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![]() | Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples |
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![]() | The effects of the RNA editing to the stability of the RNA structures |
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Editing gene: THBS1 (CAeditome ID:7057) |
Gene summary for THBS1 |
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Gene information | Gene symbol | THBS1 | Gene ID | 7057 |
Gene name | thrombospondin 1 | |
Synonyms | THBS|THBS-1|TSP|TSP-1|TSP1 | |
Cytomap | 15q14 | |
Type of gene | protein-coding | |
Description | thrombospondin-1glycoprotein Gthrombospondin-1p180thrombospondin-p50 | |
Modification date | 20210531 | |
UniProtAcc | P07996 | |
Context | - 32052380(THBS1 facilitates colorectal liver metastasis through enhancing epithelial-mesenchymal transition) |
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Gene | GO ID | GO term | PubMed ID |
THBS1 | GO:0001937 | Thrombospondin-1 | 16150726 |
THBS1 | GO:0001953 | Thrombospondin-1 | 16150726 |
THBS1 | GO:0010751 | Thrombospondin-1 | 16150726 |
THBS1 | GO:0016525 | Thrombospondin-1 | 16150726 |
THBS1 | GO:2001027 | Thrombospondin-1 | 16150726 |
THBS1 | GO:0001786 | Thrombospondin-1 | 18940719 |
THBS1 | GO:0001968 | Thrombospondin-1 | 6693501 |
THBS1 | GO:0008201 | Thrombospondin-1 | 101549 |
THBS1 | GO:0008201 | Thrombospondin-1 | 8288588 |
THBS1 | GO:0017134 | Thrombospondin-1 | 17996481 |
THBS1 | GO:0030169 | Thrombospondin-1 | 6693501 |
THBS1 | GO:0043236 | Thrombospondin-1 | 6693501 |
THBS1 | GO:0070051 | Thrombospondin-1 | 6693501 |
THBS1 | GO:0070052 | Thrombospondin-1 | 6693501 |
THBS1 | GO:0001937 | Thrombospondin-1 | 17996481 |
THBS1 | GO:0001953 | Thrombospondin-1 | 17416590 |
THBS1 | GO:0002581 | Thrombospondin-1 | 16882710 |
THBS1 | GO:0002605 | Thrombospondin-1 | 16882710 |
THBS1 | GO:0006954 | Thrombospondin-1 | 23144964 |
THBS1 | GO:0008284 | Thrombospondin-1 | 24615654 |
THBS1 | GO:0009749 | Thrombospondin-1 | 18096704 |
THBS1 | GO:0010595 | Thrombospondin-1 | 18555217 |
THBS1 | GO:0010596 | Thrombospondin-1 | 18555217 |
THBS1 | GO:0010748 | Thrombospondin-1 | 17416590 |
THBS1 | GO:0010751 | Thrombospondin-1 | 17416590 |
THBS1 | GO:0010754 | Thrombospondin-1 | 17416590 |
THBS1 | GO:0010757 | Thrombospondin-1 | 6438154 |
THBS1 | GO:0010763 | Thrombospondin-1 | 18555217 |
THBS1 | GO:0016477 | Thrombospondin-1 | 18555217 |
THBS1 | GO:0016525 | Thrombospondin-1 | 17596205 |
THBS1 | GO:0016525 | Thrombospondin-1 | 17996481 |
THBS1 | GO:0016525 | Thrombospondin-1 | 18726995 |
THBS1 | GO:0018149 | Thrombospondin-1 | 3997886 |
THBS1 | GO:0030194 | Thrombospondin-1 | 3997886 |
THBS1 | GO:0030335 | Thrombospondin-1 | 15700281 |
THBS1 | GO:0030511 | Thrombospondin-1 | 18555217 |
THBS1 | GO:0032026 | Thrombospondin-1 | 6777381 |
THBS1 | GO:0032695 | Thrombospondin-1 | 16882710 |
THBS1 | GO:0032760 | Thrombospondin-1 | 18726995 |
THBS1 | GO:0040037 | Thrombospondin-1 | 17996481 |
THBS1 | GO:0043032 | Thrombospondin-1 | 18757424 |
THBS1 | GO:0043066 | Thrombospondin-1 | 18653767 |
THBS1 | GO:0043154 | Thrombospondin-1 | 18653767 |
THBS1 | GO:0043536 | Thrombospondin-1 | 18555217 |
THBS1 | GO:0043537 | Thrombospondin-1 | 18555217 |
THBS1 | GO:0043652 | Thrombospondin-1 | 16882710 |
THBS1 | GO:0045727 | Thrombospondin-1 | 15700281 |
THBS1 | GO:0048661 | Thrombospondin-1 | 24615654 |
THBS1 | GO:0050921 | Thrombospondin-1 | 18555217 |
THBS1 | GO:0051592 | Thrombospondin-1 | 18757424 |
THBS1 | GO:0051592 | Thrombospondin-1 | 6777381 |
THBS1 | GO:0051726 | Thrombospondin-1 | 17596205 |
THBS1 | GO:0051897 | Thrombospondin-1 | 18653767 |
THBS1 | GO:0051918 | Thrombospondin-1 | 6438154 |
THBS1 | GO:1902043 | Thrombospondin-1 | 18726995 |
THBS1 | GO:2000353 | Thrombospondin-1 | 18726995 |
THBS1 | GO:2000379 | Thrombospondin-1 | 18757424 |
THBS1 | GO:0005615 | Thrombospondin-1 | 26395742 |
THBS1 | GO:0005615 | Thrombospondin-1 | 6777381 |
THBS1 | GO:0009897 | Thrombospondin-1 | 6777381 |
THBS1 | GO:0009986 | Thrombospondin-1 | 2435757 |
THBS1 | GO:0009986 | Thrombospondin-1 | 3084490 |
THBS1 | GO:0009986 | Thrombospondin-1 | 6777381 |
THBS1 | GO:0030141 | Thrombospondin-1 | 101549 |
THBS1 | GO:0031012 | Thrombospondin-1 | 6341993 |
THBS1 | GO:0031091 | Thrombospondin-1 | 6777381 |
THBS1 | GO:0005577 | Thrombospondin-1 | 3997886 |
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RNA A-to-I events for THBS1 |
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CAediting_1027900(39586634, +), CAediting_1027901(39592694, +), CAediting_1027902(39593150, +), CAediting_1027903(39593177, +), CAediting_1027904(39593186, +), CAediting_1027905(39593187, +), CAediting_1027906(39596746, +), |
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RNA editing positional annotations for THBS1 using Annovar |
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CAeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
CAediting_1027901 | chr15_39592694_+ | nonsynonymous SNV | ENST00000260356.5 | c.A2659G | p.K887E | T | D | N |
CAediting_1027903 | chr15_39593177_+ | nonsynonymous SNV | ENST00000260356.5 | c.A2945G | p.Q982R | T | D | N |
CAediting_1027904 | chr15_39593186_+ | nonsynonymous SNV | ENST00000260356.5 | c.A2954G | p.E985G | D | D | D |
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CAeditome ID | Position | Variant type |
CAediting_1027900 | chr15_39586634_+ | ncRNA_exonic |
CAediting_1027901 | chr15_39592694_+ | exonic |
CAediting_1027902 | chr15_39593150_+ | exonic |
CAediting_1027903 | chr15_39593177_+ | exonic |
CAediting_1027904 | chr15_39593186_+ | exonic |
CAediting_1027905 | chr15_39593187_+ | exonic |
CAediting_1027906 | chr15_39596746_+ | UTR3 |
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CAeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
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RNA A-to-I editing events in the alternative splicing sites for THBS1 |
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AStype | CAeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
IR | CAediting_1027903 | chr15_39593177_+ | 39593177:39593185 | 5SS | 3+0i | AGGGTAAAG | 5.2 | GGGGTAAAG | 3.53 |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for THBS1 |
![]() * The grey color means N/A. |
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Protein coding region RNA A-to-I editings for THBS1 |
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The effects of the RNA editing to the miRNA binding sites for THBS1 |
**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page. |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
CAediting_1027906 | chr15_39596746_+ | ENSG00000137801.10 | ENST00000260356 | hsa-miR-6844 | 39596743 | 39596749 | 7mer-1a | 39596728 | 39596749 | 141 | -11.73 |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
CAediting_393 | chr1_1167164_+ | ENSG00000137801.10 | ENST00000260356 | hsa-miR-200b-3p | 39595555 | 39595561 | 7mer-m8 | 39595539 | 39595562 | 150 | -12.16 |
CAediting_688081 | chr9_63819627_+ | ENSG00000137801.10 | ENST00000260356 | hsa-miR-4477b | 39597718 | 39597724 | 7mer-m8 | 39597703 | 39597725 | 154 | -9.85 |
CAediting_1229413 | chr17_67471544_+ | ENSG00000137801.10 | ENST00000260356 | hsa-miR-548aa | 39595609 | 39595615 | 7mer-m8 | 39595589 | 39595616 | 155 | -13.61 |
CAediting_1229415 | chr17_67471547_+ | ENSG00000137801.10 | ENST00000260356 | hsa-miR-548aa | 39597498 | 39597505 | 8mer-1a | 39597481 | 39597505 | 140 | -7.17 |
CAediting_1229415 | chr17_67471547_+ | ENSG00000137801.10 | ENST00000260356 | hsa-miR-548aa | 39598220 | 39598226 | 7mer-m8 | 39598200 | 39598227 | 149 | -15.94 |
CAediting_77128 | chr1_85133844_+ | ENSG00000137801.10 | ENST00000260356 | hsa-miR-4423-3p | 39595652 | 39595658 | 7mer-m8 | 39595639 | 39595659 | 145 | -20.66 |
CAediting_228905 | chr2_188297554_+ | ENSG00000137801.10 | ENST00000260356 | hsa-miR-561-3p | 39597004 | 39597010 | 7mer-m8 | 39596990 | 39597011 | 145 | -12.72 |
CAediting_396018 | chr5_1062918_- | ENSG00000137801.10 | ENST00000260356 | hsa-miR-4635 | 39595523 | 39595530 | 8mer-1a | 39595511 | 39595530 | 153 | -22.26 |
CAediting_524911 | chr7_5495852_- | ENSG00000137801.10 | ENST00000260356 | hsa-miR-589-3p | 39596636 | 39596642 | 7mer-m8 | 39596620 | 39596643 | 140 | -12.08 |
CAediting_524911 | chr7_5495852_- | ENSG00000137801.10 | ENST00000260356 | hsa-miR-589-3p | 39598951 | 39598957 | 7mer-m8 | 39598934 | 39598958 | 150 | -16.02 |
CAediting_468389 | chr6_31355314_- | ENSG00000137801.10 | ENST00000260356 | hsa-miR-6891-5p | 39597972 | 39597978 | 7mer-m8 | 39597961 | 39597979 | 142 | -16.32 |
CAediting_468389 | chr6_31355314_- | ENSG00000137801.10 | ENST00000260356 | hsa-miR-6891-5p | 39598717 | 39598723 | 7mer-m8 | 39598707 | 39598724 | 150 | -22.35 |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
CAediting_573000 | chr7_92204081_- | ENSG00000137801.10 | ENST00000260356 | hsa-miR-1285-5p | 39598260 | 39598267 | 8mer-1a | 39598246 | 39598267 | 149 | -17.7 |
CAediting_393 | chr1_1167164_+ | ENSG00000137801.10 | ENST00000260356 | hsa-miR-200b-3p | 39598860 | 39598867 | 8mer-1a | 39598846 | 39598867 | 140 | -11.85 |
CAediting_688080 | chr9_63819626_+ | ENSG00000137801.10 | ENST00000260356 | hsa-miR-4477b | 39598883 | 39598890 | 8mer-1a | 39598866 | 39598890 | 144 | -7.41 |
CAediting_688081 | chr9_63819627_+ | ENSG00000137801.10 | ENST00000260356 | hsa-miR-4477b | 39598883 | 39598890 | 8mer-1a | 39598866 | 39598890 | 144 | -7.41 |
CAediting_524911 | chr7_5495852_- | ENSG00000137801.10 | ENST00000260356 | hsa-miR-589-3p | 39596525 | 39596531 | 7mer-m8 | 39596509 | 39596532 | 142 | -8.42 |
CAediting_468389 | chr6_31355314_- | ENSG00000137801.10 | ENST00000260356 | hsa-miR-6891-5p | 39595791 | 39595797 | 7mer-m8 | 39595781 | 39595798 | 151 | -26.34 |
CAediting_468389 | chr6_31355314_- | ENSG00000137801.10 | ENST00000260356 | hsa-miR-6891-5p | 39595462 | 39595467 | 6mer | 39595462 | 39595480 | 145 | -23.07 |
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The effects of the RNA editing to the stability of the RNA structures for THBS1 |
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ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
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CAeditom_ID | ENST | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for THBS1 |
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Cancer | CAeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
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Relation with cancer stages for THBS1 |
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Cancer | Stage_type | CAeditomID | position | P-val | Coeff. |
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Relation with survival for THBS1 |
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Cancer | CAeditomID | position | KMpvalue | Coxpvalue | CoxHR |
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RelatedDrugs for THBS1 |
![]() (DrugBank Version 5.1.8 2021-01-03) |
Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for THBS1 |
![]() (DisGeNet 7.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |
THBS1 | C0006142 | Malignant neoplasm of breast | 1 | CTD_human |
THBS1 | C0011875 | Diabetic Angiopathies | 1 | CTD_human |
THBS1 | C0011884 | Diabetic Retinopathy | 1 | CTD_human |
THBS1 | C0016059 | Fibrosis | 1 | CTD_human |
THBS1 | C0023890 | Liver Cirrhosis | 1 | CTD_human |
THBS1 | C0025945 | Microangiopathy, Diabetic | 1 | CTD_human |
THBS1 | C0027707 | Nephritis, Interstitial | 1 | CTD_human |
THBS1 | C0035126 | Reperfusion Injury | 1 | CTD_human |
THBS1 | C0036341 | Schizophrenia | 1 | CTD_human |
THBS1 | C0041349 | Nephritis, Tubulointerstitial | 1 | CTD_human |
THBS1 | C0087031 | Juvenile-Onset Still Disease | 1 | CTD_human |
THBS1 | C0239946 | Fibrosis, Liver | 1 | CTD_human |
THBS1 | C0678222 | Breast Carcinoma | 1 | CTD_human |
THBS1 | C1257931 | Mammary Neoplasms, Human | 1 | CTD_human |
THBS1 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
THBS1 | C1623038 | Cirrhosis | 1 | CTD_human |
THBS1 | C3495559 | Juvenile arthritis | 1 | CTD_human |
THBS1 | C3714758 | Juvenile psoriatic arthritis | 1 | CTD_human |
THBS1 | C4552091 | Polyarthritis, Juvenile, Rheumatoid Factor Negative | 1 | CTD_human |
THBS1 | C4704862 | Polyarthritis, Juvenile, Rheumatoid Factor Positive | 1 | CTD_human |
THBS1 | C4704874 | Mammary Carcinoma, Human | 1 | CTD_human |