![]() |
||||||
|
![]() | |
![]() | |
![]() | Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples |
![]() | |
![]() | |
![]() | The effects of the RNA editing to the stability of the RNA structures |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Editing gene: TNFAIP3 (CAeditome ID:7128) |
Gene summary for TNFAIP3 |
![]() |
Gene information | Gene symbol | TNFAIP3 | Gene ID | 7128 |
Gene name | TNF alpha induced protein 3 | |
Synonyms | A20|AISBL|OTUD7C|TNFA1P2 | |
Cytomap | 6q23.3 | |
Type of gene | protein-coding | |
Description | tumor necrosis factor alpha-induced protein 3OTU domain-containing protein 7Cputative DNA-binding protein A20tumor necrosis factor inducible protein A20tumor necrosis factor, alpha induced protein 3zinc finger protein A20 | |
Modification date | 20210518 | |
UniProtAcc | P21580 | |
Context | - 31153693(The potential role of TNFAIP3 in malignant transformation of gastric carcinoma) |
![]() |
Gene | GO ID | GO term | PubMed ID |
TNFAIP3 | GO:0004842 | Tumor necrosis factor alpha-induced protein 3 | 15258597 |
TNFAIP3 | GO:0004843 | Tumor necrosis factor alpha-induced protein 3 | 15258597 |
TNFAIP3 | GO:0004843 | Tumor necrosis factor alpha-induced protein 3 | 23827681 |
TNFAIP3 | GO:0043621 | Tumor necrosis factor alpha-induced protein 3 | 15474016 |
TNFAIP3 | GO:0043621 | Tumor necrosis factor alpha-induced protein 3 | 8797804 |
TNFAIP3 | GO:0002237 | Tumor necrosis factor alpha-induced protein 3 | 19912257 |
TNFAIP3 | GO:0031397 | Tumor necrosis factor alpha-induced protein 3 | 20392859 |
TNFAIP3 | GO:0032088 | Tumor necrosis factor alpha-induced protein 3 | 18223652 |
TNFAIP3 | GO:0034140 | Tumor necrosis factor alpha-induced protein 3 | 15474016 |
TNFAIP3 | GO:0035871 | Tumor necrosis factor alpha-induced protein 3 | 23827681 |
TNFAIP3 | GO:0043124 | Tumor necrosis factor alpha-induced protein 3 | 11463333 |
TNFAIP3 | GO:0043124 | Tumor necrosis factor alpha-induced protein 3 | 15258597 |
TNFAIP3 | GO:0043124 | Tumor necrosis factor alpha-induced protein 3 | 21127049 |
TNFAIP3 | GO:0045732 | Tumor necrosis factor alpha-induced protein 3 | 21127049 |
TNFAIP3 | GO:0048662 | Tumor necrosis factor alpha-induced protein 3 | 16816117 |
TNFAIP3 | GO:0070536 | Tumor necrosis factor alpha-induced protein 3 | 15258597 |
TNFAIP3 | GO:0070936 | Tumor necrosis factor alpha-induced protein 3 | 15258597 |
TNFAIP3 | GO:0071108 | Tumor necrosis factor alpha-induced protein 3 | 23827681 |
TNFAIP3 | GO:0071222 | Tumor necrosis factor alpha-induced protein 3 | 19912257 |
TNFAIP3 | GO:0071222 | Tumor necrosis factor alpha-induced protein 3 | 21127049 |
TNFAIP3 | GO:0071222 | Tumor necrosis factor alpha-induced protein 3 | 21220427 |
TNFAIP3 | GO:1902042 | Tumor necrosis factor alpha-induced protein 3 | 12167698 |
TNFAIP3 | GO:2000352 | Tumor necrosis factor alpha-induced protein 3 | 12885753 |
TNFAIP3 | GO:0005634 | Tumor necrosis factor alpha-induced protein 3 | 11463333 |
Top |
RNA A-to-I events for TNFAIP3 |
![]() |
![]() |
![]() |
![]() |
CAediting_505985(137870332, +), CAediting_505986(137870352, +), CAediting_505987(137878692, +), |
Top |
RNA editing positional annotations for TNFAIP3 using Annovar |
![]() |
CAeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
![]() |
CAeditome ID | Position | Variant type |
CAediting_505985 | chr6_137870332_+ | intronic |
CAediting_505986 | chr6_137870352_+ | intronic |
CAediting_505987 | chr6_137878692_+ | exonic |
![]() |
CAeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
CAediting_505985 | chr6_137870332_+ | SINE | Alu | AluJb |
CAediting_505986 | chr6_137870352_+ | SINE | Alu | AluJb |
Top |
RNA A-to-I editing events in the alternative splicing sites for TNFAIP3 |
![]() |
AStype | CAeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
![]() |
![]() |
Top |
Differntial gene expression between RNA A-to-I edited versus non-edited samples for TNFAIP3 |
![]() * The grey color means N/A. |
![]() |
![]() * Click on the image to enlarge it in a new window. |
Top |
Protein coding region RNA A-to-I editings for TNFAIP3 |
![]() * Click on the image to enlarge it in a new window. |
Top |
The effects of the RNA editing to the miRNA binding sites for TNFAIP3 |
**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page. |
![]() |
CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
CAediting_505987 | chr6_137878692_+ | ENSG00000118503.13 | ENST00000615468 | hsa-miR-6885-3p | 137878689 | 137878695 | 7mer-m8 | 137878678 | 137878696 | 141.00 | -6.39 |
![]() |
CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
CAediting_505987 | chr6_137878692_+ | ENSG00000118503.13 | ENST00000615468 | hsa-miR-2052 | 137878686 | 137878693 | 8mer-1a | 137878674 | 137878693 | 145 | -10.66 |
CAediting_505987 | chr6_137878692_+ | ENSG00000118503.13 | ENST00000615468 | hsa-miR-8068 | 137878690 | 137878696 | 7mer-m8 | 137878678 | 137878697 | 149 | -7.72 |
![]() |
CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
![]() |
CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
![]() |
CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
![]() |
CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
![]() |
CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
CAediting_846604 | chr11_93733708_- | ENSG00000118503.13 | ENST00000237289 | hsa-miR-1304-3p | 137881783 | 137881789 | 7mer-m8 | 137881769 | 137881790 | 141 | -15.84 |
CAediting_688081 | chr9_63819627_+ | ENSG00000118503.13 | ENST00000237289 | hsa-miR-4477b | 137883206 | 137883212 | 7mer-m8 | 137883192 | 137883213 | 161 | -20.02 |
CAediting_846604 | chr11_93733708_- | ENSG00000118503.13 | ENST00000615468 | hsa-miR-1304-3p | 137878521 | 137878527 | 7mer-m8 | 137878507 | 137878528 | 145 | -19.1 |
CAediting_846604 | chr11_93733708_- | ENSG00000118503.13 | ENST00000615468 | hsa-miR-1304-3p | 137881783 | 137881789 | 7mer-m8 | 137881769 | 137881790 | 141 | -15.84 |
CAediting_846604 | chr11_93733708_- | ENSG00000118503.13 | ENST00000615468 | hsa-miR-1304-3p | 137881129 | 137881135 | 7mer-m8 | 137881115 | 137881136 | 148 | -19.34 |
CAediting_846604 | chr11_93733708_- | ENSG00000118503.13 | ENST00000620204 | hsa-miR-1304-3p | 137881783 | 137881789 | 7mer-m8 | 137881769 | 137881790 | 141 | -15.84 |
CAediting_846604 | chr11_93733708_- | ENSG00000118503.13 | ENST00000620204 | hsa-miR-1304-3p | 137881129 | 137881135 | 7mer-m8 | 137881115 | 137881136 | 148 | -19.34 |
CAediting_1054808 | chr15_66496985_- | ENSG00000118503.13 | ENST00000237289 | hsa-miR-4512 | 137881634 | 137881640 | 7mer-m8 | 137881620 | 137881641 | 148 | -24.88 |
CAediting_77128 | chr1_85133844_+ | ENSG00000118503.13 | ENST00000237289 | hsa-miR-4423-3p | 137881463 | 137881469 | 7mer-m8 | 137881450 | 137881470 | 159 | -20.72 |
CAediting_580943 | chr7_100356700_+ | ENSG00000118503.13 | ENST00000615468 | hsa-miR-6840-3p | 137878995 | 137879002 | 8mer-1a | 137878980 | 137879002 | 151 | -27.89 |
CAediting_573001 | chr7_92204086_- | ENSG00000118503.13 | ENST00000615468 | hsa-miR-1285-5p | 137878856 | 137878862 | 7mer-m8 | 137878843 | 137878863 | 145 | -17.85 |
CAediting_1054808 | chr15_66496985_- | ENSG00000118503.13 | ENST00000615468 | hsa-miR-4512 | 137881634 | 137881640 | 7mer-m8 | 137881620 | 137881641 | 148 | -24.88 |
CAediting_77128 | chr1_85133844_+ | ENSG00000118503.13 | ENST00000615468 | hsa-miR-4423-3p | 137881463 | 137881469 | 7mer-m8 | 137881450 | 137881470 | 159 | -20.72 |
CAediting_396018 | chr5_1062918_- | ENSG00000118503.13 | ENST00000615468 | hsa-miR-4635 | 137881077 | 137881083 | 7mer-m8 | 137881064 | 137881084 | 145 | -14.16 |
CAediting_1054808 | chr15_66496985_- | ENSG00000118503.13 | ENST00000620204 | hsa-miR-4512 | 137881634 | 137881640 | 7mer-m8 | 137881620 | 137881641 | 148 | -24.88 |
CAediting_77128 | chr1_85133844_+ | ENSG00000118503.13 | ENST00000620204 | hsa-miR-4423-3p | 137881463 | 137881469 | 7mer-m8 | 137881450 | 137881470 | 159 | -20.72 |
CAediting_396018 | chr5_1062918_- | ENSG00000118503.13 | ENST00000620204 | hsa-miR-4635 | 137881077 | 137881083 | 7mer-m8 | 137881064 | 137881084 | 145 | -14.16 |
CAediting_468389 | chr6_31355314_- | ENSG00000118503.13 | ENST00000237289 | hsa-miR-6891-5p | 137881567 | 137881573 | 7mer-m8 | 137881556 | 137881574 | 145 | -22.65 |
CAediting_468389 | chr6_31355314_- | ENSG00000118503.13 | ENST00000615468 | hsa-miR-6891-5p | 137879084 | 137879090 | 7mer-m8 | 137879073 | 137879091 | 140 | -19.54 |
CAediting_468389 | chr6_31355314_- | ENSG00000118503.13 | ENST00000615468 | hsa-miR-6891-5p | 137881567 | 137881573 | 7mer-m8 | 137881556 | 137881574 | 145 | -22.65 |
CAediting_468389 | chr6_31355314_- | ENSG00000118503.13 | ENST00000620204 | hsa-miR-6891-5p | 137881567 | 137881573 | 7mer-m8 | 137881556 | 137881574 | 145 | -22.65 |
![]() |
CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
CAediting_396018 | chr5_1062918_- | ENSG00000118503.13 | ENST00000237289 | hsa-miR-4635 | 137882326 | 137882333 | 8mer-1a | 137882313 | 137882333 | 146 | -12.05 |
CAediting_396018 | chr5_1062918_- | ENSG00000118503.13 | ENST00000237289 | hsa-miR-4635 | 137883242 | 137883248 | 7mer-m8 | 137883231 | 137883249 | 148 | -12.64 |
CAediting_524911 | chr7_5495852_- | ENSG00000118503.13 | ENST00000237289 | hsa-miR-589-3p | 137882582 | 137882588 | 7mer-m8 | 137882566 | 137882589 | 142 | -11.39 |
CAediting_580943 | chr7_100356700_+ | ENSG00000118503.13 | ENST00000237289 | hsa-miR-6840-3p | 137882713 | 137882719 | 7mer-m8 | 137882699 | 137882720 | 155 | -22.14 |
CAediting_468389 | chr6_31355314_- | ENSG00000118503.13 | ENST00000237289 | hsa-miR-6891-5p | 137882539 | 137882545 | 7mer-1a | 137882527 | 137882545 | 145 | -23.38 |
CAediting_468389 | chr6_31355314_- | ENSG00000118503.13 | ENST00000237289 | hsa-miR-6891-5p | 137882610 | 137882616 | 7mer-m8 | 137882598 | 137882617 | 149 | -19.4 |
CAediting_846604 | chr11_93733708_- | ENSG00000118503.13 | ENST00000615468 | hsa-miR-1304-3p | 137878854 | 137878861 | 8mer-1a | 137878841 | 137878861 | 144 | -14.56 |
CAediting_468389 | chr6_31355314_- | ENSG00000118503.13 | ENST00000615468 | hsa-miR-6891-5p | 137879110 | 137879116 | 7mer-m8 | 137879098 | 137879117 | 153 | -21.97 |
CAediting_396018 | chr5_1062918_- | ENSG00000118503.13 | ENST00000615468 | hsa-miR-4635 | 137882326 | 137882333 | 8mer-1a | 137882313 | 137882333 | 146 | -12.05 |
CAediting_524911 | chr7_5495852_- | ENSG00000118503.13 | ENST00000615468 | hsa-miR-589-3p | 137882582 | 137882588 | 7mer-m8 | 137882566 | 137882589 | 142 | -11.39 |
CAediting_580943 | chr7_100356700_+ | ENSG00000118503.13 | ENST00000615468 | hsa-miR-6840-3p | 137882713 | 137882719 | 7mer-m8 | 137882699 | 137882720 | 155 | -22.14 |
CAediting_468389 | chr6_31355314_- | ENSG00000118503.13 | ENST00000615468 | hsa-miR-6891-5p | 137882539 | 137882545 | 7mer-1a | 137882527 | 137882545 | 145 | -23.38 |
CAediting_468389 | chr6_31355314_- | ENSG00000118503.13 | ENST00000615468 | hsa-miR-6891-5p | 137882610 | 137882616 | 7mer-m8 | 137882598 | 137882617 | 149 | -19.4 |
CAediting_396018 | chr5_1062918_- | ENSG00000118503.13 | ENST00000620204 | hsa-miR-4635 | 137882326 | 137882333 | 8mer-1a | 137882313 | 137882333 | 146 | -12.05 |
CAediting_524911 | chr7_5495852_- | ENSG00000118503.13 | ENST00000620204 | hsa-miR-589-3p | 137882582 | 137882588 | 7mer-m8 | 137882566 | 137882589 | 142 | -11.39 |
CAediting_580943 | chr7_100356700_+ | ENSG00000118503.13 | ENST00000620204 | hsa-miR-6840-3p | 137882713 | 137882719 | 7mer-m8 | 137882699 | 137882720 | 155 | -22.14 |
CAediting_468389 | chr6_31355314_- | ENSG00000118503.13 | ENST00000620204 | hsa-miR-6891-5p | 137882539 | 137882545 | 7mer-1a | 137882527 | 137882545 | 145 | -23.38 |
CAediting_468389 | chr6_31355314_- | ENSG00000118503.13 | ENST00000620204 | hsa-miR-6891-5p | 137882610 | 137882616 | 7mer-m8 | 137882598 | 137882617 | 149 | -19.4 |
![]() |
Top |
The effects of the RNA editing to the stability of the RNA structures for TNFAIP3 |
![]() * Click on the image to enlarge it in a new window. |
![]() |
CAeditom_ID | ENST | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
CAediting_505987 | ENST00000237289.7 | chr6_137878692_+ | -1422.30 | -1421.30 | -1422.30 |
CAediting_505987 | ENST00000612899.3 | chr6_137878692_+ | -1563.20 | -1563.20 | -1563.20 |
CAediting_505987 | ENST00000614035.3 | chr6_137878692_+ | -443.10 | -443.10 | -443.10 |
CAediting_505987 | ENST00000615468.3 | chr6_137878692_+ | -1271.10 | -1270.20 | -1271.10 |
CAediting_505987 | ENST00000619035.3 | chr6_137878692_+ | -744.80 | -744.80 | -744.80 |
CAediting_505987 | ENST00000620204.3 | chr6_137878692_+ | -1271.90 | -1270.70 | -1271.90 |
CAediting_505987 | ENST00000621150.2 | chr6_137878692_+ | -506.70 | -506.70 | -506.70 |
Top |
Relation with ADAR for TNFAIP3 |
![]() |
Cancer | CAeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
Top |
Relation with cancer stages for TNFAIP3 |
![]() |
Cancer | Stage_type | CAeditomID | position | P-val | Coeff. |
Top |
Relation with survival for TNFAIP3 |
![]() |
Cancer | CAeditomID | position | KMpvalue | Coxpvalue | CoxHR |
Top |
RelatedDrugs for TNFAIP3 |
![]() (DrugBank Version 5.1.8 2021-01-03) |
Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for TNFAIP3 |
![]() (DisGeNet 7.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |
TNFAIP3 | C0024141 | Lupus Erythematosus, Systemic | 9 | CTD_human;ORPHANET |
TNFAIP3 | C0003873 | Rheumatoid Arthritis | 5 | CTD_human |
TNFAIP3 | C0242380 | Libman-Sacks Disease | 4 | CTD_human |
TNFAIP3 | C4225218 | AUTOINFLAMMATORY SYNDROME, FAMILIAL, BEHCET-LIKE | 3 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
TNFAIP3 | C0030246 | Pustulosis of Palms and Soles | 2 | CTD_human |
TNFAIP3 | C0033860 | Psoriasis | 2 | CTD_human |
TNFAIP3 | C0086981 | Sicca Syndrome | 2 | CTD_human |
TNFAIP3 | C1527336 | Sjogren's Syndrome | 2 | CTD_human |
TNFAIP3 | C0004364 | Autoimmune Diseases | 1 | CTD_human |
TNFAIP3 | C0007621 | Neoplastic Cell Transformation | 1 | CTD_human |
TNFAIP3 | C0021368 | Inflammation | 1 | CTD_human |
TNFAIP3 | C0024301 | Lymphoma, Follicular | 1 | CTD_human |
TNFAIP3 | C0026769 | Multiple Sclerosis | 1 | CTD_human |
TNFAIP3 | C0079745 | Lymphoma, Large-Cell, Follicular | 1 | CTD_human |
TNFAIP3 | C0079758 | Lymphoma, Mixed-Cell, Follicular | 1 | CTD_human |
TNFAIP3 | C0079765 | Lymphoma, Small Cleaved-Cell, Follicular | 1 | CTD_human |
TNFAIP3 | C0079773 | Lymphoma, T-Cell, Cutaneous | 1 | CTD_human |
TNFAIP3 | C0376407 | Granulomatous Slack Skin | 1 | CTD_human |
TNFAIP3 | C0751324 | Multiple Sclerosis, Acute Fulminating | 1 | CTD_human |
TNFAIP3 | C0751422 | Hereditary Autoinflammatory Diseases | 1 | CTD_human |
TNFAIP3 | C1328840 | Autoimmune Lymphoproliferative Syndrome | 1 | GENOMICS_ENGLAND |
TNFAIP3 | C1956130 | Lymphoma, Follicular, Grade 1 | 1 | CTD_human |
TNFAIP3 | C1956131 | Lymphoma, Follicular, Grade 3 | 1 | CTD_human |
TNFAIP3 | C1956132 | Lymphoma, Follicular, Grade 2 | 1 | CTD_human |
TNFAIP3 | C3860213 | Autoinflammatory disorder | 1 | GENOMICS_ENGLAND |