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Editing gene: UPP1 (CAeditome ID:7378)

Gene summary for UPP1

Gene summary

Gene information	Gene symbol	UPP1
	Gene ID	7378
	Gene name	uridine phosphorylase 1
	Synonyms	UDRPASE\|UP\|UPASE\|UPP
	Cytomap	7p12.3
	Type of gene	protein-coding
	Description	uridine phosphorylase 1UPase 1urdPase 1
	Modification date	20210518
	UniProtAcc	Q16831
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
UPP1	GO:0004850	Uridine phosphorylase 1	7488099
UPP1	GO:0006218	Uridine phosphorylase 1	7488099
UPP1	GO:0005654	Uridine phosphorylase 1	0000052

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RNA A-to-I events for UPP1

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000183696.12

RNA A-to-I editing events in Cancer.

CAediting_543689(48091818, +), CAediting_543690(48091904, +), CAediting_543691(48092616, +), CAediting_543692(48092621, +), CAediting_543693(48092680, +), CAediting_543694(48092728, +), CAediting_543695(48092746, +), CAediting_543696(48092832, +), CAediting_543697(48092939, +), CAediting_543698(48093882, +), CAediting_543699(48093898, +), CAediting_543700(48093904, +), CAediting_543701(48093905, +), CAediting_543702(48093982, +), CAediting_543703(48093983, +), CAediting_543704(48093984, +), CAediting_543705(48093995, +), CAediting_543706(48094013, +), CAediting_543707(48094039, +), CAediting_543708(48094049, +), CAediting_543709(48094066, +), CAediting_543710(48094071, +), CAediting_543711(48094293, +), CAediting_543712(48094314, +), CAediting_543713(48094331, +), CAediting_543714(48094340, +), CAediting_543715(48094342, +), CAediting_543716(48094345, +), CAediting_543717(48094371, +), CAediting_543718(48094373, +), CAediting_543719(48094381, +), CAediting_543720(48094382, +), CAediting_543721(48094396, +), CAediting_543722(48094399, +), CAediting_543723(48094413, +), CAediting_543724(48094418, +), CAediting_543725(48094423, +), CAediting_543726(48094455, +), CAediting_543727(48103924, +), CAediting_543728(48103926, +), CAediting_543729(48103928, +), CAediting_543730(48103929, +), CAediting_543731(48103930, +), CAediting_543732(48103964, +), CAediting_543733(48103970, +), CAediting_543734(48103981, +), CAediting_543735(48104000, +), CAediting_543736(48104011, +), CAediting_543737(48104019, +), CAediting_543738(48104031, +), CAediting_543739(48104032, +), CAediting_543740(48104034, +), CAediting_543741(48104040, +), CAediting_543742(48104041, +), CAediting_543743(48104042, +), CAediting_543744(48104053, +), CAediting_543745(48104057, +), CAediting_543746(48104058, +), CAediting_543747(48104059, +), CAediting_543748(48104061, +), CAediting_543749(48104063, +), CAediting_543750(48104064, +), CAediting_543751(48104065, +), CAediting_543752(48104071, +), CAediting_543753(48104097, +), CAediting_543754(48104103, +), CAediting_543755(48104114, +), CAediting_543756(48104120, +), CAediting_543757(48104127, +), CAediting_543758(48104130, +), CAediting_543759(48104138, +), CAediting_543760(48104139, +), CAediting_543761(48104146, +), CAediting_543762(48104163, +), CAediting_543763(48104178, +), CAediting_543764(48104205, +), CAediting_543765(48106331, +), CAediting_543766(48106336, +), CAediting_543767(48106375, +), CAediting_543768(48106391, +), CAediting_543769(48106410, +), CAediting_543770(48106415, +), CAediting_543771(48106428, +), CAediting_543772(48106436, +), CAediting_543773(48106440, +), CAediting_543774(48106450, +), CAediting_543775(48106452, +), CAediting_543776(48106466, +), CAediting_543777(48106476, +), CAediting_543778(48106485, +), CAediting_543779(48106491, +), CAediting_543780(48106494, +), CAediting_543781(48106496, +), CAediting_543782(48106508, +), CAediting_543783(48106511, +), CAediting_543784(48106520, +), CAediting_543785(48106533, +), CAediting_543786(48106545, +), CAediting_543787(48106550, +), CAediting_543788(48106571, +), CAediting_543789(48106572, +), CAediting_543790(48106573, +), CAediting_543791(48106586, +), CAediting_543792(48106588, +), CAediting_543793(48106608, +),

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RNA editing positional annotations for UPP1 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_543689	chr7_48091818_+	ncRNA_intronic
CAediting_543690	chr7_48091904_+	ncRNA_intronic
CAediting_543691	chr7_48092616_+	ncRNA_intronic
CAediting_543692	chr7_48092621_+	ncRNA_intronic
CAediting_543693	chr7_48092680_+	ncRNA_intronic
CAediting_543694	chr7_48092728_+	ncRNA_intronic
CAediting_543695	chr7_48092746_+	ncRNA_intronic
CAediting_543696	chr7_48092832_+	ncRNA_intronic
CAediting_543697	chr7_48092939_+	ncRNA_intronic
CAediting_543698	chr7_48093882_+	ncRNA_intronic
CAediting_543699	chr7_48093898_+	ncRNA_intronic
CAediting_543700	chr7_48093904_+	ncRNA_intronic
CAediting_543701	chr7_48093905_+	ncRNA_intronic
CAediting_543702	chr7_48093982_+	ncRNA_intronic
CAediting_543703	chr7_48093983_+	ncRNA_intronic
CAediting_543704	chr7_48093984_+	ncRNA_intronic
CAediting_543705	chr7_48093995_+	ncRNA_intronic
CAediting_543706	chr7_48094013_+	ncRNA_intronic
CAediting_543707	chr7_48094039_+	ncRNA_intronic
CAediting_543708	chr7_48094049_+	ncRNA_intronic
CAediting_543709	chr7_48094066_+	ncRNA_intronic
CAediting_543710	chr7_48094071_+	ncRNA_intronic
CAediting_543711	chr7_48094293_+	ncRNA_intronic
CAediting_543712	chr7_48094314_+	ncRNA_intronic
CAediting_543713	chr7_48094331_+	ncRNA_intronic
CAediting_543714	chr7_48094340_+	ncRNA_intronic
CAediting_543715	chr7_48094342_+	ncRNA_intronic
CAediting_543716	chr7_48094345_+	ncRNA_intronic
CAediting_543717	chr7_48094371_+	ncRNA_intronic
CAediting_543718	chr7_48094373_+	ncRNA_intronic
CAediting_543719	chr7_48094381_+	ncRNA_intronic
CAediting_543720	chr7_48094382_+	ncRNA_intronic
CAediting_543721	chr7_48094396_+	ncRNA_intronic
CAediting_543722	chr7_48094399_+	ncRNA_intronic
CAediting_543723	chr7_48094413_+	ncRNA_intronic
CAediting_543724	chr7_48094418_+	ncRNA_intronic
CAediting_543725	chr7_48094423_+	ncRNA_intronic
CAediting_543726	chr7_48094455_+	ncRNA_intronic
CAediting_543727	chr7_48103924_+	ncRNA_intronic
CAediting_543728	chr7_48103926_+	ncRNA_intronic
CAediting_543729	chr7_48103928_+	ncRNA_intronic
CAediting_543730	chr7_48103929_+	ncRNA_intronic
CAediting_543731	chr7_48103930_+	ncRNA_intronic
CAediting_543732	chr7_48103964_+	ncRNA_intronic
CAediting_543733	chr7_48103970_+	ncRNA_intronic
CAediting_543734	chr7_48103981_+	ncRNA_intronic
CAediting_543735	chr7_48104000_+	ncRNA_intronic
CAediting_543736	chr7_48104011_+	ncRNA_intronic
CAediting_543737	chr7_48104019_+	ncRNA_intronic
CAediting_543738	chr7_48104031_+	ncRNA_intronic
CAediting_543739	chr7_48104032_+	ncRNA_intronic
CAediting_543740	chr7_48104034_+	ncRNA_intronic
CAediting_543741	chr7_48104040_+	ncRNA_intronic
CAediting_543742	chr7_48104041_+	ncRNA_intronic
CAediting_543743	chr7_48104042_+	ncRNA_intronic
CAediting_543744	chr7_48104053_+	ncRNA_intronic
CAediting_543745	chr7_48104057_+	ncRNA_intronic
CAediting_543746	chr7_48104058_+	ncRNA_intronic
CAediting_543747	chr7_48104059_+	ncRNA_intronic
CAediting_543748	chr7_48104061_+	ncRNA_intronic
CAediting_543749	chr7_48104063_+	ncRNA_intronic
CAediting_543750	chr7_48104064_+	ncRNA_intronic
CAediting_543751	chr7_48104065_+	ncRNA_intronic
CAediting_543752	chr7_48104071_+	ncRNA_intronic
CAediting_543753	chr7_48104097_+	ncRNA_intronic
CAediting_543754	chr7_48104103_+	ncRNA_intronic
CAediting_543755	chr7_48104114_+	ncRNA_intronic
CAediting_543756	chr7_48104120_+	ncRNA_intronic
CAediting_543757	chr7_48104127_+	ncRNA_intronic
CAediting_543758	chr7_48104130_+	ncRNA_intronic
CAediting_543759	chr7_48104138_+	ncRNA_intronic
CAediting_543760	chr7_48104139_+	ncRNA_intronic
CAediting_543761	chr7_48104146_+	ncRNA_intronic
CAediting_543762	chr7_48104163_+	ncRNA_intronic
CAediting_543763	chr7_48104178_+	ncRNA_intronic
CAediting_543764	chr7_48104205_+	ncRNA_intronic
CAediting_543765	chr7_48106331_+	ncRNA_exonic
CAediting_543766	chr7_48106336_+	ncRNA_exonic
CAediting_543767	chr7_48106375_+	ncRNA_exonic
CAediting_543768	chr7_48106391_+	ncRNA_exonic
CAediting_543769	chr7_48106410_+	ncRNA_exonic
CAediting_543770	chr7_48106415_+	ncRNA_exonic
CAediting_543771	chr7_48106428_+	ncRNA_exonic
CAediting_543772	chr7_48106436_+	ncRNA_exonic
CAediting_543773	chr7_48106440_+	ncRNA_exonic
CAediting_543774	chr7_48106450_+	ncRNA_exonic
CAediting_543775	chr7_48106452_+	ncRNA_exonic
CAediting_543776	chr7_48106466_+	ncRNA_exonic
CAediting_543777	chr7_48106476_+	ncRNA_exonic
CAediting_543778	chr7_48106485_+	ncRNA_exonic
CAediting_543779	chr7_48106491_+	ncRNA_exonic
CAediting_543780	chr7_48106494_+	ncRNA_exonic
CAediting_543781	chr7_48106496_+	ncRNA_exonic
CAediting_543782	chr7_48106508_+	ncRNA_exonic
CAediting_543783	chr7_48106511_+	ncRNA_exonic
CAediting_543784	chr7_48106520_+	ncRNA_exonic
CAediting_543785	chr7_48106533_+	ncRNA_exonic
CAediting_543786	chr7_48106545_+	ncRNA_exonic
CAediting_543787	chr7_48106550_+	ncRNA_exonic
CAediting_543788	chr7_48106571_+	ncRNA_exonic
CAediting_543789	chr7_48106572_+	ncRNA_exonic
CAediting_543790	chr7_48106573_+	ncRNA_exonic
CAediting_543791	chr7_48106586_+	ncRNA_exonic
CAediting_543792	chr7_48106588_+	ncRNA_exonic
CAediting_543793	chr7_48106608_+	ncRNA_exonic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_543691	chr7_48092616_+	SINE	Alu	AluJr
CAediting_543692	chr7_48092621_+	SINE	Alu	AluJr
CAediting_543693	chr7_48092680_+	SINE	Alu	AluJr
CAediting_543694	chr7_48092728_+	SINE	Alu	AluSz
CAediting_543695	chr7_48092746_+	SINE	Alu	AluSz
CAediting_543696	chr7_48092832_+	SINE	Alu	AluSz
CAediting_543697	chr7_48092939_+	SINE	Alu	AluSz
CAediting_543698	chr7_48093882_+	SINE	Alu	AluSx
CAediting_543699	chr7_48093898_+	SINE	Alu	AluSx
CAediting_543700	chr7_48093904_+	SINE	Alu	AluSx
CAediting_543701	chr7_48093905_+	SINE	Alu	AluSx
CAediting_543702	chr7_48093982_+	SINE	Alu	AluSx
CAediting_543703	chr7_48093983_+	SINE	Alu	AluSx
CAediting_543704	chr7_48093984_+	SINE	Alu	AluSx
CAediting_543705	chr7_48093995_+	SINE	Alu	AluSx
CAediting_543706	chr7_48094013_+	SINE	Alu	AluSx
CAediting_543707	chr7_48094039_+	SINE	Alu	AluSx
CAediting_543708	chr7_48094049_+	SINE	Alu	AluSx
CAediting_543709	chr7_48094066_+	SINE	Alu	AluSx
CAediting_543710	chr7_48094071_+	SINE	Alu	AluSx
CAediting_543711	chr7_48094293_+	SINE	Alu	AluSg4
CAediting_543712	chr7_48094314_+	SINE	Alu	AluSg4
CAediting_543713	chr7_48094331_+	SINE	Alu	AluSg4
CAediting_543714	chr7_48094340_+	SINE	Alu	AluSg4
CAediting_543715	chr7_48094342_+	SINE	Alu	AluSg4
CAediting_543716	chr7_48094345_+	SINE	Alu	AluSg4
CAediting_543717	chr7_48094371_+	SINE	Alu	AluSg4
CAediting_543718	chr7_48094373_+	SINE	Alu	AluSg4
CAediting_543719	chr7_48094381_+	SINE	Alu	AluSg4
CAediting_543720	chr7_48094382_+	SINE	Alu	AluSg4
CAediting_543721	chr7_48094396_+	SINE	Alu	AluSg4
CAediting_543722	chr7_48094399_+	SINE	Alu	AluSg4
CAediting_543723	chr7_48094413_+	SINE	Alu	AluSg4
CAediting_543724	chr7_48094418_+	SINE	Alu	AluSg4
CAediting_543725	chr7_48094423_+	SINE	Alu	AluSg4
CAediting_543726	chr7_48094455_+	SINE	Alu	AluSg4
CAediting_543732	chr7_48103964_+	SINE	Alu	AluSc
CAediting_543733	chr7_48103970_+	SINE	Alu	AluSc
CAediting_543734	chr7_48103981_+	SINE	Alu	AluSc
CAediting_543735	chr7_48104000_+	SINE	Alu	AluSc
CAediting_543736	chr7_48104011_+	SINE	Alu	AluSc
CAediting_543737	chr7_48104019_+	SINE	Alu	AluSc
CAediting_543738	chr7_48104031_+	SINE	Alu	AluSc
CAediting_543739	chr7_48104032_+	SINE	Alu	AluSc
CAediting_543740	chr7_48104034_+	SINE	Alu	AluSc
CAediting_543741	chr7_48104040_+	SINE	Alu	AluSc
CAediting_543742	chr7_48104041_+	SINE	Alu	AluSc
CAediting_543743	chr7_48104042_+	SINE	Alu	AluSc
CAediting_543744	chr7_48104053_+	SINE	Alu	AluSc
CAediting_543745	chr7_48104057_+	SINE	Alu	AluSc
CAediting_543746	chr7_48104058_+	SINE	Alu	AluSc
CAediting_543747	chr7_48104059_+	SINE	Alu	AluSc
CAediting_543748	chr7_48104061_+	SINE	Alu	AluSc
CAediting_543749	chr7_48104063_+	SINE	Alu	AluSc
CAediting_543750	chr7_48104064_+	SINE	Alu	AluSc
CAediting_543751	chr7_48104065_+	SINE	Alu	AluSc
CAediting_543752	chr7_48104071_+	SINE	Alu	AluSc
CAediting_543753	chr7_48104097_+	SINE	Alu	AluSc
CAediting_543754	chr7_48104103_+	SINE	Alu	AluSc
CAediting_543755	chr7_48104114_+	SINE	Alu	AluSc
CAediting_543756	chr7_48104120_+	SINE	Alu	AluSc
CAediting_543757	chr7_48104127_+	SINE	Alu	AluSc
CAediting_543758	chr7_48104130_+	SINE	Alu	AluSc
CAediting_543759	chr7_48104138_+	SINE	Alu	AluSc
CAediting_543760	chr7_48104139_+	SINE	Alu	AluSc
CAediting_543761	chr7_48104146_+	SINE	Alu	AluSc
CAediting_543762	chr7_48104163_+	SINE	Alu	AluSc
CAediting_543763	chr7_48104178_+	SINE	Alu	AluSc
CAediting_543764	chr7_48104205_+	SINE	Alu	AluSc
CAediting_543765	chr7_48106331_+	SINE	Alu	AluSq
CAediting_543766	chr7_48106336_+	SINE	Alu	AluSq
CAediting_543767	chr7_48106375_+	SINE	Alu	AluSq
CAediting_543768	chr7_48106391_+	SINE	Alu	AluSq
CAediting_543769	chr7_48106410_+	SINE	Alu	AluSq
CAediting_543770	chr7_48106415_+	SINE	Alu	AluSq
CAediting_543771	chr7_48106428_+	SINE	Alu	AluSq
CAediting_543772	chr7_48106436_+	SINE	Alu	AluSq
CAediting_543773	chr7_48106440_+	SINE	Alu	AluSq
CAediting_543774	chr7_48106450_+	SINE	Alu	AluSq
CAediting_543775	chr7_48106452_+	SINE	Alu	AluSq
CAediting_543776	chr7_48106466_+	SINE	Alu	AluSq
CAediting_543777	chr7_48106476_+	SINE	Alu	AluSq
CAediting_543778	chr7_48106485_+	SINE	Alu	AluSq
CAediting_543779	chr7_48106491_+	SINE	Alu	AluSq
CAediting_543780	chr7_48106494_+	SINE	Alu	AluSq
CAediting_543781	chr7_48106496_+	SINE	Alu	AluSq
CAediting_543782	chr7_48106508_+	SINE	Alu	AluSq
CAediting_543783	chr7_48106511_+	SINE	Alu	AluSq
CAediting_543784	chr7_48106520_+	SINE	Alu	AluSq
CAediting_543785	chr7_48106533_+	SINE	Alu	AluSq
CAediting_543786	chr7_48106545_+	SINE	Alu	AluSq
CAediting_543787	chr7_48106550_+	SINE	Alu	AluSq
CAediting_543788	chr7_48106571_+	SINE	Alu	AluSq
CAediting_543789	chr7_48106572_+	SINE	Alu	AluSq
CAediting_543790	chr7_48106573_+	SINE	Alu	AluSq
CAediting_543791	chr7_48106586_+	SINE	Alu	AluSq
CAediting_543792	chr7_48106588_+	SINE	Alu	AluSq
CAediting_543793	chr7_48106608_+	SINE	Alu	AluSq

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RNA A-to-I editing events in the alternative splicing sites for UPP1

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000183696.12.UPP1.

Correlation between RNA A-to-I editing and PSI for ENSG00000183696.12.UPP1.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for UPP1

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

BRCA.CAediting_543790.ENSG00000183696.UPP1.png
Soverview

BRCA.CAediting_543791.ENSG00000183696.UPP1.png
Soverview

KIRC.CAediting_543771.ENSG00000183696.UPP1.png
Soverview

KIRC.CAediting_543780.ENSG00000183696.UPP1.png
Soverview

PCPG.CAediting_543771.ENSG00000183696.UPP1.png
Soverview

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Protein coding region RNA A-to-I editings for UPP1

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for UPP1

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_543732	chr7_48103964_+	ENSG00000183696.12	ENST00000421046	hsa-miR-513a-5p	48103958	48103964	7mer-m8	48103948	48103965	144.00	-17.77
CAediting_543732	chr7_48103964_+	ENSG00000183696.12	ENST00000421046	hsa-miR-513a-5p	48103958	48103964	7mer-m8	48103948	48103965	144.00	-17.77
CAediting_543732	chr7_48103964_+	ENSG00000183696.12	ENST00000421046	hsa-miR-638	48103963	48103969	7mer-1a	48103945	48103969	151.00	-32.52
CAediting_543727	chr7_48103924_+	ENSG00000183696.12	ENST00000421046	hsa-miR-4677-5p	48103921	48103928	8mer-1a	48103907	48103928	149.00	-12.14
CAediting_543727	chr7_48103924_+	ENSG00000183696.12	ENST00000421046	hsa-miR-6739-3p	48103922	48103929	8mer-1a	48103909	48103929	142.00	-6.55
CAediting_543728	chr7_48103926_+	ENSG00000183696.12	ENST00000421046	hsa-miR-6885-3p	48103923	48103929	7mer-m8	48103910	48103930	140.00	-9.71
CAediting_543731	chr7_48103930_+	ENSG00000183696.12	ENST00000421046	hsa-miR-362-5p	48103926	48103932	7mer-m8	48103910	48103933	142.00	-11.57
CAediting_543731	chr7_48103930_+	ENSG00000183696.12	ENST00000421046	hsa-miR-500b-5p	48103926	48103932	7mer-m8	48103916	48103933	142.00	-9.59
CAediting_543734	chr7_48103981_+	ENSG00000183696.12	ENST00000421046	hsa-miR-10392-3p	48103979	48103986	8mer-1a	48103962	48103986	144.00	-22.69
CAediting_543734	chr7_48103981_+	ENSG00000183696.12	ENST00000421046	hsa-miR-361-3p	48103976	48103981	6mer	48103962	48103982	141.00	-23.59

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_543732	chr7_48103964_+	ENSG00000183696.12	ENST00000421046	hsa-miR-10399-5p	48103959	48103965	7mer-m8	48103945	48103966	148	-11.2
CAediting_543734	chr7_48103981_+	ENSG00000183696.12	ENST00000421046	hsa-miR-150-5p	48103975	48103981	7mer-m8	48103961	48103982	140	-13.51
CAediting_543733	chr7_48103970_+	ENSG00000183696.12	ENST00000421046	hsa-miR-5089-5p	48103963	48103969	7mer-m8	48103948	48103970	148	-13.62
CAediting_543732	chr7_48103964_+	ENSG00000183696.12	ENST00000421046	hsa-miR-6504-3p	48103959	48103965	7mer-m8	48103945	48103966	145	-14.35
CAediting_543733	chr7_48103970_+	ENSG00000183696.12	ENST00000421046	hsa-miR-6506-5p	48103964	48103970	7mer-m8	48103949	48103971	144	-13.21
CAediting_543734	chr7_48103981_+	ENSG00000183696.12	ENST00000421046	hsa-miR-6778-3p	48103977	48103983	7mer-m8	48103964	48103984	140	-14.14

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_846604	chr11_93733708_-	ENSG00000183696.12	ENST00000457596	hsa-miR-1304-3p	48108287	48108293	7mer-m8	48108274	48108294	146	-19.19
CAediting_688080	chr9_63819626_+	ENSG00000183696.12	ENST00000421046	hsa-miR-4477b	48103891	48103897	7mer-m8	48103877	48103898	143	-10
CAediting_846604	chr11_93733708_-	ENSG00000183696.12	ENST00000395560	hsa-miR-1304-3p	48108287	48108293	7mer-m8	48108274	48108294	146	-19.19
CAediting_846604	chr11_93733708_-	ENSG00000183696.12	ENST00000417464	hsa-miR-1304-3p	48108287	48108293	7mer-m8	48108274	48108294	146	-19.19
CAediting_1524209	chrX_134546392_-	ENSG00000183696.12	ENST00000395560	hsa-miR-503-5p	48108358	48108364	7mer-m8	48108344	48108365	145	-21.66
CAediting_1524209	chrX_134546392_-	ENSG00000183696.12	ENST00000417464	hsa-miR-503-5p	48108358	48108364	7mer-m8	48108344	48108365	145	-21.66

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for UPP1

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000421046.4	nonsense_mediated_decay
ENST00000495446.1	retained_intron

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID	ENST	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
CAediting_543727	ENST00000421046.4	chr7_48103924_+	-365.50	-365.10	-371.90
CAediting_543728	ENST00000421046.4	chr7_48103926_+	-365.10	-365.10	-371.90
CAediting_543729	ENST00000421046.4	chr7_48103928_+	-364.80	-365.10	-371.90
CAediting_543730	ENST00000421046.4	chr7_48103929_+	-365.20	-365.10	-371.90
CAediting_543731	ENST00000421046.4	chr7_48103930_+	-365.30	-365.10	-371.90
CAediting_543732	ENST00000421046.4	chr7_48103964_+	-366.60	-365.10	-371.90
CAediting_543733	ENST00000421046.4	chr7_48103970_+	-364.70	-365.10	-371.90
CAediting_543734	ENST00000421046.4	chr7_48103981_+	-364.20	-365.10	-371.90
CAediting_543765	ENST00000495446.1	chr7_48106331_+	-933.40	-932.00	-957.90
CAediting_543766	ENST00000495446.1	chr7_48106336_+	-932.77	-932.00	-957.90
CAediting_543767	ENST00000495446.1	chr7_48106375_+	-932.00	-932.00	-957.90
CAediting_543768	ENST00000495446.1	chr7_48106391_+	-932.20	-932.00	-957.90
CAediting_543769	ENST00000495446.1	chr7_48106410_+	-933.10	-932.00	-957.90
CAediting_543770	ENST00000495446.1	chr7_48106415_+	-932.00	-932.00	-957.90
CAediting_543771	ENST00000495446.1	chr7_48106428_+	-933.00	-932.00	-957.90
CAediting_543772	ENST00000495446.1	chr7_48106436_+	-931.70	-932.00	-957.90
CAediting_543773	ENST00000495446.1	chr7_48106440_+	-933.90	-932.00	-957.90
CAediting_543774	ENST00000495446.1	chr7_48106450_+	-936.10	-932.00	-957.90
CAediting_543775	ENST00000495446.1	chr7_48106452_+	-932.60	-932.00	-957.90
CAediting_543776	ENST00000495446.1	chr7_48106466_+	-932.00	-932.00	-957.90
CAediting_543777	ENST00000495446.1	chr7_48106476_+	-934.10	-932.00	-957.90
CAediting_543778	ENST00000495446.1	chr7_48106485_+	-933.00	-932.00	-957.90
CAediting_543779	ENST00000495446.1	chr7_48106491_+	-936.00	-932.00	-957.90
CAediting_543780	ENST00000495446.1	chr7_48106494_+	-934.10	-932.00	-957.90
CAediting_543781	ENST00000495446.1	chr7_48106496_+	-932.40	-932.00	-957.90
CAediting_543782	ENST00000495446.1	chr7_48106508_+	-932.20	-932.00	-957.90
CAediting_543783	ENST00000495446.1	chr7_48106511_+	-932.00	-932.00	-957.90
CAediting_543784	ENST00000495446.1	chr7_48106520_+	-931.30	-932.00	-957.90
CAediting_543785	ENST00000495446.1	chr7_48106533_+	-933.30	-932.00	-957.90
CAediting_543786	ENST00000495446.1	chr7_48106545_+	-937.80	-932.00	-957.90
CAediting_543787	ENST00000495446.1	chr7_48106550_+	-934.80	-932.00	-957.90
CAediting_543788	ENST00000495446.1	chr7_48106571_+	-931.60	-932.00	-957.90
CAediting_543789	ENST00000495446.1	chr7_48106572_+	-935.50	-932.00	-957.90
CAediting_543790	ENST00000495446.1	chr7_48106573_+	-935.00	-932.00	-957.90
CAediting_543791	ENST00000495446.1	chr7_48106586_+	-933.90	-932.00	-957.90
CAediting_543792	ENST00000495446.1	chr7_48106588_+	-932.00	-932.00	-957.90
CAediting_543793	ENST00000495446.1	chr7_48106608_+	-931.30	-932.00	-957.90

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Relation with ADAR for UPP1

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
SKCM	CAediting_543729	chr7_48103928_+	.	.	0.0355244204060699	0.279084263230234	.	.
TGCT	CAediting_543729	chr7_48103928_+	2.76239658625957e-06	0.486113450829508	.	.	.	.
SKCM	CAediting_543730	chr7_48103929_+	.	.	0.00290882216206093	0.366340953406188	.	.
TGCT	CAediting_543730	chr7_48103929_+	6.53290485274721e-05	0.419153722301656	.	.	.	.
LUSC	CAediting_543771	chr7_48106428_+	0.00141407120989461	0.282480441466956	.	.	.	.
SKCM	CAediting_543771	chr7_48106428_+	.	.	0.0107340591296748	0.196962401160343	.	.
TGCT	CAediting_543771	chr7_48106428_+	.	.	.	.	0.00531740136062026	0.256109559075477
SKCM	CAediting_543777	chr7_48106476_+	.	.	0.0369689976260807	0.272259535202656	.	.
LGG	CAediting_543779	chr7_48106491_+	.	.	0.00159415103831068	0.439178028481337	0.000107354802111139	0.525056520823103
LUSC	CAediting_543779	chr7_48106491_+	0.035279964351829	0.192385898887849	.	.	.	.
GBM	CAediting_543779	chr7_48106491_+	.	.	.	.	0.00905535209377548	0.351962016018607
HNSC	CAediting_543779	chr7_48106491_+	.	.	0.0477001219643623	0.169492380288387	.	.
SKCM	CAediting_543779	chr7_48106491_+	.	.	1.95808040865481e-08	0.39637009250493	.	.
TGCT	CAediting_543779	chr7_48106491_+	0.000228612744004387	0.327743406622445	.	.	.	.
BLCA	CAediting_543780	chr7_48106494_+	0.0334644675900133	0.146820298972749	.	.	.	.
LUSC	CAediting_543780	chr7_48106494_+	0.0457214868723654	0.154372883455778	.	.	.	.
GBM	CAediting_543780	chr7_48106494_+	.	.	.	.	0.0141597641847587	0.344936202188966
KIRP	CAediting_543780	chr7_48106494_+	.	.	.	.	0.00566659901135438	0.274756369645198
SKCM	CAediting_543780	chr7_48106494_+	.	.	0.0250569034416396	0.154236143254672	.	.
BLCA	CAediting_543790	chr7_48106573_+	0.000542398359497172	0.251897076169959	.	.	.	.
CESC	CAediting_543790	chr7_48106573_+	0.0328252562769239	0.192596646601609	.	.	.	.
LUAD	CAediting_543790	chr7_48106573_+	0.00339145739487372	0.18724906648356	.	.	.	.
GBM	CAediting_543790	chr7_48106573_+	.	.	.	.	0.0165181110592299	0.285672690793273
KIRP	CAediting_543790	chr7_48106573_+	.	.	.	.	0.0475171291389561	0.203872379553823
SKCM	CAediting_543790	chr7_48106573_+	.	.	0.0134504651930741	0.168339341641859	.	.
TGCT	CAediting_543790	chr7_48106573_+	0.00128761800889323	0.284767522913484	.	.	.	.
LGG	CAediting_543791	chr7_48106586_+	.	.	4.66609665974025e-06	0.587555210897716	0.00197169913353482	0.419349032858469
CESC	CAediting_543791	chr7_48106586_+	6.93507804780744e-05	0.40890836424472	.	.	.	.
LUAD	CAediting_543791	chr7_48106586_+	0.00203893750561905	0.209247395395832	.	.	.	.
LUSC	CAediting_543791	chr7_48106586_+	0.00274580400460571	0.27108998546662	.	.	.	.
GBM	CAediting_543791	chr7_48106586_+	.	.	.	.	0.0312129700038309	0.254155326240658
HNSC	CAediting_543791	chr7_48106586_+	.	.	.	.	0.0375408564069871	0.173514710076616
KIRP	CAediting_543791	chr7_48106586_+	.	.	0.000196497298233303	0.393287958403504	.	.
SKCM	CAediting_543791	chr7_48106586_+	.	.	9.39592416553484e-12	0.464084020240707	.	.
TGCT	CAediting_543791	chr7_48106586_+	2.15182374524988e-06	0.421976734601444	.	.	.	.

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Relation with cancer stages for UPP1

Correlation between Cancer stages and RNA editing frequency

Cancer	Stage_type	CAeditomID	position	P-val	Coeff.
CESC	clinical_stage	CAediting_543780	chr7_48106494_+	0.00561207375914428	-0.234600446481096
KICH	pathologic_stage	CAediting_543771	chr7_48106428_+	0.0228407538320053	0.318268874651722
KIRC	pathologic_stage	CAediting_543771	chr7_48106428_+	0.00234478124447766	0.238924966778848
KIRC	pathologic_stage	CAediting_543791	chr7_48106586_+	0.0414128661344303	0.146953931289592
LUSC	pathologic_stage	CAediting_543771	chr7_48106428_+	0.0100129038559423	0.23048783419782
TGCT	clinical_stage	CAediting_543729	chr7_48103928_+	0.0289514139743479	-0.312234666740947
TGCT	pathologic_stage	CAediting_543729	chr7_48103928_+	0.00321630492864984	-0.412618535428739

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Relation with survival for UPP1

Correlation between RNA editing and survival

Cancer	CAeditomID	position	KMpvalue	Coxpvalue	CoxHR
LUAD	CAediting_543753	chr7_48104097_+	0.0109780958131303	0.0391076	3552.53
LUAD	CAediting_543771	chr7_48106428_+	0.0294604863979058	0.0151533	18.8198

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RelatedDrugs for UPP1

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for UPP1

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
UPP1	C0035228	Respiratory Hypersensitivity	1	CTD_human
UPP1	C0162820	Dermatitis, Allergic Contact	1	CTD_human

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene