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![]() | Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples |
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![]() | The effects of the RNA editing to the stability of the RNA structures |
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Editing gene: UCHL1 (CAeditome ID:7345) |
Gene summary for UCHL1 |
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Gene information | Gene symbol | UCHL1 | Gene ID | 7345 |
Gene name | ubiquitin C-terminal hydrolase L1 | |
Synonyms | HEL-117|HEL-S-53|NDGOA|PARK5|PGP 9.5|PGP9.5|PGP95|SPG79|Uch-L1 | |
Cytomap | 4p13 | |
Type of gene | protein-coding | |
Description | ubiquitin carboxyl-terminal hydrolase isozyme L1epididymis luminal protein 117epididymis secretory protein Li 53neuron cytoplasmic protein 9.5ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)ubiquitin thioesterase L1ubiquitin thioles | |
Modification date | 20210524 | |
UniProtAcc | P09936 | |
Context | - 33753553(Deubiquitinase UCHL1 Maintains Protein Homeostasis through the PSMA7-APEH-Proteasome Axis in High-grade Serous Ovarian Carcinoma) |
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Gene | GO ID | GO term | PubMed ID |
UCHL1 | GO:0005886 | Ubiquitin carboxyl-terminal hydrolase isozyme L1 | 19477270 |
UCHL1 | GO:0004197 | Ubiquitin carboxyl-terminal hydrolase isozyme L1 | 8639624 |
UCHL1 | GO:0004843 | Ubiquitin carboxyl-terminal hydrolase isozyme L1 | 9521656 |
UCHL1 | GO:0008242 | Ubiquitin carboxyl-terminal hydrolase isozyme L1 | 9521656 |
UCHL1 | GO:0043130 | Ubiquitin carboxyl-terminal hydrolase isozyme L1 | 9521656 |
UCHL1 | GO:0016579 | Ubiquitin carboxyl-terminal hydrolase isozyme L1 | 9521656 |
UCHL1 | GO:0043407 | Ubiquitin carboxyl-terminal hydrolase isozyme L1 | 19477270 |
UCHL1 | GO:0005654 | Ubiquitin carboxyl-terminal hydrolase isozyme L1 | 0000052 |
UCHL1 | GO:0005737 | Ubiquitin carboxyl-terminal hydrolase isozyme L1 | 19477270 |
UCHL1 | GO:0005829 | Ubiquitin carboxyl-terminal hydrolase isozyme L1 | 0000052 |
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RNA A-to-I events for UCHL1 |
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CAediting_361972(41262212, +), CAediting_361973(41262242, +), CAediting_361974(41262247, +), CAediting_361975(41262276, +), CAediting_361976(41262280, +), CAediting_361977(41262285, +), CAediting_361978(41262286, +), CAediting_361979(41262313, +), CAediting_361980(41262325, +), CAediting_361981(41262679, +), CAediting_361982(41262736, +), CAediting_361983(41262791, +), CAediting_361984(41262843, +), CAediting_361985(41262860, +), CAediting_361986(41262870, +), CAediting_361987(41265300, +), CAediting_361988(41265321, +), CAediting_361989(41265324, +), CAediting_361990(41265329, +), CAediting_361991(41265363, +), CAediting_361992(41265371, +), CAediting_361993(41265376, +), CAediting_361994(41265392, +), CAediting_361995(41265413, +), CAediting_361996(41265416, +), CAediting_361997(41265417, +), CAediting_361998(41265418, +), CAediting_361999(41265419, +), CAediting_362000(41265424, +), CAediting_362001(41265425, +), CAediting_362002(41265426, +), CAediting_362003(41265427, +), CAediting_362004(41265463, +), CAediting_362005(41265500, +), CAediting_362006(41265507, +), CAediting_362007(41265529, +), CAediting_362008(41265536, +), CAediting_362009(41265593, +), CAediting_362010(41265594, +), CAediting_362011(41266643, +), CAediting_362012(41266644, +), CAediting_362013(41266753, +), CAediting_362014(41266759, +), CAediting_362015(41266762, +), CAediting_362016(41266772, +), CAediting_362017(41266781, +), CAediting_362018(41266785, +), CAediting_362019(41266786, +), CAediting_362020(41266793, +), CAediting_362021(41266800, +), CAediting_362022(41266803, +), CAediting_362023(41267263, +), CAediting_362024(41267428, +), CAediting_362025(41267431, +), CAediting_362026(41267445, +), CAediting_362027(41267771, +), |
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RNA editing positional annotations for UCHL1 using Annovar |
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CAeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
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CAeditome ID | Position | Variant type |
CAediting_361972 | chr4_41262212_+ | ncRNA_intronic |
CAediting_361973 | chr4_41262242_+ | ncRNA_intronic |
CAediting_361974 | chr4_41262247_+ | ncRNA_intronic |
CAediting_361975 | chr4_41262276_+ | ncRNA_intronic |
CAediting_361976 | chr4_41262280_+ | ncRNA_intronic |
CAediting_361977 | chr4_41262285_+ | ncRNA_intronic |
CAediting_361978 | chr4_41262286_+ | ncRNA_intronic |
CAediting_361979 | chr4_41262313_+ | ncRNA_intronic |
CAediting_361980 | chr4_41262325_+ | ncRNA_intronic |
CAediting_361981 | chr4_41262679_+ | ncRNA_intronic |
CAediting_361982 | chr4_41262736_+ | ncRNA_intronic |
CAediting_361983 | chr4_41262791_+ | ncRNA_intronic |
CAediting_361984 | chr4_41262843_+ | ncRNA_intronic |
CAediting_361985 | chr4_41262860_+ | ncRNA_intronic |
CAediting_361986 | chr4_41262870_+ | ncRNA_intronic |
CAediting_361987 | chr4_41265300_+ | ncRNA_intronic |
CAediting_361988 | chr4_41265321_+ | ncRNA_intronic |
CAediting_361989 | chr4_41265324_+ | ncRNA_intronic |
CAediting_361990 | chr4_41265329_+ | ncRNA_intronic |
CAediting_361991 | chr4_41265363_+ | ncRNA_intronic |
CAediting_361992 | chr4_41265371_+ | ncRNA_intronic |
CAediting_361993 | chr4_41265376_+ | ncRNA_intronic |
CAediting_361994 | chr4_41265392_+ | ncRNA_intronic |
CAediting_361995 | chr4_41265413_+ | ncRNA_intronic |
CAediting_361996 | chr4_41265416_+ | ncRNA_intronic |
CAediting_361997 | chr4_41265417_+ | ncRNA_intronic |
CAediting_361998 | chr4_41265418_+ | ncRNA_intronic |
CAediting_361999 | chr4_41265419_+ | ncRNA_intronic |
CAediting_362000 | chr4_41265424_+ | ncRNA_intronic |
CAediting_362001 | chr4_41265425_+ | ncRNA_intronic |
CAediting_362002 | chr4_41265426_+ | ncRNA_intronic |
CAediting_362003 | chr4_41265427_+ | ncRNA_intronic |
CAediting_362004 | chr4_41265463_+ | ncRNA_intronic |
CAediting_362005 | chr4_41265500_+ | ncRNA_intronic |
CAediting_362006 | chr4_41265507_+ | ncRNA_intronic |
CAediting_362007 | chr4_41265529_+ | ncRNA_intronic |
CAediting_362008 | chr4_41265536_+ | ncRNA_intronic |
CAediting_362009 | chr4_41265593_+ | ncRNA_intronic |
CAediting_362010 | chr4_41265594_+ | ncRNA_intronic |
CAediting_362011 | chr4_41266643_+ | ncRNA_intronic |
CAediting_362012 | chr4_41266644_+ | ncRNA_intronic |
CAediting_362013 | chr4_41266753_+ | ncRNA_intronic |
CAediting_362014 | chr4_41266759_+ | ncRNA_intronic |
CAediting_362015 | chr4_41266762_+ | ncRNA_intronic |
CAediting_362016 | chr4_41266772_+ | ncRNA_intronic |
CAediting_362017 | chr4_41266781_+ | ncRNA_intronic |
CAediting_362018 | chr4_41266785_+ | ncRNA_intronic |
CAediting_362019 | chr4_41266786_+ | ncRNA_intronic |
CAediting_362020 | chr4_41266793_+ | ncRNA_intronic |
CAediting_362021 | chr4_41266800_+ | ncRNA_intronic |
CAediting_362022 | chr4_41266803_+ | ncRNA_intronic |
CAediting_362023 | chr4_41267263_+ | ncRNA_intronic |
CAediting_362024 | chr4_41267428_+ | ncRNA_intronic |
CAediting_362025 | chr4_41267431_+ | ncRNA_intronic |
CAediting_362026 | chr4_41267445_+ | ncRNA_intronic |
CAediting_362027 | chr4_41267771_+ | ncRNA_intronic |
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CAeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
CAediting_361972 | chr4_41262212_+ | SINE | Alu | AluJb |
CAediting_361973 | chr4_41262242_+ | SINE | Alu | AluJb |
CAediting_361974 | chr4_41262247_+ | SINE | Alu | AluJb |
CAediting_361975 | chr4_41262276_+ | SINE | Alu | AluJb |
CAediting_361976 | chr4_41262280_+ | SINE | Alu | AluJb |
CAediting_361977 | chr4_41262285_+ | SINE | Alu | AluJb |
CAediting_361978 | chr4_41262286_+ | SINE | Alu | AluJb |
CAediting_361979 | chr4_41262313_+ | SINE | Alu | AluJb |
CAediting_361980 | chr4_41262325_+ | SINE | Alu | AluJb |
CAediting_361981 | chr4_41262679_+ | SINE | Alu | AluSz |
CAediting_361982 | chr4_41262736_+ | SINE | Alu | AluSz |
CAediting_361983 | chr4_41262791_+ | SINE | Alu | AluSz |
CAediting_361984 | chr4_41262843_+ | SINE | Alu | AluSz |
CAediting_361985 | chr4_41262860_+ | SINE | Alu | AluSz |
CAediting_361986 | chr4_41262870_+ | SINE | Alu | AluSz |
CAediting_361987 | chr4_41265300_+ | SINE | Alu | AluSz |
CAediting_361988 | chr4_41265321_+ | SINE | Alu | AluSz |
CAediting_361989 | chr4_41265324_+ | SINE | Alu | AluSz |
CAediting_361990 | chr4_41265329_+ | SINE | Alu | AluSz |
CAediting_361991 | chr4_41265363_+ | SINE | Alu | AluSz |
CAediting_361992 | chr4_41265371_+ | SINE | Alu | AluSz |
CAediting_361993 | chr4_41265376_+ | SINE | Alu | AluSz |
CAediting_361994 | chr4_41265392_+ | SINE | Alu | AluSz |
CAediting_361995 | chr4_41265413_+ | SINE | Alu | AluSz |
CAediting_361996 | chr4_41265416_+ | SINE | Alu | AluSz |
CAediting_361997 | chr4_41265417_+ | SINE | Alu | AluSz |
CAediting_361998 | chr4_41265418_+ | SINE | Alu | AluSz |
CAediting_361999 | chr4_41265419_+ | SINE | Alu | AluSz |
CAediting_362000 | chr4_41265424_+ | SINE | Alu | AluSz |
CAediting_362001 | chr4_41265425_+ | SINE | Alu | AluSz |
CAediting_362002 | chr4_41265426_+ | SINE | Alu | AluSz |
CAediting_362003 | chr4_41265427_+ | SINE | Alu | AluSz |
CAediting_362004 | chr4_41265463_+ | SINE | Alu | AluSz |
CAediting_362005 | chr4_41265500_+ | SINE | Alu | AluSz |
CAediting_362006 | chr4_41265507_+ | SINE | Alu | AluSz |
CAediting_362007 | chr4_41265529_+ | SINE | Alu | AluSz |
CAediting_362008 | chr4_41265536_+ | SINE | Alu | AluSz |
CAediting_362009 | chr4_41265593_+ | SINE | Alu | AluSz |
CAediting_362010 | chr4_41265594_+ | SINE | Alu | AluSz |
CAediting_362011 | chr4_41266643_+ | SINE | Alu | AluJr4 |
CAediting_362012 | chr4_41266644_+ | SINE | Alu | AluJr4 |
CAediting_362013 | chr4_41266753_+ | SINE | Alu | AluJr4 |
CAediting_362014 | chr4_41266759_+ | SINE | Alu | AluJr4 |
CAediting_362015 | chr4_41266762_+ | SINE | Alu | AluJr4 |
CAediting_362016 | chr4_41266772_+ | SINE | Alu | AluJr4 |
CAediting_362017 | chr4_41266781_+ | SINE | Alu | AluJr4 |
CAediting_362018 | chr4_41266785_+ | SINE | Alu | AluJr4 |
CAediting_362019 | chr4_41266786_+ | SINE | Alu | AluJr4 |
CAediting_362020 | chr4_41266793_+ | SINE | Alu | AluJr4 |
CAediting_362021 | chr4_41266800_+ | SINE | Alu | AluJr4 |
CAediting_362022 | chr4_41266803_+ | SINE | Alu | AluJr4 |
CAediting_362023 | chr4_41267263_+ | SINE | Alu | AluY |
CAediting_362024 | chr4_41267428_+ | SINE | Alu | AluY |
CAediting_362025 | chr4_41267431_+ | SINE | Alu | AluY |
CAediting_362026 | chr4_41267445_+ | SINE | Alu | AluY |
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RNA A-to-I editing events in the alternative splicing sites for UCHL1 |
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AStype | CAeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for UCHL1 |
![]() * The grey color means N/A. |
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Protein coding region RNA A-to-I editings for UCHL1 |
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The effects of the RNA editing to the miRNA binding sites for UCHL1 |
**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page. |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
CAediting_688080 | chr9_63819626_+ | ENSG00000154277.11 | ENST00000512419 | hsa-miR-4477b | 41268392 | 41268399 | 8mer-1a | 41268380 | 41268399 | 153 | -15.58 |
CAediting_1229413 | chr17_67471544_+ | ENSG00000154277.11 | ENST00000512419 | hsa-miR-548aa | 41268345 | 41268351 | 7mer-m8 | 41268327 | 41268352 | 155 | -12.98 |
CAediting_524911 | chr7_5495852_- | ENSG00000154277.11 | ENST00000512419 | hsa-miR-589-3p | 41268073 | 41268079 | 7mer-m8 | 41268056 | 41268080 | 149 | -19.45 |
CAediting_524911 | chr7_5495852_- | ENSG00000154277.11 | ENST00000505232 | hsa-miR-589-3p | 41268073 | 41268079 | 7mer-m8 | 41268056 | 41268080 | 149 | -19.45 |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
CAediting_524911 | chr7_5495852_- | ENSG00000154277.11 | ENST00000503431 | hsa-miR-589-3p | 41268184 | 41268190 | 7mer-m8 | 41268167 | 41268191 | 153 | -12.25 |
CAediting_524911 | chr7_5495852_- | ENSG00000154277.11 | ENST00000512419 | hsa-miR-589-3p | 41268184 | 41268190 | 7mer-m8 | 41268167 | 41268191 | 153 | -12.25 |
CAediting_524911 | chr7_5495852_- | ENSG00000154277.11 | ENST00000508768 | hsa-miR-589-3p | 41268184 | 41268190 | 7mer-m8 | 41268167 | 41268191 | 153 | -12.25 |
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The effects of the RNA editing to the stability of the RNA structures for UCHL1 |
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ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
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CAeditom_ID | ENST | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for UCHL1 |
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Cancer | CAeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
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Relation with cancer stages for UCHL1 |
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Cancer | Stage_type | CAeditomID | position | P-val | Coeff. |
LUSC | pathologic_stage | CAediting_362013 | chr4_41266753_+ | 0.0243839781475266 | 0.314945428366643 |
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Relation with survival for UCHL1 |
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Cancer | CAeditomID | position | KMpvalue | Coxpvalue | CoxHR |
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RelatedDrugs for UCHL1 |
![]() (DrugBank Version 5.1.8 2021-01-03) |
Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for UCHL1 |
![]() (DisGeNet 7.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |
UCHL1 | C3150899 | PARKINSON DISEASE 5, AUTOSOMAL DOMINANT | 4 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
UCHL1 | C3809665 | SPASTIC PARAPLEGIA 79, AUTOSOMAL RECESSIVE | 3 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
UCHL1 | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human |
UCHL1 | C0014859 | Esophageal Neoplasms | 1 | CTD_human |
UCHL1 | C0016978 | gallbladder neoplasm | 1 | CTD_human |
UCHL1 | C0019284 | Diaphragmatic Hernia | 1 | CTD_human |
UCHL1 | C0153452 | Malignant neoplasm of gallbladder | 1 | CTD_human |
UCHL1 | C0546837 | Malignant neoplasm of esophagus | 1 | CTD_human |
UCHL1 | C2239176 | Liver carcinoma | 1 | CTD_human |
UCHL1 | C4721453 | Peripheral Nervous System Diseases | 1 | CTD_human |