Home

Download

Statistics

Examples

Help

Contact

Editing gene: TXN (CAeditome ID:7295)

Gene summary for TXN

Gene summary

Gene information	Gene symbol	TXN
	Gene ID	7295
	Gene name	thioredoxin
	Synonyms	TRDX\|TRX\|TRX1\|Trx80
	Cytomap	9q31.3
	Type of gene	protein-coding
	Description	thioredoxinADFATL-derived factorSASPTXN delta 3surface-associated sulphydryl proteintesticular tissue protein Li 199thioredoxin delta 3
	Modification date	20210524
	UniProtAcc	P10599
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
TXN	GO:0015035	Thioredoxin	17182577
TXN	GO:0015035	Thioredoxin	19032234
TXN	GO:0015035	Thioredoxin	2176490
TXN	GO:0042803	Thioredoxin	17260951
TXN	GO:0042803	Thioredoxin	9369469
TXN	GO:0047134	Thioredoxin	17182577
TXN	GO:0009314	Thioredoxin	11118054
TXN	GO:0009314	Thioredoxin	9108029
TXN	GO:0043388	Thioredoxin	11118054
TXN	GO:0045454	Thioredoxin	2176490
TXN	GO:0005576	Thioredoxin	1332947
TXN	GO:0005634	Thioredoxin	9108029
TXN	GO:0005654	Thioredoxin	0000052
TXN	GO:0005737	Thioredoxin	9108029
TXN	GO:0005829	Thioredoxin	0000052

Top

RNA A-to-I events for TXN

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000136810.11

RNA A-to-I editing events in Cancer.

CAediting_701357(110245486, -), CAediting_701358(110245498, -), CAediting_701359(110245507, -), CAediting_701360(110245548, -), CAediting_701361(110245570, -), CAediting_701362(110245696, -), CAediting_701363(110245706, -), CAediting_701364(110245717, -), CAediting_701365(110245730, -), CAediting_701366(110245772, -), CAediting_701367(110245774, -), CAediting_701368(110245848, -), CAediting_701369(110245877, -), CAediting_701370(110245897, -), CAediting_701371(110245939, -), CAediting_701372(110245941, -), CAediting_701373(110245943, -), CAediting_701374(110245953, -), CAediting_701375(110245964, -), CAediting_701376(110245965, -), CAediting_701377(110245978, -), CAediting_701378(110245979, -), CAediting_701379(110245982, -), CAediting_701380(110245989, -), CAediting_701381(110246002, -), CAediting_701382(110246003, -), CAediting_701383(110246013, -), CAediting_701384(110246018, -), CAediting_701385(110246029, -), CAediting_701386(110246031, -), CAediting_701387(110247105, -), CAediting_701388(110247157, -), CAediting_701389(110247160, -), CAediting_701390(110247167, -), CAediting_701391(110247201, -), CAediting_701392(110247211, -), CAediting_701393(110247276, -), CAediting_701394(110247319, -), CAediting_701395(110247321, -), CAediting_701396(110252008, -), CAediting_701397(110252039, -), CAediting_701398(110252044, -), CAediting_701399(110252061, -), CAediting_701400(110252076, -), CAediting_701401(110252124, -), CAediting_701402(110252141, -), CAediting_701403(110252142, -), CAediting_701404(110252147, -), CAediting_701405(110252673, -), CAediting_701406(110252674, -), CAediting_701407(110252679, -), CAediting_701408(110252680, -), CAediting_701409(110252707, -), CAediting_701410(110252717, -), CAediting_701411(110252723, -), CAediting_701412(110252729, -), CAediting_701413(110252730, -), CAediting_701414(110252741, -), CAediting_701415(110252742, -), CAediting_701416(110252747, -), CAediting_701417(110252750, -), CAediting_701418(110252755, -), CAediting_701419(110252777, -), CAediting_701420(110252783, -), CAediting_701421(110252809, -), CAediting_701422(110252815, -), CAediting_701423(110252818, -), CAediting_701424(110252822, -), CAediting_701425(110252823, -), CAediting_701426(110252827, -), CAediting_701427(110252838, -), CAediting_701428(110252846, -), CAediting_701429(110252864, -), CAediting_701430(110252872, -), CAediting_701431(110252895, -), CAediting_701432(110252896, -), CAediting_701433(110254264, -), CAediting_701434(110254341, -), CAediting_701435(110254358, -), CAediting_701436(110254422, -), CAediting_701437(110254439, -), CAediting_701438(110254484, -), CAediting_701439(110254486, -),

Top

RNA editing positional annotations for TXN using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_701357	chr9_110245486_-	intronic
CAediting_701358	chr9_110245498_-	intronic
CAediting_701359	chr9_110245507_-	intronic
CAediting_701360	chr9_110245548_-	intronic
CAediting_701361	chr9_110245570_-	intronic
CAediting_701362	chr9_110245696_-	intronic
CAediting_701363	chr9_110245706_-	intronic
CAediting_701364	chr9_110245717_-	intronic
CAediting_701365	chr9_110245730_-	intronic
CAediting_701366	chr9_110245772_-	intronic
CAediting_701367	chr9_110245774_-	intronic
CAediting_701368	chr9_110245848_-	intronic
CAediting_701369	chr9_110245877_-	intronic
CAediting_701370	chr9_110245897_-	intronic
CAediting_701371	chr9_110245939_-	intronic
CAediting_701372	chr9_110245941_-	intronic
CAediting_701373	chr9_110245943_-	intronic
CAediting_701374	chr9_110245953_-	intronic
CAediting_701375	chr9_110245964_-	intronic
CAediting_701376	chr9_110245965_-	intronic
CAediting_701377	chr9_110245978_-	intronic
CAediting_701378	chr9_110245979_-	intronic
CAediting_701379	chr9_110245982_-	intronic
CAediting_701380	chr9_110245989_-	intronic
CAediting_701381	chr9_110246002_-	intronic
CAediting_701382	chr9_110246003_-	intronic
CAediting_701383	chr9_110246013_-	intronic
CAediting_701384	chr9_110246018_-	intronic
CAediting_701385	chr9_110246029_-	intronic
CAediting_701386	chr9_110246031_-	intronic
CAediting_701387	chr9_110247105_-	intronic
CAediting_701388	chr9_110247157_-	intronic
CAediting_701389	chr9_110247160_-	intronic
CAediting_701390	chr9_110247167_-	intronic
CAediting_701391	chr9_110247201_-	intronic
CAediting_701392	chr9_110247211_-	intronic
CAediting_701393	chr9_110247276_-	intronic
CAediting_701394	chr9_110247319_-	intronic
CAediting_701395	chr9_110247321_-	intronic
CAediting_701396	chr9_110252008_-	intronic
CAediting_701397	chr9_110252039_-	intronic
CAediting_701398	chr9_110252044_-	intronic
CAediting_701399	chr9_110252061_-	intronic
CAediting_701400	chr9_110252076_-	intronic
CAediting_701401	chr9_110252124_-	intronic
CAediting_701402	chr9_110252141_-	intronic
CAediting_701403	chr9_110252142_-	intronic
CAediting_701404	chr9_110252147_-	intronic
CAediting_701405	chr9_110252673_-	intronic
CAediting_701406	chr9_110252674_-	intronic
CAediting_701407	chr9_110252679_-	intronic
CAediting_701408	chr9_110252680_-	intronic
CAediting_701409	chr9_110252707_-	intronic
CAediting_701410	chr9_110252717_-	intronic
CAediting_701411	chr9_110252723_-	intronic
CAediting_701412	chr9_110252729_-	intronic
CAediting_701413	chr9_110252730_-	intronic
CAediting_701414	chr9_110252741_-	intronic
CAediting_701415	chr9_110252742_-	intronic
CAediting_701416	chr9_110252747_-	intronic
CAediting_701417	chr9_110252750_-	intronic
CAediting_701418	chr9_110252755_-	intronic
CAediting_701419	chr9_110252777_-	intronic
CAediting_701420	chr9_110252783_-	intronic
CAediting_701421	chr9_110252809_-	intronic
CAediting_701422	chr9_110252815_-	intronic
CAediting_701423	chr9_110252818_-	intronic
CAediting_701424	chr9_110252822_-	intronic
CAediting_701425	chr9_110252823_-	intronic
CAediting_701426	chr9_110252827_-	intronic
CAediting_701427	chr9_110252838_-	intronic
CAediting_701428	chr9_110252846_-	intronic
CAediting_701429	chr9_110252864_-	intronic
CAediting_701430	chr9_110252872_-	intronic
CAediting_701431	chr9_110252895_-	intronic
CAediting_701432	chr9_110252896_-	intronic
CAediting_701433	chr9_110254264_-	intronic
CAediting_701434	chr9_110254341_-	intronic
CAediting_701435	chr9_110254358_-	intronic
CAediting_701436	chr9_110254422_-	intronic
CAediting_701437	chr9_110254439_-	intronic
CAediting_701438	chr9_110254484_-	intronic
CAediting_701439	chr9_110254486_-	intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_701357	chr9_110245486_-	SINE	Alu	AluJb
CAediting_701358	chr9_110245498_-	SINE	Alu	AluJb
CAediting_701359	chr9_110245507_-	SINE	Alu	AluJb
CAediting_701360	chr9_110245548_-	SINE	Alu	AluJb
CAediting_701361	chr9_110245570_-	SINE	Alu	AluJb
CAediting_701362	chr9_110245696_-	SINE	Alu	AluJb
CAediting_701363	chr9_110245706_-	SINE	Alu	AluJb
CAediting_701364	chr9_110245717_-	SINE	Alu	AluJb
CAediting_701365	chr9_110245730_-	SINE	Alu	AluJb
CAediting_701366	chr9_110245772_-	SINE	Alu	AluJb
CAediting_701367	chr9_110245774_-	SINE	Alu	AluJb
CAediting_701368	chr9_110245848_-	SINE	Alu	AluSx
CAediting_701369	chr9_110245877_-	SINE	Alu	AluSx
CAediting_701370	chr9_110245897_-	SINE	Alu	AluSx
CAediting_701371	chr9_110245939_-	SINE	Alu	AluSx
CAediting_701372	chr9_110245941_-	SINE	Alu	AluSx
CAediting_701373	chr9_110245943_-	SINE	Alu	AluSx
CAediting_701374	chr9_110245953_-	SINE	Alu	AluSx
CAediting_701375	chr9_110245964_-	SINE	Alu	AluSx
CAediting_701376	chr9_110245965_-	SINE	Alu	AluSx
CAediting_701377	chr9_110245978_-	SINE	Alu	AluSx
CAediting_701378	chr9_110245979_-	SINE	Alu	AluSx
CAediting_701379	chr9_110245982_-	SINE	Alu	AluSx
CAediting_701380	chr9_110245989_-	SINE	Alu	AluSx
CAediting_701381	chr9_110246002_-	SINE	Alu	AluSx
CAediting_701382	chr9_110246003_-	SINE	Alu	AluSx
CAediting_701383	chr9_110246013_-	SINE	Alu	AluSx
CAediting_701384	chr9_110246018_-	SINE	Alu	AluSx
CAediting_701385	chr9_110246029_-	SINE	Alu	AluSx
CAediting_701386	chr9_110246031_-	SINE	Alu	AluSx
CAediting_701387	chr9_110247105_-	SINE	Alu	AluSx1
CAediting_701388	chr9_110247157_-	SINE	Alu	AluSx1
CAediting_701389	chr9_110247160_-	SINE	Alu	AluSx1
CAediting_701390	chr9_110247167_-	SINE	Alu	AluSx1
CAediting_701391	chr9_110247201_-	SINE	Alu	AluSx1
CAediting_701392	chr9_110247211_-	SINE	Alu	AluSx1
CAediting_701393	chr9_110247276_-	SINE	Alu	AluSx1
CAediting_701394	chr9_110247319_-	SINE	Alu	AluSx1
CAediting_701395	chr9_110247321_-	SINE	Alu	AluSx1
CAediting_701396	chr9_110252008_-	SINE	Alu	AluSx4
CAediting_701397	chr9_110252039_-	SINE	Alu	AluSx4
CAediting_701398	chr9_110252044_-	SINE	Alu	AluSx4
CAediting_701399	chr9_110252061_-	SINE	Alu	AluSx4
CAediting_701400	chr9_110252076_-	SINE	Alu	AluSx4
CAediting_701401	chr9_110252124_-	SINE	Alu	AluSx4
CAediting_701402	chr9_110252141_-	SINE	Alu	AluSx4
CAediting_701403	chr9_110252142_-	SINE	Alu	AluSx4
CAediting_701404	chr9_110252147_-	SINE	Alu	AluSx4
CAediting_701405	chr9_110252673_-	SINE	Alu	AluSq2
CAediting_701406	chr9_110252674_-	SINE	Alu	AluSq2
CAediting_701407	chr9_110252679_-	SINE	Alu	AluSq2
CAediting_701408	chr9_110252680_-	SINE	Alu	AluSq2
CAediting_701409	chr9_110252707_-	SINE	Alu	AluSq2
CAediting_701410	chr9_110252717_-	SINE	Alu	AluSq2
CAediting_701411	chr9_110252723_-	SINE	Alu	AluSq2
CAediting_701412	chr9_110252729_-	SINE	Alu	AluSq2
CAediting_701413	chr9_110252730_-	SINE	Alu	AluSq2
CAediting_701414	chr9_110252741_-	SINE	Alu	AluSq2
CAediting_701415	chr9_110252742_-	SINE	Alu	AluSq2
CAediting_701416	chr9_110252747_-	SINE	Alu	AluSq2
CAediting_701417	chr9_110252750_-	SINE	Alu	AluSq2
CAediting_701418	chr9_110252755_-	SINE	Alu	AluSq2
CAediting_701419	chr9_110252777_-	SINE	Alu	AluSq2
CAediting_701420	chr9_110252783_-	SINE	Alu	AluSq2
CAediting_701421	chr9_110252809_-	SINE	Alu	AluSq2
CAediting_701422	chr9_110252815_-	SINE	Alu	AluSq2
CAediting_701423	chr9_110252818_-	SINE	Alu	AluSq2
CAediting_701424	chr9_110252822_-	SINE	Alu	AluSq2
CAediting_701425	chr9_110252823_-	SINE	Alu	AluSq2
CAediting_701426	chr9_110252827_-	SINE	Alu	AluSq2
CAediting_701427	chr9_110252838_-	SINE	Alu	AluSq2
CAediting_701428	chr9_110252846_-	SINE	Alu	AluSq2
CAediting_701429	chr9_110252864_-	SINE	Alu	AluSq2
CAediting_701430	chr9_110252872_-	SINE	Alu	AluSq2
CAediting_701431	chr9_110252895_-	SINE	Alu	AluSq2
CAediting_701432	chr9_110252896_-	SINE	Alu	AluSq2
CAediting_701433	chr9_110254264_-	SINE	Alu	AluSq
CAediting_701434	chr9_110254341_-	SINE	Alu	AluSq
CAediting_701435	chr9_110254358_-	SINE	Alu	AluSq
CAediting_701436	chr9_110254422_-	SINE	Alu	AluSq
CAediting_701437	chr9_110254439_-	SINE	Alu	AluSq
CAediting_701438	chr9_110254484_-	SINE	Alu	AluSq
CAediting_701439	chr9_110254486_-	SINE	Alu	AluSq

Top

RNA A-to-I editing events in the alternative splicing sites for TXN

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000136810.11.TXN.

Correlation between RNA A-to-I editing and PSI for ENSG00000136810.11.TXN.

Top

Differntial gene expression between RNA A-to-I edited versus non-edited samples for TXN

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

ESCA.CAediting_701369.ENSG00000136810.TXN.png
Soverview

Top

Protein coding region RNA A-to-I editings for TXN

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

Top

The effects of the RNA editing to the miRNA binding sites for TXN

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

Top

The effects of the RNA editing to the stability of the RNA structures for TXN

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

Top

Relation with ADAR for TXN

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
ESCA	CAediting_701369	chr9_110245877_-	.	.	0.0399769776826776	0.283087113999926	.	.

Top

Relation with cancer stages for TXN

Correlation between Cancer stages and RNA editing frequency

Cancer	Stage_type	CAeditomID	position	P-val	Coeff.
ESCA	clinical_stage	CAediting_701385	chr9_110246029_-	0.0349988021616637	-0.44137656115068
STAD	pathologic_stage	CAediting_701385	chr9_110246029_-	0.0354698941435577	0.250033677583011

Top

Relation with survival for TXN

Correlation between RNA editing and survival

Cancer	CAeditomID	position	KMpvalue	Coxpvalue	CoxHR
ESCA	CAediting_701369	chr9_110245877_-	0.00449226295401506	0.011396	15.5345

Top

RelatedDrugs for TXN

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

RelatedDiseases for TXN

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
TXN	C0006142	Malignant neoplasm of breast	1	CTD_human
TXN	C0006287	Bronchopulmonary Dysplasia	1	CTD_human
TXN	C0011616	Contact Dermatitis	1	CTD_human
TXN	C0023895	Liver diseases	1	CTD_human
TXN	C0027626	Neoplasm Invasiveness	1	CTD_human
TXN	C0027627	Neoplasm Metastasis	1	CTD_human
TXN	C0027659	Neoplasms, Experimental	1	CTD_human
TXN	C0086565	Liver Dysfunction	1	CTD_human
TXN	C0162351	Contact hypersensitivity	1	CTD_human
TXN	C0242488	Acute Lung Injury	1	CTD_human
TXN	C0345967	Malignant mesothelioma	1	CTD_human
TXN	C0678222	Breast Carcinoma	1	CTD_human
TXN	C1257931	Mammary Neoplasms, Human	1	CTD_human
TXN	C1458155	Mammary Neoplasms	1	CTD_human
TXN	C4704874	Mammary Carcinoma, Human	1	CTD_human

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene