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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: STX4 (CAeditome ID:6810)

Gene summary for STX4

check button Gene summary
Gene informationGene symbol

STX4

Gene ID

6810

Gene namesyntaxin 4
SynonymsSTX4A|p35-2
Cytomap

16p11.2

Type of geneprotein-coding
Descriptionsyntaxin-4renal carcinoma antigen NY-REN-31syntaxin 4A (placental)
Modification date20210518
UniProtAcc

Q12846

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
STX4

GO:0034599

Syntaxin-4

22226963

STX4

GO:0035774

Syntaxin-4

24552216

STX4

GO:0048284

Syntaxin-4

20434989

STX4

GO:0060291

Syntaxin-4

20434989

STX4

GO:1903575

Syntaxin-4

22226963

STX4

GO:0005615

Syntaxin-4

22226963

STX4

GO:0005768

Syntaxin-4

20956541

STX4

GO:0005886

Syntaxin-4

0000052

STX4

GO:0005886

Syntaxin-4

20956541

STX4

GO:0005886

Syntaxin-4

21720706

STX4

GO:0009986

Syntaxin-4

15576373

STX4

GO:0009986

Syntaxin-4

20434989

STX4

GO:0016020

Syntaxin-4

7690687

STX4

GO:0016323

Syntaxin-4

16339081

STX4

GO:0030027

Syntaxin-4

21720706

STX4

GO:0036477

Syntaxin-4

20434989

STX4

GO:0042581

Syntaxin-4

18588921

STX4

GO:0043197

Syntaxin-4

20434989

STX4

GO:0045202

Syntaxin-4

20434989

STX4

GO:0098794

Syntaxin-4

27662481

STX4

GO:0098978

Syntaxin-4

27662481

STX4

GO:0031201

Syntaxin-4

12130530

STX4

GO:0031201

Syntaxin-4

19546860


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RNA A-to-I events for STX4

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000103496.13
boxplot

check button RNA A-to-I editing events in Cancer.
CAediting_1112048(31035489, +), CAediting_1112049(31035786, +), CAediting_1112050(31036040, +), CAediting_1112051(31036062, +), CAediting_1112052(31036949, +), CAediting_1112053(31036953, +), CAediting_1112054(31037238, +), CAediting_1112055(31037344, +), CAediting_1112056(31040722, +), CAediting_1112057(31040725, +), CAediting_1112058(31040726, +), CAediting_1112059(31040731, +), CAediting_1112060(31040748, +), CAediting_1112061(31040752, +), CAediting_1112062(31040774, +), CAediting_1112063(31040790, +), CAediting_1112064(31040841, +), CAediting_1112065(31040845, +), CAediting_1112066(31040852, +), CAediting_1112067(31040857, +), CAediting_1112068(31040873, +), CAediting_1112069(31040877, +), CAediting_1112070(31040884, +), CAediting_1112071(31040890, +), CAediting_1112072(31040897, +), CAediting_1112073(31040908, +), CAediting_1112074(31040913, +), CAediting_1112075(31040921, +), CAediting_1112076(31040929, +), CAediting_1112077(31040937, +), CAediting_1112078(31040953, +), CAediting_1112079(31040968, +), CAediting_1112080(31040970, +), CAediting_1112081(31040972, +), CAediting_1112082(31040976, +), CAediting_1112083(31041191, +), CAediting_1112084(31041197, +), CAediting_1112085(31041215, +), CAediting_1112086(31041222, +), CAediting_1112087(31041246, +), CAediting_1112088(31041252, +), CAediting_1112089(31041289, +), CAediting_1112090(31041301, +), CAediting_1112091(31041337, +), CAediting_1112092(31041353, +), CAediting_1112093(31041378, +), CAediting_1112094(31041428, +), CAediting_1112095(31041429, +), CAediting_1112096(31041441, +), CAediting_1112097(31041562, +), CAediting_1112098(31041564, +), CAediting_1112099(31041566, +), CAediting_1112100(31041568, +), CAediting_1112101(31041617, +), CAediting_1112102(31041623, +), CAediting_1112103(31041647, +), CAediting_1112104(31041660, +), CAediting_1112105(31041667, +), CAediting_1112106(31041672, +), CAediting_1112107(31041684, +), CAediting_1112108(31041727, +), CAediting_1112109(31041751, +), CAediting_1112110(31041782, +), CAediting_1112111(31041787, +), CAediting_1112112(31041788, +), CAediting_1112113(31041807, +), CAediting_1112114(31041825, +), CAediting_1112115(31041837, +), CAediting_1112116(31041844, +), CAediting_1112117(31041849, +), CAediting_1112118(31041892, +), CAediting_1112119(31041914, +), CAediting_1112120(31041968, +), CAediting_1112121(31041969, +), CAediting_1112122(31041981, +),

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RNA editing positional annotations for STX4 using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_1112048chr16_31035489_+ncRNA_intronic
CAediting_1112049chr16_31035786_+ncRNA_intronic
CAediting_1112050chr16_31036040_+ncRNA_intronic
CAediting_1112051chr16_31036062_+ncRNA_intronic
CAediting_1112052chr16_31036949_+ncRNA_intronic
CAediting_1112053chr16_31036953_+ncRNA_intronic
CAediting_1112054chr16_31037238_+ncRNA_intronic
CAediting_1112055chr16_31037344_+ncRNA_intronic
CAediting_1112056chr16_31040722_+ncRNA_intronic
CAediting_1112057chr16_31040725_+ncRNA_intronic
CAediting_1112058chr16_31040726_+ncRNA_intronic
CAediting_1112059chr16_31040731_+ncRNA_intronic
CAediting_1112060chr16_31040748_+ncRNA_intronic
CAediting_1112061chr16_31040752_+ncRNA_intronic
CAediting_1112062chr16_31040774_+ncRNA_intronic
CAediting_1112063chr16_31040790_+ncRNA_intronic
CAediting_1112064chr16_31040841_+ncRNA_intronic
CAediting_1112065chr16_31040845_+ncRNA_intronic
CAediting_1112066chr16_31040852_+ncRNA_intronic
CAediting_1112067chr16_31040857_+ncRNA_intronic
CAediting_1112068chr16_31040873_+ncRNA_intronic
CAediting_1112069chr16_31040877_+ncRNA_intronic
CAediting_1112070chr16_31040884_+ncRNA_intronic
CAediting_1112071chr16_31040890_+ncRNA_intronic
CAediting_1112072chr16_31040897_+ncRNA_intronic
CAediting_1112073chr16_31040908_+ncRNA_intronic
CAediting_1112074chr16_31040913_+ncRNA_intronic
CAediting_1112075chr16_31040921_+ncRNA_intronic
CAediting_1112076chr16_31040929_+ncRNA_intronic
CAediting_1112077chr16_31040937_+ncRNA_intronic
CAediting_1112078chr16_31040953_+ncRNA_intronic
CAediting_1112079chr16_31040968_+ncRNA_intronic
CAediting_1112080chr16_31040970_+ncRNA_intronic
CAediting_1112081chr16_31040972_+ncRNA_intronic
CAediting_1112082chr16_31040976_+ncRNA_intronic
CAediting_1112083chr16_31041191_+ncRNA_intronic
CAediting_1112084chr16_31041197_+ncRNA_intronic
CAediting_1112085chr16_31041215_+ncRNA_intronic
CAediting_1112086chr16_31041222_+ncRNA_intronic
CAediting_1112087chr16_31041246_+ncRNA_intronic
CAediting_1112088chr16_31041252_+ncRNA_intronic
CAediting_1112089chr16_31041289_+ncRNA_intronic
CAediting_1112090chr16_31041301_+ncRNA_intronic
CAediting_1112091chr16_31041337_+ncRNA_intronic
CAediting_1112092chr16_31041353_+ncRNA_intronic
CAediting_1112093chr16_31041378_+ncRNA_intronic
CAediting_1112094chr16_31041428_+ncRNA_intronic
CAediting_1112095chr16_31041429_+ncRNA_intronic
CAediting_1112096chr16_31041441_+ncRNA_intronic
CAediting_1112097chr16_31041562_+ncRNA_intronic
CAediting_1112098chr16_31041564_+ncRNA_intronic
CAediting_1112099chr16_31041566_+ncRNA_intronic
CAediting_1112100chr16_31041568_+ncRNA_intronic
CAediting_1112101chr16_31041617_+ncRNA_intronic
CAediting_1112102chr16_31041623_+ncRNA_intronic
CAediting_1112103chr16_31041647_+ncRNA_intronic
CAediting_1112104chr16_31041660_+ncRNA_intronic
CAediting_1112105chr16_31041667_+ncRNA_intronic
CAediting_1112106chr16_31041672_+ncRNA_intronic
CAediting_1112107chr16_31041684_+ncRNA_intronic
CAediting_1112108chr16_31041727_+ncRNA_intronic
CAediting_1112109chr16_31041751_+ncRNA_intronic
CAediting_1112110chr16_31041782_+ncRNA_intronic
CAediting_1112111chr16_31041787_+ncRNA_intronic
CAediting_1112112chr16_31041788_+ncRNA_intronic
CAediting_1112113chr16_31041807_+ncRNA_intronic
CAediting_1112114chr16_31041825_+ncRNA_intronic
CAediting_1112115chr16_31041837_+ncRNA_intronic
CAediting_1112116chr16_31041844_+ncRNA_intronic
CAediting_1112117chr16_31041849_+ncRNA_intronic
CAediting_1112118chr16_31041892_+ncRNA_exonic
CAediting_1112119chr16_31041914_+ncRNA_exonic
CAediting_1112120chr16_31041968_+ncRNA_exonic
CAediting_1112121chr16_31041969_+ncRNA_exonic
CAediting_1112122chr16_31041981_+ncRNA_exonic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_1112048chr16_31035489_+SINEAluAluSx
CAediting_1112049chr16_31035786_+SINEAluAluSz
CAediting_1112050chr16_31036040_+SINEAluAluSz
CAediting_1112051chr16_31036062_+SINEAluAluSz
CAediting_1112052chr16_31036949_+LINEL2L2a
CAediting_1112053chr16_31036953_+SINEAluAluJo
CAediting_1112054chr16_31037238_+SINEAluAluSx1
CAediting_1112055chr16_31037344_+SINEAluAluSx1
CAediting_1112056chr16_31040722_+SINEAluAluJb
CAediting_1112057chr16_31040725_+SINEAluAluJb
CAediting_1112058chr16_31040726_+SINEAluAluJb
CAediting_1112059chr16_31040731_+SINEAluAluJb
CAediting_1112060chr16_31040748_+SINEAluAluJb
CAediting_1112061chr16_31040752_+SINEAluAluJb
CAediting_1112062chr16_31040774_+SINEAluAluJb
CAediting_1112063chr16_31040790_+SINEAluAluJb
CAediting_1112064chr16_31040841_+SINEAluAluJb
CAediting_1112065chr16_31040845_+SINEAluAluJb
CAediting_1112066chr16_31040852_+SINEAluAluJb
CAediting_1112067chr16_31040857_+SINEAluAluJb
CAediting_1112068chr16_31040873_+SINEAluAluJb
CAediting_1112069chr16_31040877_+SINEAluAluJb
CAediting_1112070chr16_31040884_+SINEAluAluJb
CAediting_1112071chr16_31040890_+SINEAluAluJb
CAediting_1112072chr16_31040897_+SINEAluAluJb
CAediting_1112073chr16_31040908_+SINEAluAluJb
CAediting_1112074chr16_31040913_+SINEAluAluJb
CAediting_1112075chr16_31040921_+SINEAluAluJb
CAediting_1112076chr16_31040929_+SINEAluAluJb
CAediting_1112077chr16_31040937_+SINEAluAluJb
CAediting_1112078chr16_31040953_+SINEAluAluJb
CAediting_1112079chr16_31040968_+SINEAluAluJb
CAediting_1112080chr16_31040970_+SINEAluAluJb
CAediting_1112081chr16_31040972_+SINEAluAluJb
CAediting_1112082chr16_31040976_+SINEAluAluJb
CAediting_1112083chr16_31041191_+SINEAluAluYk3
CAediting_1112084chr16_31041197_+SINEAluAluYk3
CAediting_1112085chr16_31041215_+SINEAluAluYk3
CAediting_1112086chr16_31041222_+SINEAluAluYk3
CAediting_1112087chr16_31041246_+SINEAluAluYk3
CAediting_1112088chr16_31041252_+SINEAluAluYk3
CAediting_1112089chr16_31041289_+SINEAluAluYk3
CAediting_1112090chr16_31041301_+SINEAluAluYk3
CAediting_1112091chr16_31041337_+SINEAluAluYk3
CAediting_1112092chr16_31041353_+SINEAluAluYk3
CAediting_1112093chr16_31041378_+SINEAluAluYk3
CAediting_1112094chr16_31041428_+SINEAluAluYk3
CAediting_1112095chr16_31041429_+SINEAluAluYk3
CAediting_1112096chr16_31041441_+SINEAluAluYk3
CAediting_1112097chr16_31041562_+SINEAluAluYh3
CAediting_1112098chr16_31041564_+SINEAluAluYh3
CAediting_1112099chr16_31041566_+SINEAluAluYh3
CAediting_1112100chr16_31041568_+SINEAluAluYh3
CAediting_1112101chr16_31041617_+SINEAluAluYh3
CAediting_1112102chr16_31041623_+SINEAluAluYh3
CAediting_1112103chr16_31041647_+SINEAluAluYh3
CAediting_1112104chr16_31041660_+SINEAluAluYh3
CAediting_1112105chr16_31041667_+SINEAluAluYh3
CAediting_1112106chr16_31041672_+SINEAluAluYh3
CAediting_1112107chr16_31041684_+SINEAluAluYh3
CAediting_1112108chr16_31041727_+SINEAluAluY
CAediting_1112109chr16_31041751_+SINEAluAluY
CAediting_1112110chr16_31041782_+SINEAluAluY
CAediting_1112111chr16_31041787_+SINEAluAluY
CAediting_1112112chr16_31041788_+SINEAluAluY
CAediting_1112113chr16_31041807_+SINEAluAluY
CAediting_1112114chr16_31041825_+SINEAluAluY
CAediting_1112115chr16_31041837_+SINEAluAluY
CAediting_1112116chr16_31041844_+SINEAluAluY
CAediting_1112117chr16_31041849_+SINEAluAluY
CAediting_1112118chr16_31041892_+SINEAluAluY
CAediting_1112119chr16_31041914_+SINEAluAluY
CAediting_1112120chr16_31041968_+SINEAluAluY
CAediting_1112121chr16_31041969_+SINEAluAluY
CAediting_1112122chr16_31041981_+SINEAluAluY

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RNA A-to-I editing events in the alternative splicing sites for STX4

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000103496.13.STX4.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000103496.13.STX4.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for STX4

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.
boxplot

check button Correlation between RNA A-to-I editing and gene expression.
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.
BRCA.CAediting_1112063.ENSG00000103496.STX4.png
Soverview
KIRC.CAediting_1112065.ENSG00000103496.STX4.png
Soverview
KIRC.CAediting_1112074.ENSG00000103496.STX4.png
Soverview
KIRC.CAediting_1112080.ENSG00000103496.STX4.png
Soverview
LAML.CAediting_1112080.ENSG00000103496.STX4.png
Soverview

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Protein coding region RNA A-to-I editings for STX4

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for STX4

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_1351755chr19_40282625_-ENSG00000103496.13ENST00000613541hsa-miR-64131034665310346706mer3103464831034671140-16.54

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for STX4

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for STX4

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
BRCACAediting_1112063chr16_31040790_+0.01927668563876520.135731887759423....
THCACAediting_1112063chr16_31040790_+0.01241638532336290.202351683086024....
BRCACAediting_1112065chr16_31040845_+0.001686649441082470.251853530294934....
LUADCAediting_1112065chr16_31040845_+0.007804342393526710.306987710178495....
BRCACAediting_1112067chr16_31040857_+0.0007840450470229940.294288913341068....
LUADCAediting_1112067chr16_31040857_+0.0202832426890920.28959385315764....
STADCAediting_1112067chr16_31040857_+0.009621449294046450.334465633048309....
THCACAediting_1112067chr16_31040857_+0.0201982731773050.277137476049039....
OVCAediting_1112067chr16_31040857_+0.01818255847833080.252749625127248....
KIRPCAediting_1112073chr16_31040908_+....0.03206989520026740.277114441787819
OVCAediting_1112073chr16_31040908_+0.01889930085689570.307429777557309....
GBMCAediting_1112074chr16_31040913_+....0.0319169575239090.279697166669503
BRCACAediting_1112080chr16_31040970_+0.00351156153190980.172972334500776....
THCACAediting_1112080chr16_31040970_+0.01783572541890160.188872018776157....
KIRPCAediting_1112080chr16_31040970_+0.02942635729185590.214689263043424....

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Relation with cancer stages for STX4

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.
BRCApathologic_stageCAediting_1112074chr16_31040913_+0.04776752359260190.144569707545606
KIRCpathologic_stageCAediting_1112067chr16_31040857_+0.001076082958126530.230695526484615
KIRCpathologic_stageCAediting_1112073chr16_31040908_+0.01945922746403540.162703400382357
OVclinical_stageCAediting_1112067chr16_31040857_+0.02697093014410290.239954389283436
THCApathologic_stageCAediting_1112112chr16_31041788_+0.006453862726879350.237752408871168

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Relation with survival for STX4

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR
LGGCAediting_1112112chr16_31041788_+0.003989429805586480.00364677.93697e-07
KIRCCAediting_1112058chr16_31040726_+0.02821427456970580.0254229541327

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RelatedDrugs for STX4

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for STX4

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource