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Editing gene: ACTG1 (CAeditome ID:71)

Gene summary for ACTG1

Gene summary

Gene information	Gene symbol	ACTG1
	Gene ID	71
	Gene name	actin gamma 1
	Synonyms	ACT\|ACTG\|DFNA20\|DFNA26\|HEL-176
	Cytomap	17q25.3
	Type of gene	protein-coding
	Description	actin, cytoplasmic 2cytoskeletal gamma-actinepididymis luminal protein 176
	Modification date	20210518
	UniProtAcc	P63261
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
ACTG1	GO:0005522	Actin, cytoplasmic 2	28493397
ACTG1	GO:0005884	Actin, cytoplasmic 2	28493397
ACTG1	GO:0005911	Actin, cytoplasmic 2	22855531
ACTG1	GO:0043296	Actin, cytoplasmic 2	22855531
ACTG1	GO:0070062	Actin, cytoplasmic 2	21557262

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RNA A-to-I events for ACTG1

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000184009.8

RNA A-to-I editing events in Cancer.

CAediting_1245605(81510432, -), CAediting_1245606(81510558, -), CAediting_1245607(81510587, -), CAediting_1245608(81512085, -),

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RNA editing positional annotations for ACTG1 using Annovar

Protein coding RNA editing(s).

CAeditome ID	Position	Variant type	ENST	NTchange	AAchange	SIFT_score	Polyphen2_HVAR_score	PROVEAN_pred
CAediting_1245608	chr17_81512085_-	nonsynonymous SNV	ENST00000570382.1	c.A181G	p.K61E	.	D	N
CAediting_1245608	chr17_81512085_-	nonsynonymous SNV	ENST00000571691.4	c.A154G	p.K52E	.	D	N
CAediting_1245608	chr17_81512085_-	nonsynonymous SNV	ENST00000571721.4	c.A181G	p.K61E	.	D	N
CAediting_1245608	chr17_81512085_-	nonsynonymous SNV	ENST00000572105.5	c.A181G	p.K61E	.	D	N
CAediting_1245608	chr17_81512085_-	nonsynonymous SNV	ENST00000573283.4	c.A181G	p.K61E	.	D	N
CAediting_1245608	chr17_81512085_-	nonsynonymous SNV	ENST00000575087.4	c.A181G	p.K61E	.	D	N
CAediting_1245608	chr17_81512085_-	nonsynonymous SNV	ENST00000575659.4	c.A181G	p.K61E	.	D	N
CAediting_1245608	chr17_81512085_-	nonsynonymous SNV	ENST00000575842.4	c.A181G	p.K61E	.	D	N
CAediting_1245608	chr17_81512085_-	nonsynonymous SNV	ENST00000575994.4	c.A181G	p.K61E	.	D	N
CAediting_1245608	chr17_81512085_-	nonsynonymous SNV	ENST00000576544.4	c.A181G	p.K61E	.	D	N
CAediting_1245608	chr17_81512085_-	nonsynonymous SNV	ENST00000615544.3	c.A181G	p.K61E	.	D	N

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_1245605	chr17_81510432_-	ncRNA_exonic
CAediting_1245606	chr17_81510558_-	ncRNA_exonic
CAediting_1245607	chr17_81510587_-	ncRNA_exonic
CAediting_1245608	chr17_81512085_-	exonic

Repat-regional RNA editing(s).

CAeditome ID

Position

Repeat family

Repeat sub family

Repeat name

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RNA A-to-I editing events in the alternative splicing sites for ACTG1

RNA A-to-I editing(s) in the alternative splicing sites.

AStype	CAeditomID	Editing position	AS position	AS direction	Exonic location	Wildtype sequence	Wildtype splicing strength	RNA edited sequence	RNA edited splicing strength
IR	CAediting_1245605	chr17_81510432_-	81510424:81510432	5SS	3+0i	ACGTGTGGC	-13.3	GCGTGTGGC	-16.38

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000184009.8.ACTG1.

Correlation between RNA A-to-I editing and PSI for ENSG00000184009.8.ACTG1.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for ACTG1

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for ACTG1

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for ACTG1

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1245605	chr17_81510432_-	ENSG00000184009.8	ENST00000575842	hsa-miR-521	81510429	81510435	7mer-m8	81510428	81510449	140.00	-11.80
CAediting_1245605	chr17_81510432_-	ENSG00000184009.8	ENST00000575842	hsa-miR-521	81510429	81510435	7mer-m8	81510428	81510449	140.00	-11.80
CAediting_1245605	chr17_81510432_-	ENSG00000184009.8	ENST00000575087	hsa-miR-521	81510429	81510435	7mer-m8	81510428	81510449	140.00	-11.80
CAediting_1245605	chr17_81510432_-	ENSG00000184009.8	ENST00000575087	hsa-miR-521	81510429	81510435	7mer-m8	81510428	81510449	140.00	-11.80
CAediting_1245606	chr17_81510558_-	ENSG00000184009.8	ENST00000575842	hsa-miR-7109-3p	81510554	81510560	7mer-m8	81510553	81510574	140.00	-15.44
CAediting_1245606	chr17_81510558_-	ENSG00000184009.8	ENST00000575087	hsa-miR-7109-3p	81510554	81510560	7mer-m8	81510553	81510574	140.00	-15.44
CAediting_1245607	chr17_81510587_-	ENSG00000184009.8	ENST00000575842	hsa-miR-3925-3p	81510587	81510593	7mer-m8	81510586	81510605	152.00	-16.79
CAediting_1245607	chr17_81510587_-	ENSG00000184009.8	ENST00000575842	hsa-miR-508-5p	81510585	81510592	8mer-1a	81510585	81510607	140.00	-16.93
CAediting_1245607	chr17_81510587_-	ENSG00000184009.8	ENST00000575842	hsa-miR-550b-3p	81510583	81510589	7mer-m8	81510582	81510601	145.00	-12.59
CAediting_1245607	chr17_81510587_-	ENSG00000184009.8	ENST00000575842	hsa-miR-550b-3p	81510583	81510589	7mer-m8	81510582	81510601	145.00	-12.59
CAediting_1245607	chr17_81510587_-	ENSG00000184009.8	ENST00000575087	hsa-miR-3925-3p	81510587	81510593	7mer-m8	81510586	81510605	152.00	-16.79
CAediting_1245607	chr17_81510587_-	ENSG00000184009.8	ENST00000575087	hsa-miR-508-5p	81510585	81510592	8mer-1a	81510585	81510607	140.00	-16.93
CAediting_1245607	chr17_81510587_-	ENSG00000184009.8	ENST00000575087	hsa-miR-550b-3p	81510583	81510589	7mer-m8	81510582	81510601	145.00	-12.59
CAediting_1245607	chr17_81510587_-	ENSG00000184009.8	ENST00000575087	hsa-miR-550b-3p	81510583	81510589	7mer-m8	81510582	81510601	145.00	-12.59

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_980496	chr14_31014685_-	ENSG00000184009.8	ENST00000575842	hsa-miR-624-3p	81510458	81510465	8mer-1a	81510458	81510480	158	-21.39
CAediting_980496	chr14_31014685_-	ENSG00000184009.8	ENST00000575087	hsa-miR-624-3p	81510458	81510465	8mer-1a	81510458	81510480	158	-21.39
CAediting_1054808	chr15_66496985_-	ENSG00000184009.8	ENST00000575842	hsa-miR-4512	81510018	81510025	8mer-1a	81510018	81510039	152	-20.1
CAediting_1054808	chr15_66496985_-	ENSG00000184009.8	ENST00000575087	hsa-miR-4512	81510018	81510025	8mer-1a	81510018	81510039	152	-20.1

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_524911	chr7_5495852_-	ENSG00000184009.8	ENST00000575842	hsa-miR-589-3p	81510300	81510306	7mer-m8	81510299	81510323	141	-17.55
CAediting_980496	chr14_31014685_-	ENSG00000184009.8	ENST00000575842	hsa-miR-624-3p	81510501	81510508	8mer-1a	81510501	81510525	145	-10.16
CAediting_524911	chr7_5495852_-	ENSG00000184009.8	ENST00000575087	hsa-miR-589-3p	81510300	81510306	7mer-m8	81510299	81510323	141	-17.55
CAediting_980496	chr14_31014685_-	ENSG00000184009.8	ENST00000575087	hsa-miR-624-3p	81510501	81510508	8mer-1a	81510501	81510525	145	-10.16

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for ACTG1

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for ACTG1

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for ACTG1

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for ACTG1

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for ACTG1

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
ACTG1	P63261	DB09130	Copper	Actin, cytoplasmic 2	SmallMoleculeDrug	approved\|investigational

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RelatedDiseases for ACTG1

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
ACTG1	C3711374	Nonsyndromic Deafness	18	CLINGEN
ACTG1	C1858172	Deafness, Autosomal Dominant 20	8	CTD_human;GENOMICS_ENGLAND;UNIPROT
ACTG1	C3281235	BARAITSER-WINTER SYNDROME 2	4	CLINGEN;CTD_human;GENOMICS_ENGLAND;UNIPROT
ACTG1	C0001787	Osteoporosis, Age-Related	1	CTD_human
ACTG1	C0005745	Blepharoptosis	1	GENOMICS_ENGLAND
ACTG1	C0007097	Carcinoma	1	CTD_human
ACTG1	C0007621	Neoplastic Cell Transformation	1	CTD_human
ACTG1	C0009363	Congenital ocular coloboma (disorder)	1	CTD_human
ACTG1	C0014544	Epilepsy	1	GENOMICS_ENGLAND
ACTG1	C0024433	Macrostomia	1	GENOMICS_ENGLAND
ACTG1	C0024667	Animal Mammary Neoplasms	1	CTD_human
ACTG1	C0024668	Mammary Neoplasms, Experimental	1	CTD_human
ACTG1	C0029456	Osteoporosis	1	CTD_human
ACTG1	C0029459	Osteoporosis, Senile	1	CTD_human
ACTG1	C0033377	Ptosis	1	GENOMICS_ENGLAND
ACTG1	C0205696	Anaplastic carcinoma	1	CTD_human
ACTG1	C0205697	Carcinoma, Spindle-Cell	1	CTD_human
ACTG1	C0205698	Undifferentiated carcinoma	1	CTD_human
ACTG1	C0205699	Carcinomatosis	1	CTD_human
ACTG1	C0240583	Short upturned nose	1	GENOMICS_ENGLAND
ACTG1	C0265541	Cranioschisis	1	CTD_human
ACTG1	C0266551	Congenital coloboma of iris	1	ORPHANET
ACTG1	C0376634	Craniofacial Abnormalities	1	CTD_human
ACTG1	C0497552	Congenital neurologic anomalies	1	CTD_human
ACTG1	C0751406	Post-Traumatic Osteoporosis	1	CTD_human
ACTG1	C0857379	Abnormality of the pinna	1	GENOMICS_ENGLAND
ACTG1	C0948089	Acute Coronary Syndrome	1	CTD_human
ACTG1	C1257925	Mammary Carcinoma, Animal	1	CTD_human
ACTG1	C1384666	hearing impairment	1	GENOMICS_ENGLAND
ACTG1	C1843156	Progressive sensorineural hearing impairment	1	GENOMICS_ENGLAND
ACTG1	C1844505	Pointed chin	1	GENOMICS_ENGLAND
ACTG1	C1849340	Long palpebral fissure	1	GENOMICS_ENGLAND
ACTG1	C1855722	Iris Coloboma with Ptosis, Hypertelorism, and Mental Retardation	1	ORPHANET
ACTG1	C1865014	Long philtrum	1	GENOMICS_ENGLAND
ACTG1	C1865017	Thin upper lip vermilion	1	GENOMICS_ENGLAND
ACTG1	C1868571	Highly arched eyebrow	1	GENOMICS_ENGLAND
ACTG1	C1970280	Hearing loss begins with loss of high frequencies	1	GENOMICS_ENGLAND
ACTG1	C1970281	Audiogram shows sloping configuration	1	GENOMICS_ENGLAND
ACTG1	C1970282	Deafness, profound, by 6th decade	1	GENOMICS_ENGLAND
ACTG1	C3279369	Microphthalmia (in some patients)	1	GENOMICS_ENGLAND
ACTG1	C3549665	Deafness (in some patients)	1	GENOMICS_ENGLAND
ACTG1	C3808883	Short neck (in some patients)	1	GENOMICS_ENGLAND
ACTG1	C4012410	Enlarged ventricles (in some patients)	1	GENOMICS_ENGLAND
ACTG1	C4229649	Heart defect (in some patients)	1	GENOMICS_ENGLAND
ACTG1	C4229650	Pterygium colli (in some patients)	1	GENOMICS_ENGLAND
ACTG1	C4229651	Hypertelorism/telecanthus	1	GENOMICS_ENGLAND
ACTG1	C4229652	Eye coloboma (in some patients)	1	GENOMICS_ENGLAND
ACTG1	C4229653	Trigonocephaly/metopic ridge	1	GENOMICS_ENGLAND
ACTG1	C4231117	Pectus (in some patients)	1	GENOMICS_ENGLAND
ACTG1	C4231118	Kyphosis/scoliosis (in some patients)	1	GENOMICS_ENGLAND
ACTG1	C4231120	Prominent nasal root on profile	1	GENOMICS_ENGLAND
ACTG1	C4231121	Large, squared nose tip	1	GENOMICS_ENGLAND
ACTG1	C4231123	Retrognathia (in some patients)	1	GENOMICS_ENGLAND
ACTG1	C4231124	Prominent/full/wide cheeks	1	GENOMICS_ENGLAND
ACTG1	C4554007	Uveoretinal Coloboma	1	CTD_human
ACTG1	C4708599	Coloboma of choroid and retina	1	ORPHANET

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene