top |
RNA A-to-I events for BEST1 |
![]() |
![]() |
![]() |
![]() |
CAediting_817913(61954497, +), CAediting_817914(61954551, +), CAediting_817915(61954672, +), CAediting_817916(61954702, +), CAediting_817917(61954726, +), CAediting_817918(61957468, +), CAediting_817919(61957739, +), CAediting_817920(61957806, +), CAediting_817921(61958439, +), CAediting_817922(61958440, +), CAediting_817923(61958445, +), CAediting_817924(61958449, +), CAediting_817925(61958462, +), CAediting_817926(61958466, +), CAediting_817927(61958469, +), CAediting_817928(61958471, +), CAediting_817929(61958472, +), |
Top |
RNA editing positional annotations for BEST1 using Annovar |
![]() |
CAeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
CAediting_817925 | chr11_61958462_+ | nonsynonymous SNV | ENST00000524926.4 | c.A1031G | p.E344G | D | B | N |
CAediting_817925 | chr11_61958462_+ | nonsynonymous SNV | ENST00000526988.1 | c.A713G | p.E238G | D | B | N |
CAediting_817928 | chr11_61958471_+ | nonsynonymous SNV | ENST00000524926.4 | c.A1040G | p.E347G | D | B | N |
CAediting_817928 | chr11_61958471_+ | nonsynonymous SNV | ENST00000526988.1 | c.A722G | p.E241G | D | B | N |
![]() |
CAeditome ID | Position | Variant type |
CAediting_817913 | chr11_61954497_+ | ncRNA_intronic |
CAediting_817914 | chr11_61954551_+ | ncRNA_intronic |
CAediting_817915 | chr11_61954672_+ | ncRNA_intronic |
CAediting_817916 | chr11_61954702_+ | ncRNA_intronic |
CAediting_817917 | chr11_61954726_+ | ncRNA_intronic |
CAediting_817918 | chr11_61957468_+ | ncRNA_intronic |
CAediting_817919 | chr11_61957739_+ | ncRNA_intronic |
CAediting_817920 | chr11_61957806_+ | ncRNA_intronic |
CAediting_817921 | chr11_61958439_+ | exonic |
CAediting_817922 | chr11_61958440_+ | exonic |
CAediting_817923 | chr11_61958445_+ | exonic |
CAediting_817924 | chr11_61958449_+ | exonic |
CAediting_817925 | chr11_61958462_+ | exonic |
CAediting_817926 | chr11_61958466_+ | exonic |
CAediting_817927 | chr11_61958469_+ | exonic |
CAediting_817928 | chr11_61958471_+ | exonic |
CAediting_817929 | chr11_61958472_+ | exonic |
![]() |
CAeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
CAediting_817913 | chr11_61954497_+ | SINE | Alu | AluJo |
CAediting_817914 | chr11_61954551_+ | SINE | Alu | AluJo |
CAediting_817915 | chr11_61954672_+ | SINE | Alu | AluJo |
CAediting_817916 | chr11_61954702_+ | SINE | Alu | AluJo |
CAediting_817917 | chr11_61954726_+ | SINE | Alu | AluJo |
CAediting_817919 | chr11_61957739_+ | SINE | Alu | AluSx |
CAediting_817920 | chr11_61957806_+ | SINE | Alu | AluSx |
CAediting_817921 | chr11_61958439_+ | SINE | Alu | AluSp |
CAediting_817922 | chr11_61958440_+ | SINE | Alu | AluSp |
CAediting_817923 | chr11_61958445_+ | SINE | Alu | AluSp |
CAediting_817924 | chr11_61958449_+ | SINE | Alu | AluSp |
CAediting_817925 | chr11_61958462_+ | SINE | Alu | AluSp |
CAediting_817926 | chr11_61958466_+ | SINE | Alu | AluSp |
CAediting_817927 | chr11_61958469_+ | SINE | Alu | AluSp |
CAediting_817928 | chr11_61958471_+ | SINE | Alu | AluSp |
CAediting_817929 | chr11_61958472_+ | SINE | Alu | AluSp |
Top |
RNA A-to-I editing events in the alternative splicing sites for BEST1 |
![]() |
AStype | CAeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
ES | CAediting_817918 | chr11_61957468_+ | 61957462:61957470 | 5SS | 0+4i | CAGGTGAGG | 10.07 | CAGGTGGGG | 6.92 |
IR | CAediting_817918 | chr11_61957468_+ | 61957462:61957470 | 5SS | 0+4i | CAGGTGAGG | 10.07 | CAGGTGGGG | 6.92 |
![]() |
![]() |
Top |
Differntial gene expression between RNA A-to-I edited versus non-edited samples for BEST1 |
![]() * The grey color means N/A. |
![]() |
![]() * Click on the image to enlarge it in a new window. |
Top |
Protein coding region RNA A-to-I editings for BEST1 |
![]() * Click on the image to enlarge it in a new window. |
Top |
The effects of the RNA editing to the miRNA binding sites for BEST1 |
**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page. |
![]() |
CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
![]() |
CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
![]() |
CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
![]() |
CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
![]() |
CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
![]() |
CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
![]() |
CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
CAediting_748296 | chr10_51299626_+ | ENSG00000167995.14 | ENST00000449131 | hsa-miR-605-3p | 61964022 | 61964028 | 7mer-m8 | 61964006 | 61964029 | 144 | -18.77 |
CAediting_688081 | chr9_63819627_+ | ENSG00000167995.14 | ENST00000449131 | hsa-miR-4477b | 61964934 | 61964940 | 7mer-m8 | 61964923 | 61964941 | 145 | -11.84 |
CAediting_524911 | chr7_5495852_- | ENSG00000167995.14 | ENST00000534553 | hsa-miR-589-3p | 61962953 | 61962960 | 8mer-1a | 61962934 | 61962960 | 147 | -16.55 |
CAediting_1229413 | chr17_67471544_+ | ENSG00000167995.14 | ENST00000449131 | hsa-miR-548aa | 61965106 | 61965112 | 7mer-m8 | 61965089 | 61965113 | 144 | -10.81 |
CAediting_1229415 | chr17_67471547_+ | ENSG00000167995.14 | ENST00000449131 | hsa-miR-548aa | 61964842 | 61964848 | 7mer-m8 | 61964824 | 61964849 | 152 | -12.34 |
CAediting_604450 | chr7_133034877_- | ENSG00000167995.14 | ENST00000449131 | hsa-miR-3654 | 61963401 | 61963407 | 7mer-m8 | 61963390 | 61963408 | 152 | -18.22 |
CAediting_468389 | chr6_31355314_- | ENSG00000167995.14 | ENST00000449131 | hsa-miR-6891-5p | 61965440 | 61965446 | 7mer-1a | 61965428 | 61965446 | 145 | -25.1 |
![]() |
CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
CAediting_396018 | chr5_1062918_- | ENSG00000167995.14 | ENST00000534553 | hsa-miR-4635 | 61962509 | 61962515 | 7mer-m8 | 61962496 | 61962516 | 142 | -15.13 |
CAediting_396018 | chr5_1062918_- | ENSG00000167995.14 | ENST00000524926 | hsa-miR-4635 | 61962509 | 61962515 | 7mer-m8 | 61962496 | 61962516 | 142 | -15.13 |
CAediting_573001 | chr7_92204086_- | ENSG00000167995.14 | ENST00000449131 | hsa-miR-1285-5p | 61963939 | 61963945 | 7mer-m8 | 61963926 | 61963946 | 151 | -16.65 |
CAediting_573000 | chr7_92204081_- | ENSG00000167995.14 | ENST00000449131 | hsa-miR-1285-5p | 61963939 | 61963945 | 7mer-m8 | 61963926 | 61963946 | 151 | -16.65 |
![]() |
Top |
The effects of the RNA editing to the stability of the RNA structures for BEST1 |
![]() * Click on the image to enlarge it in a new window. |
ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
![]() |
CAeditom_ID | ENST | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
Top |
Relation with ADAR for BEST1 |
![]() |
Cancer | CAeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
Top |
Relation with cancer stages for BEST1 |
![]() |
Cancer | Stage_type | CAeditomID | position | P-val | Coeff. |
Top |
Relation with survival for BEST1 |
![]() |
Cancer | CAeditomID | position | KMpvalue | Coxpvalue | CoxHR |
Top |
RelatedDrugs for BEST1 |
![]() (DrugBank Version 5.1.8 2021-01-03) |
Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for BEST1 |
![]() (DisGeNet 7.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |
BEST1 | C0339510 | Vitelliform Macular Dystrophy | 20 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
BEST1 | C3888198 | BESTROPHINOPATHY, AUTOSOMAL RECESSIVE | 6 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
BEST1 | C3888099 | Autosomal dominant vitreoretinochoroidopathy | 3 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
BEST1 | C2750789 | RETINITIS PIGMENTOSA, CONCENTRIC (disorder) | 2 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
BEST1 | C0015397 | Disorder of eye | 1 | GENOMICS_ENGLAND |
BEST1 | C0026010 | Microphthalmos | 1 | ORPHANET |
BEST1 | C0155359 | Scleral staphyloma | 1 | GENOMICS_ENGLAND |
BEST1 | C1842914 | Adult-Onset Vitelliform Macular Dystrophy | 1 | CTD_human;GENOMICS_ENGLAND;ORPHANET |
BEST1 | C2674009 | Microcornea, Rod-Cone Dystrophy, Cataract, And Posterior Staphyloma | 1 | CTD_human;ORPHANET |
BEST1 | C2745945 | Juvenile-Onset Vitelliform Macular Dystrophy | 1 | CTD_human;ORPHANET |