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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: TTPA (CAeditome ID:7274)

Gene summary for TTPA

check button Gene summary
Gene informationGene symbol

TTPA

Gene ID

7274

Gene namealpha tocopherol transfer protein
SynonymsATTP|AVED|TTP1|alphaTTP
Cytomap

8q12.3

Type of geneprotein-coding
Descriptionalpha-tocopherol transfer proteinalpha-TTPtocopherol (alpha) transfer protein (ataxia (Friedreich-like) with vitamin E deficiency)
Modification date20210518
UniProtAcc

P49638

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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RNA A-to-I events for TTPA

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000137561.4
boxplot

check button RNA A-to-I editing events in Cancer.
CAediting_642035(63059079, -), CAediting_642036(63059089, -), CAediting_642037(63059196, -), CAediting_642038(63059207, -), CAediting_642039(63059299, -), CAediting_642040(63059305, -), CAediting_642041(63059313, -), CAediting_642042(63059905, -), CAediting_642043(63059910, -), CAediting_642044(63059919, -), CAediting_642045(63059924, -), CAediting_642046(63059963, -), CAediting_642047(63059968, -), CAediting_642048(63059969, -), CAediting_642049(63059975, -), CAediting_642050(63059977, -), CAediting_642051(63059982, -), CAediting_642052(63060452, -), CAediting_642053(63060459, -), CAediting_642054(63060461, -), CAediting_642055(63060475, -), CAediting_642056(63060496, -), CAediting_642057(63060500, -), CAediting_642058(63060513, -), CAediting_642059(63060514, -), CAediting_642060(63060515, -), CAediting_642061(63060525, -), CAediting_642062(63060526, -), CAediting_642063(63060556, -), CAediting_642064(63060561, -), CAediting_642065(63060570, -), CAediting_642066(63060580, -), CAediting_642067(63060596, -), CAediting_642068(63060602, -), CAediting_642069(63060622, -), CAediting_642070(63060633, -), CAediting_642071(63061940, -), CAediting_642072(63061958, -), CAediting_642073(63061982, -), CAediting_642074(63062086, -), CAediting_642075(63062095, -), CAediting_642076(63062151, -), CAediting_642077(63069055, -), CAediting_642078(63083977, -), CAediting_642079(63083999, -), CAediting_642080(63084022, -), CAediting_642081(63084023, -), CAediting_642082(63084033, -), CAediting_642083(63084045, -), CAediting_642084(63084172, -),

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RNA editing positional annotations for TTPA using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_642035chr8_63059079_-ncRNA_intronic
CAediting_642036chr8_63059089_-ncRNA_intronic
CAediting_642037chr8_63059196_-ncRNA_intronic
CAediting_642038chr8_63059207_-ncRNA_intronic
CAediting_642039chr8_63059299_-ncRNA_intronic
CAediting_642040chr8_63059305_-ncRNA_intronic
CAediting_642041chr8_63059313_-ncRNA_intronic
CAediting_642042chr8_63059905_-ncRNA_intronic
CAediting_642043chr8_63059910_-ncRNA_intronic
CAediting_642044chr8_63059919_-ncRNA_intronic
CAediting_642045chr8_63059924_-ncRNA_intronic
CAediting_642046chr8_63059963_-ncRNA_intronic
CAediting_642047chr8_63059968_-ncRNA_intronic
CAediting_642048chr8_63059969_-ncRNA_intronic
CAediting_642049chr8_63059975_-ncRNA_intronic
CAediting_642050chr8_63059977_-ncRNA_intronic
CAediting_642051chr8_63059982_-ncRNA_intronic
CAediting_642052chr8_63060452_-ncRNA_intronic
CAediting_642053chr8_63060459_-ncRNA_intronic
CAediting_642054chr8_63060461_-ncRNA_intronic
CAediting_642055chr8_63060475_-ncRNA_intronic
CAediting_642056chr8_63060496_-ncRNA_intronic
CAediting_642057chr8_63060500_-ncRNA_intronic
CAediting_642058chr8_63060513_-ncRNA_intronic
CAediting_642059chr8_63060514_-ncRNA_intronic
CAediting_642060chr8_63060515_-ncRNA_intronic
CAediting_642061chr8_63060525_-ncRNA_intronic
CAediting_642062chr8_63060526_-ncRNA_intronic
CAediting_642063chr8_63060556_-ncRNA_intronic
CAediting_642064chr8_63060561_-ncRNA_intronic
CAediting_642065chr8_63060570_-ncRNA_intronic
CAediting_642066chr8_63060580_-ncRNA_intronic
CAediting_642067chr8_63060596_-ncRNA_intronic
CAediting_642068chr8_63060602_-ncRNA_intronic
CAediting_642069chr8_63060622_-ncRNA_intronic
CAediting_642070chr8_63060633_-ncRNA_intronic
CAediting_642071chr8_63061940_-ncRNA_intronic
CAediting_642072chr8_63061958_-ncRNA_intronic
CAediting_642073chr8_63061982_-ncRNA_intronic
CAediting_642074chr8_63062086_-ncRNA_intronic
CAediting_642075chr8_63062095_-ncRNA_intronic
CAediting_642076chr8_63062151_-ncRNA_intronic
CAediting_642077chr8_63069055_-ncRNA_intronic
CAediting_642078chr8_63083977_-ncRNA_intronic
CAediting_642079chr8_63083999_-ncRNA_intronic
CAediting_642080chr8_63084022_-ncRNA_intronic
CAediting_642081chr8_63084023_-ncRNA_intronic
CAediting_642082chr8_63084033_-ncRNA_intronic
CAediting_642083chr8_63084045_-ncRNA_intronic
CAediting_642084chr8_63084172_-ncRNA_intronic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_642035chr8_63059079_-SINEAluAluYa5
CAediting_642036chr8_63059089_-SINEAluAluYa5
CAediting_642037chr8_63059196_-SINEAluAluYa5
CAediting_642038chr8_63059207_-SINEAluAluYa5
CAediting_642039chr8_63059299_-SINEAluAluYa5
CAediting_642040chr8_63059305_-SINEAluAluYa5
CAediting_642041chr8_63059313_-SINEAluAluYa5
CAediting_642042chr8_63059905_-SINEAluFLAM_C
CAediting_642043chr8_63059910_-SINEAluFLAM_C
CAediting_642044chr8_63059919_-SINEAluFLAM_C
CAediting_642045chr8_63059924_-SINEAluFLAM_C
CAediting_642046chr8_63059963_-SINEAluFLAM_C
CAediting_642047chr8_63059968_-SINEAluFLAM_C
CAediting_642048chr8_63059969_-SINEAluFLAM_C
CAediting_642049chr8_63059975_-SINEAluFLAM_C
CAediting_642050chr8_63059977_-SINEAluFLAM_C
CAediting_642051chr8_63059982_-SINEAluFLAM_C
CAediting_642052chr8_63060452_-SINEAluAluSz6
CAediting_642053chr8_63060459_-SINEAluAluSz6
CAediting_642054chr8_63060461_-SINEAluAluSz6
CAediting_642055chr8_63060475_-SINEAluAluSz6
CAediting_642056chr8_63060496_-SINEAluAluSz6
CAediting_642057chr8_63060500_-SINEAluAluSz6
CAediting_642058chr8_63060513_-SINEAluAluSz6
CAediting_642059chr8_63060514_-SINEAluAluSz6
CAediting_642060chr8_63060515_-SINEAluAluSz6
CAediting_642061chr8_63060525_-SINEAluAluSz6
CAediting_642062chr8_63060526_-SINEAluAluSz6
CAediting_642063chr8_63060556_-SINEAluAluSz6
CAediting_642064chr8_63060561_-SINEAluAluSz6
CAediting_642065chr8_63060570_-SINEAluAluSz6
CAediting_642066chr8_63060580_-SINEAluAluSz6
CAediting_642067chr8_63060596_-SINEAluAluSz6
CAediting_642068chr8_63060602_-SINEAluAluSz6
CAediting_642069chr8_63060622_-SINEAluAluSz6
CAediting_642070chr8_63060633_-SINEAluAluSz6
CAediting_642071chr8_63061940_-SINEAluAluJb
CAediting_642072chr8_63061958_-SINEAluAluJb
CAediting_642073chr8_63061982_-SINEAluAluJb
CAediting_642074chr8_63062086_-SINEAluAluJb
CAediting_642075chr8_63062095_-SINEAluAluJb
CAediting_642076chr8_63062151_-SINEAluAluJb
CAediting_642077chr8_63069055_-SINEAluAluSz
CAediting_642078chr8_63083977_-SINEAluAluJb
CAediting_642079chr8_63083999_-SINEAluAluJb
CAediting_642080chr8_63084022_-SINEAluAluJb
CAediting_642081chr8_63084023_-SINEAluAluJb
CAediting_642082chr8_63084033_-SINEAluAluJb
CAediting_642083chr8_63084045_-SINEAluAluJb
CAediting_642084chr8_63084172_-SINEAluAluJb

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RNA A-to-I editing events in the alternative splicing sites for TTPA

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000137561.4.TTPA.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000137561.4.TTPA.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for TTPA

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.
boxplot

check button Correlation between RNA A-to-I editing and gene expression.
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.
COAD.CAediting_642054.ENSG00000137561.TTPA.png
Soverview

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Protein coding region RNA A-to-I editings for TTPA

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for TTPA

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for TTPA

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.
ENST00000260116.4protein_codingSoverviewSoverview

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI
CAediting_642042ENST00000260116.4chr8_63059905_--725.60-726.30-739.60
CAediting_642043ENST00000260116.4chr8_63059910_--726.00-726.30-739.60
CAediting_642044ENST00000260116.4chr8_63059919_--725.60-726.30-739.60
CAediting_642045ENST00000260116.4chr8_63059924_--725.40-726.30-739.60
CAediting_642046ENST00000260116.4chr8_63059963_--725.60-726.30-739.60
CAediting_642047ENST00000260116.4chr8_63059968_--726.30-726.30-739.60
CAediting_642048ENST00000260116.4chr8_63059969_--726.40-726.30-739.60
CAediting_642049ENST00000260116.4chr8_63059975_--729.70-726.30-739.60
CAediting_642050ENST00000260116.4chr8_63059977_--725.90-726.30-739.60
CAediting_642051ENST00000260116.4chr8_63059982_--729.80-726.30-739.60
CAediting_642052ENST00000260116.4chr8_63060452_--725.40-726.30-739.60
CAediting_642053ENST00000260116.4chr8_63060459_--726.00-726.30-739.60
CAediting_642054ENST00000260116.4chr8_63060461_--726.30-726.30-739.60
CAediting_642055ENST00000260116.4chr8_63060475_--725.50-726.30-739.60
CAediting_642056ENST00000260116.4chr8_63060496_--726.30-726.30-739.60
CAediting_642057ENST00000260116.4chr8_63060500_--726.00-726.30-739.60
CAediting_642058ENST00000260116.4chr8_63060513_--726.30-726.30-739.60
CAediting_642059ENST00000260116.4chr8_63060514_--726.20-726.30-739.60
CAediting_642060ENST00000260116.4chr8_63060515_--729.50-726.30-739.60
CAediting_642061ENST00000260116.4chr8_63060525_--732.90-726.30-739.60
CAediting_642062ENST00000260116.4chr8_63060526_--725.60-726.30-739.60
CAediting_642063ENST00000260116.4chr8_63060556_--729.10-726.30-739.60
CAediting_642064ENST00000260116.4chr8_63060561_--726.70-726.30-739.60
CAediting_642065ENST00000260116.4chr8_63060570_--727.10-726.30-739.60
CAediting_642066ENST00000260116.4chr8_63060580_--726.10-726.30-739.60
CAediting_642067ENST00000260116.4chr8_63060596_--728.00-726.30-739.60
CAediting_642068ENST00000260116.4chr8_63060602_--727.10-726.30-739.60
CAediting_642069ENST00000260116.4chr8_63060622_--727.60-726.30-739.60
CAediting_642070ENST00000260116.4chr8_63060633_--725.00-726.30-739.60

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Relation with ADAR for TTPA

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
LIHCCAediting_642046chr8_63059963_-0.0003664117858076350.416866250545764....
LGGCAediting_642047chr8_63059968_-..0.02348171332988880.167893328587603..
LIHCCAediting_642047chr8_63059968_-1.18540215575224e-080.315772565372878....
LGGCAediting_642048chr8_63059969_-0.006741914839334320.1797484784870850.0225381332962690.151703368851464..
BRCACAediting_642048chr8_63059969_-0.001727452584795730.424132309617864....
LIHCCAediting_642048chr8_63059969_-2.80292378823367e-100.329886853987179....
COADCAediting_642048chr8_63059969_-0.001739614178422920.312374214319288....
LGGCAediting_642049chr8_63059975_-..0.01228758842560380.17375087745417..
LIHCCAediting_642049chr8_63059975_-1.1457694277798e-070.279534129373523....
COADCAediting_642049chr8_63059975_-0.01678074732735610.243581488577809....
LGGCAediting_642054chr8_63060461_-0.02014523491200890.161420461386416....
LIHCCAediting_642054chr8_63060461_-2.74669128750159e-050.233558318933799....
LIHCCAediting_642061chr8_63060525_-0.0002449400765365130.203349986112935....
COADCAediting_642061chr8_63060525_-0.01552526886195930.235641992411324....
LIHCCAediting_642062chr8_63060526_-2.12320480557128e-080.304938326002524....

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Relation with cancer stages for TTPA

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.

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Relation with survival for TTPA

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR

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RelatedDrugs for TTPA

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TTPA

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource
TTPAC1848533Ataxia with vitamin E deficiency10CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TTPAC0004138Ataxias, Hereditary1GENOMICS_ENGLAND
TTPAC0004153Atherosclerosis1CTD_human
TTPAC0009090Cluttering1CTD_human
TTPAC0018975Hemeralopia1CTD_human
TTPAC0026846Muscular Atrophy1CTD_human
TTPAC0027765nervous system disorder1CTD_human
TTPAC0034933Reflex, Abnormal1CTD_human
TTPAC0035309Retinal Diseases1CTD_human
TTPAC0035334Retinitis Pigmentosa1CTD_human
TTPAC0037822Speech Disorders1CTD_human
TTPAC0042035Urination Disorders1CTD_human
TTPAC0042790Vision Disorders1CTD_human
TTPAC0042875Vitamin E Deficiency1CTD_human
TTPAC0151572Reflex, Corneal, Decreased1CTD_human
TTPAC0151888Hyporeflexia1CTD_human
TTPAC0151889Hyperreflexia1CTD_human
TTPAC0155536Paracousis1CTD_human
TTPAC0233726Aprosodia1CTD_human
TTPAC0233769Micropsia1CTD_human
TTPAC0233771Macropsia1CTD_human
TTPAC0234146Absent reflex1CTD_human
TTPAC0234784Reflex, Gag, Absent1CTD_human
TTPAC0241772Reflex, Deep Tendon, Absent1CTD_human
TTPAC0260662Hearing problem1CTD_human
TTPAC0270948Neurogenic Muscular Atrophy1CTD_human
TTPAC0271185Metamorphopsia1CTD_human
TTPAC0277839Hoffman's Reflex1CTD_human
TTPAC0277850Reflex, Pendular1CTD_human
TTPAC0278211Reflex, Corneal, Absent1CTD_human
TTPAC0522345Reflex, Acoustic, Abnormal1CTD_human
TTPAC0558845Reflex, Ankle, Absent1CTD_human
TTPAC0558846Reflex, Triceps, Absent1CTD_human
TTPAC0558847Reflex, Biceps, Absent1CTD_human
TTPAC0576612Reflex, Anal, Absent1CTD_human
TTPAC0743002Abnormal Deep Tendon Reflex1CTD_human
TTPAC0751468Bulbocavernosus Reflex, Decreased1CTD_human
TTPAC0751469Bulbocavernousus Reflex Absent1CTD_human
TTPAC0751470Palmo-Mental Reflex1CTD_human
TTPAC0751471Reflex, Anal, Decreased1CTD_human
TTPAC0751472Reflex, Ankle, Abnormal1CTD_human
TTPAC0751473Reflex, Ankle, Decreased1CTD_human
TTPAC0751474Reflex, Biceps, Abnormal1CTD_human
TTPAC0751475Reflex, Biceps, Decreased1CTD_human
TTPAC0751476Reflex, Gag, Decreased1CTD_human
TTPAC0751477Reflex, Knee, Abnormal1CTD_human
TTPAC0751478Reflex, Knee, Decreased1CTD_human
TTPAC0751479Reflex, Moro, Asymmetric1CTD_human
TTPAC0751480Reflex, Triceps, Abnormal1CTD_human
TTPAC0751481Reflex, Triceps, Decreased1CTD_human
TTPAC0751512Dysglossia1CTD_human
TTPAC0751513Rhinolalia1CTD_human
TTPAC0751514Verbal Fluency Disorders1CTD_human
TTPAC0752255Impairment, Light Touch Sensation1CTD_human
TTPAC0752256Pain Sensation Diminished1CTD_human
TTPAC0752257Pinprick Sensation Diminished1CTD_human
TTPAC0752258Position Sense Disorders1CTD_human
TTPAC0752260Proprioceptive Disorders1CTD_human
TTPAC0752261Thermal Sensation Disorders1CTD_human
TTPAC0752262Somatosensory Disorders1CTD_human
TTPAC0877848Distorted hearing1CTD_human
TTPAC1510450Dysacusis1CTD_human
TTPAC1563937Atherogenesis1CTD_human
TTPAC3489704Vision Disability1CTD_human
TTPAC3495145Dyslalia1CTD_human
TTPAC3665347Visual Impairment1CTD_human