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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: TGM2 (CAeditome ID:7052)

Gene summary for TGM2

check button Gene summary
Gene informationGene symbol

TGM2

Gene ID

7052

Gene nametransglutaminase 2
SynonymsG(h)|TG(C)|TGC|hTG2|tTG
Cytomap

20q11.23

Type of geneprotein-coding
Descriptionprotein-glutamine gamma-glutamyltransferase 2C polypeptide, protein-glutamine-gamma-glutamyltransferaseTGase CTGase HTGase IITGase-2erythrocyte transglutaminaseheart G alpha(h)hhG alpha(h)isopeptidase TGM2protein G alpha(h)protein-glutamine dea
Modification date20210518
UniProtAcc

P21980

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
TGM2

GO:0003810

Protein-glutamine gamma-glutamyltransferase 2

12506096

TGM2

GO:0003810

Protein-glutamine gamma-glutamyltransferase 2

23941696

TGM2

GO:0003810

Protein-glutamine gamma-glutamyltransferase 2

7649299

TGM2

GO:0003810

Protein-glutamine gamma-glutamyltransferase 2

9252372

TGM2

GO:0005509

Protein-glutamine gamma-glutamyltransferase 2

23941696

TGM2

GO:0005525

Protein-glutamine gamma-glutamyltransferase 2

7649299

TGM2

GO:0050568

Protein-glutamine gamma-glutamyltransferase 2

20547769

TGM2

GO:0050568

Protein-glutamine gamma-glutamyltransferase 2

9623982

TGM2

GO:0120295

Protein-glutamine gamma-glutamyltransferase 2

30867594

TGM2

GO:0120297

Protein-glutamine gamma-glutamyltransferase 2

32273471

TGM2

GO:0120299

Protein-glutamine gamma-glutamyltransferase 2

23797785

TGM2

GO:0018149

Protein-glutamine gamma-glutamyltransferase 2

12506096

TGM2

GO:0018149

Protein-glutamine gamma-glutamyltransferase 2

23941696

TGM2

GO:0018149

Protein-glutamine gamma-glutamyltransferase 2

30458214

TGM2

GO:0018149

Protein-glutamine gamma-glutamyltransferase 2

9252372

TGM2

GO:0018277

Protein-glutamine gamma-glutamyltransferase 2

20547769

TGM2

GO:0018277

Protein-glutamine gamma-glutamyltransferase 2

9623982

TGM2

GO:0042981

Protein-glutamine gamma-glutamyltransferase 2

9252372

TGM2

GO:0043277

Protein-glutamine gamma-glutamyltransferase 2

19628791

TGM2

GO:0050769

Protein-glutamine gamma-glutamyltransferase 2

30867594

TGM2

GO:0071314

Protein-glutamine gamma-glutamyltransferase 2

32273471

TGM2

GO:1903351

Protein-glutamine gamma-glutamyltransferase 2

32273471

TGM2

GO:1904015

Protein-glutamine gamma-glutamyltransferase 2

30867594

TGM2

GO:2000425

Protein-glutamine gamma-glutamyltransferase 2

7935379

TGM2

GO:0000785

Protein-glutamine gamma-glutamyltransferase 2

9575137

TGM2

GO:0005634

Protein-glutamine gamma-glutamyltransferase 2

9575137

TGM2

GO:0005739

Protein-glutamine gamma-glutamyltransferase 2

24349085

TGM2

GO:0005829

Protein-glutamine gamma-glutamyltransferase 2

0000052

TGM2

GO:0005829

Protein-glutamine gamma-glutamyltransferase 2

24349085

TGM2

GO:0005829

Protein-glutamine gamma-glutamyltransferase 2

9575137

TGM2

GO:0005886

Protein-glutamine gamma-glutamyltransferase 2

0000052

TGM2

GO:0031012

Protein-glutamine gamma-glutamyltransferase 2

12506096

TGM2

GO:0031226

Protein-glutamine gamma-glutamyltransferase 2

2578891


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RNA A-to-I events for TGM2

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000198959.10
boxplot

check button RNA A-to-I editing events in Cancer.
CAediting_1427201(38129483, -), CAediting_1427202(38129486, -), CAediting_1427203(38133863, -), CAediting_1427204(38133879, -), CAediting_1427205(38133899, -), CAediting_1427206(38135595, -), CAediting_1427207(38135619, -), CAediting_1427208(38135680, -), CAediting_1427209(38137151, -), CAediting_1427210(38142622, -), CAediting_1427211(38142623, -), CAediting_1427212(38142626, -), CAediting_1427213(38142633, -), CAediting_1427214(38142646, -), CAediting_1427215(38142649, -), CAediting_1427216(38142695, -), CAediting_1427217(38143875, -), CAediting_1427218(38144228, -), CAediting_1427219(38144248, -), CAediting_1427220(38144288, -), CAediting_1427221(38145498, -), CAediting_1427222(38145503, -), CAediting_1427223(38145508, -), CAediting_1427224(38145544, -), CAediting_1427225(38145687, -), CAediting_1427226(38145717, -), CAediting_1427227(38145723, -), CAediting_1427228(38145845, -), CAediting_1427229(38145846, -), CAediting_1427230(38145875, -), CAediting_1427231(38145879, -), CAediting_1427232(38145883, -), CAediting_1427233(38145889, -), CAediting_1427234(38145896, -), CAediting_1427235(38145906, -), CAediting_1427236(38145973, -), CAediting_1427237(38153425, -), CAediting_1427238(38153462, -), CAediting_1427239(38153909, -), CAediting_1427240(38153925, -), CAediting_1427241(38153932, -), CAediting_1427242(38153941, -), CAediting_1427243(38153945, -), CAediting_1427244(38153948, -), CAediting_1427245(38153955, -), CAediting_1427246(38153965, -), CAediting_1427247(38153987, -), CAediting_1427248(38153995, -), CAediting_1427249(38153996, -), CAediting_1427250(38154037, -), CAediting_1427251(38154076, -), CAediting_1427252(38154090, -), CAediting_1427253(38154097, -), CAediting_1427254(38154926, -), CAediting_1427255(38155067, -), CAediting_1427256(38155404, -), CAediting_1427257(38155434, -), CAediting_1427258(38155444, -), CAediting_1427259(38155470, -), CAediting_1427260(38155565, -), CAediting_1427261(38155620, -), CAediting_1427262(38155621, -), CAediting_1427263(38160846, -),

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RNA editing positional annotations for TGM2 using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_1427201chr20_38129483_-ncRNA_exonic
CAediting_1427202chr20_38129486_-ncRNA_exonic
CAediting_1427203chr20_38133863_-intronic
CAediting_1427204chr20_38133879_-intronic
CAediting_1427205chr20_38133899_-intronic
CAediting_1427206chr20_38135595_-intronic
CAediting_1427207chr20_38135619_-intronic
CAediting_1427208chr20_38135680_-intronic
CAediting_1427209chr20_38137151_-intronic
CAediting_1427210chr20_38142622_-ncRNA_intronic
CAediting_1427211chr20_38142623_-ncRNA_intronic
CAediting_1427212chr20_38142626_-ncRNA_intronic
CAediting_1427213chr20_38142633_-ncRNA_intronic
CAediting_1427214chr20_38142646_-ncRNA_intronic
CAediting_1427215chr20_38142649_-ncRNA_intronic
CAediting_1427216chr20_38142695_-ncRNA_intronic
CAediting_1427217chr20_38143875_-ncRNA_intronic
CAediting_1427218chr20_38144228_-ncRNA_intronic
CAediting_1427219chr20_38144248_-ncRNA_intronic
CAediting_1427220chr20_38144288_-ncRNA_intronic
CAediting_1427221chr20_38145498_-ncRNA_exonic
CAediting_1427222chr20_38145503_-ncRNA_exonic
CAediting_1427223chr20_38145508_-ncRNA_exonic
CAediting_1427224chr20_38145544_-ncRNA_exonic
CAediting_1427225chr20_38145687_-ncRNA_exonic
CAediting_1427226chr20_38145717_-ncRNA_exonic
CAediting_1427227chr20_38145723_-ncRNA_exonic
CAediting_1427228chr20_38145845_-ncRNA_exonic
CAediting_1427229chr20_38145846_-ncRNA_exonic
CAediting_1427230chr20_38145875_-ncRNA_exonic
CAediting_1427231chr20_38145879_-ncRNA_exonic
CAediting_1427232chr20_38145883_-ncRNA_exonic
CAediting_1427233chr20_38145889_-ncRNA_exonic
CAediting_1427234chr20_38145896_-ncRNA_exonic
CAediting_1427235chr20_38145906_-ncRNA_exonic
CAediting_1427236chr20_38145973_-ncRNA_exonic
CAediting_1427237chr20_38153425_-ncRNA_intronic
CAediting_1427238chr20_38153462_-ncRNA_intronic
CAediting_1427239chr20_38153909_-ncRNA_intronic
CAediting_1427240chr20_38153925_-ncRNA_intronic
CAediting_1427241chr20_38153932_-ncRNA_intronic
CAediting_1427242chr20_38153941_-ncRNA_intronic
CAediting_1427243chr20_38153945_-ncRNA_intronic
CAediting_1427244chr20_38153948_-ncRNA_intronic
CAediting_1427245chr20_38153955_-ncRNA_intronic
CAediting_1427246chr20_38153965_-ncRNA_intronic
CAediting_1427247chr20_38153987_-ncRNA_intronic
CAediting_1427248chr20_38153995_-ncRNA_intronic
CAediting_1427249chr20_38153996_-ncRNA_intronic
CAediting_1427250chr20_38154037_-ncRNA_intronic
CAediting_1427251chr20_38154076_-ncRNA_intronic
CAediting_1427252chr20_38154090_-ncRNA_intronic
CAediting_1427253chr20_38154097_-ncRNA_intronic
CAediting_1427254chr20_38154926_-ncRNA_intronic
CAediting_1427255chr20_38155067_-ncRNA_intronic
CAediting_1427256chr20_38155404_-ncRNA_intronic
CAediting_1427257chr20_38155434_-ncRNA_intronic
CAediting_1427258chr20_38155444_-ncRNA_intronic
CAediting_1427259chr20_38155470_-ncRNA_intronic
CAediting_1427260chr20_38155565_-ncRNA_intronic
CAediting_1427261chr20_38155620_-ncRNA_intronic
CAediting_1427262chr20_38155621_-ncRNA_intronic
CAediting_1427263chr20_38160846_-ncRNA_intronic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_1427203chr20_38133863_-SINEAluAluJb
CAediting_1427204chr20_38133879_-SINEAluAluJb
CAediting_1427205chr20_38133899_-SINEAluAluJb
CAediting_1427206chr20_38135595_-SINEMIRMIR3
CAediting_1427209chr20_38137151_-DNAhAT-CharlieMER3
CAediting_1427210chr20_38142622_-SINEAluAluSx
CAediting_1427211chr20_38142623_-SINEAluAluSx
CAediting_1427212chr20_38142626_-SINEAluAluSx
CAediting_1427213chr20_38142633_-SINEAluAluSx
CAediting_1427214chr20_38142646_-SINEAluAluSx
CAediting_1427215chr20_38142649_-SINEAluAluSx
CAediting_1427216chr20_38142695_-SINEAluAluSx
CAediting_1427218chr20_38144228_-SINEMIRMIRb
CAediting_1427219chr20_38144248_-SINEMIRMIRb
CAediting_1427220chr20_38144288_-SINEMIRMIRb
CAediting_1427221chr20_38145498_-SINEAluAluJb
CAediting_1427222chr20_38145503_-SINEAluAluJb
CAediting_1427223chr20_38145508_-SINEAluAluJb
CAediting_1427224chr20_38145544_-SINEAluAluJb
CAediting_1427225chr20_38145687_-SINEMIRMIR
CAediting_1427226chr20_38145717_-SINEMIRMIR
CAediting_1427227chr20_38145723_-SINEMIRMIR
CAediting_1427228chr20_38145845_-SINEAluAluJr
CAediting_1427229chr20_38145846_-SINEAluAluJr
CAediting_1427230chr20_38145875_-SINEAluAluJr
CAediting_1427231chr20_38145879_-SINEAluAluJr
CAediting_1427232chr20_38145883_-SINEAluAluJr
CAediting_1427233chr20_38145889_-SINEAluAluJr
CAediting_1427234chr20_38145896_-SINEAluAluJr
CAediting_1427235chr20_38145906_-SINEAluAluJr
CAediting_1427236chr20_38145973_-SINEAluAluJr
CAediting_1427237chr20_38153425_-SINEAluAluSx
CAediting_1427238chr20_38153462_-SINEAluAluSx
CAediting_1427239chr20_38153909_-SINEAluAluJb
CAediting_1427240chr20_38153925_-SINEAluAluJb
CAediting_1427241chr20_38153932_-SINEAluAluJb
CAediting_1427242chr20_38153941_-SINEAluAluJb
CAediting_1427243chr20_38153945_-SINEAluAluJb
CAediting_1427244chr20_38153948_-SINEAluAluJb
CAediting_1427245chr20_38153955_-SINEAluAluJb
CAediting_1427246chr20_38153965_-SINEAluAluJb
CAediting_1427247chr20_38153987_-SINEAluAluJb
CAediting_1427248chr20_38153995_-SINEAluAluJb
CAediting_1427249chr20_38153996_-SINEAluAluJb
CAediting_1427250chr20_38154037_-SINEAluAluJb
CAediting_1427251chr20_38154076_-SINEAluAluJb
CAediting_1427252chr20_38154090_-SINEAluAluJb
CAediting_1427253chr20_38154097_-SINEAluAluJb
CAediting_1427254chr20_38154926_-SINEAluAluSq2
CAediting_1427255chr20_38155067_-SINEAluAluSq2
CAediting_1427256chr20_38155404_-SINEAluAluJr
CAediting_1427257chr20_38155434_-SINEAluAluJr
CAediting_1427258chr20_38155444_-SINEAluAluJr
CAediting_1427259chr20_38155470_-SINEAluAluJr
CAediting_1427260chr20_38155565_-SINEAluAluJr
CAediting_1427261chr20_38155620_-SINEAluAluJr
CAediting_1427262chr20_38155621_-SINEAluAluJr
CAediting_1427263chr20_38160846_-SINEAluAluSp

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RNA A-to-I editing events in the alternative splicing sites for TGM2

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength
IRCAediting_1427201chr20_38129483_-38129475:381294973SS0+6iGCCTCGTGGTTATTAGCAAGGCT-5.59GCCTCGTGGTTATTGGCAAGGCT-1.23
IRCAediting_1427202chr20_38129486_-38129475:381294973SS0+9iGCCTCGTGGTTATTAGCAAGGCT-5.59GCCTCGTGGTTGTTAGCAAGGCT-4.07

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000198959.10.TGM2.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000198959.10.TGM2.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for TGM2

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

check button Correlation between RNA A-to-I editing and gene expression.

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for TGM2

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for TGM2

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for TGM2

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for TGM2

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)

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Relation with cancer stages for TGM2

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.

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Relation with survival for TGM2

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR

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RelatedDrugs for TGM2

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TGM2P21980DB11254HexylresorcinolProtein-glutamine gamma-glutamyltransferase 2 SmallMoleculeDrugapproved

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RelatedDiseases for TGM2

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource
TGM2C0005586Bipolar Disorder2PSYGENET
TGM2C0017636Glioblastoma2CTD_human
TGM2C0036341Schizophrenia2PSYGENET
TGM2C0334588Giant Cell Glioblastoma2CTD_human
TGM2C1621958Glioblastoma Multiforme2CTD_human
TGM2C0006118Brain Neoplasms1CTD_human
TGM2C0006142Malignant neoplasm of breast1CTD_human
TGM2C0007134Renal Cell Carcinoma1CTD_human
TGM2C0007570Celiac Disease1CTD_human
TGM2C0014859Esophageal Neoplasms1CTD_human
TGM2C0020538Hypertensive disease1CTD_human
TGM2C0029408Degenerative polyarthritis1CTD_human
TGM2C0030297Pancreatic Neoplasm1CTD_human
TGM2C0086743Osteoarthrosis Deformans1CTD_human
TGM2C0153633Malignant neoplasm of brain1CTD_human
TGM2C0279702Conventional (Clear Cell) Renal Cell Carcinoma1CTD_human
TGM2C0346647Malignant neoplasm of pancreas1CTD_human
TGM2C0496899Benign neoplasm of brain, unspecified1CTD_human
TGM2C0546837Malignant neoplasm of esophagus1CTD_human
TGM2C0678222Breast Carcinoma1CTD_human
TGM2C0750974Brain Tumor, Primary1CTD_human
TGM2C0750977Recurrent Brain Neoplasm1CTD_human
TGM2C0750979Primary malignant neoplasm of brain1CTD_human
TGM2C1257931Mammary Neoplasms, Human1CTD_human
TGM2C1266042Chromophobe Renal Cell Carcinoma1CTD_human
TGM2C1266043Sarcomatoid Renal Cell Carcinoma1CTD_human
TGM2C1266044Collecting Duct Carcinoma of the Kidney1CTD_human
TGM2C1306837Papillary Renal Cell Carcinoma1CTD_human
TGM2C1458155Mammary Neoplasms1CTD_human
TGM2C1527390Neoplasms, Intracranial1CTD_human
TGM2C4704874Mammary Carcinoma, Human1CTD_human