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![]() | Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples |
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![]() | The effects of the RNA editing to the stability of the RNA structures |
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Editing gene: TLR2 (CAeditome ID:7097) |
Gene summary for TLR2 |
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Gene information | Gene symbol | TLR2 | Gene ID | 7097 |
Gene name | toll like receptor 2 | |
Synonyms | CD282|TIL4 | |
Cytomap | 4q31.3 | |
Type of gene | protein-coding | |
Description | toll-like receptor 2toll/interleukin-1 receptor-like protein 4 | |
Modification date | 20210531 | |
UniProtAcc | O60603 | |
Context |
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Gene | GO ID | GO term | PubMed ID |
TLR2 | GO:0042495 | Toll-like receptor 2 | 19931471 |
TLR2 | GO:0042496 | Toll-like receptor 2 | 19931471 |
TLR2 | GO:0051092 | Toll-like receptor 2 | 12594207 |
TLR2 | GO:0071223 | Toll-like receptor 2 | 12594207 |
TLR2 | GO:0071726 | Toll-like receptor 2 | 19931471 |
TLR2 | GO:0071727 | Toll-like receptor 2 | 19931471 |
TLR2 | GO:0001530 | Toll-like receptor 2 | 11274165 |
TLR2 | GO:0001540 | Toll-like receptor 2 | 22198949 |
TLR2 | GO:0038187 | Toll-like receptor 2 | 10384090 |
TLR2 | GO:0042497 | Toll-like receptor 2 | 17889651 |
TLR2 | GO:0042834 | Toll-like receptor 2 | 11986301 |
TLR2 | GO:0001775 | Toll-like receptor 2 | 15294986 |
TLR2 | GO:0007252 | Toll-like receptor 2 | 19740627 |
TLR2 | GO:0032722 | Toll-like receptor 2 | 19740627 |
TLR2 | GO:0032755 | Toll-like receptor 2 | 19740627 |
TLR2 | GO:0032757 | Toll-like receptor 2 | 17128265 |
TLR2 | GO:0032757 | Toll-like receptor 2 | 19740627 |
TLR2 | GO:0034123 | Toll-like receptor 2 | 17128265 |
TLR2 | GO:0050830 | Toll-like receptor 2 | 11521063 |
TLR2 | GO:0051092 | Toll-like receptor 2 | 21618349 |
TLR2 | GO:0071346 | Toll-like receptor 2 | 11672593 |
TLR2 | GO:0071726 | Toll-like receptor 2 | 16880211 |
TLR2 | GO:0071727 | Toll-like receptor 2 | 16880211 |
TLR2 | GO:1901224 | Toll-like receptor 2 | 19740627 |
TLR2 | GO:1903974 | Toll-like receptor 2 | 11672593 |
TLR2 | GO:0005737 | Toll-like receptor 2 | 19740627 |
TLR2 | GO:0005794 | Toll-like receptor 2 | 16880211 |
TLR2 | GO:0005886 | Toll-like receptor 2 | 19740627 |
TLR2 | GO:0009986 | Toll-like receptor 2 | 12443841 |
TLR2 | GO:0031226 | Toll-like receptor 2 | 11274165 |
TLR2 | GO:0045121 | Toll-like receptor 2 | 16880211 |
TLR2 | GO:0005887 | Toll-like receptor 2 | 19509287 |
TLR2 | GO:0035354 | Toll-like receptor 2 | 17889651 |
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RNA A-to-I events for TLR2 |
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CAediting_390397(153702627, +), |
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RNA editing positional annotations for TLR2 using Annovar |
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CAeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
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CAeditome ID | Position | Variant type |
CAediting_390397 | chr4_153702627_+ | UTR5 |
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CAeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
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RNA A-to-I editing events in the alternative splicing sites for TLR2 |
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AStype | CAeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for TLR2 |
![]() * The grey color means N/A. |
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Protein coding region RNA A-to-I editings for TLR2 |
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The effects of the RNA editing to the miRNA binding sites for TLR2 |
**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page. |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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The effects of the RNA editing to the stability of the RNA structures for TLR2 |
![]() * Click on the image to enlarge it in a new window. |
ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
ENST00000260010.6 | protein_coding | ![]() | ![]() |
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CAeditom_ID | ENST | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
CAediting_390397 | ENST00000260010.6 | chr4_153702627_+ | -1138.80 | -1138.70 | -1138.80 |
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Relation with ADAR for TLR2 |
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Cancer | CAeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
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Relation with cancer stages for TLR2 |
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Cancer | Stage_type | CAeditomID | position | P-val | Coeff. |
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Relation with survival for TLR2 |
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Cancer | CAeditomID | position | KMpvalue | Coxpvalue | CoxHR |
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RelatedDrugs for TLR2 |
![]() (DrugBank Version 5.1.8 2021-01-03) |
Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
TLR2 | O60603 | DB00210 | Adapalene | Toll-like receptor 2 | SmallMoleculeDrug | approved |
TLR2 | O60603 | DB11601 | Tuberculin purified protein derivative | Toll-like receptor 2 | BiotechDrug | approved |
TLR2 | O60603 | DB00045 | Lyme disease vaccine (recombinant OspA) | Toll-like receptor 2 | BiotechDrug | approved|withdrawn |
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RelatedDiseases for TLR2 |
![]() (DisGeNet 7.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |
TLR2 | C0009402 | Colorectal Carcinoma | 2 | CTD_human |
TLR2 | C0009404 | Colorectal Neoplasms | 2 | CTD_human |
TLR2 | C0036341 | Schizophrenia | 2 | PSYGENET |
TLR2 | C0003873 | Rheumatoid Arthritis | 1 | CTD_human |
TLR2 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
TLR2 | C0008370 | Cholestasis | 1 | CTD_human |
TLR2 | C0013221 | Drug toxicity | 1 | CTD_human |
TLR2 | C0014457 | Eosinophilia | 1 | CTD_human |
TLR2 | C0014458 | Eosinophilia, Tropical | 1 | CTD_human |
TLR2 | C0015404 | Eye Infections, Bacterial | 1 | CTD_human |
TLR2 | C0018801 | Heart failure | 1 | CTD_human |
TLR2 | C0018802 | Congestive heart failure | 1 | CTD_human |
TLR2 | C0021368 | Inflammation | 1 | CTD_human |
TLR2 | C0022568 | Keratitis | 1 | CTD_human |
TLR2 | C0022660 | Kidney Failure, Acute | 1 | CTD_human |
TLR2 | C0023212 | Left-Sided Heart Failure | 1 | CTD_human |
TLR2 | C0033141 | Cardiomyopathies, Primary | 1 | CTD_human |
TLR2 | C0035126 | Reperfusion Injury | 1 | CTD_human |
TLR2 | C0036529 | Myocardial Diseases, Secondary | 1 | CTD_human |
TLR2 | C0038160 | Staphylococcal Infections | 1 | CTD_human |
TLR2 | C0041755 | Adverse reaction to drug | 1 | CTD_human |
TLR2 | C0085762 | Alcohol abuse | 1 | PSYGENET |
TLR2 | C0235527 | Heart Failure, Right-Sided | 1 | CTD_human |
TLR2 | C0876994 | Cardiotoxicity | 1 | CTD_human |
TLR2 | C0878544 | Cardiomyopathies | 1 | CTD_human |
TLR2 | C1318973 | Staphylococcus aureus infection | 1 | CTD_human |
TLR2 | C1565662 | Acute Kidney Insufficiency | 1 | CTD_human |
TLR2 | C1959583 | Myocardial Failure | 1 | CTD_human |
TLR2 | C1961112 | Heart Decompensation | 1 | CTD_human |
TLR2 | C2609414 | Acute kidney injury | 1 | CTD_human |
TLR2 | C2713368 | Hematopoetic Myelodysplasia | 1 | CTD_human |
TLR2 | C3463824 | MYELODYSPLASTIC SYNDROME | 1 | CTD_human |