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Editing gene: TOP1 (CAeditome ID:7150)

Gene summary for TOP1

Gene summary

Gene information	Gene symbol	TOP1
	Gene ID	7150
	Gene name	DNA topoisomerase I
	Synonyms	TOPI
	Cytomap	20q12
	Type of gene	protein-coding
	Description	DNA topoisomerase 1Scl-70 antigentopoisomerase (DNA) Itype I DNA topoisomerase
	Modification date	20210531
	UniProtAcc	P11387
	Context	- 33144457(Implications of Topoisomerase (TOP1 and TOP2a) Expression in Patients With Breast Cancer)

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
TOP1	GO:0000228	DNA topoisomerase 1	9049244
TOP1	GO:0000978	DNA topoisomerase 1	22904072
TOP1	GO:0003677	DNA topoisomerase 1	17355975
TOP1	GO:0003682	DNA topoisomerase 1	9049244
TOP1	GO:0003917	DNA topoisomerase 1	14594810
TOP1	GO:0006265	DNA topoisomerase 1	14594810
TOP1	GO:0000932	DNA topoisomerase 1	12878161
TOP1	GO:0001650	DNA topoisomerase 1	0000052
TOP1	GO:0005634	DNA topoisomerase 1	11016921
TOP1	GO:0005634	DNA topoisomerase 1	9049244
TOP1	GO:0005654	DNA topoisomerase 1	0000052
TOP1	GO:0005654	DNA topoisomerase 1	9049244
TOP1	GO:0005730	DNA topoisomerase 1	9049244

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RNA A-to-I events for TOP1

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000198900.5

RNA A-to-I editing events in Cancer.

CAediting_1427956(41036895, +), CAediting_1427957(41037037, +), CAediting_1427958(41038716, +), CAediting_1427959(41038731, +), CAediting_1427960(41038761, +), CAediting_1427961(41038779, +), CAediting_1427962(41038784, +), CAediting_1427963(41038800, +), CAediting_1427964(41038807, +), CAediting_1427965(41038821, +), CAediting_1427966(41038823, +), CAediting_1427967(41038824, +), CAediting_1427968(41038826, +), CAediting_1427969(41038828, +), CAediting_1427970(41038829, +), CAediting_1427971(41038832, +), CAediting_1427972(41038859, +), CAediting_1427973(41038873, +), CAediting_1427974(41038881, +), CAediting_1427975(41038897, +), CAediting_1427976(41038907, +), CAediting_1427977(41038908, +), CAediting_1427978(41039653, +), CAediting_1427979(41039654, +), CAediting_1427980(41039667, +), CAediting_1427981(41039756, +), CAediting_1427982(41039757, +), CAediting_1427983(41039761, +), CAediting_1427984(41039787, +), CAediting_1427985(41040634, +), CAediting_1427986(41040643, +), CAediting_1427987(41040646, +), CAediting_1427988(41040647, +), CAediting_1427989(41040653, +), CAediting_1427990(41040654, +), CAediting_1427991(41040659, +), CAediting_1427992(41040685, +), CAediting_1427993(41040699, +), CAediting_1427994(41040708, +), CAediting_1427995(41040709, +), CAediting_1427996(41040712, +), CAediting_1427997(41040715, +), CAediting_1427998(41040718, +), CAediting_1427999(41040721, +), CAediting_1428000(41040727, +), CAediting_1428001(41040738, +), CAediting_1428002(41040756, +), CAediting_1428003(41040763, +), CAediting_1428004(41041214, +), CAediting_1428005(41041215, +), CAediting_1428006(41041216, +), CAediting_1428007(41041233, +), CAediting_1428008(41041248, +), CAediting_1428009(41041249, +), CAediting_1428010(41041252, +), CAediting_1428011(41041262, +), CAediting_1428012(41041285, +), CAediting_1428013(41041286, +), CAediting_1428014(41041288, +), CAediting_1428015(41041289, +), CAediting_1428016(41041290, +), CAediting_1428017(41041291, +), CAediting_1428018(41041294, +), CAediting_1428019(41041296, +), CAediting_1428020(41041297, +), CAediting_1428021(41041298, +), CAediting_1428022(41041299, +), CAediting_1428023(41041300, +), CAediting_1428024(41041303, +), CAediting_1428025(41041308, +), CAediting_1428026(41041311, +), CAediting_1428027(41041327, +), CAediting_1428028(41041329, +), CAediting_1428029(41041335, +), CAediting_1428030(41041339, +), CAediting_1428031(41041365, +), CAediting_1428032(41041370, +), CAediting_1428033(41041375, +), CAediting_1428034(41041399, +), CAediting_1428035(41041932, +), CAediting_1428036(41041964, +), CAediting_1428037(41041968, +), CAediting_1428038(41041970, +), CAediting_1428039(41041995, +), CAediting_1428040(41042008, +), CAediting_1428041(41042009, +), CAediting_1428042(41042013, +), CAediting_1428043(41042038, +), CAediting_1428044(41042048, +), CAediting_1428045(41042050, +), CAediting_1428046(41042059, +), CAediting_1428047(41042062, +), CAediting_1428048(41042067, +), CAediting_1428049(41042075, +), CAediting_1428050(41042076, +), CAediting_1428051(41042084, +), CAediting_1428052(41042090, +), CAediting_1428053(41042130, +), CAediting_1428054(41042144, +), CAediting_1428055(41042145, +), CAediting_1428056(41042162, +), CAediting_1428057(41044022, +), CAediting_1428058(41044091, +), CAediting_1428059(41044129, +), CAediting_1428060(41044149, +), CAediting_1428061(41044155, +), CAediting_1428062(41044156, +), CAediting_1428063(41044225, +), CAediting_1428064(41044226, +), CAediting_1428065(41044231, +), CAediting_1428066(41044834, +), CAediting_1428067(41044860, +), CAediting_1428068(41044865, +), CAediting_1428069(41044870, +), CAediting_1428070(41044917, +), CAediting_1428071(41044921, +), CAediting_1428072(41044927, +), CAediting_1428073(41044929, +), CAediting_1428074(41044973, +), CAediting_1428075(41045008, +), CAediting_1428076(41045040, +), CAediting_1428077(41045050, +), CAediting_1428078(41045065, +), CAediting_1428079(41056493, +), CAediting_1428080(41056504, +), CAediting_1428081(41056525, +), CAediting_1428082(41056531, +), CAediting_1428083(41056549, +), CAediting_1428084(41056582, +), CAediting_1428085(41056585, +), CAediting_1428086(41056594, +), CAediting_1428087(41056610, +), CAediting_1428088(41056614, +), CAediting_1428089(41056620, +), CAediting_1428090(41056622, +), CAediting_1428091(41056716, +), CAediting_1428092(41056717, +), CAediting_1428093(41056759, +), CAediting_1428094(41057119, +), CAediting_1428095(41057288, +), CAediting_1428096(41068669, +), CAediting_1428097(41085991, +), CAediting_1428098(41086008, +), CAediting_1428099(41086068, +), CAediting_1428100(41086087, +), CAediting_1428101(41086103, +), CAediting_1428102(41086112, +), CAediting_1428103(41086116, +), CAediting_1428104(41086152, +), CAediting_1428105(41086160, +), CAediting_1428106(41086184, +), CAediting_1428107(41088249, +), CAediting_1428108(41088274, +), CAediting_1428109(41088458, +), CAediting_1428110(41089164, +), CAediting_1428111(41090567, +), CAediting_1428112(41090604, +), CAediting_1428113(41090620, +), CAediting_1428114(41090632, +), CAediting_1428115(41090741, +), CAediting_1428116(41090767, +), CAediting_1428117(41091759, +), CAediting_1428118(41093924, +), CAediting_1428119(41093932, +), CAediting_1428120(41093954, +), CAediting_1428121(41093978, +), CAediting_1428122(41093981, +), CAediting_1428123(41093985, +), CAediting_1428124(41094003, +), CAediting_1428125(41095062, +), CAediting_1428126(41095071, +), CAediting_1428127(41095073, +), CAediting_1428128(41095075, +), CAediting_1428129(41095077, +), CAediting_1428130(41095113, +), CAediting_1428131(41095115, +), CAediting_1428132(41095126, +), CAediting_1428133(41095138, +), CAediting_1428134(41095145, +), CAediting_1428135(41095153, +), CAediting_1428136(41095181, +), CAediting_1428137(41095186, +), CAediting_1428138(41095342, +), CAediting_1428139(41096088, +), CAediting_1428140(41096117, +), CAediting_1428141(41096122, +), CAediting_1428142(41096131, +), CAediting_1428143(41096146, +), CAediting_1428144(41096147, +), CAediting_1428145(41096167, +), CAediting_1428146(41096206, +), CAediting_1428147(41096208, +),

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RNA editing positional annotations for TOP1 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_1427956	chr20_41036895_+	intronic
CAediting_1427957	chr20_41037037_+	intronic
CAediting_1427958	chr20_41038716_+	intronic
CAediting_1427959	chr20_41038731_+	intronic
CAediting_1427960	chr20_41038761_+	intronic
CAediting_1427961	chr20_41038779_+	intronic
CAediting_1427962	chr20_41038784_+	intronic
CAediting_1427963	chr20_41038800_+	intronic
CAediting_1427964	chr20_41038807_+	intronic
CAediting_1427965	chr20_41038821_+	intronic
CAediting_1427966	chr20_41038823_+	intronic
CAediting_1427967	chr20_41038824_+	intronic
CAediting_1427968	chr20_41038826_+	intronic
CAediting_1427969	chr20_41038828_+	intronic
CAediting_1427970	chr20_41038829_+	intronic
CAediting_1427971	chr20_41038832_+	intronic
CAediting_1427972	chr20_41038859_+	intronic
CAediting_1427973	chr20_41038873_+	intronic
CAediting_1427974	chr20_41038881_+	intronic
CAediting_1427975	chr20_41038897_+	intronic
CAediting_1427976	chr20_41038907_+	intronic
CAediting_1427977	chr20_41038908_+	intronic
CAediting_1427978	chr20_41039653_+	intronic
CAediting_1427979	chr20_41039654_+	intronic
CAediting_1427980	chr20_41039667_+	intronic
CAediting_1427981	chr20_41039756_+	intronic
CAediting_1427982	chr20_41039757_+	intronic
CAediting_1427983	chr20_41039761_+	intronic
CAediting_1427984	chr20_41039787_+	intronic
CAediting_1427985	chr20_41040634_+	intronic
CAediting_1427986	chr20_41040643_+	intronic
CAediting_1427987	chr20_41040646_+	intronic
CAediting_1427988	chr20_41040647_+	intronic
CAediting_1427989	chr20_41040653_+	intronic
CAediting_1427990	chr20_41040654_+	intronic
CAediting_1427991	chr20_41040659_+	intronic
CAediting_1427992	chr20_41040685_+	intronic
CAediting_1427993	chr20_41040699_+	intronic
CAediting_1427994	chr20_41040708_+	intronic
CAediting_1427995	chr20_41040709_+	intronic
CAediting_1427996	chr20_41040712_+	intronic
CAediting_1427997	chr20_41040715_+	intronic
CAediting_1427998	chr20_41040718_+	intronic
CAediting_1427999	chr20_41040721_+	intronic
CAediting_1428000	chr20_41040727_+	intronic
CAediting_1428001	chr20_41040738_+	intronic
CAediting_1428002	chr20_41040756_+	intronic
CAediting_1428003	chr20_41040763_+	intronic
CAediting_1428004	chr20_41041214_+	intronic
CAediting_1428005	chr20_41041215_+	intronic
CAediting_1428006	chr20_41041216_+	intronic
CAediting_1428007	chr20_41041233_+	intronic
CAediting_1428008	chr20_41041248_+	intronic
CAediting_1428009	chr20_41041249_+	intronic
CAediting_1428010	chr20_41041252_+	intronic
CAediting_1428011	chr20_41041262_+	intronic
CAediting_1428012	chr20_41041285_+	intronic
CAediting_1428013	chr20_41041286_+	intronic
CAediting_1428014	chr20_41041288_+	intronic
CAediting_1428015	chr20_41041289_+	intronic
CAediting_1428016	chr20_41041290_+	intronic
CAediting_1428017	chr20_41041291_+	intronic
CAediting_1428018	chr20_41041294_+	intronic
CAediting_1428019	chr20_41041296_+	intronic
CAediting_1428020	chr20_41041297_+	intronic
CAediting_1428021	chr20_41041298_+	intronic
CAediting_1428022	chr20_41041299_+	intronic
CAediting_1428023	chr20_41041300_+	intronic
CAediting_1428024	chr20_41041303_+	intronic
CAediting_1428025	chr20_41041308_+	intronic
CAediting_1428026	chr20_41041311_+	intronic
CAediting_1428027	chr20_41041327_+	intronic
CAediting_1428028	chr20_41041329_+	intronic
CAediting_1428029	chr20_41041335_+	intronic
CAediting_1428030	chr20_41041339_+	intronic
CAediting_1428031	chr20_41041365_+	intronic
CAediting_1428032	chr20_41041370_+	intronic
CAediting_1428033	chr20_41041375_+	intronic
CAediting_1428034	chr20_41041399_+	intronic
CAediting_1428035	chr20_41041932_+	intronic
CAediting_1428036	chr20_41041964_+	intronic
CAediting_1428037	chr20_41041968_+	intronic
CAediting_1428038	chr20_41041970_+	intronic
CAediting_1428039	chr20_41041995_+	intronic
CAediting_1428040	chr20_41042008_+	intronic
CAediting_1428041	chr20_41042009_+	intronic
CAediting_1428042	chr20_41042013_+	intronic
CAediting_1428043	chr20_41042038_+	intronic
CAediting_1428044	chr20_41042048_+	intronic
CAediting_1428045	chr20_41042050_+	intronic
CAediting_1428046	chr20_41042059_+	intronic
CAediting_1428047	chr20_41042062_+	intronic
CAediting_1428048	chr20_41042067_+	intronic
CAediting_1428049	chr20_41042075_+	intronic
CAediting_1428050	chr20_41042076_+	intronic
CAediting_1428051	chr20_41042084_+	intronic
CAediting_1428052	chr20_41042090_+	intronic
CAediting_1428053	chr20_41042130_+	intronic
CAediting_1428054	chr20_41042144_+	intronic
CAediting_1428055	chr20_41042145_+	intronic
CAediting_1428056	chr20_41042162_+	intronic
CAediting_1428057	chr20_41044022_+	intronic
CAediting_1428058	chr20_41044091_+	intronic
CAediting_1428059	chr20_41044129_+	intronic
CAediting_1428060	chr20_41044149_+	intronic
CAediting_1428061	chr20_41044155_+	intronic
CAediting_1428062	chr20_41044156_+	intronic
CAediting_1428063	chr20_41044225_+	intronic
CAediting_1428064	chr20_41044226_+	intronic
CAediting_1428065	chr20_41044231_+	intronic
CAediting_1428066	chr20_41044834_+	intronic
CAediting_1428067	chr20_41044860_+	intronic
CAediting_1428068	chr20_41044865_+	intronic
CAediting_1428069	chr20_41044870_+	intronic
CAediting_1428070	chr20_41044917_+	intronic
CAediting_1428071	chr20_41044921_+	intronic
CAediting_1428072	chr20_41044927_+	intronic
CAediting_1428073	chr20_41044929_+	intronic
CAediting_1428074	chr20_41044973_+	intronic
CAediting_1428075	chr20_41045008_+	intronic
CAediting_1428076	chr20_41045040_+	intronic
CAediting_1428077	chr20_41045050_+	intronic
CAediting_1428078	chr20_41045065_+	intronic
CAediting_1428079	chr20_41056493_+	intronic
CAediting_1428080	chr20_41056504_+	intronic
CAediting_1428081	chr20_41056525_+	intronic
CAediting_1428082	chr20_41056531_+	intronic
CAediting_1428083	chr20_41056549_+	intronic
CAediting_1428084	chr20_41056582_+	intronic
CAediting_1428085	chr20_41056585_+	intronic
CAediting_1428086	chr20_41056594_+	intronic
CAediting_1428087	chr20_41056610_+	intronic
CAediting_1428088	chr20_41056614_+	intronic
CAediting_1428089	chr20_41056620_+	intronic
CAediting_1428090	chr20_41056622_+	intronic
CAediting_1428091	chr20_41056716_+	intronic
CAediting_1428092	chr20_41056717_+	intronic
CAediting_1428093	chr20_41056759_+	intronic
CAediting_1428094	chr20_41057119_+	intronic
CAediting_1428095	chr20_41057288_+	intronic
CAediting_1428096	chr20_41068669_+	intronic
CAediting_1428097	chr20_41085991_+	intronic
CAediting_1428098	chr20_41086008_+	intronic
CAediting_1428099	chr20_41086068_+	intronic
CAediting_1428100	chr20_41086087_+	intronic
CAediting_1428101	chr20_41086103_+	intronic
CAediting_1428102	chr20_41086112_+	intronic
CAediting_1428103	chr20_41086116_+	intronic
CAediting_1428104	chr20_41086152_+	intronic
CAediting_1428105	chr20_41086160_+	intronic
CAediting_1428106	chr20_41086184_+	intronic
CAediting_1428107	chr20_41088249_+	intronic
CAediting_1428108	chr20_41088274_+	intronic
CAediting_1428109	chr20_41088458_+	intronic
CAediting_1428110	chr20_41089164_+	intronic
CAediting_1428111	chr20_41090567_+	intronic
CAediting_1428112	chr20_41090604_+	intronic
CAediting_1428113	chr20_41090620_+	intronic
CAediting_1428114	chr20_41090632_+	intronic
CAediting_1428115	chr20_41090741_+	intronic
CAediting_1428116	chr20_41090767_+	intronic
CAediting_1428117	chr20_41091759_+	intronic
CAediting_1428118	chr20_41093924_+	intronic
CAediting_1428119	chr20_41093932_+	intronic
CAediting_1428120	chr20_41093954_+	intronic
CAediting_1428121	chr20_41093978_+	intronic
CAediting_1428122	chr20_41093981_+	intronic
CAediting_1428123	chr20_41093985_+	intronic
CAediting_1428124	chr20_41094003_+	intronic
CAediting_1428125	chr20_41095062_+	intronic
CAediting_1428126	chr20_41095071_+	intronic
CAediting_1428127	chr20_41095073_+	intronic
CAediting_1428128	chr20_41095075_+	intronic
CAediting_1428129	chr20_41095077_+	intronic
CAediting_1428130	chr20_41095113_+	intronic
CAediting_1428131	chr20_41095115_+	intronic
CAediting_1428132	chr20_41095126_+	intronic
CAediting_1428133	chr20_41095138_+	intronic
CAediting_1428134	chr20_41095145_+	intronic
CAediting_1428135	chr20_41095153_+	intronic
CAediting_1428136	chr20_41095181_+	intronic
CAediting_1428137	chr20_41095186_+	intronic
CAediting_1428138	chr20_41095342_+	intronic
CAediting_1428139	chr20_41096088_+	intronic
CAediting_1428140	chr20_41096117_+	intronic
CAediting_1428141	chr20_41096122_+	intronic
CAediting_1428142	chr20_41096131_+	intronic
CAediting_1428143	chr20_41096146_+	intronic
CAediting_1428144	chr20_41096147_+	intronic
CAediting_1428145	chr20_41096167_+	intronic
CAediting_1428146	chr20_41096206_+	intronic
CAediting_1428147	chr20_41096208_+	intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_1427956	chr20_41036895_+	SINE	Alu	AluY
CAediting_1427957	chr20_41037037_+	SINE	Alu	AluY
CAediting_1427958	chr20_41038716_+	SINE	Alu	AluJb
CAediting_1427959	chr20_41038731_+	SINE	Alu	AluJb
CAediting_1427960	chr20_41038761_+	SINE	Alu	AluJb
CAediting_1427961	chr20_41038779_+	SINE	Alu	AluJb
CAediting_1427962	chr20_41038784_+	SINE	Alu	AluJb
CAediting_1427963	chr20_41038800_+	SINE	Alu	AluJb
CAediting_1427964	chr20_41038807_+	SINE	Alu	AluJb
CAediting_1427965	chr20_41038821_+	SINE	Alu	AluJb
CAediting_1427966	chr20_41038823_+	SINE	Alu	AluJb
CAediting_1427967	chr20_41038824_+	SINE	Alu	AluJb
CAediting_1427968	chr20_41038826_+	SINE	Alu	AluJb
CAediting_1427969	chr20_41038828_+	SINE	Alu	AluJb
CAediting_1427970	chr20_41038829_+	SINE	Alu	AluJb
CAediting_1427971	chr20_41038832_+	SINE	Alu	AluJb
CAediting_1427972	chr20_41038859_+	SINE	Alu	AluJb
CAediting_1427973	chr20_41038873_+	SINE	Alu	AluJb
CAediting_1427974	chr20_41038881_+	SINE	Alu	AluJb
CAediting_1427975	chr20_41038897_+	SINE	Alu	AluJb
CAediting_1427976	chr20_41038907_+	SINE	Alu	AluJb
CAediting_1427977	chr20_41038908_+	SINE	Alu	AluJb
CAediting_1427978	chr20_41039653_+	SINE	Alu	AluY
CAediting_1427979	chr20_41039654_+	SINE	Alu	AluY
CAediting_1427980	chr20_41039667_+	SINE	Alu	AluY
CAediting_1427981	chr20_41039756_+	SINE	Alu	AluY
CAediting_1427982	chr20_41039757_+	SINE	Alu	AluY
CAediting_1427983	chr20_41039761_+	SINE	Alu	AluY
CAediting_1427984	chr20_41039787_+	SINE	Alu	AluY
CAediting_1427985	chr20_41040634_+	SINE	Alu	AluSx3
CAediting_1427986	chr20_41040643_+	SINE	Alu	AluSx3
CAediting_1427987	chr20_41040646_+	SINE	Alu	AluSx3
CAediting_1427988	chr20_41040647_+	SINE	Alu	AluSx3
CAediting_1427989	chr20_41040653_+	SINE	Alu	AluSx3
CAediting_1427990	chr20_41040654_+	SINE	Alu	AluSx3
CAediting_1427991	chr20_41040659_+	SINE	Alu	AluSx3
CAediting_1427992	chr20_41040685_+	SINE	Alu	AluSx3
CAediting_1427993	chr20_41040699_+	SINE	Alu	AluSx3
CAediting_1427994	chr20_41040708_+	SINE	Alu	AluSx3
CAediting_1427995	chr20_41040709_+	SINE	Alu	AluSx3
CAediting_1427996	chr20_41040712_+	SINE	Alu	AluSx3
CAediting_1427997	chr20_41040715_+	SINE	Alu	AluSx3
CAediting_1427998	chr20_41040718_+	SINE	Alu	AluSx3
CAediting_1427999	chr20_41040721_+	SINE	Alu	AluSx3
CAediting_1428000	chr20_41040727_+	SINE	Alu	AluSx3
CAediting_1428001	chr20_41040738_+	SINE	Alu	AluSx3
CAediting_1428002	chr20_41040756_+	SINE	Alu	AluSx3
CAediting_1428003	chr20_41040763_+	SINE	Alu	AluSx3
CAediting_1428004	chr20_41041214_+	SINE	Alu	AluJo
CAediting_1428005	chr20_41041215_+	SINE	Alu	AluJo
CAediting_1428006	chr20_41041216_+	SINE	Alu	AluJo
CAediting_1428007	chr20_41041233_+	SINE	Alu	AluJo
CAediting_1428008	chr20_41041248_+	SINE	Alu	AluJo
CAediting_1428009	chr20_41041249_+	SINE	Alu	AluJo
CAediting_1428010	chr20_41041252_+	SINE	Alu	AluJo
CAediting_1428011	chr20_41041262_+	SINE	Alu	AluJo
CAediting_1428012	chr20_41041285_+	SINE	Alu	AluJo
CAediting_1428013	chr20_41041286_+	SINE	Alu	AluJo
CAediting_1428014	chr20_41041288_+	SINE	Alu	AluJo
CAediting_1428015	chr20_41041289_+	SINE	Alu	AluJo
CAediting_1428016	chr20_41041290_+	SINE	Alu	AluJo
CAediting_1428017	chr20_41041291_+	SINE	Alu	AluJo
CAediting_1428018	chr20_41041294_+	SINE	Alu	AluJo
CAediting_1428019	chr20_41041296_+	SINE	Alu	AluJo
CAediting_1428020	chr20_41041297_+	SINE	Alu	AluJo
CAediting_1428021	chr20_41041298_+	SINE	Alu	AluJo
CAediting_1428022	chr20_41041299_+	SINE	Alu	AluJo
CAediting_1428023	chr20_41041300_+	SINE	Alu	AluJo
CAediting_1428024	chr20_41041303_+	SINE	Alu	AluJo
CAediting_1428025	chr20_41041308_+	SINE	Alu	AluJo
CAediting_1428026	chr20_41041311_+	SINE	Alu	AluJo
CAediting_1428027	chr20_41041327_+	SINE	Alu	AluJo
CAediting_1428028	chr20_41041329_+	SINE	Alu	AluJo
CAediting_1428029	chr20_41041335_+	SINE	Alu	AluJo
CAediting_1428030	chr20_41041339_+	SINE	Alu	AluJo
CAediting_1428031	chr20_41041365_+	SINE	Alu	AluJo
CAediting_1428032	chr20_41041370_+	SINE	Alu	AluJo
CAediting_1428033	chr20_41041375_+	SINE	Alu	AluJo
CAediting_1428034	chr20_41041399_+	SINE	Alu	AluJo
CAediting_1428035	chr20_41041932_+	SINE	Alu	AluSz6
CAediting_1428036	chr20_41041964_+	SINE	Alu	AluSz6
CAediting_1428037	chr20_41041968_+	SINE	Alu	AluSz6
CAediting_1428038	chr20_41041970_+	SINE	Alu	AluSz6
CAediting_1428039	chr20_41041995_+	SINE	Alu	AluSz6
CAediting_1428040	chr20_41042008_+	SINE	Alu	AluSz6
CAediting_1428041	chr20_41042009_+	SINE	Alu	AluSz6
CAediting_1428042	chr20_41042013_+	SINE	Alu	AluSz6
CAediting_1428043	chr20_41042038_+	SINE	Alu	AluSz6
CAediting_1428044	chr20_41042048_+	SINE	Alu	AluSz6
CAediting_1428045	chr20_41042050_+	SINE	Alu	AluSz6
CAediting_1428046	chr20_41042059_+	SINE	Alu	AluSz6
CAediting_1428047	chr20_41042062_+	SINE	Alu	AluSz6
CAediting_1428048	chr20_41042067_+	SINE	Alu	AluSz6
CAediting_1428049	chr20_41042075_+	SINE	Alu	AluSz6
CAediting_1428050	chr20_41042076_+	SINE	Alu	AluSz6
CAediting_1428051	chr20_41042084_+	SINE	Alu	AluSz6
CAediting_1428052	chr20_41042090_+	SINE	Alu	AluSz6
CAediting_1428053	chr20_41042130_+	SINE	Alu	AluSz6
CAediting_1428054	chr20_41042144_+	SINE	Alu	AluSz6
CAediting_1428055	chr20_41042145_+	SINE	Alu	AluSz6
CAediting_1428056	chr20_41042162_+	SINE	Alu	AluSz6
CAediting_1428057	chr20_41044022_+	SINE	Alu	AluSp
CAediting_1428058	chr20_41044091_+	SINE	Alu	AluSp
CAediting_1428059	chr20_41044129_+	SINE	Alu	AluSp
CAediting_1428060	chr20_41044149_+	SINE	Alu	AluSp
CAediting_1428061	chr20_41044155_+	SINE	Alu	AluSp
CAediting_1428062	chr20_41044156_+	SINE	Alu	AluSp
CAediting_1428063	chr20_41044225_+	SINE	Alu	AluSp
CAediting_1428064	chr20_41044226_+	SINE	Alu	AluSp
CAediting_1428065	chr20_41044231_+	SINE	Alu	AluSp
CAediting_1428066	chr20_41044834_+	SINE	Alu	AluSz6
CAediting_1428067	chr20_41044860_+	SINE	Alu	AluSz6
CAediting_1428068	chr20_41044865_+	SINE	Alu	AluSz6
CAediting_1428069	chr20_41044870_+	SINE	Alu	AluSz6
CAediting_1428070	chr20_41044917_+	SINE	Alu	AluSz6
CAediting_1428071	chr20_41044921_+	SINE	Alu	AluSz6
CAediting_1428072	chr20_41044927_+	SINE	Alu	AluSz6
CAediting_1428073	chr20_41044929_+	SINE	Alu	AluSz6
CAediting_1428074	chr20_41044973_+	SINE	Alu	AluSz6
CAediting_1428075	chr20_41045008_+	SINE	Alu	AluSz6
CAediting_1428076	chr20_41045040_+	SINE	Alu	AluSz6
CAediting_1428077	chr20_41045050_+	SINE	Alu	AluSz6
CAediting_1428078	chr20_41045065_+	SINE	Alu	AluSz6
CAediting_1428079	chr20_41056493_+	SINE	Alu	AluJr
CAediting_1428080	chr20_41056504_+	SINE	Alu	AluJr
CAediting_1428081	chr20_41056525_+	SINE	Alu	AluJr
CAediting_1428082	chr20_41056531_+	SINE	Alu	AluJr
CAediting_1428083	chr20_41056549_+	SINE	Alu	AluJr
CAediting_1428084	chr20_41056582_+	SINE	Alu	AluJr
CAediting_1428085	chr20_41056585_+	SINE	Alu	AluJr
CAediting_1428086	chr20_41056594_+	SINE	Alu	AluJr
CAediting_1428087	chr20_41056610_+	SINE	Alu	AluJr
CAediting_1428088	chr20_41056614_+	SINE	Alu	AluJr
CAediting_1428089	chr20_41056620_+	SINE	Alu	AluJr
CAediting_1428090	chr20_41056622_+	SINE	Alu	AluJr
CAediting_1428091	chr20_41056716_+	SINE	Alu	AluJr
CAediting_1428092	chr20_41056717_+	SINE	Alu	AluJr
CAediting_1428093	chr20_41056759_+	SINE	Alu	AluJr
CAediting_1428094	chr20_41057119_+	SINE	Alu	AluSx3
CAediting_1428095	chr20_41057288_+	SINE	Alu	AluSx3
CAediting_1428096	chr20_41068669_+	SINE	Alu	AluJo
CAediting_1428097	chr20_41085991_+	SINE	Alu	AluSx
CAediting_1428098	chr20_41086008_+	SINE	Alu	AluSx
CAediting_1428099	chr20_41086068_+	SINE	Alu	AluSx
CAediting_1428100	chr20_41086087_+	SINE	Alu	AluSx
CAediting_1428101	chr20_41086103_+	SINE	Alu	AluSx
CAediting_1428102	chr20_41086112_+	SINE	Alu	AluSx
CAediting_1428103	chr20_41086116_+	SINE	Alu	AluSx
CAediting_1428104	chr20_41086152_+	SINE	Alu	AluSx
CAediting_1428105	chr20_41086160_+	SINE	Alu	AluSx
CAediting_1428106	chr20_41086184_+	SINE	Alu	AluSx
CAediting_1428107	chr20_41088249_+	SINE	Alu	AluY
CAediting_1428108	chr20_41088274_+	SINE	Alu	AluY
CAediting_1428109	chr20_41088458_+	SINE	Alu	AluY
CAediting_1428110	chr20_41089164_+	SINE	Alu	AluSx1
CAediting_1428111	chr20_41090567_+	SINE	Alu	AluSz6
CAediting_1428112	chr20_41090604_+	SINE	Alu	AluSz6
CAediting_1428113	chr20_41090620_+	SINE	Alu	AluSz6
CAediting_1428114	chr20_41090632_+	SINE	Alu	AluSz6
CAediting_1428115	chr20_41090741_+	SINE	Alu	AluSz6
CAediting_1428116	chr20_41090767_+	SINE	Alu	AluSz6
CAediting_1428117	chr20_41091759_+	SINE	Alu	AluSx4
CAediting_1428118	chr20_41093924_+	SINE	Alu	AluJb
CAediting_1428119	chr20_41093932_+	SINE	Alu	AluJb
CAediting_1428120	chr20_41093954_+	SINE	Alu	AluJb
CAediting_1428121	chr20_41093978_+	SINE	Alu	AluJb
CAediting_1428122	chr20_41093981_+	SINE	Alu	AluJb
CAediting_1428123	chr20_41093985_+	SINE	Alu	AluJb
CAediting_1428124	chr20_41094003_+	SINE	Alu	AluJb
CAediting_1428125	chr20_41095062_+	SINE	Alu	AluSz6
CAediting_1428126	chr20_41095071_+	SINE	Alu	AluSz6
CAediting_1428127	chr20_41095073_+	SINE	Alu	AluSz6
CAediting_1428128	chr20_41095075_+	SINE	Alu	AluSz6
CAediting_1428129	chr20_41095077_+	SINE	Alu	AluSz6
CAediting_1428130	chr20_41095113_+	SINE	Alu	AluSz6
CAediting_1428131	chr20_41095115_+	SINE	Alu	AluSz6
CAediting_1428132	chr20_41095126_+	SINE	Alu	AluSz6
CAediting_1428133	chr20_41095138_+	SINE	Alu	AluSz6
CAediting_1428134	chr20_41095145_+	SINE	Alu	AluSz6
CAediting_1428135	chr20_41095153_+	SINE	Alu	AluSz6
CAediting_1428136	chr20_41095181_+	SINE	Alu	AluSz6
CAediting_1428137	chr20_41095186_+	SINE	Alu	AluSz6
CAediting_1428138	chr20_41095342_+	SINE	Alu	AluSz6
CAediting_1428139	chr20_41096088_+	SINE	Alu	AluSx1
CAediting_1428140	chr20_41096117_+	SINE	Alu	AluSx1
CAediting_1428141	chr20_41096122_+	SINE	Alu	AluSx1
CAediting_1428142	chr20_41096131_+	SINE	Alu	AluSx1
CAediting_1428143	chr20_41096146_+	SINE	Alu	AluSx1
CAediting_1428144	chr20_41096147_+	SINE	Alu	AluSx1
CAediting_1428145	chr20_41096167_+	SINE	Alu	AluSx1
CAediting_1428146	chr20_41096206_+	SINE	Alu	AluSx1
CAediting_1428147	chr20_41096208_+	SINE	Alu	AluSx1

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RNA A-to-I editing events in the alternative splicing sites for TOP1

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000198900.5.TOP1.

Correlation between RNA A-to-I editing and PSI for ENSG00000198900.5.TOP1.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for TOP1

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for TOP1

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for TOP1

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_748296	chr10_51299626_+	ENSG00000198900.5	ENST00000361337	hsa-miR-605-3p	41123370	41123376	7mer-m8	41123357	41123377	154	-23.91
CAediting_688080	chr9_63819626_+	ENSG00000198900.5	ENST00000361337	hsa-miR-4477b	41124401	41124407	7mer-m8	41124387	41124408	156	-13.98
CAediting_1229415	chr17_67471547_+	ENSG00000198900.5	ENST00000361337	hsa-miR-548aa	41123848	41123854	7mer-m8	41123831	41123855	166	-14.85
CAediting_396018	chr5_1062918_-	ENSG00000198900.5	ENST00000361337	hsa-miR-4635	41124402	41124408	7mer-m8	41124389	41124409	149	-15.19

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for TOP1

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for TOP1

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
STAD	CAediting_1428006	chr20_41041216_+	.	.	.	.	0.0220706872090019	0.262314508261009
STAD	CAediting_1428022	chr20_41041299_+	0.0460679467107903	0.27524826818833	.	.	0.0464147522479021	0.274828073906734

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Relation with cancer stages for TOP1

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for TOP1

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for TOP1

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
TOP1	P11387	DB11254	Hexylresorcinol	DNA topoisomerase 1	SmallMoleculeDrug	approved
TOP1	P11387	DB00762	Irinotecan	DNA topoisomerase 1	SmallMoleculeDrug	approved\|investigational
TOP1	P11387	DB01030	Topotecan	DNA topoisomerase 1	SmallMoleculeDrug	approved\|investigational
TOP1	P11387	DB05630	Sodium stibogluconate	DNA topoisomerase 1	SmallMoleculeDrug	approved\|investigational
TOP1	P11387	DB12893	Sacituzumab govitecan	DNA topoisomerase 1	BiotechDrug	approved\|investigational
TOP1	P11387	DB14962	Trastuzumab deruxtecan	DNA topoisomerase 1	BiotechDrug	approved\|investigational

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RelatedDiseases for TOP1

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
TOP1	C0006826	Malignant Neoplasms	1	CTD_human
TOP1	C0013221	Drug toxicity	1	CTD_human
TOP1	C0023903	Liver neoplasms	1	CTD_human
TOP1	C0027651	Neoplasms	1	CTD_human
TOP1	C0041755	Adverse reaction to drug	1	CTD_human
TOP1	C0086692	Benign Neoplasm	1	CTD_human
TOP1	C0235874	Disease Exacerbation	1	CTD_human
TOP1	C0345904	Malignant neoplasm of liver	1	CTD_human

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene