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Editing gene: UGP2 (CAeditome ID:7360)

Gene summary for UGP2

Gene summary

Gene information	Gene symbol	UGP2
	Gene ID	7360
	Gene name	UDP-glucose pyrophosphorylase 2
	Synonyms	DEE83\|EIEE83\|SVUGP2\|UDPG\|UDPGP\|UDPGP2\|UGP1\|UGPP1\|UGPP2\|pHC379
	Cytomap	2p15
	Type of gene	protein-coding
	Description	UTP--glucose-1-phosphate uridylyltransferaseUDP-glucose diphosphorylaseUDP-glucose pyrophosphorylase 1UGPase 2UTP--glucose-1-phosphate uridylyltransferase 2UTP-glucose-1-phosphate uridyltransferaseUridyl diphosphate glucose pyrophosphorylase-1testi
	Modification date	20210531
	UniProtAcc	Q16851
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
UGP2	GO:0003983	UTP--glucose-1-phosphate uridylyltransferase	31820119
UGP2	GO:0006011	UTP--glucose-1-phosphate uridylyltransferase	8354390
UGP2	GO:0006011	UTP--glucose-1-phosphate uridylyltransferase	8631325

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RNA A-to-I events for UGP2

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000169764.13

RNA A-to-I editing events in Cancer.

CAediting_187120(63857038, +), CAediting_187121(63857186, +), CAediting_187122(63857190, +), CAediting_187123(63857220, +), CAediting_187124(63857221, +), CAediting_187125(63857235, +), CAediting_187126(63857492, +), CAediting_187127(63857508, +), CAediting_187128(63857512, +), CAediting_187129(63857574, +), CAediting_187130(63857601, +), CAediting_187131(63857607, +), CAediting_187132(63857627, +), CAediting_187133(63860734, +), CAediting_187134(63861541, +), CAediting_187135(63861577, +), CAediting_187136(63861594, +), CAediting_187137(63861598, +), CAediting_187138(63861608, +), CAediting_187139(63861613, +), CAediting_187140(63861632, +), CAediting_187141(63861633, +), CAediting_187142(63868812, +), CAediting_187143(63868815, +), CAediting_187144(63868920, +), CAediting_187145(63872004, +), CAediting_187146(63872026, +), CAediting_187147(63880394, +), CAediting_187148(63890128, +), CAediting_187149(63891033, +), CAediting_187150(63891066, +), CAediting_187151(63891072, +),

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RNA editing positional annotations for UGP2 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_187120	chr2_63857038_+	ncRNA_intronic
CAediting_187121	chr2_63857186_+	ncRNA_intronic
CAediting_187122	chr2_63857190_+	ncRNA_intronic
CAediting_187123	chr2_63857220_+	ncRNA_intronic
CAediting_187124	chr2_63857221_+	ncRNA_intronic
CAediting_187125	chr2_63857235_+	ncRNA_intronic
CAediting_187126	chr2_63857492_+	ncRNA_intronic
CAediting_187127	chr2_63857508_+	ncRNA_intronic
CAediting_187128	chr2_63857512_+	ncRNA_intronic
CAediting_187129	chr2_63857574_+	exonic
CAediting_187130	chr2_63857601_+	ncRNA_exonic
CAediting_187131	chr2_63857607_+	ncRNA_exonic
CAediting_187132	chr2_63857627_+	ncRNA_intronic
CAediting_187133	chr2_63860734_+	ncRNA_intronic
CAediting_187134	chr2_63861541_+	ncRNA_intronic
CAediting_187135	chr2_63861577_+	ncRNA_intronic
CAediting_187136	chr2_63861594_+	ncRNA_intronic
CAediting_187137	chr2_63861598_+	ncRNA_intronic
CAediting_187138	chr2_63861608_+	ncRNA_intronic
CAediting_187139	chr2_63861613_+	ncRNA_intronic
CAediting_187140	chr2_63861632_+	ncRNA_intronic
CAediting_187141	chr2_63861633_+	ncRNA_intronic
CAediting_187142	chr2_63868812_+	ncRNA_intronic
CAediting_187143	chr2_63868815_+	ncRNA_intronic
CAediting_187144	chr2_63868920_+	ncRNA_intronic
CAediting_187145	chr2_63872004_+	ncRNA_intronic
CAediting_187146	chr2_63872026_+	ncRNA_intronic
CAediting_187147	chr2_63880394_+	ncRNA_intronic
CAediting_187148	chr2_63890128_+	exonic
CAediting_187149	chr2_63891033_+	ncRNA_intronic
CAediting_187150	chr2_63891066_+	ncRNA_intronic
CAediting_187151	chr2_63891072_+	ncRNA_intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_187120	chr2_63857038_+	SINE	Alu	AluJb
CAediting_187121	chr2_63857186_+	SINE	Alu	AluJb
CAediting_187122	chr2_63857190_+	SINE	Alu	AluJb
CAediting_187123	chr2_63857220_+	SINE	Alu	AluJb
CAediting_187124	chr2_63857221_+	SINE	Alu	AluJb
CAediting_187125	chr2_63857235_+	SINE	Alu	AluJb
CAediting_187126	chr2_63857492_+	SINE	Alu	AluJb
CAediting_187127	chr2_63857508_+	SINE	Alu	AluJb
CAediting_187128	chr2_63857512_+	SINE	Alu	AluJb
CAediting_187129	chr2_63857574_+	SINE	Alu	AluJb
CAediting_187130	chr2_63857601_+	SINE	Alu	AluJb
CAediting_187131	chr2_63857607_+	SINE	Alu	AluJb
CAediting_187132	chr2_63857627_+	SINE	Alu	AluJb
CAediting_187133	chr2_63860734_+	SINE	Alu	AluJr
CAediting_187134	chr2_63861541_+	SINE	Alu	AluJo
CAediting_187135	chr2_63861577_+	SINE	Alu	AluJo
CAediting_187136	chr2_63861594_+	SINE	Alu	AluJo
CAediting_187137	chr2_63861598_+	SINE	Alu	AluJo
CAediting_187138	chr2_63861608_+	SINE	Alu	AluJo
CAediting_187139	chr2_63861613_+	SINE	Alu	AluJo
CAediting_187140	chr2_63861632_+	SINE	Alu	AluJo
CAediting_187141	chr2_63861633_+	SINE	Alu	AluJo
CAediting_187142	chr2_63868812_+	SINE	Alu	AluSq2
CAediting_187143	chr2_63868815_+	SINE	Alu	AluSq2
CAediting_187144	chr2_63868920_+	SINE	Alu	AluSq2
CAediting_187145	chr2_63872004_+	DNA	hAT-Charlie	MER58A
CAediting_187146	chr2_63872026_+	DNA	hAT-Charlie	MER58A
CAediting_187147	chr2_63880394_+	SINE	Alu	AluJb

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RNA A-to-I editing events in the alternative splicing sites for UGP2

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000169764.13.UGP2.

Correlation between RNA A-to-I editing and PSI for ENSG00000169764.13.UGP2.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for UGP2

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for UGP2

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for UGP2

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_187129	chr2_63857574_+	ENSG00000169764.13	ENST00000493222	hsa-miR-10396a-3p	63857570	63857576	7mer-m8	63857557	63857577	140.00	-22.68
CAediting_187129	chr2_63857574_+	ENSG00000169764.13	ENST00000493222	hsa-miR-10396b-3p	63857570	63857576	7mer-m8	63857556	63857577	140.00	-19.10
CAediting_187129	chr2_63857574_+	ENSG00000169764.13	ENST00000493222	hsa-miR-4707-5p	63857569	63857575	7mer-m8	63857552	63857576	144.00	-38.24
CAediting_187129	chr2_63857574_+	ENSG00000169764.13	ENST00000467999	hsa-miR-10396a-3p	63857570	63857576	7mer-m8	63857557	63857577	140.00	-22.68
CAediting_187129	chr2_63857574_+	ENSG00000169764.13	ENST00000467999	hsa-miR-10396b-3p	63857570	63857576	7mer-m8	63857556	63857577	140.00	-19.10
CAediting_187129	chr2_63857574_+	ENSG00000169764.13	ENST00000467999	hsa-miR-4707-5p	63857569	63857575	7mer-m8	63857552	63857576	144.00	-38.24
CAediting_187132	chr2_63857627_+	ENSG00000169764.13	ENST00000466642	hsa-miR-3189-3p	63857621	63857627	7mer-m8	63857609	63857628	141.00	-17.70
CAediting_187132	chr2_63857627_+	ENSG00000169764.13	ENST00000466642	hsa-miR-3200-3p	63857623	63857628	6mer	63857608	63857629	140.00	-26.23
CAediting_187132	chr2_63857627_+	ENSG00000169764.13	ENST00000466642	hsa-miR-6813-3p	63857622	63857628	7mer-m8	63857609	63857629	140.00	-16.76
CAediting_187132	chr2_63857627_+	ENSG00000169764.13	ENST00000493222	hsa-miR-3189-3p	63857621	63857627	7mer-m8	63857609	63857628	141.00	-17.70
CAediting_187132	chr2_63857627_+	ENSG00000169764.13	ENST00000493222	hsa-miR-3200-3p	63857623	63857628	6mer	63857608	63857629	140.00	-26.23
CAediting_187132	chr2_63857627_+	ENSG00000169764.13	ENST00000493222	hsa-miR-6813-3p	63857622	63857628	7mer-m8	63857609	63857629	140.00	-16.76
CAediting_187132	chr2_63857627_+	ENSG00000169764.13	ENST00000487640	hsa-miR-3189-3p	63857621	63857627	7mer-m8	63857609	63857628	141.00	-17.70
CAediting_187132	chr2_63857627_+	ENSG00000169764.13	ENST00000487640	hsa-miR-3200-3p	63857623	63857628	6mer	63857608	63857629	140.00	-26.23
CAediting_187132	chr2_63857627_+	ENSG00000169764.13	ENST00000487640	hsa-miR-6813-3p	63857622	63857628	7mer-m8	63857609	63857629	140.00	-16.76
CAediting_187132	chr2_63857627_+	ENSG00000169764.13	ENST00000467999	hsa-miR-3189-3p	63857621	63857627	7mer-m8	63857609	63857628	141.00	-17.70
CAediting_187132	chr2_63857627_+	ENSG00000169764.13	ENST00000467999	hsa-miR-3200-3p	63857623	63857628	6mer	63857608	63857629	140.00	-26.23
CAediting_187132	chr2_63857627_+	ENSG00000169764.13	ENST00000467999	hsa-miR-6813-3p	63857622	63857628	7mer-m8	63857609	63857629	140.00	-16.76
CAediting_187132	chr2_63857627_+	ENSG00000169764.13	ENST00000487042	hsa-miR-3189-3p	63857621	63857627	7mer-m8	63857609	63857628	141.00	-17.70
CAediting_187132	chr2_63857627_+	ENSG00000169764.13	ENST00000487042	hsa-miR-3200-3p	63857623	63857628	6mer	63857608	63857629	140.00	-26.23
CAediting_187132	chr2_63857627_+	ENSG00000169764.13	ENST00000487042	hsa-miR-6813-3p	63857622	63857628	7mer-m8	63857609	63857629	140.00	-16.76

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_187130	chr2_63857601_+	ENSG00000169764.13	ENST00000493222	hsa-miR-5707	63857596	63857603	8mer-1a	63857582	63857603	144	-13.96
CAediting_187130	chr2_63857601_+	ENSG00000169764.13	ENST00000467999	hsa-miR-5707	63857596	63857603	8mer-1a	63857582	63857603	144	-13.96

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for UGP2

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000337130.8	protein_coding
ENST00000394417.5	protein_coding
ENST00000445915.5	protein_coding
ENST00000466642.4	nonsense_mediated_decay
ENST00000467648.5	protein_coding
ENST00000467999.5	nonsense_mediated_decay
ENST00000475550.4	retained_intron
ENST00000484056.5	processed_transcript
ENST00000487042.4	nonsense_mediated_decay
ENST00000487640.4	nonsense_mediated_decay
ENST00000493222.4	nonsense_mediated_decay
ENST00000613823.1	protein_coding
ENST00000626380.1	protein_coding

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID	ENST	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
CAediting_187148	ENST00000337130.8	chr2_63890128_+	-654.80	-654.50	-654.80
CAediting_187148	ENST00000394417.5	chr2_63890128_+	-596.30	-597.70	-596.30
CAediting_187148	ENST00000445915.5	chr2_63890128_+	-515.40	-515.40	-515.40
CAediting_187129	ENST00000466642.4	chr2_63857574_+	-327.10	-327.10	-327.60
CAediting_187130	ENST00000466642.4	chr2_63857601_+	-326.30	-327.10	-327.60
CAediting_187131	ENST00000466642.4	chr2_63857607_+	-326.40	-327.10	-327.60
CAediting_187132	ENST00000466642.4	chr2_63857627_+	-327.90	-327.10	-327.60
CAediting_187148	ENST00000467648.5	chr2_63890128_+	-587.20	-589.20	-587.20
CAediting_187129	ENST00000467999.5	chr2_63857574_+	-231.20	-231.20	-232.80
CAediting_187130	ENST00000467999.5	chr2_63857601_+	-232.10	-231.20	-232.80
CAediting_187131	ENST00000467999.5	chr2_63857607_+	-231.10	-231.20	-232.80
CAediting_187132	ENST00000467999.5	chr2_63857627_+	-231.20	-231.20	-232.80
CAediting_187148	ENST00000475550.4	chr2_63890128_+	-1165.90	-1165.90	-1165.90
CAediting_187129	ENST00000484056.5	chr2_63857574_+	-173.00	-172.60	-172.60
CAediting_187130	ENST00000484056.5	chr2_63857601_+	-172.90	-172.60	-172.60
CAediting_187131	ENST00000484056.5	chr2_63857607_+	-171.90	-172.60	-172.60
CAediting_187129	ENST00000487042.4	chr2_63857574_+	-248.60	-249.60	-250.70
CAediting_187130	ENST00000487042.4	chr2_63857601_+	-250.30	-249.60	-250.70
CAediting_187131	ENST00000487042.4	chr2_63857607_+	-249.70	-249.60	-250.70
CAediting_187132	ENST00000487042.4	chr2_63857627_+	-249.60	-249.60	-250.70
CAediting_187129	ENST00000487640.4	chr2_63857574_+	-177.70	-177.80	-183.20
CAediting_187130	ENST00000487640.4	chr2_63857601_+	-178.40	-177.80	-183.20
CAediting_187131	ENST00000487640.4	chr2_63857607_+	-180.40	-177.80	-183.20
CAediting_187132	ENST00000487640.4	chr2_63857627_+	-177.80	-177.80	-183.20
CAediting_187129	ENST00000493222.4	chr2_63857574_+	-275.60	-276.10	-279.00
CAediting_187130	ENST00000493222.4	chr2_63857601_+	-274.50	-276.10	-279.00
CAediting_187131	ENST00000493222.4	chr2_63857607_+	-275.40	-276.10	-279.00
CAediting_187132	ENST00000493222.4	chr2_63857627_+	-276.90	-276.10	-279.00
CAediting_187148	ENST00000613823.1	chr2_63890128_+	-483.40	-483.40	-483.40
CAediting_187129	ENST00000626380.1	chr2_63857574_+	-77.00	-73.00	-77.00

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Relation with ADAR for UGP2

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for UGP2

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for UGP2

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for UGP2

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for UGP2

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
UGP2	C0036572	Seizures	1	GENOMICS_ENGLAND
UGP2	C0232466	Feeding difficulties	1	GENOMICS_ENGLAND
UGP2	C0557874	Global developmental delay	1	GENOMICS_ENGLAND
UGP2	C3714756	Intellectual Disability	1	GENOMICS_ENGLAND
UGP2	C4025846	Abnormality of vision	1	GENOMICS_ENGLAND
UGP2	C4025871	Abnormality of the face	1	GENOMICS_ENGLAND

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene