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Editing gene: BSG (CAeditome ID:682)

Gene summary for BSG

Gene summary

Gene information	Gene symbol	BSG
	Gene ID	682
	Gene name	basigin (Ok blood group)
	Synonyms	5F7\|CD147\|EMMPRIN\|EMPRIN\|HAb18G\|OK\|SLC7A11\|TCSF
	Cytomap	19p13.3
	Type of gene	protein-coding
	Description	basiginOK blood group antigencollagenase stimulatory factorextracellular matrix metalloproteinase inducerhepatoma-associated antigenleukocyte activation antigen M6tumor cell-derived collagenase stimulatory factor
	Modification date	20210531
	UniProtAcc	P35613
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
BSG	GO:0005886	Basigin	15946952
BSG	GO:0005886	Basigin	26195724
BSG	GO:0043231	Basigin	0000052

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RNA A-to-I events for BSG

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000172270.17

RNA A-to-I editing events in Cancer.

CAediting_1269446(576601, +), CAediting_1269447(576640, +), CAediting_1269448(576641, +), CAediting_1269449(577578, +), CAediting_1269450(578083, +), CAediting_1269451(578937, +), CAediting_1269452(582868, +), CAediting_1269453(582905, +), CAediting_1269454(583198, +),

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RNA editing positional annotations for BSG using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_1269446	chr19_576601_+	ncRNA_intronic
CAediting_1269447	chr19_576640_+	ncRNA_intronic
CAediting_1269448	chr19_576641_+	ncRNA_intronic
CAediting_1269449	chr19_577578_+	ncRNA_intronic
CAediting_1269450	chr19_578083_+	exonic
CAediting_1269451	chr19_578937_+	ncRNA_exonic
CAediting_1269452	chr19_582868_+	ncRNA_exonic
CAediting_1269453	chr19_582905_+	ncRNA_exonic
CAediting_1269454	chr19_583198_+	ncRNA_exonic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_1269446	chr19_576601_+	SINE	Alu	AluSg7
CAediting_1269447	chr19_576640_+	SINE	Alu	AluSg7
CAediting_1269448	chr19_576641_+	SINE	Alu	AluSg7
CAediting_1269451	chr19_578937_+	SINE	Alu	AluSc8

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RNA A-to-I editing events in the alternative splicing sites for BSG

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000172270.17.BSG.

Correlation between RNA A-to-I editing and PSI for ENSG00000172270.17.BSG.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for BSG

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for BSG

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for BSG

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1269453	chr19_582905_+	ENSG00000172270.17	ENST00000545507	hsa-miR-887-3p	582902	582908	7mer-m8	582889	582909	154.00	-20.48
CAediting_1269453	chr19_582905_+	ENSG00000172270.17	ENST00000346916	hsa-miR-887-3p	582902	582908	7mer-m8	582889	582909	154.00	-20.48
CAediting_1269453	chr19_582905_+	ENSG00000172270.17	ENST00000333511	hsa-miR-887-3p	582902	582908	7mer-m8	582889	582909	154.00	-20.48
CAediting_1269453	chr19_582905_+	ENSG00000172270.17	ENST00000353555	hsa-miR-887-3p	582902	582908	7mer-m8	582889	582909	154.00	-20.48
CAediting_1269453	chr19_582905_+	ENSG00000172270.17	ENST00000618006	hsa-miR-887-3p	582902	582908	7mer-m8	582889	582909	154.00	-20.48
CAediting_1269452	chr19_582868_+	ENSG00000172270.17	ENST00000545507	hsa-miR-519a-3p	582866	582872	7mer-m8	582852	582873	145.00	-10.65
CAediting_1269452	chr19_582868_+	ENSG00000172270.17	ENST00000545507	hsa-miR-519a-3p	582866	582872	7mer-m8	582852	582873	145.00	-10.65
CAediting_1269452	chr19_582868_+	ENSG00000172270.17	ENST00000545507	hsa-miR-519b-3p	582866	582872	7mer-m8	582852	582873	145.00	-10.05
CAediting_1269452	chr19_582868_+	ENSG00000172270.17	ENST00000545507	hsa-miR-519c-3p	582866	582872	7mer-m8	582852	582873	145.00	-10.14
CAediting_1269452	chr19_582868_+	ENSG00000172270.17	ENST00000346916	hsa-miR-519a-3p	582866	582872	7mer-m8	582852	582873	145.00	-10.65
CAediting_1269452	chr19_582868_+	ENSG00000172270.17	ENST00000346916	hsa-miR-519a-3p	582866	582872	7mer-m8	582852	582873	145.00	-10.65
CAediting_1269452	chr19_582868_+	ENSG00000172270.17	ENST00000346916	hsa-miR-519b-3p	582866	582872	7mer-m8	582852	582873	145.00	-10.05
CAediting_1269452	chr19_582868_+	ENSG00000172270.17	ENST00000346916	hsa-miR-519c-3p	582866	582872	7mer-m8	582852	582873	145.00	-10.14
CAediting_1269452	chr19_582868_+	ENSG00000172270.17	ENST00000333511	hsa-miR-519a-3p	582866	582872	7mer-m8	582852	582873	145.00	-10.65
CAediting_1269452	chr19_582868_+	ENSG00000172270.17	ENST00000333511	hsa-miR-519a-3p	582866	582872	7mer-m8	582852	582873	145.00	-10.65
CAediting_1269452	chr19_582868_+	ENSG00000172270.17	ENST00000333511	hsa-miR-519b-3p	582866	582872	7mer-m8	582852	582873	145.00	-10.05
CAediting_1269452	chr19_582868_+	ENSG00000172270.17	ENST00000333511	hsa-miR-519c-3p	582866	582872	7mer-m8	582852	582873	145.00	-10.14
CAediting_1269452	chr19_582868_+	ENSG00000172270.17	ENST00000353555	hsa-miR-519a-3p	582866	582872	7mer-m8	582852	582873	145.00	-10.65
CAediting_1269452	chr19_582868_+	ENSG00000172270.17	ENST00000353555	hsa-miR-519a-3p	582866	582872	7mer-m8	582852	582873	145.00	-10.65
CAediting_1269452	chr19_582868_+	ENSG00000172270.17	ENST00000353555	hsa-miR-519b-3p	582866	582872	7mer-m8	582852	582873	145.00	-10.05
CAediting_1269452	chr19_582868_+	ENSG00000172270.17	ENST00000353555	hsa-miR-519c-3p	582866	582872	7mer-m8	582852	582873	145.00	-10.14
CAediting_1269452	chr19_582868_+	ENSG00000172270.17	ENST00000618006	hsa-miR-519a-3p	582866	582872	7mer-m8	582852	582873	145.00	-10.65
CAediting_1269452	chr19_582868_+	ENSG00000172270.17	ENST00000618006	hsa-miR-519a-3p	582866	582872	7mer-m8	582852	582873	145.00	-10.65
CAediting_1269452	chr19_582868_+	ENSG00000172270.17	ENST00000618006	hsa-miR-519b-3p	582866	582872	7mer-m8	582852	582873	145.00	-10.05
CAediting_1269452	chr19_582868_+	ENSG00000172270.17	ENST00000618006	hsa-miR-519c-3p	582866	582872	7mer-m8	582852	582873	145.00	-10.14
CAediting_1269454	chr19_583198_+	ENSG00000172270.17	ENST00000545507	hsa-miR-1199-5p	583196	583202	7mer-m8	583185	583203	143.00	-20.95
CAediting_1269454	chr19_583198_+	ENSG00000172270.17	ENST00000545507	hsa-miR-4537	583194	583201	8mer-1a	583180	583201	151.00	-22.61
CAediting_1269454	chr19_583198_+	ENSG00000172270.17	ENST00000545507	hsa-miR-6751-3p	583196	583202	7mer-m8	583183	583203	140.00	-15.94
CAediting_1269454	chr19_583198_+	ENSG00000172270.17	ENST00000346916	hsa-miR-1199-5p	583196	583202	7mer-m8	583185	583203	143.00	-20.95
CAediting_1269454	chr19_583198_+	ENSG00000172270.17	ENST00000346916	hsa-miR-4537	583194	583201	8mer-1a	583180	583201	151.00	-22.61
CAediting_1269454	chr19_583198_+	ENSG00000172270.17	ENST00000346916	hsa-miR-6751-3p	583196	583202	7mer-m8	583183	583203	140.00	-15.94
CAediting_1269454	chr19_583198_+	ENSG00000172270.17	ENST00000333511	hsa-miR-1199-5p	583196	583202	7mer-m8	583185	583203	143.00	-20.95
CAediting_1269454	chr19_583198_+	ENSG00000172270.17	ENST00000333511	hsa-miR-4537	583194	583201	8mer-1a	583180	583201	151.00	-22.61
CAediting_1269454	chr19_583198_+	ENSG00000172270.17	ENST00000333511	hsa-miR-6751-3p	583196	583202	7mer-m8	583183	583203	140.00	-15.94
CAediting_1269454	chr19_583198_+	ENSG00000172270.17	ENST00000353555	hsa-miR-1199-5p	583196	583202	7mer-m8	583185	583203	143.00	-20.95
CAediting_1269454	chr19_583198_+	ENSG00000172270.17	ENST00000353555	hsa-miR-4537	583194	583201	8mer-1a	583180	583201	151.00	-22.61
CAediting_1269454	chr19_583198_+	ENSG00000172270.17	ENST00000353555	hsa-miR-6751-3p	583196	583202	7mer-m8	583183	583203	140.00	-15.94
CAediting_1269454	chr19_583198_+	ENSG00000172270.17	ENST00000618006	hsa-miR-1199-5p	583196	583202	7mer-m8	583185	583203	143.00	-20.95
CAediting_1269454	chr19_583198_+	ENSG00000172270.17	ENST00000618006	hsa-miR-4537	583194	583201	8mer-1a	583180	583201	151.00	-22.61
CAediting_1269454	chr19_583198_+	ENSG00000172270.17	ENST00000618006	hsa-miR-6751-3p	583196	583202	7mer-m8	583183	583203	140.00	-15.94

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1269453	chr19_582905_+	ENSG00000172270.17	ENST00000545507	hsa-miR-4531	582898	582904	7mer-m8	582889	582905	149	-16.56
CAediting_1269453	chr19_582905_+	ENSG00000172270.17	ENST00000346916	hsa-miR-4531	582898	582904	7mer-m8	582889	582905	149	-16.56
CAediting_1269453	chr19_582905_+	ENSG00000172270.17	ENST00000333511	hsa-miR-4531	582898	582904	7mer-m8	582889	582905	149	-16.56
CAediting_1269453	chr19_582905_+	ENSG00000172270.17	ENST00000353555	hsa-miR-4531	582898	582904	7mer-m8	582889	582905	149	-16.56
CAediting_1269453	chr19_582905_+	ENSG00000172270.17	ENST00000618006	hsa-miR-4531	582898	582904	7mer-m8	582889	582905	149	-16.56

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_1054808	chr15_66496985_-	ENSG00000172270.17	ENST00000545507	hsa-miR-4512	583101	583106	6mer	583087	583107	142	-26.08
CAediting_1229415	chr17_67471547_+	ENSG00000172270.17	ENST00000545507	hsa-miR-548aa	582987	582993	7mer-m8	582970	582994	150	-16.62
CAediting_1368054	chr19_46709310_-	ENSG00000172270.17	ENST00000545507	hsa-miR-320e	583386	583393	8mer-1a	583378	583393	147	-17.75
CAediting_86358	chr1_109598906_+	ENSG00000172270.17	ENST00000545507	hsa-miR-197-5p	583483	583489	7mer-m8	583468	583490	155	-27.06
CAediting_396018	chr5_1062918_-	ENSG00000172270.17	ENST00000545507	hsa-miR-4635	583274	583280	7mer-m8	583261	583281	141	-12.66
CAediting_1054808	chr15_66496985_-	ENSG00000172270.17	ENST00000346916	hsa-miR-4512	583101	583106	6mer	583087	583107	142	-26.08
CAediting_1229415	chr17_67471547_+	ENSG00000172270.17	ENST00000346916	hsa-miR-548aa	582987	582993	7mer-m8	582970	582994	150	-16.62
CAediting_1368054	chr19_46709310_-	ENSG00000172270.17	ENST00000346916	hsa-miR-320e	583386	583393	8mer-1a	583378	583393	147	-17.75
CAediting_86358	chr1_109598906_+	ENSG00000172270.17	ENST00000346916	hsa-miR-197-5p	583483	583489	7mer-m8	583468	583490	155	-27.06
CAediting_396018	chr5_1062918_-	ENSG00000172270.17	ENST00000346916	hsa-miR-4635	583274	583280	7mer-m8	583261	583281	141	-12.66
CAediting_1054808	chr15_66496985_-	ENSG00000172270.17	ENST00000333511	hsa-miR-4512	583101	583106	6mer	583087	583107	142	-26.08
CAediting_1229415	chr17_67471547_+	ENSG00000172270.17	ENST00000333511	hsa-miR-548aa	582987	582993	7mer-m8	582970	582994	150	-16.62
CAediting_1368054	chr19_46709310_-	ENSG00000172270.17	ENST00000333511	hsa-miR-320e	583386	583393	8mer-1a	583378	583393	147	-17.75
CAediting_86358	chr1_109598906_+	ENSG00000172270.17	ENST00000333511	hsa-miR-197-5p	583483	583489	7mer-m8	583468	583490	155	-27.06
CAediting_396018	chr5_1062918_-	ENSG00000172270.17	ENST00000333511	hsa-miR-4635	583274	583280	7mer-m8	583261	583281	141	-12.66
CAediting_1054808	chr15_66496985_-	ENSG00000172270.17	ENST00000353555	hsa-miR-4512	583101	583106	6mer	583087	583107	142	-26.08
CAediting_1229415	chr17_67471547_+	ENSG00000172270.17	ENST00000353555	hsa-miR-548aa	582987	582993	7mer-m8	582970	582994	150	-16.62
CAediting_1368054	chr19_46709310_-	ENSG00000172270.17	ENST00000353555	hsa-miR-320e	583386	583393	8mer-1a	583378	583393	147	-17.75
CAediting_86358	chr1_109598906_+	ENSG00000172270.17	ENST00000353555	hsa-miR-197-5p	583483	583489	7mer-m8	583468	583490	155	-27.06
CAediting_396018	chr5_1062918_-	ENSG00000172270.17	ENST00000353555	hsa-miR-4635	583274	583280	7mer-m8	583261	583281	141	-12.66
CAediting_1054808	chr15_66496985_-	ENSG00000172270.17	ENST00000618006	hsa-miR-4512	583101	583106	6mer	583087	583107	142	-26.08
CAediting_1229415	chr17_67471547_+	ENSG00000172270.17	ENST00000618006	hsa-miR-548aa	582987	582993	7mer-m8	582970	582994	150	-16.62
CAediting_1368054	chr19_46709310_-	ENSG00000172270.17	ENST00000618006	hsa-miR-320e	583386	583393	8mer-1a	583378	583393	147	-17.75
CAediting_396018	chr5_1062918_-	ENSG00000172270.17	ENST00000618006	hsa-miR-4635	583274	583280	7mer-m8	583261	583281	141	-12.66

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for BSG

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for BSG

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for BSG

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for BSG

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for BSG

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for BSG

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
BSG	C0015697	Arterial Fatty Streak	1	CTD_human
BSG	C0027626	Neoplasm Invasiveness	1	CTD_human
BSG	C0027627	Neoplasm Metastasis	1	CTD_human
BSG	C0027659	Neoplasms, Experimental	1	CTD_human
BSG	C0264956	Atheroma	1	CTD_human
BSG	C1862939	AMYOTROPHIC LATERAL SCLEROSIS 1	1	CTD_human
BSG	C1862941	Amyotrophic Lateral Sclerosis, Sporadic	1	CTD_human
BSG	C2936350	Plaque, Atherosclerotic	1	CTD_human
BSG	C2936351	Fibroatheroma	1	CTD_human
BSG	C4551993	Amyotrophic Lateral Sclerosis, Familial	1	CTD_human

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene